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Gene Dmel\alpha-catenin-related

General Information
Symbol	Dmel\alpha-catenin-related	Species	D. melanogaster
Name	alpha-catenin related	Annotation symbol	CG2987
Feature type	protein_coding_gene	FlyBase ID	FBgn0029105
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A14-60A14	Sequence location	2R:19,845,365..19,849,154 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene alpha-catenin related is referred to in FlyBase by the symbol Dmel\alpha-catenin-related (CG2987, FBgn0029105). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cell adhesion. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Vinculin/alpha-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1630043_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of alpha-catenin-related. Gene sequence location is 2R:19845365..19849154.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A14-60A14   Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A-60A     (Wu, 1998.12.11)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\alpha-catenin-related for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884 Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) alpha-catenin-related-RA FBtr0072148  NM_143816   3007   787 alpha-catenin-related-RC FBtr0330254  NM_166641   3007   810
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alpha-catenin-related-PA   FBpp0072057   88.8   787   6.76     NP_652073   AAF47116 alpha-catenin-related-PC   FBpp0303286   91.4   810   7.29     NP_726389   AAM68283
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vinculin/alpha-catenin (IPR006077)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47116   AE013599 AAM68283   AF113936 AAF22509   BT024411   BT099538   EL871815   EL871943
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1F1 Q9U523
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic antennal sense organ   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    196.675 Larval Midgut    11.7 Larval Hindgut    5.4 Larval Malpighian Tubules    8.6 Larval Fat Body    3.2 Larval Salivary Gland    9 Larval Trachea    7.275 Larval Carcass    7.1 Adult Head    96.2 Adult Eye    158.45 Adult Brain    315.2 Adult Thoracic-Abdominal Ganglion    272.9 Adult Crop    7.9 Adult Midgut    8.6 Adult Hindgut    7.4 Adult Malpighian Tubules    12.9 Adult Fat Body    3.6 Adult Salivary Gland    19 Adult Heart    5.575 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    12.4 Adult Ovary    4.9 Adult Testis    9.4 Adult Male Accessory Gland    5.6 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    96.2   NA  Eye    158.45   NA  Brain    315.2   196.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    272.9   NA  Crop    7.9   no informative data  Midgut    8.6   5.4  Hindgut    7.4   8.6  Malpighian Tubules    no informative data   3.2  Fat Body    3.6   9  Salivary Gland    no informative data   NA  Heart    5.575   7.275  Trachea    NA   NA  VirginFemale Spermatheca    9.8   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4.9   NA  Testis    9.4   NA  Male Accessory Gland    5.6   7.1  Carcass    17.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male  26 head, mated 20-day male  (30) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male  26 head, mated 20-day male  30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    16 head, virgin 1-day female    14 head, virgin 4-day female    13 head, virgin 20-day female    12 head, mated 1-day female    12 head, mated 4-day female    15 head, mated 20-day female    12 head, mated 1-day male    22 head, mated 4-day male    26 head, mated 20-day male    30 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    3 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    10 larva L1    9 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    4 pupae 3d postWPP    5 pupae 4d postWPP    4 adult male 01day    5 adult male 05day    5 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    3 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • IP03755 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2987-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 alpha-catenin-relatedGD1632 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of alpha-catenin-related Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of alpha-catenin-related Class Mutagen Stocks Known lesion alpha-catenin-relatedGD1632 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes alpha-catenin-relatedJF01772 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes alpha-catenin-relatedKK107455 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes alpha-catenin-relatedNIG.2987R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes alpha-catenin-relatedtBRV in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6080 (Ryder, 2004.4.26) Df(2R)Exel7182 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1632} NA P{KK107455} NA P{NIG.2987R} NA P{TRiP.JF01772} NA characterization construct P{BRV} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with EMBL:AF006071 (FlyBase, 1992-) structural molecule activity inferred from electronic annotation with InterPro:IPR006077 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from electronic annotation with InterPro:IPR006077 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR006077 (FlyBase Curators et al., 2004-) zonula adherens inferred from sequence or structural similarity with EMBL:AF006071 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions alpha-catenin-related allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72428 DroID - A comprehensive database of gene and protein interactions. • FBgn0029105 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49713
