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Gene Dmel\Spn42Dd

General Information
Symbol	Dmel\Spn42Dd	Species	D. melanogaster
Name	Serpin 42Dd	Annotation symbol	CG9456
Feature type	protein_coding_gene	FlyBase ID	FBgn0028988
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Spn1, sp1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42D6-42D6	Sequence location	2R:2,770,785..2,772,378 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serpin 42Dd is referred to in FlyBase by the symbol Dmel\Spn42Dd (CG9456, FBgn0028988). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: defense response to fungus; regulation of antimicrobial peptide production; multicellular organism reproduction. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Serpin domain; Serpin family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult fat body, adult spermathecae, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult hindgut, adult heart, adult salivary gland, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1630619_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Spn1. Gene sequence location is 2R:2770785..2772378.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms negative regulation of endopeptidase activity regulation of proteolysis
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42D6-42D6   Limits computationally determined from genome sequence between P{lacW}ublk03203&P{PZ}CG328709967 and P{EP}EP2303&P{EP}EP2105
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42E1-42E2   (determined by in situ hybridisation)   (Han et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spn42Dd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.40 Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spn42Dd-RB FBtr0300357  NM_001169596   1195   372
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spn42Dd-PB   FBpp0289586   41.2   372   5.31     NP_001163067   ACZ94347
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Serpin domain (IPR023796)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141646   AE013599 ACZ94347   AI107322   AI107669   AI401942   AI516943   AI517567   AJ251744 CAB63096   BI618135   BT010110 AAQ22579   CK661448   CO288921   CO338413   CZ484646   EC059488   EC081906   EC262552
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7YTY6 Q7KA42
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult fat body, adult spermathecae, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval/adult hindgut, adult heart, adult salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body    1398.2 Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland    5221 Adult Carcass    550.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body  (1398.2) Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head  (705.2) Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body  (556.5) Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca  (647.1) Adult InseminatedFemale Spermatheca  (556.9) Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland  (5221) Adult Carcass  (550.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body  (1398.2) Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland  (5221) Adult Carcass    550.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body    1398.2 Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland    5221 Adult Carcass    550.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body    1398.2 Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland    5221 Adult Carcass    550.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body  (1398.2) Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head  705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body  556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca  647.1 Adult InseminatedFemale Spermatheca  556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland  (5221) Adult Carcass  550.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body  1398.2 Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland  (5221) Adult Carcass    550.