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Gene Dmel\ced-6

General Information
Symbol	Dmel\ced-6	Species	D. melanogaster
Name	ced-6	Annotation symbol	CG11804
Feature type	protein_coding_gene	FlyBase ID	FBgn0029092
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	dCed-6, drced-6, ced6
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45D7-45D8	Sequence location	2R:5,322,174..5,332,442 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ced-6 is referred to in FlyBase by the symbol Dmel\ced-6 (CG11804, FBgn0029092). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: apoptotic cell clearance; neuron remodeling. 10 alleles are reported. The phenotypes of these alleles are annotated with: ensheathing neuropil associated glial cell; glial cell; embryonic hemocyte. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Phosphotyrosine interaction domain; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1638738_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of ced-6. Gene sequence location is 2R:5322174..5332442.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45D7-45D8   Limits computationally determined from genome sequence between P{lacW}wunk09507&P{lacW}l(2)k12402k12402 and P{EP}EP2165&P{lacW}l(2)k01301k01301
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ced-6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ced-6-RA FBtr0088550  NM_165675   2382   517 ced-6-RB FBtr0088548  NM_165676   2572   517 ced-6-RC FBtr0088549  NM_136644   2257   517 ced-6-RD FBtr0306808  NM_001259296   2462   533 ced-6-RF FBtr0339384     2563   514
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ced-6-PA   FBpp0087633   56.1   517   6.87     NP_724789   AAG22292 ced-6-PB   FBpp0087631   56.1   517   6.87     NP_724790   AAF58937 ced-6-PC   FBpp0087632   56.1   517   6.87     NP_610488   AAM71067 ced-6-PD   FBpp0297720   57.9   533   8.22     NP_001246225   AFH07980 ced-6-PF   FBpp0308475   55.8   514   6.87
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141391   AA201943   AA202813   AA202873   AA202928   AA263721   AA390841   AA439693   AA440040   AA536585   AA538624   AA538977   AA539957   AA540019   AA540723   AA941384   AA949516   AA979256   AE013599 AAF58937   AE013599 AAG22292   AE013599 AAM71067   AF204777 AAF22653   AE013599 AFH07980   AI064159   AI534393   AW942524   AX149386   AX149388   AY119596 AAM50250   BG638523   BH809437   BH809438   BI163578   BI164496   BI165165   BI165775   BI167068   BI167628   BI167816   BI169786   BI169921   BI170260   BI170467   BI170808   BI171222   BI171422   BI171684   BI213541   BI213554   BI214611   BI216450   BI227644   BI229016   BI229595   BI230393   BI231146   BI232686   BI233094   BI234263   BI235221   BI235317   BI235509   BI237182   BI237223   BI237732   BI238497   BI239805   BI239897   BI240459   BI240705   BI241792   BI242292   BI243847   BI356045   BI357972   BI362256   BI366753   BI369858   BI370290   BI370507   BI373039   BI374295   BI374459   BI375000   BI375768   BI375960   BI481566   BI481850   BI483636   BI484418   BI484986   BI485542   BI486301   BI486315   BI566181   BI567170   BI567266   BI575602   BI576515   BI576850   BI578412   BI579724   BI583386   BI587147   BI588947   BI589065   BI589267   BI589299   BI606242   BI611472   BI625525   BT125651   CA804909   CA806306   CA807393   CK659092   CK661873   CL943497   CO183754   CO186970   CO188524   CO189051   CO193406   CO193879   CO194013   CO265862   CO267949   CO271219   CO279951   CO284833   CO286305   CO291065   CO300023   CO316300   CO331019   CO333111   CZ474883   CZ477639   CZ477640   EC059528   EC067564   EC080320   EC085226   EC195425   EC202335   EC202336   EC210276   EC218846   EC222151   EC228834   EC228835   EC240974   EC242515   EC249803   EC251215   EV576864   EV587720   EV594776   EV598799   GH738887   GH740149   GH742750   GH744837   GH745294   GH766093   GH767394   GH943169   GH943522   GH946406   GH947693   GH949263   GH952748   GH959583   GH960215   GH961269   GH964309   GH965582   GH967145   GH967680   GH968246   GH969252   GH970857   GH975825   GH983814   GO254448
UniProtKB/Swiss-Prot	Q7JUY7
UniProtKB/TrEMBL	E2QC90
