FlyBase Gene Report: Dmel\α-Catr

General Information

Symbol

Dmel\α-Catr

Species

D. melanogaster

Name

alpha-catenin related

Annotation Symbol

CG2987

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029105

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

60A14-60A14

Sequence location

2R:23,957,842..23,961,631 [+]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23957842..23961631

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables actin filament binding

inferred from electronic annotation with InterPro:IPR006077

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell adhesion

inferred from electronic annotation with InterPro:IPR006077

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in Rho protein signal transduction

inferred from electronic annotation with InterPro:IPR030045

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\α-Catr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

α-Catr-RA

FBtr0072148

NM_143816

3007

787

α-Catr-RC

FBtr0330254

NM_166641

3007

810

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

α-Catr-PA

FBpp0072057

88.8

787

6.76

NP_652073

AAF47116

α-Catr-PC

FBpp0303286

91.4

810

7.29

NP_726389

AAM68283

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\α-Catr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

a-catenin-rel_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic antennal sense organ

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\α-Catr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\α-Catr

View exonic expression by tissue for Dmel\α-Catr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029105

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0029105

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2987-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0029105

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of α-Catr

Transgenic constructs containing regulatory region of α-Catr

Deletions and Duplications ( 2 )

Disrupted in

Df(2R)Exel6080

(Ryder, 2004.4.26)

Df(2R)Exel7182

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

α-Catr^GD1632

viable, with Scer\GAL4^Mef2.PR

α-Catr^GD1632

viable, with Scer\GAL4^pnr-MD237

α-Catr^GD1632

viable, with Scer\GAL4^tin.CΔ4

α-Catr^GD1632

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CTNNAL1

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ctnnal1

13 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (5)

Rnor\Ctnnal1

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (3)

Xtro\ctnnal1

9 of 12

Yes

Xtro\ctnna1

1 of 12

Xtro\vcl

1 of 12

Danio rerio (Zebrafish) (3)

Drer\ctnnal1

13 of 15

Yes

Drer\ctnna1

1 of 15

Drer\ctnna2

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\ctn-1

14 of 15

Yes

Cele\deb-1

1 of 15

Cele\hmp-1

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903H4 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila persimilis

Dper\GL11185

Drosophila willistoni

Dwil\GK15721

Drosophila virilis

Dvir\GJ20451

Drosophila mojavensis

Dmoj\GI20712

Drosophila grimshawi

Dgri\GH20184

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501QA )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17004376

Musca domestica

House fly

Mdoa\17004686

Glossina morsitans

Tsetse fly

Gmor\GMOY011969

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01832

Mayetiola destructor

Hessian fly

Mdes\Mdes011446

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010927

Anopheles darlingi

American malaria mosquito

Adar\ADAC006283

Anopheles gambiae

Malaria mosquito

Agam\AGAP011097

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007820

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01IJ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003455

Danaus plexippus

Monarch butterfly

Dple\DPOGS203658-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006944

Apis florea

Little honeybee

Aflo\3461396356

Apis mellifera

Western honey bee

Amel\GB43719

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18134

Bombus terrestris

Buff-tailed bumblebee

Bter\15205044

Linepithema humile

Argentine ant

Lhum\LH18686

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001dfb

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006572

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10803

Tribolium castaneum

Red flour beetle

Tcas\TC003589

Pediculus humanus

Human body louse

Phum\PHUM308290

Rhodnius prolixus

Kissing bug

Rpro\RPRC009439

Cimex lectularius

Bed bug

Clec\CLEC004855

Cimex lectularius

Bed bug

Clec\CLEC004854

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI069530

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009968

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01467

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01GP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005858

Ixodes scapularis

Black-legged tick

Isca\ISCW001082

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57300.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70557.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g11010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g02430

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_106828

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_54984

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BL2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028006gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017431gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-C9orf5L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CtnaL1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_016146gn

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000006913

Ciona intestinalis

Vase tunicate

Cint\LOC100182025

Gallus gallus

Domestic chicken

Ggal\CTNNAL1

Gallus gallus

Domestic chicken

Ggal\C9orf5

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (2)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CTNNAL1; catenin alpha like 1

14 of 15

604785

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

α-Catr - CG10257

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

72428

DroID - A comprehensive database of gene and protein interactions.

FBgn0029105

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

49713

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-105

Cytogenetic map

60A14-60A14

Sequence location

2R:23,957,842..23,961,631 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A14-60A14

Limits computationally determined from genome sequence between P{EP}Tal^EP489&P{EP}CG3065^EP316 and P{lacW}Phm^k07623&P{lacW}tsr^k05633

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A-60A

(Wu, 1998.12.11)

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Bloomington

31217

y¹ v¹; P{TRiP.JF01772}attP2

78975

y¹ w^*; TI{CRIMIC.TG4.0}α-Catr^{CR00660-TG4.0}/SM6a

VDRC

v104566

P{KK107455}VIE-260B

v7182

w¹¹¹⁸; P{GD1632}v7182

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP03655

Other clones

IP03755

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029105

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029105

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49713

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: α-Catr alpha-catenin-related

(FlyBase, 2009-)

Source for database merge of

Source for merge of: alpha-catenin-related CG2987

(Bayraktaroglu, 2000.8.7)

Additional comments

Previously, the 'symbol' for this gene was "alpha-catenin-related". It has now been given the abbreviated symbol "α-Catr", which is based on its fullname and the existing symbol of the "α-Cat" gene (FBgn0010215).

(FlyBase, 2009-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

49713

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF113936

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis