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Gene Dmel\Uba2

General Information
Symbol	Dmel\Uba2	Species	D. melanogaster
Name	Smt3 activating enzyme 2	Annotation symbol	CG7528
Feature type	protein_coding_gene	FlyBase ID	FBgn0029113
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	SAE2, sip2, DmUba2, DmSae2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66B7-66B7	Sequence location	3L:8,118,423..8,120,919 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Smt3 activating enzyme 2 is referred to in FlyBase by the symbol Dmel\Uba2 (CG7528, FBgn0029113). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: small protein activating enzyme activity; protein binding. There is experimental evidence that it is involved in the biological process: humoral immune response; positive regulation of NF-kappaB transcription factor activity. 7 alleles are reported. The phenotypes of these alleles are annotated with: eye; embryonic/larval fat body; ommatidium; embryonic/larval hemocoel; pigment cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold; Ubiquitin-activating enzyme; Ubiquitin-activating enzyme repeat; Ubiquitin-activating enzyme, E1, active site; Ubiquitin-like 1 activating enzyme, catalytic cysteine domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631381_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Uba2. Gene sequence location is 3L:8118423..8120919.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
FB2012_01	Sequence features HFA11311 BKN22286
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66B7-66B7   Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65B5-65C3   (determined by in situ hybridisation)   (Long and Griffith, 2000) 66B6-66B11     (Shih, 1999.10.8) 66B5-66B11   Cytological location based on P1 blot screening and PCR checking.   (Shih, 1998.3.17) 66B6-66B10   Mapped using a high-density filter of P1 clones.   (Shih et al., 2002)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Uba2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Uba2-RA FBtr0076734  NM_080017   2334   700
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Uba2-PA   FBpp0076457   77.6   700   4.63     NP_524756   AAF50484
Additional Polypeptide Data & Comments
Reported size (kDa)	700 (aa) (Bhaskar et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-activating enzyme, E1, active site (IPR018074) Ubiquitin-activating enzyme repeat (IPR000127) UBA/THIF-type NAD/FAD binding fold (IPR000594) Molybdenum cofactor biosynthesis, MoeB (IPR009036) Ubiquitin-activating enzyme (IPR019572) NAD(P)-binding domain (IPR016040) Ubiquitin-like 1 activating enzyme, catalytic cysteine domain (IPR023280)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201643   AA201817   AA246406   AA263257   AA264231   AA390338   AA390912   AA392484   AA438602   AA439635   AA440034   AA440929   AA540876   AA540947   AA695661   AA735923   AA816313   AA817331   AA941243   AA949728   AA952079   AA952257   AA978851   AA979053   AE014296 AAF50484   AF193553 AAF25197   AF218864 AAF31704   AI455283   AI455973   AI512119   AI512338   AI514846   AI518245   AI519264   AI519370   AI519402   AI531319   AI531336   AI531785   AI532940   AI542368   AI543040   AI543494   AI544338   AY113361 AAM29366   BF495892   BG636676   BI162944   BI166266   BI172832   BI216136   BI227665   BI241877   BI242787   BI352718   BI353928   BI355205   BI355216   BI356941   BI363226   BI368152   BI369801   BI370784   BI371621   BI373518   BI481562   BI482667   BI579437   BI633818   BI637529   BI639200   BI639896   BI640909   BP550512   BP550920   BP551526   CK657788   CO187447   CO271975   CO273118   CO276817   CO279378   CO284980   CO311750   CO315731   CO326131   CO329465   EC060161   EC066415   EC076272   EC090127   EC209067   EC211495   EC225037   EC227119   EC227807   EC232427   EC251074   EV577943   EV581718   EV588977   EV596053   EV597885   GH748270   GH753081   GH753376   