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   embryonic/larval garland cell   (Fisher et al., 2012) third instar larval stage   glial cell | subset of brain | faint   (Awasaki et al., 2006) prepupal stage P3   glial cell | subset of brain   (Awasaki et al., 2006) Comment:6h APF mushroom body vertical lobe | restricted   (Awasaki et al., 2006) Comment:6h APF prepupal stage P4(ii)   glial cell | subset of brain | faint   (Awasaki et al., 2006) Comment:12h APF
Additional Descriptive Data
	ced-6 transcript is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes. (Awasaki et al., 2006)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference prepupal stage P3   glial cell | subset of brain   (Awasaki et al., 2006) Comment:6h APF mushroom body vertical lobe | restricted   (Awasaki et al., 2006) Comment:6h APF adult stage   adult cortex associated glial cell of adult antennal lobe   (Doherty et al., 2009) ensheathing neuropil associated glial cell of adult antennal lobe   (Doherty et al., 2009)
Additional Descriptive Data
	ced-6 protein is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes. These cells also express drpr protein. Expression in also detected in glial processes that infiltrate the vertical lobes. (Awasaki et al., 2006)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, adult Malpighian tubules, larval salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules    1495.4 Larval Fat Body    2749.8 Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head    1116.9 Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut    1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body    1435.2 Adult Salivary Gland    511.5 Adult Heart    2326.85 Adult VirginFemale Spermatheca    1240.8 Adult InseminatedFemale Spermatheca    1202.2 Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules  (1495.4) Larval Fat Body  (2749.8) Larval Salivary Gland    136.5 Larval Trachea  (569.525) Larval Carcass  (612.925) Adult Head  (1116.9) Adult Eye  (644.975) Adult Brain  (619.9) Adult Thoracic-Abdominal Ganglion  (561.7) Adult Crop  (895.1) Adult Midgut    24.9 Adult Hindgut  (1024.4) Adult Malpighian Tubules    438.2 Adult Fat Body  (1435.2) Adult Salivary Gland  511.5 Adult Heart  (2326.85) Adult VirginFemale Spermatheca  (1240.8) Adult InseminatedFemale Spermatheca  (1202.2) Adult Ovary  (952.4) Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass  (988.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules  (1495.4) Larval Fat Body  (2749.8) Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head  (1116.9) Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut  1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body  (1435.2) Adult Salivary Gland    511.5 Adult Heart  (2326.85) Adult VirginFemale Spermatheca  (1240.8) Adult InseminatedFemale Spermatheca  (1202.2) Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules    1495.4 Larval Fat Body    2749.8 Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head    1116.9 Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut    1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body    1435.2 Adult Salivary Gland    511.5 Adult Heart    2326.85 Adult VirginFemale Spermatheca    1240.8 Adult InseminatedFemale Spermatheca    1202.2 Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules    1495.4 Larval Fat Body    2749.8 Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head    1116.9 Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut    1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body    1435.2 Adult Salivary Gland    511.5 Adult Heart    2326.85 Adult VirginFemale Spermatheca    1240.8 Adult InseminatedFemale Spermatheca    1202.2 Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules  (1495.4) Larval Fat Body  (2749.8) Larval Salivary Gland    136.5 Larval Trachea  569.525 Larval Carcass  612.925 Adult Head  (1116.9) Adult Eye  644.975 Adult Brain  619.9 Adult Thoracic-Abdominal Ganglion  561.7 Adult Crop  (895.1) Adult Midgut    24.9 Adult Hindgut  (1024.4) Adult Malpighian Tubules    438.2 Adult Fat Body  (1435.2) Adult Salivary Gland  511.5 Adult Heart  (2326.85) Adult VirginFemale Spermatheca  (1240.8) Adult InseminatedFemale Spermatheca  (1202.2) Adult Ovary  (952.4) Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass  (988.