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.65 Larval Midgut    14.7 Larval Hindgut    133.1 Larval Malpighian Tubules    11.4 Larval Fat Body    1398.2 Larval Salivary Gland    20.9 Larval Trachea    269.375 Larval Carcass    24.35 Adult Head    705.2 Adult Eye    273.85 Adult Brain    79.5 Adult Thoracic-Abdominal Ganglion    96.8 Adult Crop    376.4 Adult Midgut    18.7 Adult Hindgut    345.7 Adult Malpighian Tubules    30.6 Adult Fat Body    556.5 Adult Salivary Gland    144.4 Adult Heart    350.7 Adult VirginFemale Spermatheca    647.1 Adult InseminatedFemale Spermatheca    556.9 Adult Ovary    7.8 Adult Testis    24.1 Adult Male Accessory Gland    5221 Adult Carcass    550.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    705.2   NA  Eye    273.85   NA  Brain    79.5   6.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    96.8   NA  Crop    376.4   no informative data  Midgut    18.7   133.1  Hindgut    345.7   no informative data  Malpighian Tubules    30.6   1398.2  Fat Body    556.5   20.9  Salivary Gland    144.4   NA  Heart    350.7   269.375  Trachea    NA   NA  VirginFemale Spermatheca    647.1   NA  InseminatedFemale Spermatheca    556.9   NA  Ovary    7.8   NA  Testis    24.1   NA  Male Accessory Gland    5221   24.35  Carcass    550.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female    127 head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male    109 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae    200 fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male    402 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female  (30) head, virgin 4-day female  (42) head, virgin 20-day female  (127) head, mated 1-day female  (31) head, mated 4-day female  (56) head, mated 20-day female  (91) head, mated 1-day male  (35) head, mated 4-day male  (78) head, mated 20-day male  (109) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (44) fat body, white prepupae  (200) fat body, pupae P8  (85) carcass, larvae L3 wandering    6 carcass, 1-day adult  (37) carcass, 4-day adult  (43) carcass, 20-day adult  (93) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (49) accessory gland, mated 4-day male  (402) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female  (127) head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male  (109) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae  (200) fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male  (402) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female    127 head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male    109 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae    200 fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male    402 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female    127 head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male    109 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae    200 fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male    402 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female  30 head, virgin 4-day female  (42) head, virgin 20-day female  (127) head, mated 1-day female  31 head, mated 4-day female  (56) head, mated 20-day female  (91) head, mated 1-day male  (35) head, mated 4-day male  (78) head, mated 20-day male  (109) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (44) fat body, white prepupae  (200) fat body, pupae P8  (85) carcass, larvae L3 wandering    6 carcass, 1-day adult  (37) carcass, 4-day adult  (43) carcass, 20-day adult  (93) ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (49) accessory gland, mated 4-day male  (402) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female  127 head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male  109 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae  (200) fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male  (402) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    8 head, virgin 1-day female    30 head, virgin 4-day female    42 head, virgin 20-day female    127 head, mated 1-day female    31 head, mated 4-day female    56 head, mated 20-day female    91 head, mated 1-day male    35 head, mated 4-day male    78 head, mated 20-day male    109 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    11 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    44 fat body, white prepupae    200 fat body, pupae P8    85 carcass, larvae L3 wandering    6 carcass, 1-day adult    37 carcass, 4-day adult    43 carcass, 20-day adult    93 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    49 accessory gland, mated 4-day male    402 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new  (31) white prepupae 12hr  (44) white prepupae 24hr  (46) pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP  (27) adult male 01day  (31) adult male 05day  (39) adult male 30day  (39) adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new  31 white prepupae 12hr  (44) white prepupae 24hr  (46) pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP  27 adult male 01day  31 adult male 05day  (39) adult male 30day  (39) adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    5 embryo 12-14hr    5 embryo 14-16hr    3 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    23 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    46 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    27 adult male 01day    31 adult male 05day    39 adult male 30day    39 adult female 01day    9 adult female 05day    7 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2  (29) embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS  (30) ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2  29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS  30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    6 embryonic GM2    29 embryonic Kc167    12 embryonic S1    4 embryonic S3    3 leg disc CME L1    4 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    1 wing disc ML-DmD32    8 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    1 ovary fGS/OSS    30 ovary OSC    5 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3  (27) Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3  27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    10 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • GH04125 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028988 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9456-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Spn42DdGD5272 Other Phenotypes Allele immune response defective Spn42Ddoka Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Spn42Dd Class Mutagen Stocks Known lesion Spn42Ddf02145 piggyBac transposase 2 -- Spn42Ddoka amorphic allele - molecular evidence FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spn42Dd Class Mutagen Stocks Known lesion Spn42DdGD5272 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Spn42DdGL01199 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn42DdNIG.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Spn42DdScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6051 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL01199} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Spn42Ddf02145 NA insertion of mobile activating element PBac{WHr}Spn42Ddoka NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from direct assay (Fullaondo et al., 2011)
Biological Process
CV term Evidence References
defense response to fungus inferred from mutant phenotype (Fullaondo et al., 2011) multicellular organism reproduction inferred from expression pattern (Findlay et al., 2008) regulation of antimicrobial peptide production inferred from mutant phenotype (Fullaondo et al., 2011)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Findlay et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with UniProtKB:Q60854 (FlyBase, 1992-) non-traceable author statement (Hashimoto, 1999.12.9)
Biological Process
CV term Evidence References
negative regulation of endopeptidase activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) negative regulation of proteolysis inferred from sequence model (Garrett et al., 2009) regulation of proteolysis inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spn42Dd allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72479 DroID - A comprehensive database of gene and protein interactions. • FBgn0028988 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49808
Orthologs
OrthoDB Orthologs (279) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QVCZ1 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6DV4HB Arthropod inclusive ortholog search EOG6XWDDG Metazoa inclusive ortholog search EOG6TXQN0
Orthologs in Drosophila Species (EOG6QVCZ1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Spn42Dd     Drosophila simulans   Dsim\GD10432     Drosophila sechellia   Dsec\GM20904 Y   Drosophila erecta   Dere\GG23230 Y   Drosophila yakuba   Dyak\GE19081 Y   Drosophila ananassae   Dana\GF13146 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24617     Drosophila persimilis   Dper\GL20626
