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Gene Dmel\debcl

General Information
Symbol	Dmel\debcl	Species	D. melanogaster
Name	death executioner Bcl-2 homologue	Annotation symbol	CG33134
Feature type	protein_coding_gene	FlyBase ID	FBgn0029131
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	Drob-1, dBOK, dBorg-1, CG12397, dBorg1, debcl/Borg1, Drob-1/Debcl/dBorg-1/dBok, Bok, bcl-2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42B2-42C1	Sequence location	2R:2,536,159..2,540,347 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene death executioner Bcl-2 homologue is referred to in FlyBase by the symbol Dmel\debcl (CG33134, FBgn0029131). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: apoptotic process; induction of apoptosis; negative regulation of neuron apoptotic process; neuron homeostasis; intrinsic apoptotic signaling pathway in response to DNA damage. 23 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; salivary gland; interommatidial bristle; eye photoreceptor cell; wing; ommatidium; pigment cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Bcl2-like; Blc2 family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629916_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of debcl. Gene sequence location is 2R:2536159..2540347.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42B2-42C1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42B-42B     (Zhou, 2000.1.6) 42E-43A     (Brachmann, 2000.3.10) 42E-43A     (Kurada, 1999.12.14) 42E-43A     (Colussi, 1999.8.17)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\debcl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) debcl-RA FBtr0086108  NM_176098   1724   300
Additional Transcript Data & Comments
Reported size (kB)	1.5 (northern blot) (Colussi et al., 2000) 1.3 (northern blot) (Igaki et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein debcl-PA   FBpp0085443   32.9   300   9.53     NP_788278   AAF57365
Additional Polypeptide Data & Comments
Reported size (kDa)	325 (aa); 35 (kD predicted) (Igaki et al., 2000) 300 (aa); 33 (kD predicted) (Colussi et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bcl2-like (IPR002475) Blc2 family (IPR026298) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12397
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440915   AA441231   AE013599 AAF57365   AB032430 BAA89603   AC007593   AC007624   AF149798 AAF26841   AF178430 AAF26289   AF216752 AAF25955   AF222004 AAF44324   AF228044 AAF89165   AF244352 AAF44714   AI062163   AI062455   AI513093   AX094083   AY058249 AAL13478   BE978604   BF501211   BI628807   BI637477   BI637949   BI639165   BI641895   BQ102940   BT022157   CL705920   CO154324   CO188191   CZ478657   CZ487445   CZ487446   EC242962   EC257199   EC260961   EV593502   GH941766   GH946934   GH948576   GH949947   GH960495   GH963513   GH964610   GH965761   GH966448   GH976011   GH979035   GH979164   GH979882   GH983060
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V9C8 Q7KJ42 Q7KM33 Q95U83
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11   posterior midgut primordium   (Colussi et al., 2000) mesoderm   (Brachmann et al., 2000) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13   embryonic/larval gut   (Brachmann et al., 2000) embryonic stage 13 -- 16   embryonic hindgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) third instar larval stage   brain | restricted   (Colussi et al., 2000) eye-antennal disc | restricted   (Colussi et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Colussi et al., 2000) embryonic stage 5   organism | ubiquitous   (Colussi et al., 2000) embryonic stage 11   proctodeum   (Colussi et al., 2000) embryonic stage 14 -- 16   embryonic/larval midgut   (Colussi et al., 2000) embryonic head segment | restricted   (Colussi et al., 2000) third instar larval stage   embryonic/larval salivary gland duct   (Colussi et al., 2000) adult stage & oogenesis   nurse cell   (Colussi et al., 2000) oocyte   (Colussi et al., 2000) pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Igaki et al., 2000) embryonic stage -- adult stage     (Igaki et al., 2000) third instar larval stage   wing disc   (Igaki et al., 2000) eye disc   (Igaki et al., 2000) embryonic/larval midgut   (Igaki et al., 2000) ventral thoracic disc   (Igaki et al., 2000) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Brachmann et al., 2000) adult stage | male   head   (Brachmann et al., 2000) abdomen & thorax   (Brachmann et al., 2000) adult stage | female   head   (Brachmann et al., 2000) abdomen & thorax   (Brachmann et al., 2000)
Additional Descriptive Data