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules  1495.4 Larval Fat Body  (2749.8) Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head  1116.9 Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut  1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body  1435.2 Adult Salivary Gland    511.5 Adult Heart  (2326.85) Adult VirginFemale Spermatheca  1240.8 Adult InseminatedFemale Spermatheca  1202.2 Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.75 Larval Midgut    256.4 Larval Hindgut    346.4 Larval Malpighian Tubules    1495.4 Larval Fat Body    2749.8 Larval Salivary Gland    136.5 Larval Trachea    569.525 Larval Carcass    612.925 Adult Head    1116.9 Adult Eye    644.975 Adult Brain    619.9 Adult Thoracic-Abdominal Ganglion    561.7 Adult Crop    895.1 Adult Midgut    24.9 Adult Hindgut    1024.4 Adult Malpighian Tubules    438.2 Adult Fat Body    1435.2 Adult Salivary Gland    511.5 Adult Heart    2326.85 Adult VirginFemale Spermatheca    1240.8 Adult InseminatedFemale Spermatheca    1202.2 Adult Ovary    952.4 Adult Testis    97.6 Adult Male Accessory Gland    196.9 Adult Carcass    988.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1116.9   NA  Eye    644.975   NA  Brain    619.9   159.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    561.7   NA  Crop    895.1   256.4  Midgut    24.9   346.4  Hindgut    1024.4   1495.4  Malpighian Tubules    438.2   2749.8  Fat Body    1435.2   136.5  Salivary Gland    511.5   NA  Heart    2326.85   569.525  Trachea    NA   NA  VirginFemale Spermatheca    1240.8   NA  InseminatedFemale Spermatheca    1202.2   NA  Ovary    952.4   NA  Testis    97.6   NA  Male Accessory Gland    196.9   612.925  Carcass    988.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male    103 head, mated 4-day male    92 head, mated 20-day male    107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    125 digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering    132 fat body, white prepupae    259 fat body, pupae P8    169 carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female    193 ovary, mated 4-day female    182 testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (32) central nervous system, pupae P8  (33) head, virgin 1-day female  (75) head, virgin 4-day female  (79) head, virgin 20-day female  (56) head, mated 1-day female  (84) head, mated 4-day female  (68) head, mated 20-day female  (58) head, mated 1-day male  (103) head, mated 4-day male  (92) head, mated 20-day male  (107) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (125) digestive system, 1-day adult    19 digestive system, 4-day adult  (27) digestive system, 20-day adult    15 fat body, larvae L3 wandering  (132) fat body, white prepupae  (259) fat body, pupae P8  (169) carcass, larvae L3 wandering  (74) carcass, 1-day adult  (65) carcass, 4-day adult  (71) carcass, 20-day adult  (81) ovary, virgin 4-day female  (193) ovary, mated 4-day female  (182) testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male  103 head, mated 4-day male    92 head, mated 20-day male  107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (125) digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering  (132) fat body, white prepupae  (259) fat body, pupae P8  (169) carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female  (193) ovary, mated 4-day female  (182) testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male    103 head, mated 4-day male    92 head, mated 20-day male    107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    125 digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering    132 fat body, white prepupae    259 fat body, pupae P8    169 carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female    193 ovary, mated 4-day female    182 testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male    103 head, mated 4-day male    92 head, mated 20-day male    107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    125 digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering    132 fat body, white prepupae    259 fat body, pupae P8    169 carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female    193 ovary, mated 4-day female    182 testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  32 central nervous system, pupae P8  (33) head, virgin 1-day female  (75) head, virgin 4-day female  (79) head, virgin 20-day female  (56) head, mated 1-day female  (84) head, mated 4-day female  (68) head, mated 20-day female  (58) head, mated 1-day male  (103) head, mated 