GH754258   GH760805   GH770197   GH773638   GH777912   GH778286   GH780156   GH781925   GH788984   GH794062   GH796345   GH796778   GH798944   GH809147   GH814340   GH815226   GH818460   GH821081   GH821551   GH823929   GH824353   GH826995   GH827159   GH828743   GH834675   GH838167   GH838305   GH839670   GH841131   GH845253   GH847203   GH847209   GH850208   GH851379   GH856951   GH859006   GH860309   GH863846   GH871808   GH872194   GH872500   GH873618   GH873799   GH875947   GH884376   GH894159   GH896563   GH903205   GH906309   GH907768   GH908924   GH912505   GH913015   GH917144   GH920453   GH922968   GH931126
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KJV6 Q7KUA4 Q9VSD9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic cycle 10 -- embryonic cycle 14   organism   • nucleus (Shih et al., 2002) Comment:interphase   • cell cortex (Shih et al., 2002) Comment:mitosis embryonic stage 6 -- 15   organism   • cytoplasm (Shih et al., 2002) Comment:mitosis organism   • nucleus (Shih et al., 2002) Comment:interphase adult stage   germarium   • nucleus (Shih et al., 2002) oocyte   • nucleus (Shih et al., 2002)
Additional Descriptive Data
	During embryonic cycles 10-14 protein was detected distributes around the cortex during mitotic divisions but concentrated in the nuclei during interphase. In later embryos postcellularization protein was detected in the cytoplasm of mitotic cells and primarily in the nuclei of interphase cells. No substantial colocalization with Septins was observed. During oogenesis Uba2 protein was detected in the nuclei of oocytes and of the follicle cells in the germarium. (Shih et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0029113    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0029113 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0029113 expression level Developmental Stage   Expression Level embryo 00-02hr    10243 embryo 02-04hr    12570 embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10243) embryo 02-04hr  (12570) embryo 04-06hr  (9088) embryo 06-08hr  (7887) embryo 08-10hr  (7705) embryo 10-12hr  (5352) embryo 12-14hr  (4082) embryo 14-16hr  (3586) embryo 16-18hr  (2840) embryo 18-20hr  (1310) embryo 20-22hr  (3544) embryo 22-24hr  (3246) larva L1  (1841) larva L2  (2356) larva L3 12hr old  (1978) larva L3 puffstage 1-2  (2601) larva L3 puffstage 3-6  (3595) larva L3 puffstage 7-9  (4578) white prepupae new  (4138) white prepupae 12hr  (5147) white prepupae 24hr  (6030) pupae 2d postWPP  (2450) pupae 3d postWPP  (1026) pupae 4d postWPP  (974) adult male 01day  (1119) adult male 05day  (1366) adult male 30day  (1291) adult female 01day  (3560) adult female 05day  (6601) adult female 30day  (6485) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10243) embryo 02-04hr  (12570) embryo 04-06hr  (9088) embryo 06-08hr  (7887) embryo 08-10hr  (7705) embryo 10-12hr  (5352) embryo 12-14hr  (4082) embryo 14-16hr  (3586) embryo 16-18hr  (2840) embryo 18-20hr    1310 embryo 20-22hr  (3544) embryo 22-24hr  (3246) larva L1  (1841) larva L2  (2356) larva L3 12hr old  (1978) larva L3 puffstage 1-2  (2601) larva L3 puffstage 3-6  (3595) larva L3 puffstage 7-9  (4578) white prepupae new  (4138) white prepupae 12hr  (5147) white prepupae 24hr  (6030) pupae 2d postWPP  (2450) pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day  (3560) adult female 05day  (6601) adult female 30day  (6485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10243 embryo 02-04hr  (12570) embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10243 embryo 02-04hr    12570 embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0029113 expression level Developmental Stage   Expression Level embryo 00-02hr    10243 embryo 02-04hr    12570 embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10243) embryo 02-04hr  (12570) embryo 04-06hr  (9088) embryo 06-08hr  (7887) embryo 08-10hr  (7705) embryo 10-12hr  (5352) embryo 