	RT-PCR analysis indicates that debcl transcripts are expressed at all stages of development. In situ hybridization reveals that debcl transcripts are expressed at high levels in early embryos. Expression is also observed in third instar larvae in leg, wing, and eye disc and in the midgut. (Igaki et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mitochondrial envelope inferred from direct assay (Igaki et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules    1474.8 Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules  (1474.8) Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules  (1474.8) Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules    1474.8 Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules    1474.8 Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules  (1474.8) Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules  1474.8 Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    72.675 Larval Midgut    83.1 Larval Hindgut    127.5 Larval Malpighian Tubules    187.9 Larval Fat Body    94.8 Larval Salivary Gland    224 Larval Trachea    192.725 Larval Carcass    167.05 Adult Head    186.1 Adult Eye    195.375 Adult Brain    109.6 Adult Thoracic-Abdominal Ganglion    134.9 Adult Crop    252.6 Adult Midgut    80.6 Adult Hindgut    199.7 Adult Malpighian Tubules    1474.8 Adult Fat Body    266.1 Adult Salivary Gland    190.8 Adult Heart    182.875 Adult VirginFemale Spermatheca    336.5 Adult InseminatedFemale Spermatheca    337.8 Adult Ovary    487.2 Adult Testis    139.6 Adult Male Accessory Gland    180 Adult Carcass    215.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    186.1   NA  Eye    195.375   NA  Brain    109.6   72.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    134.9   NA  Crop    252.6   83.1  Midgut    80.6   127.5  Hindgut    199.7   187.9  Malpighian Tubules    1474.8   94.8  Fat Body    266.1   224  Salivary Gland    190.8   NA  Heart    182.875   192.725  Trachea    NA   NA  VirginFemale Spermatheca    336.5   NA  InseminatedFemale Spermatheca    337.8   NA  Ovary    487.2   NA  Testis    139.6   NA  Male Accessory Gland    180   167.05  Carcass    215.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (43) ovary, mated 4-day female  (35) testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (43) ovary, mated 4-day female  (35) testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    4 central nervous system, pupae P8    2 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    4 fat body, pupae P8    9 carcass, larvae L3 wandering    7 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    43 ovary, mated 4-day female    35 testis, mated 4-day male    7 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day  (31) adult female 05day  (39) adult female 30day  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day  31 adult female 05day  (39) adult female 30day  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    6 embryo 04-06hr    1 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    11 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    6 larva L1    9 larva L2    10 larva L3 12hr old    12 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    20 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    21 adult male 01day    14 adult male 05day    14 adult male 30day    16 adult female 01day    31 adult female 05day    39 adult female 30day    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4  (28) embryonic 1182-4H    9 embryonic GM2  (32) embryonic Kc167  (31) embryonic S1    15 embryonic S3    15 leg disc CME L1  (27) wing disc CME-W2  (39) wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1  (27) CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  (31) ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (37) Schneider line 2 Sg4  28 embryonic 1182-4H    9 embryonic GM2  32 embryonic Kc167  31 embryonic S1    15 embryonic S3    15 leg disc CME L1  27 wing disc CME-W2  (39) wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1  27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    37 Schneider line 2 Sg4    28 embryonic 1182-4H    9 embryonic GM2    32 embryonic Kc167    31 embryonic S1    15 embryonic S3    15 leg disc CME L1    27 wing disc CME-W2    39 wing disc ML-DmD8    20 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    16 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    11 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    0 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    4 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • GH01265 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029131 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33134-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for debcl Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage, with Scer\GAL4da.G32 debcldsRNA.Scer\UAS