FB2020_01, released Feb 12, 2020

Gene: Dmel\α-Catr

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General Information
Symbol
Dmel\α-Catr
Species
D. melanogaster
Name
alpha-catenin related
Annotation Symbol
CG2987
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029105
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Key Links
Genomic Location
Cytogenetic map
60A14-60A14
Sequence location
2R:23,957,842..23,961,631 [+]
Recombination map

2-105

RefSeq locus
NT_033778 REGION:23957842..23961631
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
actin filament binding
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\α-Catr or the JBrowse view of Dmel\α-Catr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
α-Catr-RA
FBtr0072148
NM_143816
3007
787
α-Catr-RC
FBtr0330254
NM_166641
3007
810
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
α-Catr-PA
FBpp0072057
88.8
787
6.76
NP_652073
AAF47116
α-Catr-PC
FBpp0303286
91.4
810
7.29
NP_726389
AAM68283
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\α-Catr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
actin filament binding
inferred from electronic annotation with InterPro:IPR006077
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cell adhesion
inferred from electronic annotation with InterPro:IPR006077
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Rho protein signal transduction
inferred from electronic annotation with InterPro:IPR030045
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\α-Catr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of α-Catr
Transgenic constructs containing regulatory region of α-Catr
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CTNNAL1
14 of 15
Yes
Yes
Hsap\CTNNA1
1 of 15
No
No
Hsap\CTNNA2
1 of 15
No
No
Hsap\CTNNA3
1 of 15
No
No
Hsap\TMEM245
1 of 15
No
No
Hsap\VCL
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ctnnal1
13 of 15
Yes
Yes
Mmus\Ctnna1
1 of 15
No
No
Mmus\Ctnna2
1 of 15
No
No
Mmus\Ctnna3
1 of 15
No
No
Mmus\Gm14025
1 of 15
No
Yes
Mmus\Tmem245
1 of 15
No
No
Mmus\Vcl
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Ctnnal1
13 of 13
Yes
Yes
Rnor\Ctnna1
1 of 13
No
No
Rnor\Ctnna2
1 of 13
No
No
Rnor\Ctnna3
1 of 13
No
No
Rnor\Tmem245
1 of 13
No
No
Rnor\Vcl
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ctnnal1
8 of 12
Yes
Yes
Xtro\ctnna1
1 of 12
No
No
Xtro\vcl
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\ctnnal1
13 of 15
Yes
Yes
Drer\ctnna1
1 of 15
No
No
Drer\ctnna2
1 of 15
No
No
Drer\tmem245
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\ctn-1
14 of 15
Yes
Yes
Cele\deb-1
1 of 15
No
No
Cele\hmp-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903H4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\α-Catr
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002325
Drosophila simulans
Dsim\GD15454
Drosophila sechellia
Dsec\GM16069
Drosophila erecta
Dere\GG22909
Drosophila yakuba
Dyak\GE14347
Drosophila ananassae
Dana\GF12881
Drosophila persimilis
Dper\GL11185
Drosophila willistoni
Dwil\GK15721
Drosophila virilis
Dvir\GJ20451
Drosophila mojavensis
Dmoj\GI20712
Drosophila grimshawi
Dgri\GH20184
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501QA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004376
Musca domestica
House fly
Mdoa\17004686
Glossina morsitans
Tsetse fly
Gmor\GMOY011969
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01832
Mayetiola destructor
Hessian fly
Mdes\Mdes011446
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010927
Anopheles darlingi
American malaria mosquito
Adar\ADAC006283
Anopheles gambiae
Malaria mosquito
Agam\AGAP011097
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007820
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003455
Danaus plexippus
Monarch butterfly
Dple\DPOGS203658-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006944
Apis florea
Little honeybee
Aflo\3461396356
Apis mellifera
Western honey bee
Amel\GB43719
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18134
Bombus terrestris
Buff-tailed bumblebee
Bter\15205044
Linepithema humile
Argentine ant
Lhum\LH18686
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001dfb
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006572
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10803
Tribolium castaneum
Red flour beetle
Tcas\TC003589
Pediculus humanus
Human body louse
Phum\PHUM308290
Rhodnius prolixus
Kissing bug
Rpro\RPRC009439
Cimex lectularius
Bed bug
Clec\CLEC004855
Cimex lectularius
Bed bug
Clec\CLEC004854
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069530
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009968
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01467
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01GP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005858
Ixodes scapularis
Black-legged tick
Isca\ISCW001082
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57300.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70557.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g11010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g02430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_106828
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54984
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BL2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_028006gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017431gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-C9orf5L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CtnaL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016146gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006913
Ciona intestinalis
Vase tunicate
Cint\LOC100182025
Gallus gallus
Domestic chicken
Ggal\CTNNAL1
Gallus gallus
Domestic chicken
Ggal\C9orf5
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
α-Cat
2 of 10
Vinc
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CTNNAL1; catenin alpha like 1
    14 of 15
    604785
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        α-Catr - CG10257
        two hybrid
        (Hu et al., 2017.6.13)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-105

        Cytogenetic map
        60A14-60A14
        Sequence location
        2R:23,957,842..23,961,631 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        60A14-60A14
        Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        60A-60A
        (Wu, 1998.12.11)
        Experimentally Determined Recombination Data
        Location

        2-105

        (FlyBase, 2016)

        2-109.8

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (21)
        cDNA Clones (4)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: α-Catr alpha-catenin-related

          (FlyBase, 2009-)
          Source for database merge of

          Source for merge of: alpha-catenin-related CG2987

          (Bayraktaroglu, 2000.8.7)
          Additional comments

          Previously, the 'symbol' for this gene was "alpha-catenin-related". It has now been given the abbreviated symbol "α-Catr", which is based on its fullname and the existing symbol of the "α-Cat" gene (FBgn0010215).

          (FlyBase, 2009-)
          Other Comments

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 34 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Synonyms and Secondary IDs (7)
          Reported As
          Symbol Synonym
          CG2987
          (Moon et al., 2011, Keleman et al., 2009.8.5, Ni et al., 2008)
          alpha-Catr
          (Gene Disruption Project members, 2018-)
          alpha-catenin-Related
          (Jungreis et al., 2011)
          alpha-catenin-related
          (Aradska et al., 2015, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21)
          α-Catr
          (Hu et al., 2017.6.13)
          Name Synonyms
          alpha-catenin related
          alpha-catenin-related
          (Bakal et al., 2007)
          α-catenin-related
          (Moon et al., 2011)
          Secondary FlyBase IDs
          • FBgn0034941
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (30)