4-day male  (92) head, mated 20-day male  (107) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  (125) digestive system, 1-day adult    19 digestive system, 4-day adult  27 digestive system, 20-day adult    15 fat body, larvae L3 wandering  (132) fat body, white prepupae  (259) fat body, pupae P8  (169) carcass, larvae L3 wandering  (74) carcass, 1-day adult  (65) carcass, 4-day adult  (71) carcass, 20-day adult  (81) ovary, virgin 4-day female  (193) ovary, mated 4-day female  (182) testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male  103 head, mated 4-day male    92 head, mated 20-day male  107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering  125 digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering  132 fat body, white prepupae  (259) fat body, pupae P8  (169) carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female  (193) ovary, mated 4-day female  (182) testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    32 central nervous system, pupae P8    33 head, virgin 1-day female    75 head, virgin 4-day female    79 head, virgin 20-day female    56 head, mated 1-day female    84 head, mated 4-day female    68 head, mated 20-day female    58 head, mated 1-day male    103 head, mated 4-day male    92 head, mated 20-day male    107 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    125 digestive system, 1-day adult    19 digestive system, 4-day adult    27 digestive system, 20-day adult    15 fat body, larvae L3 wandering    132 fat body, white prepupae    259 fat body, pupae P8    169 carcass, larvae L3 wandering    74 carcass, 1-day adult    65 carcass, 4-day adult    71 carcass, 20-day adult    81 ovary, virgin 4-day female    193 ovary, mated 4-day female    182 testis, mated 4-day male    8 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day    101 adult female 30day    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr  (66) embryo 04-06hr  (41) embryo 06-08hr  (42) embryo 08-10hr  (58) embryo 10-12hr  (66) embryo 12-14hr  (57) embryo 14-16hr  (55) embryo 16-18hr  (56) embryo 18-20hr  (38) embryo 20-22hr  (61) embryo 22-24hr  (65) larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2  (31) larva L3 puffstage 3-6  (82) larva L3 puffstage 7-9  (94) white prepupae new  (69) white prepupae 12hr  (90) white prepupae 24hr  (50) pupae 2d postWPP  (58) pupae 3d postWPP  (35) pupae 4d postWPP  (49) adult male 01day  (38) adult male 05day  (36) adult male 30day  (29) adult female 01day  (58) adult female 05day  (101) adult female 30day  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day  101 adult female 30day    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day    101 adult female 30day    99 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day    101 adult female 30day    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr  (66) embryo 04-06hr  (41) embryo 06-08hr  (42) embryo 08-10hr  (58) embryo 10-12hr  (66) embryo 12-14hr  (57) embryo 14-16hr  (55) embryo 16-18hr  (56) embryo 18-20hr  (38) embryo 20-22hr  (61) embryo 22-24hr  (65) larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2  31 larva L3 puffstage 3-6  (82) larva L3 puffstage 7-9  (94) white prepupae new  (69) white prepupae 12hr  (90) white prepupae 24hr  (50) pupae 2d postWPP  (58) pupae 3d postWPP  (35) pupae 4d postWPP  (49) adult male 01day  (38) adult male 05day  (36) adult male 30day  29 adult female 01day  (58) adult female 05day  (101) adult female 30day  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  109 embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day  101 adult female 30day    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    66 embryo 04-06hr    41 embryo 06-08hr    42 embryo 08-10hr    58 embryo 10-12hr    66 embryo 12-14hr    57 embryo 14-16hr    55 embryo 16-18hr    56 embryo 18-20hr    38 embryo 20-22hr    61 embryo 22-24hr    65 larva L1    12 larva L2    25 larva L3 12hr old    22 larva L3 puffstage 1-2    31 larva L3 puffstage 3-6    82 larva L3 puffstage 7-9    94 white prepupae new    69 white prepupae 12hr    90 white prepupae 24hr    50 pupae 2d postWPP    58 pupae 3d postWPP    35 pupae 4d postWPP    49 adult male 01day    38 adult male 05day    36 adult male 30day    29 adult female 01day    58 adult female 05day    101 adult female 30day    