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6DV4HB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46970 Y Apis mellifera Western honey bee  Amel\GB48820 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007826 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007817 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004051 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007825 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007190 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19678 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15231 Y Atta cephalotes Leafcutter ant  Acep\ACEP13675 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20012 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12281 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18070 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26126 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20846 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20634 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19553 Y Linepithema humile Argentine ant  Lhum\LH24668 Y Linepithema humile Argentine ant  Lhum\LH26242 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23525 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24320 Y Solenopsis invicta Red fire ant  Sinv\SINV14300 Y Solenopsis invicta Red fire ant  Sinv\SINV12644 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000344 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005016 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006911 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004935 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004123 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008381 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI086194 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI060557 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002244 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008775 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007530 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI080561 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007720 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009953 Y Pediculus humanus Human body louse  Phum\PHUM220550 Y Tribolium castaneum Red flour beetle  Tcas\TC005747 Y Tribolium castaneum Red flour beetle  Tcas\serpin23 Y Tribolium castaneum Red flour beetle  Tcas\serpin29 Y Tribolium castaneum Red flour beetle  Tcas\serpin17 Y Tribolium castaneum Red flour beetle  Tcas\serpin25 Y Tribolium castaneum Red flour beetle  Tcas\serpin21 Y Tribolium castaneum Red flour beetle  Tcas\serpin20 Y Tribolium castaneum Red flour beetle  Tcas\serpin7 Y Tribolium castaneum Red flour beetle  Tcas\serpin18 Y Tribolium castaneum Red flour beetle  Tcas\TC005754 Y Tribolium castaneum Red flour beetle  Tcas\serpin19 Y Tribolium castaneum Red flour beetle  Tcas\TC005746 Y Tribolium castaneum Red flour beetle  Tcas\serpin12 Y Tribolium castaneum Red flour beetle  Tcas\serpin3 Y Tribolium castaneum Red flour beetle  Tcas\serpin24 Y Tribolium castaneum Red flour beetle  Tcas\serpin1 Y Tribolium castaneum Red flour beetle  Tcas\serpin31 Y
Orthologs in non-Insect Arthropods (EOG6XWDDG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Csda Y Daphnia pulex Water flea  Dpux\RHBG Y Daphnia pulex Water flea  Dpux\cyp-33d3 Y Ixodes scapularis Deer tick  Isca\ISCW018607 Y Ixodes scapularis Deer tick  Isca\ISCW011013 Y Ixodes scapularis Deer tick  Isca\ISCW014779 Y Ixodes scapularis Deer tick  Isca\ISCW005088 Y Ixodes scapularis Deer tick  Isca\ISCW023623 Y Ixodes scapularis Deer tick  Isca\ISCW024342 Y Ixodes scapularis Deer tick  Isca\ISCW000427 Y Ixodes scapularis Deer tick  Isca\ISCW014652 Y Ixodes scapularis Deer tick  Isca\ISCW023624 Y Ixodes scapularis Deer tick  Isca\ISCW009616 Y Ixodes scapularis Deer tick  Isca\ISCW004156 Y Ixodes scapularis Deer tick  Isca\ISCW023618 Y Ixodes scapularis Deer tick  Isca\ISCW023620 Y Ixodes scapularis Deer tick  Isca\ISCW024109 Y Ixodes scapularis Deer tick  Isca\ISCW024046 Y Ixodes scapularis Deer tick  Isca\ISCW024387 Y Ixodes scapularis Deer tick  Isca\ISCW024435 Y Ixodes scapularis Deer tick  Isca\ISCW015198 Y Ixodes scapularis Deer tick  Isca\ISCW024495 Y Ixodes scapularis Deer tick  Isca\ISCW024500 Y Ixodes scapularis Deer tick  Isca\ISCW011017 Y Ixodes scapularis Deer tick  Isca\ISCW023619 Y Ixodes scapularis Deer tick  Isca\ISCW023617 Y Ixodes scapularis Deer tick  Isca\ISCW024013 Y Ixodes scapularis Deer tick  Isca\ISCW023622 Y Ixodes scapularis Deer tick  Isca\ISCW023621 Y Ixodes scapularis Deer tick  Isca\ISCW015204 Y