12-14hr  (4082) embryo 14-16hr  (3586) embryo 16-18hr  (2840) embryo 18-20hr  (1310) embryo 20-22hr  (3544) embryo 22-24hr  (3246) larva L1  (1841) larva L2  (2356) larva L3 12hr old  (1978) larva L3 puffstage 1-2  (2601) larva L3 puffstage 3-6  (3595) larva L3 puffstage 7-9  (4578) white prepupae new  (4138) white prepupae 12hr  (5147) white prepupae 24hr  (6030) pupae 2d postWPP  (2450) pupae 3d postWPP  (1026) pupae 4d postWPP  (974) adult male 01day  (1119) adult male 05day  (1366) adult male 30day  (1291) adult female 01day  (3560) adult female 05day  (6601) adult female 30day  (6485) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10243) embryo 02-04hr  (12570) embryo 04-06hr  (9088) embryo 06-08hr  (7887) embryo 08-10hr  (7705) embryo 10-12hr  (5352) embryo 12-14hr  (4082) embryo 14-16hr  (3586) embryo 16-18hr  (2840) embryo 18-20hr    1310 embryo 20-22hr  (3544) embryo 22-24hr  (3246) larva L1  1841 larva L2  2356 larva L3 12hr old  1978 larva L3 puffstage 1-2  (2601) larva L3 puffstage 3-6  (3595) larva L3 puffstage 7-9  (4578) white prepupae new  (4138) white prepupae 12hr  (5147) white prepupae 24hr  (6030) pupae 2d postWPP  2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day  (3560) adult female 05day  (6601) adult female 30day  (6485) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10243 embryo 02-04hr  12570 embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10243 embryo 02-04hr    12570 embryo 04-06hr    9088 embryo 06-08hr    7887 embryo 08-10hr    7705 embryo 10-12hr    5352 embryo 12-14hr    4082 embryo 14-16hr    3586 embryo 16-18hr    2840 embryo 18-20hr    1310 embryo 20-22hr    3544 embryo 22-24hr    3246 larva L1    1841 larva L2    2356 larva L3 12hr old    1978 larva L3 puffstage 1-2    2601 larva L3 puffstage 3-6    3595 larva L3 puffstage 7-9    4578 white prepupae new    4138 white prepupae 12hr    5147 white prepupae 24hr    6030 pupae 2d postWPP    2450 pupae 3d postWPP    1026 pupae 4d postWPP    974 adult male 01day    1119 adult male 05day    1366 adult male 30day    1291 adult female 01day    3560 adult female 05day    6601 adult female 30day    6485 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0029113    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0029113 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0029113 expression level Tissue   Expression Level Larval Central Nervous System    1308.55 Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary    1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1308.55) Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland  (572.2) Larval Trachea  535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary  (1000.7) Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1308.55) Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary  1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1308.55 Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary    1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0029113 expression level Tissue   Expression Level Larval Central Nervous System    1308.55 Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary    1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1308.55) Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland  572.2 Larval Trachea  535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary  (1000.7) Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1308.55 Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary  1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1308.55 Larval Midgut    101.4 Larval Hindgut    388.1 Larval Malpighian Tubules    279.5 Larval Fat Body    257.3 Larval Salivary Gland    572.2 Larval Trachea    535.175 Larval Carcass    365.375 Adult Head    195.4 Adult Eye    257.25 Adult Brain    243.5 Adult Thoracic-Abdominal Ganglion    269.8 Adult Crop    307 Adult Midgut    136.7 Adult Hindgut    252.1 Adult Malpighian Tubules    208.7 Adult Fat Body    140.6 Adult Salivary Gland    133.4 Adult Heart    194.2 Adult VirginFemale Spermatheca    135.6 Adult InseminatedFemale Spermatheca    133 Adult Ovary    1000.7 Adult Testis    202.2 Adult Male Accessory Gland    216.4 Adult Carcass    154.