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    300 Schneider line 2 Sg4    226 embryonic 1182-4H    135 embryonic GM2    129 embryonic Kc167    333 embryonic S1    56 embryonic S3    153 leg disc CME L1    138 wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    203 wing disc ML-DmD21    93 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    136 tumorous blood cells mbn2    212 ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (300) Schneider line 2 Sg4  (226) embryonic 1182-4H  (135) embryonic GM2  (129) embryonic Kc167  (333) embryonic S1  (56) embryonic S3  (153) leg disc CME L1  (138) wing disc CME-W2  (99) wing disc ML-DmD8    21 wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (203) wing disc ML-DmD21  (93) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (74) eye-antennal disc ML-DmD11  (76) antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (136) tumorous blood cells mbn2  (212) ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (300) Schneider line 2 Sg4  (226) embryonic 1182-4H  (135) embryonic GM2  (129) embryonic Kc167  (333) embryonic S1    56 embryonic S3  (153) leg disc CME L1  (138) wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3  (203) wing disc ML-DmD21    93 wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2  (136) tumorous blood cells mbn2  (212) ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    300 Schneider line 2 Sg4    226 embryonic 1182-4H    135 embryonic GM2    129 embryonic Kc167    333 embryonic S1    56 embryonic S3    153 leg disc CME L1    138 wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    203 wing disc ML-DmD21    93 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    136 tumorous blood cells mbn2    212 ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    300 Schneider line 2 Sg4    226 embryonic 1182-4H    135 embryonic GM2    129 embryonic Kc167    333 embryonic S1    56 embryonic S3    153 leg disc CME L1    138 wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    203 wing disc ML-DmD21    93 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    136 tumorous blood cells mbn2    212 ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (300) Schneider line 2 Sg4  (226) embryonic 1182-4H  (135) embryonic GM2  (129) embryonic Kc167  (333) embryonic S1  (56) embryonic S3  (153) leg disc CME L1  (138) wing disc CME-W2  (99) wing disc ML-DmD8    21 wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (203) wing disc ML-DmD21  (93) wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3  (74) eye-antennal disc ML-DmD11  (76) antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (53) CNS ML-DmBG2-c2  (136) tumorous blood cells mbn2  (212) ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (300) Schneider line 2 Sg4  (226) embryonic 1182-4H  135 embryonic GM2  129 embryonic Kc167  (333) embryonic S1    56 embryonic S3  (153) leg disc CME L1  138 wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3  (203) wing disc ML-DmD21    93 wing disc ML-DmD32  (195) haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5  137 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2  136 tumorous blood cells mbn2  (212) ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    300 Schneider line 2 Sg4    226 embryonic 1182-4H    135 embryonic GM2    129 embryonic Kc167    333 embryonic S1    56 embryonic S3    153 leg disc CME L1    138 wing disc CME-W2    99 wing disc ML-DmD8    21 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    203 wing disc ML-DmD21    93 wing disc ML-DmD32    195 haltere disc ML-DmD17-c3    74 eye-antennal disc ML-DmD11    76 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    53 CNS ML-DmBG2-c2    136 tumorous blood cells mbn2    212 ovary fGS/OSS    6 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    201 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    146 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    113 Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (68) cold shock, 4-day adult  (63) heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  (27) Cadmium 50 mM 12 hrs, larvae L3  (86) Cadmium 50 mM 48 hrs, 4-day adult  (57) Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (201) Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  (107) Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (49) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (146) Caffeine 25 mg/ml 48 hrs, 4-day adult  (85) Paraquat 5 mM 48 hrs, 4-day adult  (113) Paraquat 10 mM 48 hrs, 4-day adult  (84) Rotenone 2 μg 12 hrs, larvae L3  (31) Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (201) Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (146) Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult  (113) Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    201 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    146 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    113 Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    201 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    146 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    113 Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (68) cold shock, 4-day adult  (63) heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  27 Cadmium 50 mM 12 hrs, larvae L3  (86) Cadmium 50 mM 48 hrs, 4-day adult  (57) Cadmium 100 mM 48 hrs, 4-day adult  (136) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (201) Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  (114) Ethanol 2.5% 3 hrs, larvae L3  (107) Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (49) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (146) Caffeine 25 mg/ml 48 hrs, 4-day adult  (85) Paraquat 5 mM 48 hrs, 4-day adult  (113) Paraquat 10 mM 48 hrs, 4-day adult  (84) Rotenone 2 μg 12 hrs, larvae L3  31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult  136 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (201) Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  114 Ethanol 2.5% 3 hrs, larvae L3  107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (146) Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult  113 Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    68 cold shock, 4-day adult    63 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    86 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    136 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    201 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    114 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    49 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    146 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    113 Paraquat 10 mM 48 hrs, 4-day adult    84 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD19266 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029092 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11804-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ced-6 Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable ced-6EY11592 viable, with Scer\GAL4pnr-MD237 ced-6GD7389 Sterility Allele fertile ced-6EY11592 Other Phenotypes Allele neuroanatomy defective | P-stage, with Scer\GAL4repo ced-6dsRNA.Scer\UAS.cAa Phenotype manifest in Allele embryonic hemocyte ced-6J26 ensheathing neuropil associated glial cell, with Scer\GAL4repo.PU ced-6dsRNA.Scer\UAS.cAa glial cell, with Scer\GAL4repo ced-6dsRNA.Scer\UAS.cAa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of ced-6 Class Mutagen Stocks Known lesion ced-6d11244 P-element activity 1 -- ced-6EY11592 P-element activity 1 -- ced-6KG03411a P-element activity 1 -- ced-6MI06215 1 -- ced-6d06028 P-element activity 0 -- ced-6J26 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ced-6 Class Mutagen Stocks Known lesion ced-6GD7389 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ced-6KK102556 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ced-6dsRNA.Scer\UAS.cAa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ced-6NIG.11804R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)w45-19g (Georgiev et al., 2012) Df(2R)w73-1 (Georgiev et al., 2012) Df(2R)wun-GL (Georgiev et al., 2012)
Disrupted in	Df(2R)11 (Georgiev et al., 2012) Df(2R)BSC29 (Georgiev et al., 2012) Df(2R)Np5 (Georgiev et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7389} NA P{KK102556} NA P{NIG.11804R} NA P{UAS-ced-6.IR.A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}ced-6EY11592 NA P{XP}ced-6d06028 NA P{XP}ced-6d11244 NA miscellaneous insertions Mi{MIC}ced-6MI06215 NA P{SUPor-P}ced-6KG03411a NA insertion of enhancer trap P{lacZ}arap1 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2007-07-26)