Orthologs in non-Arthropod Metazoa (EOG6TXQN0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\srp-7 Y Caenorhabditis elegans Nematode  Cele\srp-1 Y Caenorhabditis elegans Nematode  Cele\srp-8 Y Caenorhabditis elegans Nematode  Cele\srp-6 Y Caenorhabditis elegans Nematode  Cele\srp-2 Y Caenorhabditis elegans Nematode  Cele\srp-3 Y Caenorhabditis elegans Nematode  Cele\srp-5 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013378gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018631gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018630gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018196gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013377gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020278gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002711gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024263gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028469gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004543gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009346gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018632gn Y Danio rerio Zebrafish  Drer\ENSDARG00000090916 Y Danio rerio Zebrafish  Drer\serpind1 Y Danio rerio Zebrafish  Drer\zgc:174259 Y Danio rerio Zebrafish  Drer\zgc:173729 Y Danio rerio Zebrafish  Drer\serpinb1l4 Y Danio rerio Zebrafish  Drer\ENSDARG00000091800 Y Danio rerio Zebrafish  Drer\serpinb1l1 Y Danio rerio Zebrafish  Drer\serpine2 Y Danio rerio Zebrafish  Drer\serpine3 Y Danio rerio Zebrafish  Drer\serpinb1l3 Y Danio rerio Zebrafish  Drer\serpinb1l2 Y Danio rerio Zebrafish  Drer\serpina1 Y Danio rerio Zebrafish  Drer\serpinc1 Y Danio rerio Zebrafish  Drer\serpine1 Y Danio rerio Zebrafish  Drer\serpini1 Y Danio rerio Zebrafish  Drer\ENSDARG00000036968 Y Danio rerio Zebrafish  Drer\serpina1l Y Danio rerio Zebrafish  Drer\si:ch73-303g23.4 Y Danio rerio Zebrafish  Drer\serpinb1 Y Danio rerio Zebrafish  Drer\si:ch211-186e20.2 Y Xenopus tropicalis Western clawed frog  Xtro\serpinc1 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb4 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb6 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3k-prov Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000009423 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032417 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032542 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb1 Y Xenopus tropicalis Western clawed frog  Xtro\serpini1 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb11 Y Xenopus tropicalis Western clawed frog  Xtro\serpine1 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3 Y Xenopus tropicalis Western clawed frog  Xtro\serpini2 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3m Y Xenopus tropicalis Western clawed frog  Xtro\serpina1 Y Xenopus tropicalis Western clawed frog  Xtro\serpine2 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb5 Y Xenopus tropicalis Western clawed frog  Xtro\serpind1 Y Gallus gallus Domestic chicken  Ggal\SERPINE2 Y Gallus gallus Domestic chicken  Ggal\SERPINB14B Y Gallus gallus Domestic chicken  Ggal\SERPINC1 Y Gallus gallus Domestic chicken  Ggal\SERPINB10 Y Gallus gallus Domestic chicken  Ggal\SERPINB1 Y Gallus gallus Domestic chicken  Ggal\SERPINE3 Y Gallus gallus Domestic chicken  Ggal\SERPINB12 Y Gallus gallus Domestic chicken  Ggal\SERPINBP1 Y Gallus gallus Domestic chicken  Ggal\SERPINB5 Y Gallus gallus Domestic chicken  Ggal\SERPINB14 Y Gallus gallus Domestic chicken  Ggal\SERPINA3 Y Gallus gallus Domestic chicken  Ggal\SERPINB10 Y Gallus gallus Domestic chicken  Ggal\SERPINA4 Y Gallus gallus Domestic chicken  Ggal\SERPIND1 Y Gallus gallus Domestic chicken  Ggal\SERPINI1 Y Gallus gallus Domestic chicken  Ggal\SERPINA9 Y Gallus gallus Domestic chicken  Ggal\SERPINA5 Y Gallus gallus Domestic chicken  Ggal\SERPINB2 Y Gallus gallus Domestic chicken  Ggal\SERPINA1 Y Gallus gallus Domestic chicken  Ggal\SERPINB6 Y Mus musculus House mouse  Mmus\Serpinb9e Y Mus musculus House mouse  