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Gene: Dmel\α-Catr

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General Information
Symbol
Dmel\α-Catr
Species
D. melanogaster
Name
alpha-catenin related
Annotation Symbol
CG2987
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029105
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
alpha-catenin-related
Key Links
Genomic Location
Cytogenetic map
60A14-60A14
Sequence location
2R:23,957,842..23,961,631 [+]
Recombination map
2-105
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
Vinculin/alpha-catenin; Alpha-catulin 1; Alpha-catenin/vinculin-like superfamily
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
actin binding; actin filament binding
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\α-Catr or the JBrowse view of Dmel\α-Catr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884
Gene model reviewed during 5.44
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
α-Catr-RA
FBtr0072148
NM_143816
3007
787
α-Catr-RC
FBtr0330254
NM_166641
3007
810
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
α-Catr-PA
FBpp0072057
88.8
787
6.76
NP_652073
AAF47116
α-Catr-PC
FBpp0303286
91.4
810
7.29
NP_726389
AAM68283
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\α-Catr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
actin binding
inferred from sequence or structural similarity
(Goldstein and Gunawardena, 2000)
actin filament binding
inferred from electronic annotation with InterPro:IPR006077
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cell adhesion
inferred from electronic annotation with InterPro:IPR006077
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Rho protein signal transduction
inferred from electronic annotation with InterPro:IPR030045
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\α-Catr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Allele of α-Catr
Class
Mutagen
Associated Insertion
Stocks
Known lesion
α-CatrCR00660-TG4.0
1
Yes
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of α-Catr
Allele of α-Catr
Mutagen
Associated Transgenic Construct
Stocks
α-CatrGD1632
1
α-CatrJF01772
1
α-CatrKK107455
1
α-CatrNIG.2987R
0
α-CatrtBRV
0
Transgenic constructs containing regulatory region of α-Catr
Deletions and Duplications ( 2 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CTNNAL1
14 of 15
Yes
Yes
Hsap\CTNNA1
1 of 15
No
No
Hsap\CTNNA2
1 of 15
No
No
Hsap\CTNNA3
1 of 15
No
No
Hsap\TMEM245
1 of 15
No
No
Hsap\VCL
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ctnnal1
13 of 15
Yes
Yes
Mmus\Ctnna1
1 of 15
No
No
Mmus\Ctnna2
1 of 15
No
No
Mmus\Ctnna3
1 of 15
No
No
Mmus\Gm14025
1 of 15
No
Yes
Mmus\Tmem245
1 of 15
No
No
Mmus\Vcl
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Ctnnal1
13 of 13
Yes
Yes
Rnor\Ctnna1
1 of 13
No
No
Rnor\Ctnna2
1 of 13
No
No
Rnor\Ctnna3
1 of 13
No
No
Rnor\Tmem245
1 of 13
No
No
Rnor\Vcl
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ctnnal1
8 of 12
Yes
Yes
Xtro\ctnna1
1 of 12
No
No
Xtro\vcl
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\ctnnal1
13 of 15
Yes
Yes
Drer\ctnna1
1 of 15
No
No
Drer\ctnna2
1 of 15
No
No
Drer\tmem245
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\ctn-1
14 of 15
Yes
Yes
Cele\deb-1
1 of 15
No
No
Cele\hmp-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903H4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\α-Catr
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002325
Drosophila simulans
Dsim\GD15454
Drosophila sechellia
Dsec\GM16069
Drosophila erecta
Dere\GG22909
Drosophila yakuba
Dyak\GE14347
Drosophila ananassae
Dana\GF12881
Drosophila persimilis
Dper\GL11185
Drosophila willistoni
Dwil\GK15721
Drosophila virilis
Dvir\GJ20451
Drosophila mojavensis
Dmoj\GI20712
Drosophila grimshawi
Dgri\GH20184
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501QA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004376
Musca domestica
House fly
Mdoa\17004686
Glossina morsitans
Tsetse fly
Gmor\GMOY011969
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01832
Mayetiola destructor
Hessian fly
Mdes\Mdes011446
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010927
Anopheles darlingi
American malaria mosquito
Adar\ADAC006283
Anopheles gambiae
Malaria mosquito
Agam\AGAP011097
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007820
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003455
Danaus plexippus
Monarch butterfly
Dple\DPOGS203658-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006944
Apis florea
Little honeybee
Aflo\3461396356
Apis mellifera
Western honey bee
Amel\GB43719
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18134
Bombus terrestris
Buff-tailed bumblebee
Bter\15205044
Linepithema humile
Argentine ant
Lhum\LH18686
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001dfb
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006572
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10803
Tribolium castaneum
Red flour beetle
Tcas\TC003589
Pediculus humanus
Human body louse
Phum\PHUM308290
Rhodnius prolixus
Kissing bug
Rpro\RPRC009439
Cimex lectularius
Bed bug
Clec\CLEC004855
Cimex lectularius
Bed bug
Clec\CLEC004854
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069530
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009968
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01467
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01GP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005858
Ixodes scapularis
Black-legged tick
Isca\ISCW001082
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57300.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70557.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g11010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g02430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_106828
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54984
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BL2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_028006gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017431gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-C9orf5L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-CtnaL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_016146gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006913
Ciona intestinalis
Vase tunicate
Cint\LOC100182025
Gallus gallus
Domestic chicken
Ggal\CTNNAL1
Gallus gallus
Domestic chicken
Ggal\C9orf5
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    CTNNAL1; catenin alpha like 1
    14 of 15
    604785
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please look at the Interaction Group reports for full details of the physical interactions
      protein-protein
      Interacting group
      Assay
      References
      α-Catr - CG10257
      two hybrid
      (Hu et al., 2017.6.13)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-105
      Cytogenetic map
      60A14-60A14
      Sequence location
      2R:23,957,842..23,961,631 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      60A14-60A14
      Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      60A-60A
      (Wu, 1998.12.11)
      Experimentally Determined Recombination Data
      Location
      2-105
      (FlyBase, 2016)
      2-109.8
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (4)
      Genomic Clones (21)
      cDNA Clones (4)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: α-Catr alpha-catenin-related
        (FlyBase, 2009-)
        Source for database merge of
        Source for merge of: alpha-catenin-related CG2987
        (Bayraktaroglu, 2000.8.7)
        Additional comments
        Previously, the 'symbol' for this gene was "alpha-catenin-related". It has now been given the abbreviated symbol "α-Catr", which is based on its fullname and the existing symbol of the "α-Cat" gene (FBgn0010215).
        (FlyBase, 2009-)
        Other Comments
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 33 )
        Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        InterPro - A database of protein families, domains and functional sites
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Synonyms and Secondary IDs (7)
        Reported As
        Symbol Synonym
        CG2987
        (Moon et al., 2011, Keleman et al., 2009.8.5, Ni et al., 2008)
        alpha-Catr
        (Gene Disruption Project members, 2018-)
        alpha-catenin-Related
        (Jungreis et al., 2011)
        alpha-catenin-related
        (Aradska et al., 2015, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21)
        α-Catr
        (Hu et al., 2017.6.13)
        Name Synonyms
        alpha-catenin related
        alpha-catenin-related
        (Bakal et al., 2007)
        α-catenin-related
        (Moon et al., 2011)
        Secondary FlyBase IDs
        • FBgn0034941
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (29)