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Gene Dmel\Spn88Ea

General Information
Symbol	Dmel\Spn88Ea	Species	D. melanogaster
Name	Serpin 88Ea	Annotation symbol	CG18525
Feature type	protein_coding_gene	FlyBase ID	FBgn0028984
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	sp5, spn5
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88E3-88E3	Sequence location	3R:11,028,791..11,032,169 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serpin 88Ea is referred to in FlyBase by the symbol Dmel\Spn88Ea (CG18525, FBgn0028984). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing expansion; negative regulation of Toll signaling pathway. 9 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protease inhibitor I4, serpin, conserved site; Serpin domain; Serpin family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval hindgut, larval trachea, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult heart, larval salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636943_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Spn5. Gene sequence location is 3R:11028791..11032169.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms negative regulation of endopeptidase activity regulation of proteolysis
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E3-88E3   Limits computationally determined from genome sequence between P{EP}CG33967EP666 and P{lacW}Hsc70-4L3929
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88E3-88E5   (determined by in situ hybridisation)   (Han et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spn88Ea for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spn88Ea-RA FBtr0083141  NM_080215   1521   427 Spn88Ea-RB FBtr0083142  NM_176501   1518   427
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spn88Ea-PA   FBpp0082595   48.5   427   5.23     NP_524954   AAF55138 Spn88Ea-PB   FBpp0082596   48.5   427   5.23     NP_788678   AAO41566
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Protease inhibitor I4, serpin, conserved site (IPR023795) Serpin domain (IPR023796)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202738   AA390967   AA392212   AA979707   AE014297 AAF55138   AE014297 AAO41566   AI107882   AI238189   AI238401   AI257544   AI257713   AI258969   AI260936   AI295572   AI513307   AJ251748 CAB63100   AY094712 AAM11065   BG640095   BG640400   BG641214   BG641372   BG641421   BI168933   BI234562   BI486453   CA806594   CK132037   CO177239   CO282935   CO287478   CO306833   CO335605   CO335870   CO336889   CO337531   CO337693   CO338299   CZ466987   CZ466988   EC087656   EC197736   EC210986   EC249287   EC261495   EC264098   EC267933   EC267949   EC267997   GH948356   GH948852   GH950140   GH952601   GH953897   GH958457   GH962275   GH963353   GH967198   GH977128   GH977826   GH978300   GH980153
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VFC2 Q9U1I4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Arbeitman et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   • cytoplasm | basal (Fisher et al., 2012) Comment:apically cleared embryonic stage 13 -- 16   atrium   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval dorsal branch   (Fisher et al., 2012) embryonic/larval dorsal trunk   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) embryonic/larval visceral branch   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval hindgut, larval trachea, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult heart, larval salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea    3063.65 Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca    1133.9 Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut  536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea  (3063.65) Larval Carcass    452.425 Adult Head  (553.9) Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca  (997.1) Adult InseminatedFemale Spermatheca  (1133.9) Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea  (3063.65) Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca  (1133.9) Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea    3063.65 Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca    1133.9 Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea    3063.65 Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca    1133.9 Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut  536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea  (3063.65) Larval Carcass    452.425 Adult Head  553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca  (997.1) Adult InseminatedFemale Spermatheca  (1133.9) Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea  (3063.65) Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca  1133.9 Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    184.125 Larval Midgut    38.2 Larval Hindgut    536.9 Larval Malpighian Tubules    12.2 Larval Fat Body    20.8 Larval Salivary Gland    114 Larval Trachea    3063.65 Larval Carcass    452.425 Adult Head    553.9 Adult Eye    329.125 Adult Brain    300.7 Adult Thoracic-Abdominal Ganglion    374.7 Adult Crop    294.2 Adult Midgut    13.6 Adult Hindgut    307.2 Adult Malpighian Tubules    12 Adult Fat Body    85.1 Adult Salivary Gland    71.8 Adult Heart    296.05 Adult VirginFemale Spermatheca    997.1 Adult InseminatedFemale Spermatheca    1133.9 Adult Ovary    301.9 Adult Testis    41.7 Adult Male Accessory Gland    119.7 Adult Carcass    226.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    553.9   NA  Eye    329.125   NA  Brain    300.7   184.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    374.7   NA  Crop    294.2   no informative data  Midgut    no informative data   536.9  Hindgut    307.2   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   114  Salivary Gland    no informative data   NA  Heart    296.05   3063.65  Trachea    NA   NA  VirginFemale Spermatheca    997.1   NA  InseminatedFemale Spermatheca    1133.9   NA  Ovary    301.9   NA  Testis    no informative data   NA  Male Accessory Gland    119.7   452.425  Carcass    226.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8  (28) head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male  (32) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8  (57) carcass, larvae L3 wandering  (42) carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female  (28) ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8  28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male  32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8  (57) carcass, larvae L3 wandering  (42) carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female  28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    11 central nervous system, pupae P8    28 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    20 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    14 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    57 carcass, larvae L3 wandering    42 carcass, 1-day adult    13 carcass, 4-day adult    19 carcass, 20-day adult    20 ovary, virgin 4-day female    28 ovary, mated 4-day female    18 testis, mated 4-day male    8 accessory gland, mated 4-day male    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr    131 embryo 16-18hr    250 embryo 18-20hr    127 embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new    127 white prepupae 12hr    175 white prepupae 24hr    95 pupae 2d postWPP    246 pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (85) embryo 02-04hr  (71) embryo 04-06hr  (27) embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr  (36) embryo 12-14hr  (39) embryo 14-16hr  (131) embryo 16-18hr  (250) embryo 18-20hr  (127) embryo 20-22hr  (51) embryo 22-24hr  (68) larva L1  (33) larva L2  (85) larva L3 12hr old  (60) larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (46) larva L3 puffstage 7-9  (70) white prepupae new  (127) white prepupae 12hr  (175) white prepupae 24hr  (95) pupae 2d postWPP  (246) pupae 3d postWPP  (73) pupae 4d postWPP  (74) adult male 01day  (27) adult male 05day  (33) adult male 30day  (39) adult female 01day  (53) adult female 05day  (56) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr  (131) embryo 16-18hr  (250) embryo 18-20hr  (127) embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new  (127) white prepupae 12hr  (175) white prepupae 24hr    95 pupae 2d postWPP  (246) pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr    131 embryo 16-18hr    250 embryo 18-20hr    127 embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new    127 white prepupae 12hr    175 white prepupae 24hr    95 pupae 2d postWPP    246 pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr    131 embryo 16-18hr    250 embryo 18-20hr    127 embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new    127 white prepupae 12hr    175 white prepupae 24hr    95 pupae 2d postWPP    246 pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (85) embryo 02-04hr  (71) embryo 04-06hr  27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr  (36) embryo 12-14hr  (39) embryo 14-16hr  (131) embryo 16-18hr  (250) embryo 18-20hr  (127) embryo 20-22hr  (51) embryo 22-24hr  (68) larva L1  (33) larva L2  (85) larva L3 12hr old  (60) larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (46) larva L3 puffstage 