Mmus\Serpinb3d Y Mus musculus House mouse  Mmus\ENSMUSG00000069248 Y Mus musculus House mouse  Mmus\Serpina9 Y Mus musculus House mouse  Mmus\Serpina1b Y Mus musculus House mouse  Mmus\Serpine3 Y Mus musculus House mouse  Mmus\Serpina3f Y Mus musculus House mouse  Mmus\Serpinb9b Y Mus musculus House mouse  Mmus\Serpinb9f Y Mus musculus House mouse  Mmus\Serpina5 Y Mus musculus House mouse  Mmus\Serpina11 Y Mus musculus House mouse  Mmus\Serpina3m Y Mus musculus House mouse  Mmus\Serpine1 Y Mus musculus House mouse  Mmus\Serpinb1c Y Mus musculus House mouse  Mmus\Serpinb1b Y Mus musculus House mouse  Mmus\Serpina3i Y Mus musculus House mouse  Mmus\Serpinb6d Y Mus musculus House mouse  Mmus\Serpina6 Y Mus musculus House mouse  Mmus\Serpinb3a Y Mus musculus House mouse  Mmus\Serpind1 Y Mus musculus House mouse  Mmus\Serpinb9 Y Mus musculus House mouse  Mmus\Serpine2 Y Mus musculus House mouse  Mmus\Serpinb9d Y Mus musculus House mouse  Mmus\Serpinb5 Y Mus musculus House mouse  Mmus\ENSMUSG00000042842 Y Mus musculus House mouse  Mmus\Serpina1d Y Mus musculus House mouse  Mmus\Serpinb11 Y Mus musculus House mouse  Mmus\Serpina1a Y Mus musculus House mouse  Mmus\Serpinb3c Y Mus musculus House mouse  Mmus\Serpinb3b Y Mus musculus House mouse  Mmus\Serpina12 Y Mus musculus House mouse  Mmus\Serpinc1 Y Mus musculus House mouse  Mmus\ENSMUSG00000044734 Y Mus musculus House mouse  Mmus\Serpina1e Y Mus musculus House mouse  Mmus\Serpina3c Y Mus musculus House mouse  Mmus\Serpina3n Y Mus musculus House mouse  Mmus\Serpina3a Y Mus musculus House mouse  Mmus\Serpini1 Y Mus musculus House mouse  Mmus\Serpinb6c Y Mus musculus House mouse  Mmus\ENSMUSG00000048775 Y Mus musculus House mouse  Mmus\Serpinb8 Y Mus musculus House mouse  Mmus\Serpina3j Y Mus musculus House mouse  Mmus\ENSMUSG00000021404 Y Mus musculus House mouse  Mmus\Serpinb7 Y Mus musculus House mouse  Mmus\Serpini2 Y Mus musculus House mouse  Mmus\Serpinb6a Y Mus musculus House mouse  Mmus\ENSMUSG00000079015 Y Rattus norvegicus Norway rat  Rnor\Serpinb13 Y Rattus norvegicus Norway rat  Rnor\Serpinb6b Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029949 Y Rattus norvegicus Norway rat  Rnor\Serpine1 Y Rattus norvegicus Norway rat  Rnor\Serpinb1b Y Rattus norvegicus Norway rat  Rnor\Serpini2 Y Rattus norvegicus Norway rat  Rnor\Serpina4 Y Rattus norvegicus Norway rat  Rnor\Serpinb10 Y Rattus norvegicus Norway rat  Rnor\Serpina9 Y Rattus norvegicus Norway rat  Rnor\Serpinb7 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011141 Y Rattus norvegicus Norway rat  Rnor\Serpina7 Y Rattus norvegicus Norway rat  Rnor\Serpini1 Y Rattus norvegicus Norway rat  Rnor\Serpinb3a Y Rattus norvegicus Norway rat  Rnor\Serpind1 Y Rattus norvegicus Norway rat  Rnor\Serpinb6a Y Rattus norvegicus Norway rat  Rnor\Serpinb1a Y Rattus norvegicus Norway rat  Rnor\LOC299282 Y Rattus norvegicus Norway rat  Rnor\Serpinb5 Y Rattus norvegicus Norway rat  Rnor\Serpinc1 Y Rattus norvegicus Norway rat  Rnor\Serpina12 Y Rattus norvegicus Norway rat  Rnor\Serpinb2 Y Rattus norvegicus Norway rat  Rnor\LOC299277 Y Rattus norvegicus Norway rat  Rnor\Serpine2 Y Rattus norvegicus Norway rat  Rnor\Serpinb11 Y Rattus norvegicus Norway rat  Rnor\Serpinb9 Y Rattus norvegicus Norway rat  Rnor\Serpina6 Y Rattus norvegicus Norway rat  Rnor\Serpine3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032669 Y Rattus norvegicus Norway rat  Rnor\Serpina5 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000010410 Y Rattus norvegicus Norway rat  Rnor\Serpinb12 Y Rattus norvegicus Norway rat  Rnor\Serpinb9e Y Rattus norvegicus Norway rat  Rnor\Serpinb8 Y Rattus norvegicus Norway rat  Rnor\Serpina3n Y Rattus norvegicus Norway rat  Rnor\Serpinb3 Y Rattus norvegicus Norway rat  Rnor\Serpinb6e Y Homo sapiens Human  Hsap\SERPINB2 Y Homo sapiens Human  Hsap\SERPINC1 Y Homo sapiens Human  Hsap\SERPINA3 Y Homo sapiens Human  Hsap\SERPINB9 Y Homo sapiens Human  Hsap\SERPINA4 Y Homo sapiens Human  Hsap\SERPINI2 Y Homo sapiens Human  Hsap\SERPIND1 Y Homo sapiens Human  Hsap\ENSG00000170054 Y Homo sapiens Human  Hsap\SERPINI1 Y Homo sapiens Human  Hsap\SERPINB8 Y Homo sapiens Human  Hsap\ENSG00000135919 Y Homo sapiens Human  Hsap\SERPINE3 Y Homo sapiens Human  Hsap\SERPINB5 Y Homo sapiens Human  Hsap\SERPINA12 Y Homo sapiens Human  Hsap\SERPINA7 Y Homo sapiens Human  Hsap\ENSG00000242550 Y Homo sapiens Human  Hsap\SERPINA11 Y Homo sapiens Human  Hsap\SERPINB4 Y Homo sapiens Human  Hsap\SERPINB1 Y Homo sapiens Human  Hsap\SERPINA6 Y Homo sapiens Human  Hsap\SERPINB12 Y Homo sapiens Human  Hsap\SERPINA1 Y Homo sapiens Human  Hsap\SERPINB3 Y Homo sapiens Human  Hsap\SERPINA5 Y Homo sapiens Human  Hsap\SERPINE1 Y
Human Orthologs (25)
Gene OMIM HGNC Hsap\SERPINB2     Hsap\SERPINC1     Hsap\SERPINA3     Hsap\SERPINB9     Hsap\SERPINA4     Hsap\SERPINI2     Hsap\SERPIND1     Hsap\ENSG00000170054     Hsap\SERPINI1     Hsap\SERPINB8     Hsap\ENSG00000135919     Hsap\SERPINE3     Hsap\SERPINB5     Hsap\SERPINA12     Hsap\SERPINA7     Hsap\ENSG00000242550     Hsap\SERPINA11     Hsap\SERPINB4     Hsap\SERPINB1     Hsap\SERPINA6     Hsap\SERPINB12     Hsap\SERPINA1     Hsap\SERPINB3     Hsap\SERPINA5     Hsap\SERPINE1
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM20904 Drosophila erecta Dere\GG23230 Drosophila yakuba Dyak\GE19081 Drosophila ananassae Dana\GF13146
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	41617 y1 v1; P{TRiP.GL01199}attP40 18518 w1118; PBac{WH}Spn42Ddf02145/CyO
Harvard	- PBac{WH}Spn42Ddf02145
VDRC	v37955 w1118; P{GD5272}v37955 v37956 w1118; P{GD5272}v37956
Genomic Clones ( 2 )
	BACR04F03 BACR07J20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04125
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05478 GH27551 GH28573 LP20971 RH48695
Other clones	571377 CK01.88C.G10 CK01.100C.C2 CK02196 EK069659 EN16736
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028988 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49808
Antibody Information
	polyclonal (Fullaondo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Spn42Dd Spn1 (Hashimoto et al., 2012.10.8)
Source for database merge of	Source for merge of: sp1 CG9456 (Whitfield, 2000.5.15)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001169596 RefSeq (Proteins) • NP_001163067 DDBJ / EMBL / GenBank • AAF57408 AAQ22579 ACZ94347 AI107322 AI401942 AJ251744 BT010110 CAB63096 CZ484646 Entrez Gene - A searchable database of RefSeq genes. • 49808 UniProtKB/TrEMBL • Q7KA42 Q7YTY6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Serpin domain (IPR023796) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH04125
Linkouts
	BioGRID - A database of protein and genetic interactions • 72479 DroID - A comprehensive database of gene and protein interactions. • FBgn0028988 DRSC - Results from RNAi screens. • FBgn0028988 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028988 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9456-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028988 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49808 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49808 modMine - Data generated by the modENCODE project. • FBgn0028988
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG9456 (Arbeitman et al., 2004, Misra et al., 2002, Whitfield, 2000.5.15, Whitfield, 2000.5.15, Garrett et al., 2009, Riedl et al., 2005, Cammarato et al., 2011, Wong et al., 2012, Ni et al., 2010.12.1) sp1 (Mahaffey, 2005, van Steensel et al., 2003, Han et al., 2000, ) Spn1 (Nfonsam et al., 2012, Fullaondo et al., 2011, Gradilla et al., 2011, Takemori and Yamamoto, 2009, Riedl et al., 2005) Spn42Dd (Garrett et al., 2009, Reichhart et al., 2011, Hashimoto et al., 2012.10.8)
Name Synonym	Serine protease inhibitor 1 (Hurlbut et al., 2009, Takemori and Yamamoto, 2009, Cammarato et al., 2011) serpin 1 (Han et al., 2000, ) Serpin 42Dd (Hashimoto et al., 2012.10.8, )
Secondary FlyBase IDs
	FBgn0033114
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Wong et al., 2012, Mol. Biol. Evol. 29(1): 229--238 Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. [FBrf0217443] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Fullaondo et al., 2011, Mol. Cell. Biol. 31(14): 2960--2972 Spn1 Regulates the GNBP3-Dependent Toll Signaling Pathway in Drosophila melanogaster. [FBrf0214037] Gradilla et al., 2011, Genetics 189(3): 871--883 Isoform-Specific Regulation of a Steroid Hormone Nuclear Receptor by an E3 Ubiquitin Ligase in Drosophila melanogaster. [FBrf0216551] Show all research papers ...
Recent reviews ( 1 )
	Reichhart et al., 2011, Methods Enzymol. 499: 205--225 The Drosophila serpins multiple functions in immunity and morphogenesis. [FBrf0213937] Show all reviews ...