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    195.4   NA  Eye    257.25   NA  Brain    243.5   1308.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    269.8   NA  Crop    307   101.4  Midgut    136.7   388.1  Hindgut    252.1   279.5  Malpighian Tubules    208.7   257.3  Fat Body    140.6   572.2  Salivary Gland    133.4   NA  Heart    194.2   535.175  Trachea    NA   NA  VirginFemale Spermatheca    135.6   NA  InseminatedFemale Spermatheca    133   NA  Ovary    1000.7   NA  Testis    202.2   NA  Male Accessory Gland    216.4   365.375  Carcass    154.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029113 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7528-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Uba2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele immune response defective, with Scer\GAL4Cg.PA Uba2HM05055 immune response defective, with Scer\GAL4Hml.PG Uba2HM05055 immune response defective, with Scer\GAL4Lsp2.PH Uba2HM05055 increased cell death | temperature conditional, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS tumorigenic, with Scer\GAL4Cg.PA Uba2HM05055 tumorigenic, with Scer\GAL4Hml.PG Uba2HM05055 tumorigenic, with Scer\GAL4Lsp2.PH Uba2HM05055 visible, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS Phenotype manifest in Allele embryonic/larval fat body, with Scer\GAL4Cg.PA Uba2HM05055 embryonic/larval fat body, with Scer\GAL4Hml.PG Uba2HM05055 embryonic/larval hemocoel, with Scer\GAL4Cg.PA Uba2HM05055 embryonic/larval hemocoel, with Scer\GAL4Hml.PG Uba2HM05055 embryonic/larval hemocoel, with Scer\GAL4Lsp2.PH Uba2HM05055 eye, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS eye | temperature conditional, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS ommatidium, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS ommatidium | temperature conditional, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS pigment cell, with Scer\GAL4GMR.PF Uba2C175S.Scer\UAS
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Uba2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Uba2 Class Mutagen Stocks Known lesion Uba2GL00452 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Uba2HM05055 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Uba2Act5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Uba2C175S.Scer\UAS in vitro construct - regulatory fusion 0 Yes Uba2GD12265 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Uba2KK102220 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Uba2Scer\UAS.cLa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6112 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12265} NA P{KK102220} NA P{TRiP.GL00452} NA P{TRiP.HM05055} NA P{UAS-Uba2.C175S} NA P{UAS-Uba2.L} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Aos1 AND inferred from physical interaction with lwr (Shih et al., 2002) small protein activating enzyme activity inferred from physical interaction with lwr AND inferred from physical interaction with smt3 AND inferred from sequence or structural similarity (Shih et al., 2000)
Biological Process
CV term Evidence References
humoral immune response inferred from mutant phenotype (Paddibhatla et al., 2010) positive regulation of NF-kappaB transcription factor activity inferred from direct assay (Bhaskar et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Shih et al., 2002) nucleus inferred from direct assay (Shih et al., 2002, Smith et al., 2004)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000127 (FlyBase Curators et al., 2004-) small protein activating enzyme activity inferred from sequence or structural similarity (FlyBase, 1992-) non-traceable author statement (Shih, 1999.10.8) SUMO activating enzyme activity inferred from sequence or structural similarity (Bhaskar et al., 2000) inferred from sequence or structural similarity with EMBL:AF090384 (FlyBase, 1992-) non-traceable author statement (Bhaskar, 1999.12.27) ubiquitin activating enzyme activity non-traceable author statement (Shih et al., 1998)