7-9  (70) white prepupae new  (127) white prepupae 12hr  (175) white prepupae 24hr  (95) pupae 2d postWPP  (246) pupae 3d postWPP  (73) pupae 4d postWPP  (74) adult male 01day  27 adult male 05day  (33) adult male 30day  (39) adult female 01day  (53) adult female 05day  (56) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr  131 embryo 16-18hr  (250) embryo 18-20hr  127 embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new  127 white prepupae 12hr  (175) white prepupae 24hr    95 pupae 2d postWPP  (246) pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    85 embryo 02-04hr    71 embryo 04-06hr    27 embryo 06-08hr    11 embryo 08-10hr    22 embryo 10-12hr    36 embryo 12-14hr    39 embryo 14-16hr    131 embryo 16-18hr    250 embryo 18-20hr    127 embryo 20-22hr    51 embryo 22-24hr    68 larva L1    33 larva L2    85 larva L3 12hr old    60 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    46 larva L3 puffstage 7-9    70 white prepupae new    127 white prepupae 12hr    175 white prepupae 24hr    95 pupae 2d postWPP    246 pupae 3d postWPP    73 pupae 4d postWPP    74 adult male 01day    27 adult male 05day    33 adult male 30day    39 adult female 01day    53 adult female 05day    56 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1    111 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    164 ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4  (34) embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1  (111) embryonic S3    12 leg disc CME L1  26 wing disc CME-W2  (63) wing disc ML-DmD8  (28) wing disc ML-DmD9  (43) wing disc ML-DmD16-c3  (57) wing disc ML-DmD21  (42) wing disc ML-DmD32  (70) haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (69) mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (164) ovary fGS/OSS  26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1  (111) embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (164) ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1    111 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    164 ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1    111 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    164 ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (120) Schneider line 2 Sg4  (34) embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1  (111) embryonic S3    12 leg disc CME L1  26 wing disc CME-W2  (63) wing disc ML-DmD8  28 wing disc ML-DmD9  (43) wing disc ML-DmD16-c3  (57) wing disc ML-DmD21  (42) wing disc ML-DmD32  (70) haltere disc ML-DmD17-c3  (46) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (69) mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1  (127) CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (164) ovary fGS/OSS  26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  120 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1  111 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1  127 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (164) ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    120 Schneider line 2 Sg4    34 embryonic 1182-4H    22 embryonic GM2    16 embryonic Kc167    25 embryonic S1    111 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    63 wing disc ML-DmD8    28 wing disc ML-DmD9    43 wing disc ML-DmD16-c3    57 wing disc ML-DmD21    42 wing disc ML-DmD32    70 haltere disc ML-DmD17-c3    46 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    127 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    164 ovary fGS/OSS    26 ovary OSC    15 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (27) Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH14439 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028984 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18525-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Spn88Ea Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Spn88EaGD12724 Other Phenotypes Allele short lived, with Scer\GAL4da.G32 Spn88EadsRNA.Scer\UAS.P\T Phenotype manifest in Allele wing, with Scer\GAL4da.G32 Spn88EadsRNA.Scer\UAS.P\T