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q9W0A0 (assigned by UniProtKB) (Awasaki et al., 2006)
Biological Process
CV term Evidence References
apoptotic cell clearance inferred from mutant phenotype (Doherty et al., 2009) neuron remodeling inferred from mutant phenotype (Awasaki et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ced-6 - CG1902 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ced-6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61802 DroID - A comprehensive database of gene and protein interactions. • FBgn0029092 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35971 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7JUY7
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MGSTJ Dipteran inclusive ortholog search EOG6H72M2 Insect inclusive ortholog search EOG6TX9N8 Arthropod inclusive ortholog search EOG644J1R Metazoa inclusive ortholog search EOG6CGC34
Orthologs in Drosophila Species (EOG6MGSTJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ced-6     Drosophila simulans   Dsim\GD10073 Y   Drosophila sechellia   Dsec\GM20601 Y   Drosophila erecta   Dere\GG25283 Y   Drosophila yakuba   Dyak\GE22280 Y   Drosophila ananassae   Dana\GF12503 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11210 Y   Drosophila persimilis   Dper\GL17132 Y   Drosophila willistoni   Dwil\GK15827 Y   Drosophila virilis   Dvir\GJ15034 Y   Drosophila mojavensis   Dmoj\GI19669 Y   Drosophila grimshawi   Dgri\GH21964 Y
Orthologs in non-Drosophila Dipterans (EOG6H72M2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012967   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012821   Anopheles gambiae Malaria mosquito  Agam\AGAP006921   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015081   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011241
Orthologs in non-Dipteran Insects (EOG6TX9N8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\ced-6   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004894   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21076   Atta cephalotes Leafcutter ant  Acep\ACEP22311   Atta cephalotes Leafcutter ant  Acep\ACEP22316   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12879   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17104   Linepithema humile Argentine ant  Lhum\LH16917   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20178   Solenopsis invicta Red fire ant  Sinv\SINV20858   Acyrthosiphon pisum Pea aphid  Apim\ACYPI31758   Bombyx mori Silkmoth  Bmor\BGIBMGA009770   Tribolium castaneum Red flour beetle  Tcas\TC010167
Orthologs in non-Insect Arthropods (EOG644J1R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Mtor   Ixodes scapularis Deer tick  Isca\ISCW006989
Orthologs in non-Arthropod Metazoa (EOG6CGC34)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ced-6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023975gn   Danio rerio Zebrafish  Drer\ENSDARG00000057833   Danio rerio Zebrafish  Drer\ENSDARG00000001733   Xenopus tropicalis Western clawed frog  Xtro\gulp1   Gallus gallus Domestic chicken  Ggal\GULP1   Mus musculus House mouse  Mmus\Gulp1   Rattus norvegicus Norway rat  Rnor\Gulp1   Homo sapiens Human  Hsap\GULP1
Human Orthologs (1)
Gene OMIM HGNC Hsap\GULP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10073 Drosophila sechellia Dsec\GM20601 Drosophila erecta Dere\GG25283 Drosophila yakuba Dyak\GE22280 Drosophila ananassae Dana\GF12503 Drosophila pseudoobscura pseudoobscura Dpse\GA11210 Drosophila persimilis Dper\GL17132 Drosophila willistoni Dwil\GK15827 Drosophila virilis Dvir\GJ15034 Drosophila mojavensis Dmoj\GI19669 Drosophila grimshawi Dgri\GH21964
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	20805 y1 w67c23; P{EPgy2}ced-6EY11592 41096 y1 w*; Mi{MIC}ced-6MI06215/SM6a 13954 y1 w67c23; P{SUPor-P}ced-6KG03411a; P{SUPor-P}KG03411b ry506
Harvard	- P{XP}ced-6d11244
VDRC	v108101 P{KK102556}VIE-260B v16313 w1118; P{GD7389}v16313/CyO
Genomic Clones ( 1 )
	BACR14J24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 169 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD19266 RE47146