Biological Process
CV term Evidence References
protein modification process inferred from electronic annotation with InterPro:IPR000127 (FlyBase Curators et al., 2004-) protein sumoylation inferred from sequence or structural similarity (Bhaskar et al., 2000) SMT3-dependent protein catabolic process non-traceable author statement (Bhaskar, 1999.12.27)
Cellular Component
CV term Evidence References
SUMO activating enzyme complex inferred from sequence or structural similarity (Bhaskar et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Uba2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69084 DroID - A comprehensive database of gene and protein interactions. • FBgn0029113 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44496
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10481 Dere\GG14919 Dgri\GH15287 Dmoj\GI11997 Dper\GL22481 Dpse\GA20416 Dsec\GM24970 Dsim\GD13019 Dvir\GJ12222 Dwil\GK19989 Dyak\GE20372
Curated drosophilid orthologs	Dpse\GA20416
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010641-PA Aedes aegypti (mosquito) AGAP008637-PA Anopheles gambiae (mosquito) XP_392715.3 Apis mellifera (honey bee) XP_001947714.1 Acyrthosiphon pisum (pea aphid) At2g21470.2 Arabidopsis thaliana (wall cress) 1352 Batrachochytrium dendrobatidis (chytrid fungus) 201265 Branchiostoma floridae (lancelet) XP_001902233.1 Brugia malayi (roundworm nematode) BGIBMGA012116-PA Bombyx mori (silk worm) ENSBTAP00000003333 Bos taurus (bovine) CAL0001757 Candida albicans (a form of yeast) CN06129 Caenorhabditis brenneri (small nematode) CBP27792 Caenorhabditis briggsae (nematode) CE40719 Caenorhabditis elegans (worm) ENSCAFP00000010792 Canis familiaris (dog) CAGL0M01606g Candida glabrata (haploid yeast) Chro.20160 Cryptosporidium hominis (obligate parasite) JA12722 Caenorhabditis japonica (nematode) CME143C Cyanidioschyzon merolae (red alga) cn06389 Cryptococcus neoformans (yeast-like fungus) cgd2_1460 Cryptosporidium parvum (protozoan parasite) CPIJ007700 Culex pipens (mosquito) ENSCPOP00000009465 Cavia porcellus (guinea pig) RP29873 Caenorhabditis remanei (nematode) 219156 Capitella spl (polychaete worm) DDB0302360 Dictyostelium discoideum (amoeba) DEHA2G15114g Debaryomyces Hansenii (yeast) 300104 Daphnia pulex (daphnia) ENSDARP00000068081 Danio rerio (zebra fish) ENSECAP00000000109 Equus caballus (horse) XP_656129 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004237 Gymnopilus aculeatus (mushroom) ENSGALP00000038502 Gallus gallus (chicken) GL50803_6288 Giardia lamblia (flagellated protozoan) 71557 Hypsipyla robusta (cedar shoot borer) ENSP00000246548 Homo sapiens (human) ISCW007746-PA Ixodes scapularis (deer tick) KLLA0E03103g Kluyveromyces lactis (yeast) 178117 Lottia gigantea (owl limpet) LmjF08.0220 Leishmania major (virus) 33435 Monocosta brevicollis (choanoflagellate) ENSMODP00000030149 Monodelphis domestica (gray opossum) ENSMMUP00000007742 Macaca mulatta (rhesus monkey) ENSMUSP00000099807 Mus musculus (house mouse) 161397 Nematostella vectensis (starlet anemone) XP_001604879.1 Nasonia vitripennis (wasp) ENSOANP00000015208 Ornithorynchus anatinus (platypus) ENSORLP00000015752 Oryzias latipes (japanese killifish) LOC_Os07g39780.1 Oryza sativa (asian rice) 1518 Ostreococcus tauri (green alga) PFL1790w Plasmodium falciparum (protozoal parasite) PHUM002350-PA Pediculus humanus (human body louse) PP08241 Pristionchus pacificus (nematode) 75619 Physcomitrella patens (moss) ENSPPYP00000011014 Pongo pygmaeus (orangutan) 43972 Phytophthora ramorum (sudden oak death pathogen) 129825 Phytophthora