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Spn88Ea Class Mutagen Stocks Known lesion Spn88Eac01214 piggyBac transposase 2 -- Spn88EaGS9853 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spn88Ea Class Mutagen Stocks Known lesion Spn88EaGD12724 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Spn88EaGL01344 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn88EaHMS01371 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn88EadsRNA.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Spn88EaScer\UAS.cAa in vitro construct - regulatory fusion 0 Yes Spn88EaScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Spn88EaΔsig.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)ED5664 (Ahmad et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL01344} NA P{UASp-Spn88Ea.RNAi} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Spn88Eac01214 NA insertion of mobile activating element P{GSV6}Spn88EaGS9853 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing expansion inferred from mutant phenotype (Charron et al., 2008) negative regulation of Toll signaling pathway inferred from mutant phenotype (Ahmad et al., 2009)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) non-traceable author statement (Hashimoto, 1999.12.9)
Biological Process
CV term Evidence References
negative regulation of endopeptidase activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) negative regulation of proteolysis inferred from sequence model (Garrett et al., 2009) regulation of proteolysis inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Spn88Ea - CG11911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spn88Ea allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72475 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028984 DroID - A comprehensive database of gene and protein interactions. • FBgn0028984 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49804
Orthologs
OrthoDB Orthologs (65) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BRX5P Dipteran inclusive ortholog search EOG680J5F Insect inclusive ortholog search EOG68PKFV Arthropod inclusive ortholog search EOG6XWDDG Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6BRX5P)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Spn88Ea     Drosophila simulans   Dsim\GD20378 Y   Drosophila sechellia   Dsec\GM25802 Y   Drosophila erecta   Dere\GG20858 Y   Drosophila yakuba   Dyak\GE26407 Y   Drosophila ananassae   Dana\GF17157 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14973 Y   Drosophila persimilis   Dper\GL21686 Y   Drosophila willistoni   Dwil\GK13977 Y   Drosophila virilis   Dvir\GJ10214 Y   Drosophila mojavensis   Dmoj\GI23459 Y   Drosophila grimshawi   Dgri\GH18614 Y
Orthologs in non-Drosophila Dipterans (EOG680J5F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008364 Y Anopheles gambiae Malaria mosquito  Agam\SRPN15 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017784 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000472 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801862 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013111 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011775 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005227 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003759 Y
Orthologs in non-Dipteran Insects (EOG68PKFV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\serpin-5 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019672 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22071 Y Atta cephalotes Leafcutter ant  Acep\ACEP15159 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17033 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21262 Y Linepithema humile Argentine ant  Lhum\LH17996 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB10773 Y Solenopsis invicta Red fire ant  Sinv\SINV21480 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI30247 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004516 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007729 Y Pediculus humanus Human body louse  Phum\PHUM075870 Y Tribolium castaneum Red flour beetle  Tcas\serpin28 Y
Orthologs in non-Insect Arthropods (EOG6XWDDG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Csda Y Daphnia pulex Water flea  Dpux\RHBG Y Daphnia pulex Water flea  Dpux\cyp-33d3 Y Ixodes scapularis Deer tick  Isca\ISCW018607 Y Ixodes scapularis Deer tick  Isca\ISCW011013 Y Ixodes scapularis Deer tick  Isca\ISCW014779 Y Ixodes scapularis Deer tick  Isca\ISCW005088 Y Ixodes scapularis Deer tick  Isca\ISCW023623 Y Ixodes scapularis Deer tick  Isca\ISCW024342 Y Ixodes scapularis Deer tick  Isca\ISCW000427 Y Ixodes scapularis Deer tick  Isca\ISCW014652 Y Ixodes scapularis Deer tick  Isca\ISCW023624 Y Ixodes scapularis Deer tick  Isca\ISCW009616 Y Ixodes scapularis Deer tick  Isca\ISCW004156 Y Ixodes scapularis Deer tick  Isca\ISCW023618 Y Ixodes scapularis Deer tick  Isca\ISCW023620 Y Ixodes scapularis Deer tick  Isca\ISCW024109 Y Ixodes scapularis Deer tick  Isca\ISCW024046 Y Ixodes scapularis Deer tick  Isca\ISCW024387 Y Ixodes scapularis Deer tick  Isca\ISCW024435 Y Ixodes scapularis Deer tick  Isca\ISCW015198 Y Ixodes scapularis Deer tick  Isca\ISCW024495 