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6J6S9B Dipteran inclusive ortholog search EOG64MZ15 Insect inclusive ortholog search EOG6KSNDS Arthropod inclusive ortholog search EOG6NS1SF Metazoa inclusive ortholog search EOG642349
Orthologs in Drosophila Species (EOG6J6S9B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\alpha-catenin-related     Drosophila simulans   Dsim\GD15454 Y   Drosophila sechellia   Dsec\GM16069 Y   Drosophila erecta   Dere\GG22909 Y   Drosophila yakuba   Dyak\GE14347 Y   Drosophila ananassae   Dana\GF12881 Y   Drosophila persimilis   Dper\GL11185 Y   Drosophila willistoni   Dwil\GK15721 Y   Drosophila virilis   Dvir\GJ20451 Y   Drosophila mojavensis   Dmoj\GI20712 Y   Drosophila grimshawi   Dgri\GH20184 Y
Orthologs in non-Drosophila Dipterans (EOG64MZ15)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010927   Anopheles gambiae Malaria mosquito  Agam\AGAP011097   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007820
Orthologs in non-Dipteran Insects (EOG6KSNDS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43719   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006572   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20785   Atta cephalotes Leafcutter ant  Acep\ACEP13772   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12765   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17653   Linepithema humile Argentine ant  Lhum\LH18686   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17835   Solenopsis invicta Red fire ant  Sinv\SINV25293   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069530   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009968   Bombyx mori Silkmoth  Bmor\BGIBMGA003455   Pediculus humanus Human body louse  Phum\PHUM308290   Tribolium castaneum Red flour beetle  Tcas\TC003589
Orthologs in non-Insect Arthropods (EOG6NS1SF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ELH2   Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\PINX1   Ixodes scapularis Deer tick  Isca\ISCW001082
Orthologs in non-Arthropod Metazoa (EOG642349)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y23H5A.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017431gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007547gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007302gn   Danio rerio Zebrafish  Drer\si:ch211-254e15.1   Xenopus tropicalis Western clawed frog  Xtro\ctnnal1   Gallus gallus Domestic chicken  Ggal\CTNNAL1   Mus musculus House mouse  Mmus\Ctnnal1   Rattus norvegicus Norway rat  Rnor\Ctnnal1   Homo sapiens Human  Hsap\CTNNAL1
Human Orthologs (1)
Gene OMIM HGNC Hsap\CTNNAL1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15454 Drosophila sechellia Dsec\GM16069 Drosophila erecta Dere\GG22909 Drosophila yakuba Dyak\GE14347 Drosophila ananassae Dana\GF12881 Drosophila persimilis Dper\GL11185 Drosophila willistoni Dwil\GK15721 Drosophila virilis Dvir\GJ20451 Drosophila mojavensis Dmoj\GI20712 Drosophila grimshawi Dgri\GH20184
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	31217 y1 v1; P{TRiP.JF01772}attP2
VDRC	v104566 P{KK107455}VIE-260B v7182 w1118; P{GD1632}v7182
Genomic Clones ( 1 )
	BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP03655
Other clones	IP03755
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP03855 IP03955
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49713
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: alpha-catenin-related CG2987 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143816 NM_166641 RefSeq (Proteins) • NP_652073 NP_726389 DDBJ / EMBL / GenBank • AAF22509 AAF47116 AAF47116.2 AAM68283 AAM68283.1 AAM68283.2 AF113936 Entrez Gene - A searchable database of RefSeq genes. • 49713 UniProtKB/TrEMBL • Q9U523 Q9W1F1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Vinculin/alpha-catenin (IPR006077) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP03755
Linkouts
	BioGRID - A database of protein and genetic interactions • 72428 DroID - A comprehensive database of gene and protein interactions. • FBgn0029105 DRSC - Results from RNAi screens. • FBgn0029105 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2987-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49713 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49713 modMine - Data generated by the modENCODE project. • FBgn0029105
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	alpha-catenin-related (Japanese National Institute of Genetics, 2012.5.21) alpha-catenin-Related (Jungreis et al., 2011) CG2987 (Keleman et al., 2009.8.5, Moon et al., 2011, Ni et al., 2008)
Name Synonym	alpha-catenin related   alpha-catenin-related (Bakal et al., 2007) α-catenin-related (Moon et al., 2011)
Secondary FlyBase IDs
	FBgn0034941
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 2 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Moon et al., 2011, Development 138(17): 3835--3845 The THO complex is required for nucleolar integrity in Drosophila spermatocytes. [FBrf0214600] Show all research papers ...