sojae (root rot pathogen) 195584 Populus trichocarpa (black cottonwood) ENSPTRP00000018512 Pan troglodytes (chimpanzee) PVX_100800 Plasmodium vivax (protozoal parasite) 4749599 Sorghum bicolor (sorghum) YDR390C Saccharomyces cerevisiae (budding yeast) Smp_166220 Schistosoma mansoni (trematode parasite) SPBC16H5.03c Schizosaccharomyces pombe (fission yeast) XP_001179978.1 Strongylocentrotus purpuratus (purple sea urchin) 24020 Trichoplax adhaerens (metazoa) TA18995 Theileria annulata (apicomplexan parasite) XP_969731.1 Tribolium castaneum (red flour beetle) Tc00.1047053509777.100 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005165 Tetraodon nigroviridis (green spotted pufferfish) TP01_0127 Theileria parva (parasitic protozoan) ENSTRUP00000016721 Takifugu rubripes (pufferfish Takifugu) 3813.m01445 Tetrahymena thermophila (ciliate protozoa) 87349.m00190 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000005057 Xenopus tropicalis (frog) YALI0D06259g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11236 NV10104 LH19493 ISCW007746 FBgn0237688 FBgn0221986 FBgn0199472 FBgn0184741 FBgn0179831 JGI_V11_300104 FBgn0080411 FBgn0160073 FBgn0152968 FBgn0134754 FBgn0122762 FBgn0107173 FBgn0087522 CPIJ007700 BGIBMGA012116 ACYPI006138 GB12173 AGAP008637 AAEL010641 PHUM280660 GLEAN_02294
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	35806 y1 sc* v1; P{TRiP.GL00452}attP2 28569 y1 v1; P{TRiP.HM05055}attP2/TM3, Sb1
Genomic Clones ( 2 )
	BACR06E04 BACR09I19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 158 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22577
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09569 GM03210 GM10118 GM20503 GM25621 GM29927 GM29953 LD01184 LD03281 LD03967 LD04731 LD05280 LD07232 LD07585 LD09943 LD11358 LD12741 LD12918 LD14253 LD15109 LD20144 LD20715 LD25277 LD29126 LD29367 LD29722 LD33023 LD33306 LD35739 LD37708 LD38786 LD38937 LD38995 LD41270 LD43844 LD44180 LP24357 RE02225 RE06332 RE15521 RE23062 RE24774 RE39069 RE40215 RE43243 RE47987 RE54071 RE56105 RE57528 RE58549 RE60830 RE64135 RE65384 RE73466 SD02306 SD02328 SD03048 SD04593 SD08662 SD09620 SD10269 SD10859 SD14434 SD19568 SD21717 SD22603 SD23938 SD27983
Other clones	343 863 10104 57115 97565 102459 159273 165732 183167 191032 274596 Dmel_dig_006772_0710_2740 Dmel_dig_015818_0615_1119 Dmel_neb_009682_0933_0597 Dmel_neb_010832_0122_1139 Dmel_neb_012474_0585_1978 EK029406 EK105349 EK109622 EK122133 EK134204 EK167801 EK226055 EK262329 EK292916 EP03302 FGM207E11 FGM210A01 FGM213D04 RP003026227 RP003059695 RP003065065 RP003088854 RP003109274 RP003110306 RP003126238 RP003127340 RP003135495 RP003142398 RP003145150 RP003165770 RP003170293 RP003170434 RP003173745 RP003193397 RP003200950 RP003204319 RP003204711 RP003220237 RP003232581 RP003237275 RP003239152 RP003256347 RP003259845 RP003272262 RP003282072 RP003284109 RP003287543 RP003288431 RP003293294 RP003299237 RP003300769 RP003303009 RP003314182 RP003315216 RP003317892 RP003321926 RP003334949 RP003336819 RP003341350 RP003367763 RP003436610 RP003466056 RP003474930 RP003480841 RP003486715 RP003488090 RP003518207 RP003536632 RP003539591 RP003576151 RP003578225 RP003602584 RP003612514 RP003628189 RP003632944 RP003635688 RP003661855 RP003665672
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029113 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44496
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Uba2 SAE2 CG7528 (Bayraktaroglu, 2000.5.25)