Y Ixodes scapularis Deer tick  Isca\ISCW024500 Y Ixodes scapularis Deer tick  Isca\ISCW011017 Y Ixodes scapularis Deer tick  Isca\ISCW023619 Y Ixodes scapularis Deer tick  Isca\ISCW023617 Y Ixodes scapularis Deer tick  Isca\ISCW024013 Y Ixodes scapularis Deer tick  Isca\ISCW023622 Y Ixodes scapularis Deer tick  Isca\ISCW023621 Y Ixodes scapularis Deer tick  Isca\ISCW015204 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20378 Drosophila sechellia Dsec\GM25802 Drosophila erecta Dere\GG20858 Drosophila yakuba Dyak\GE26407 Drosophila ananassae Dana\GF17157 Drosophila pseudoobscura pseudoobscura Dpse\GA14973 Drosophila persimilis Dper\GL21686 Drosophila willistoni Dwil\GK13977 Drosophila virilis Dvir\GJ10214 Drosophila mojavensis Dmoj\GI23459 Drosophila grimshawi Dgri\GH18614
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	42485 y1 v1; P{TRiP.GL01344}attP40 34381 y1 sc* v1; P{TRiP.HMS01371}attP2 10425 w1118; PBac{PB}Spn88Eac01214/TM6B, Tb1
Harvard	- PBac{PB}Spn88Eac01214
VDRC	v28340 w1118; P{GD12724}v28340 v29048 w1118; P{GD12724}v29048/TM3
Genomic Clones ( 1 )
	BACR32A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14439
Other clones	DPiM_GH14439
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05759 GH14194 LD02956 LD09724 LD11594 LD26348 LP02280 LP04972 LP05945 LP06165 LP09245 LP13240 RE09845 RE30279 RE69880 SD11043 SD11410 SD12496 SD12694 SD12755
Other clones	1504 45756 101303 146344 542538 561948 569203 569535 571250 EK053002 EK065946 EK161811 EK252531 EN10821 EN11403 EN13432 EN14733 EN15112 EN16430 ESG014a.E21_E02 RP004033021 RP004122399 RP004141848 RP004176775 RP004192738 RP004199859 RP004245174 RP004261769 RP004276973 RP004301117 RP004471242 RP004515390 RP004528025
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49804
Antibody Information
	polyclonal (Ahmad et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Spn88Ea Spn5 (Hashimoto et al., 2012.10.8)
Source for database merge of	Source for merge of: sp5 CG18525 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080215 NM_176501 RefSeq (Proteins) • NP_524954 NP_788678 DDBJ / EMBL / GenBank • AA392212 AAF55138 AAM11065 AAO41566 AI238401 AI513307 AJ251748 AY094712 CAB63100 CZ466987 CZ466988 Entrez Gene - A searchable database of RefSeq genes. • 49804 UniProtKB/TrEMBL • Q9U1I4 Q9VFC2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Protease inhibitor I4, serpin, conserved site (IPR023795) Serpin domain (IPR023796) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH14439
Linkouts
	BioGRID - A database of protein and genetic interactions • 72475 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028984 DroID - A comprehensive database of gene and protein interactions. • FBgn0028984 DRSC - Results from RNAi screens. • FBgn0028984 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028984 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18525-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028984 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49804 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49804 modMine - Data generated by the modENCODE project. • FBgn0028984
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG18525 (Karlsson et al., 2004, Arbeitman et al., 2004, De Gregorio et al., 2002, Irving et al., 2001, De Gregorio et al., 2001, Allen and Spradling, 2008, Ahmad et al., 2009, Garrett et al., 2009, Ellis and Carney, 2011, Ni et al., 2010.12.1, Wong et al., 2012) sp5 (Irving et al., 2001, Han et al., 2000, ) Sp5 (De Gregorio et al., 2001, Christophides et al., 2002) spn5 (Ahmad et al., 2009) Spn5 (Ellis and Carney, 2011, Takemori and Yamamoto, 2009, Ahmad et al., 2009, Charron et al., 2008) Spn88Ea (Garrett et al., 2009, Reichhart et al., 2011, Hashimoto et al., 2012.10.8)
Name Synonym	Dm-serpin-88Ea (Colinet et al., 2009) Serine protease inhibitor 5 (Takemori and Yamamoto, 2009) serpin (Charron et al., 2008) serpin 5 (Han et al., 2000, ) serpin5 (Ahmad et al., 2009) Serpin 88Ea (Hashimoto et al., 2012.10.8, )
Secondary FlyBase IDs
	FBgn0038298
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 2 )
Recent research papers ( 3 )
	Wong et al., 2012, Mol. Biol. Evol. 29(1): 229--238 Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. [FBrf0217443] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Ellis and Carney, 2011, Genetics 187(1): 157--169 Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. [FBrf0212780] Show all research papers ...
Recent reviews ( 1 )
	Reichhart et al., 2011, Methods Enzymol. 499: 205--225 The Drosophila serpins multiple functions in immunity and morphogenesis. [FBrf0213937] Show all reviews ...