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04435 LD03145 LD03218 LD03345 LD04073 LD07001 LD09044 LD14328 LD15115 LD17348 LD18195 LD18660 LD19342 LD20509 LD25508 LD33622 LP16578 LP21641 RE03012 RE04189 RE04991 RE05731 RE07358 RE08051 RE08291 RE10192 RE11058 RE11237 RE11653 RE11920 RE12396 RE12940 RE13195 RE13511 RE18963 RE18976 RE19348 RE20571 RE23585 RE24749 RE26711 RE27409 RE28790 RE29373 RE29938 RE31038 RE31148 RE31363 RE33360 RE33411 RE34017 RE34978 RE36392 RE36526 RE37308 RE37618 RE38961 RE39573 RE41641 RE42073 RE44616 RE46772 RE52355 RE56182 RE56754 RE57153 RE60251 RE61849 RE62053 RE62704 RE63639 RE63870 RE64139 RE64457 RE66554 RE67517 RE68190 RE68893 RE69718 RE69732 RE72280 RE73796 RH17695 RH21985 RH27623 RH30438 RH30740 RH31336 RH31647 RH31693 RH33091 RH33491 RH35353 RH37028 RH37168 RH65971 RH72477 SD07203
Other clones	33539 39005 50997 102866 102868 160809 193955 280924 CK01.16C.A6 CK01.16C.A8 CK01.26B.D4 CK01.34D.F7 CK01.53A.G8 CK01.80D.F11 CK01.98B.H5 CK01.118A.C4 CK01668 Dmel_dig_012747_0628_2349 Dmel_neb_009087_0676_0687 Dmel_neb_013008_0183_1680 Dmel_neb_016418_0927_0644 EC26269 EC35738 EC36938 EC37269 EK025035 EK040805 EK042860 EK062424 EK076031 EK089732 EK102347 EK144224 EK152043 EK166940 EK177238 EK264429 EK297249 EK305737 ESG012d.E21_A05 ESG017d.E21_A08 ESG0115d.B21_A05 LD28347 RP01434 RP01567 RP001003113 RP001012250 RP001019315 RP001033702 RP001034424 RP001039231 RP004139384 RP004190773 RP004206082 RP004206931 RP004220737 RP004249994 RP004252107 RP004335408 RP004420948 RP004444003 RP004457651 RP004464431 RP004470708 RP004491366 RP004505952 RP004536719 RP004547909 RP004555718
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029092 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35971
Antibody Information
	polyclonal (Awasaki et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ced-6 CG11804 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136644 NM_165675 NM_165676 NM_001259296 RefSeq (Proteins) • NP_610488 NP_724789 NP_724790 NP_001246225 DDBJ / EMBL / GenBank • AA539957 AAF22653 AAF58937 AAG22292 AAM50250 AAM71067 AF204777 AFH07980 AFH07981 AW942524 AX149386 AX149388 AY119596 BH809437 BH809438 CL943497 CZ474883 CZ477639 CZ477640 Entrez Gene - A searchable database of RefSeq genes. • 35971 UniProtKB/Swiss-Prot • Q7JUY7 UniProtKB/TrEMBL • E2QC90
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phosphotyrosine interaction domain (IPR006020) Pleckstrin homology-like domain (IPR011993) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD19266
Linkouts
	BioGRID - A database of protein and genetic interactions • 61802 DroID - A comprehensive database of gene and protein interactions. • FBgn0029092 DRSC - Results from RNAi screens. • FBgn0029092 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029092 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11804-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029092 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35971 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35971 modMine - Data generated by the modENCODE project. • FBgn0029092 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7JUY7
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	ced-6 (Miller et al., 2009, Han et al., 2006, Haerty et al., 2007, Hashimoto et al., 2009, Markstein et al., 2008, Awasaki et al., 2006, Doherty et al., 2009, Kuraishi et al., 2009, McPhee et al., 2010, Georgiev et al., 2012, Azad et al., 2012, Japanese National Institute of Genetics, 2012.5.21) ced6 (Latouche et al., 2007, Azad et al., 2012) Ced-6 (Logan et al., 2012) CG11804 (Brody et al., 2002, Labourier et al., 2002, Keleman et al., 2009.8.5, Azad et al., 2012) dCed-6 (Doherty et al., 2009, Fuentes-Medel et al., 2009, Ziegenfuss et al., 2012) dced-6 (Franc et al., 2008) drced-6 (Van Criekinge, 1999.11.15, Cuttell et al., 2008) drCed-6 (Cuttell et al., 2008)
Name Synonym	ced-6 (McPhee et al., 2010)
Secondary FlyBase IDs
	FBgn0033414
References ( 43 )
Generate a list of	All references relating to this gene ( 43 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 4 )
	Azad et al., 2012, G3 (Bethesda) 2(10): 1169--1178 Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen. [FBrf0219647] Georgiev et al., 2012, J. Neurogenet. 26(3-4): 338--347 Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. [FBrf0220084] Logan et al., 2012, Nat. Neurosci. 15(5): 722--730 Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. [FBrf0218175] Ziegenfuss et al., 2012, Nat. Neurosci. 15(7): 979--987 Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. [FBrf0218752] Show all research papers ...