Additional comments	FlyBase curator comment: the symbol "sip2" has been used to refer to two genes; both the gene referred to in FlyBase as Uba2 (CG7528, FBgn0029113) - in FBrf0108803, FBrf0102083 and FBrf0101408 and also the gene referred to in FlyBase as sip2 (CG9188, FBgn0031878) - in FBrf0144953. (Shih, 2003.6.25) FlyBase curator comment: the gene referred to as "sip2" in FBrf0108803 corresponds to the gene referred to in FlyBase as Uba2 (CG7528, FBgn0029113) and does NOT correspond to the gene referred to in FlyBase as sip2 (CG9188, FBgn0031878). (Hsin-Pei et al., 1998) FlyBase curator comment: the gene referred to as "sip2" in FBrf0101408 corresponds to the gene referred to in FlyBase as Uba2 (CG7528, FBgn0029113) and does NOT correspond to the gene referred to in FlyBase as sip2 (CG9188, FBgn0031878). (Shih et al., 1998) FlyBase curator comment: the gene referred to as "sip2" in FBrf0102083 corresponds to the gene referred to in FlyBase as Uba2 (CG7528, FBgn0029113) and does NOT correspond to the gene referred to in FlyBase as sip2 (CG9188, FBgn0031878). (Shih, 1998.3.17)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) Identification: Yeast two-hybrid screen for proteins that interact with the pnut, Sep1 or Sep2 proteins. Uba2 interacts with Sep1 and Sep2 in the two-hybrid system and does not interact with pnut. (Shih et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080017 RefSeq (Proteins) • NP_524756 DDBJ / EMBL / GenBank • AA201817 AA392484 AA817331 AAF25197 AAF31704 AAF50484 AAM29366 AF193553 AF218864 AI455283 AY113361 Entrez Gene - A searchable database of RefSeq genes. • 44496 UniProtKB/TrEMBL • Q7KJV6 Q7KUA4 Q9VSD9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-activating enzyme, E1, active site (IPR018074) Ubiquitin-activating enzyme repeat (IPR000127) UBA/THIF-type NAD/FAD binding fold (IPR000594) Molybdenum cofactor biosynthesis, MoeB (IPR009036) Ubiquitin-activating enzyme (IPR019572) NAD(P)-binding domain (IPR016040) Ubiquitin-like 1 activating enzyme, catalytic cysteine domain (IPR023280)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69084 DroID - A comprehensive database of gene and protein interactions. • FBgn0029113 DRSC - Results from RNAi screens. • FBgn0029113 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029113 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7528-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029113 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44496 InParanoid A subset of ortholog calls from InParanoid. • AAEL010641-PA Aedes aegypti (mosquito) AGAP008637-PA Anopheles gambiae (mosquito) XP_392715.3 Apis mellifera (honey bee) XP_001947714.1 Acyrthosiphon pisum (pea aphid) At2g21470.2 Arabidopsis thaliana (wall cress) 1352 Batrachochytrium dendrobatidis (chytrid fungus) 201265 Branchiostoma floridae (lancelet) XP_001902233.1 Brugia malayi (roundworm nematode) BGIBMGA012116-PA Bombyx mori (silk worm) ENSBTAP00000003333 Bos taurus (bovine) CAL0001757 Candida albicans (a form of yeast) CN06129 Caenorhabditis brenneri (small nematode) CBP27792 Caenorhabditis briggsae (nematode) CE40719 Caenorhabditis elegans (worm) ENSCAFP00000010792 Canis familiaris (dog) CAGL0M01606g Candida glabrata (haploid yeast) Chro.20160 Cryptosporidium hominis (obligate parasite) JA12722 Caenorhabditis japonica (nematode) CME143C Cyanidioschyzon merolae (red alga) cn06389 Cryptococcus neoformans (yeast-like fungus) cgd2_1460 Cryptosporidium parvum (protozoan parasite) CPIJ007700 Culex pipens (mosquito) ENSCPOP00000009465 Cavia porcellus (guinea pig) RP29873 Caenorhabditis remanei (nematode) 219156 Capitella spl (polychaete worm) DDB0302360 Dictyostelium discoideum (amoeba) DEHA2G15114g Debaryomyces Hansenii (yeast) 300104 Daphnia pulex (daphnia) ENSDARP00000068081 Danio rerio (zebra fish) ENSECAP00000000109 Equus caballus (horse) XP_656129 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004237 Gymnopilus aculeatus (mushroom) ENSGALP00000038502 Gallus gallus (chicken) GL50803_6288 Giardia lamblia (flagellated protozoan) 71557 Hypsipyla robusta (cedar shoot borer) ENSP00000246548 Homo sapiens (human) ISCW007746-PA Ixodes scapularis (deer tick) KLLA0E03103g Kluyveromyces lactis (yeast) 178117 Lottia gigantea (owl limpet) LmjF08.0220 Leishmania major (virus) 33435 Monocosta brevicollis (choanoflagellate) ENSMODP00000030149 Monodelphis domestica (gray opossum) ENSMMUP00000007742 Macaca mulatta (rhesus monkey) ENSMUSP00000099807 Mus musculus (house mouse) 161397 Nematostella vectensis (starlet anemone) XP_001604879.1 Nasonia vitripennis (wasp) ENSOANP00000015208 Ornithorynchus anatinus (platypus) ENSORLP00000015752 Oryzias latipes (japanese killifish) LOC_Os07g39780.1 Oryza sativa (asian rice) 1518 Ostreococcus tauri (green alga) PFL1790w Plasmodium falciparum (protozoal parasite) PHUM002350-PA Pediculus humanus (human body louse) PP08241 Pristionchus pacificus (nematode) 75619 Physcomitrella patens (moss) ENSPPYP00000011014 Pongo pygmaeus (orangutan) 43972 Phytophthora ramorum (sudden oak death pathogen) 129825 Phytophthora sojae (root rot pathogen) 195584 Populus trichocarpa (black cottonwood) ENSPTRP00000018512 Pan troglodytes (chimpanzee) PVX_100800 Plasmodium vivax (protozoal parasite) 4749599 Sorghum bicolor (sorghum) YDR390C Saccharomyces cerevisiae (budding yeast) Smp_166220 Schistosoma mansoni (trematode parasite) SPBC16H5.03c Schizosaccharomyces pombe (fission yeast) XP_001179978.1 Strongylocentrotus purpuratus (purple sea urchin) 24020 Trichoplax adhaerens (metazoa) TA18995 Theileria annulata (apicomplexan parasite) XP_969731.1 Tribolium castaneum (red flour beetle) Tc00.1047053509777.100 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005165 Tetraodon nigroviridis (green spotted pufferfish) TP01_0127 Theileria parva (parasitic protozoan) ENSTRUP00000016721 Takifugu rubripes (pufferfish Takifugu) 3813.m01445 Tetrahymena thermophila (ciliate protozoa) 87349.m00190 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000005057 Xenopus tropicalis (frog) YALI0D06259g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44496 modMine - Data generated by the modENCODE project. • FBgn0029113 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11236 NV10104 LH19493 ISCW007746 FBgn0237688 FBgn0221986 FBgn0199472 FBgn0184741 FBgn0179831 JGI_V11_300104 FBgn0080411 FBgn0160073 FBgn0152968 FBgn0134754 FBgn0122762 FBgn0107173 FBgn0087522 CPIJ007700 BGIBMGA012116 ACYPI006138 GB12173 AGAP008637 AAEL010641 PHUM280660 GLEAN_02294
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG7528 (Suzuki et al., 2001, Bayraktaroglu, 2000.5.25, Dorer et al., 2006, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Vidal et al., 2010) DmSae2 (Smith et al., 2001) DmSAE2 (Bhaskar et al., 2000) DmUba2 (Shih, 2003.6.25, Shih et al., 2002, Long and Griffith, 2000) Dmuba2 (Shih et al., 2000) dUba2 (Donaghue et al., 2001) L36 (Suzuki et al., 2001) SAE2 (Bhaskar et al., 2002, Smith et al., 2004, Bayraktaroglu, 2000.5.25, Bhaskar, 1999.12.27, Nie et al., 2009) Sae2 (Smith et al., 2002) sip2 (Shih, 2003.6.25, Hsin-Pei et al., 1998, Shih, 1998.3.17, Shih et al., 1998, ) Uba2 (Altenhein et al., 2006, Shigenobu et al., 2006, Chan et al., 2002, Hashiyama et al., 2009, Jacques et al., 2009, Zhang et al., 2010, Arya et al., 2010, Paddibhatla et al., 2010, Vidal et al., 2010) UBA2 (Dorer et al., 2006) uba2 (Kim et al., 2010, Zhang et al., 2010) Ubc2 (Toba and White, 2003)
Name Synonym	Smt3 activating enzyme 2 (Bhaskar, 1999.12.27) Smt3-activating enzyme 2 (Kiss et al., 2005) ubiquitin-activating enzyme (E1) (Speese et al., 2003)
Secondary FlyBase IDs
	FBgn0024190 FBgn0035840 FBgn0040287
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Arya et al., 2010, Ann. Neurosci. 17(1): 8--17 Hsp60D - A novel modifier of polyglutamine-mediated neuro degeneration in Drosophila. [FBrf0211649] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Paddibhatla et al., 2010, PLoS Pathog. 6(12): e1001234 Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. [FBrf0212643] Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466 Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993] Zhang et al., 2010, Genetics 184(4): 1165--1179 A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. [FBrf0210722] Show all research papers ...