partially lethal - majority die | larval stage, with Scer\GAL4elav-C155 debcldsRNA.Scer\UAS partially lethal - majority die | pupal stage, with Scer\GAL4elav-C155 debcldsRNA.Scer\UAS viable debclE26 debclEY05743 viable, with Scer\GAL4pnr-MD237 debclGD1637 Sterility Allele fertile debclE26 debclEY05743 Other Phenotypes Allele cell death defective debclMtnA.T:Ivir\HA1 cell death defective, with Scer\GAL4Act5C.PHb debclScer\UAS.I.T:Ivir\HA1 decreased cell death debcldsRNA.cCa decreased cell death | embryonic stage, with Scer\GAL4da.G32 debcldsRNA.Scer\UAS increased cell death debclMtnA.T:Ivir\HA1 increased cell death, with Scer\GAL4109-88 debclScer\UAS.T:Ivir\HA1 increased cell death, with Scer\GAL4ey.PH debclScer\UAS.T:Ivir\HA1 increased cell death, with Scer\GAL4GMR.PF debclScer\UAS.T:Ivir\HA1 increased cell death, with Scer\GAL4hs.PB debclScer\UAS.T:Ivir\HA1 locomotor behavior defective, with Scer\GAL4elav-C155 debcldsRNA.Scer\UAS long lived, with Scer\GAL4elav-C155 debclGS2263 neuroanatomy defective | somatic clone, with Scer\GAL4ppk.1.9 debclScer\UAS.T:Ivir\HA1 short lived, with Scer\GAL4elav-C155 debcldsRNA.Scer\UAS visible debclGMR.PI visible, with Scer\GAL4GMR.PF debclScer\UAS.cUa debclScer\UAS.T:Ivir\HA1 Phenotype manifest in Allele central nervous system | ectopic debcldsRNA.cBa dendrite & abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9 debclScer\UAS.T:Ivir\HA1 dendrite & class IV dendritic arborising neuron, with Scer\GAL4ppk.1.9 debclScer\UAS.T:Ivir\HA1 dendrite & dorsal multidendritic neuron ddaC | somatic clone, with Scer\GAL4ppk.1.9 debclScer\UAS.T:Ivir\HA1 eye debclGMR.PB debclGMR.PI eye, with Scer\GAL4GMR.PF debclScer\UAS.T:Ivir\HA1 debclScer\UAS.cUa eye disc, with Scer\GAL4ey.PH debclScer\UAS.T:Ivir\HA1 eye disc, with Scer\GAL4GMR.PF debclScer\UAS.T:Ivir\HA1 eye disc | posterior, with Scer\GAL4GMR.PF debclScer\UAS.T:Ivir\HA1 eye photoreceptor cell debclGMR.PI interommatidial bristle debclGMR.PB mitochondrion & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9 debclScer\UAS.T:Ivir\HA1 ommatidium debclGMR.PI pigment cell debclGMR.PB pigment cell, with Scer\GAL4GMR.PF debclScer\UAS.T:Ivir\HA1 salivary gland, with Scer\GAL4109-88 debclScer\UAS.T:Ivir\HA1 wing, with Scer\GAL4en-e16E debclScer\UAS.T:Ivir\HA1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of debcl Class Mutagen Stocks Known lesion debclE26 loss of function allele Delta2-3 2 Yes debclW105 Delta2-3 2 Yes debcle00816 piggyBac transposase 1 -- debclEY05743 P-element activity 1 -- debclf04864 piggyBac transposase 1 -- debclGS2263 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of debcl Class Mutagen Stocks Known lesion debclGD1637 in vitro construct - RNAi in vitro construct - regulatory fusion 4 Yes debclJF02429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes debclKK100738 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes debclcBa in vitro construct 0 -- debcldsRNA.cBa in vitro construct - RNAi 0 -- debcldsRNA.cCa in vitro construct - RNAi 0 Yes debcldsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes debclE151G.MtnA.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes debclGMR.PB in vitro construct - regulatory fusion 0 Yes debclGMR.PI in vitro construct - regulatory fusion 0 Yes debclL146G.MtnA.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes debclMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes debclNIG.12397R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes debclScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes debclScer\UAS.I.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes debclScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes debclΔTM.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)hfl-37 (Rendina et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1637} NA P{KK100738} NA P{NIG.12397R} NA P{TRiP.JF02429} NA P{UAS-debcl.dsRNA} NA P{UAS-debcl.HA} NA P{UAS-debcl.U} NA characterization construct P{GMR-dborg-1} NA P{GMR-drob-1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}debclEY05743 NA P{GSV1}debclGS2263 NA insertion of enhancer trap P{lacW}l(2)SH1233SH1233 No miscellaneous insertions PBac{RB}debcle00816 NA PBac{WH}debclf04864 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process inferred from expression pattern (Colussi et al., 2000) inferred from mutant phenotype (Brachmann et al., 2000) inferred from mutant phenotype AND inferred from sequence or structural similarity with human BCL2 AND inferred from sequence or structural similarity with mouse Bok AND inferred from sequence or structural similarity with worm ced-9 (Igaki et al., 2000) induction of apoptosis inferred from mutant phenotype (Colussi et al., 2000) intrinsic apoptotic signaling pathway in response to DNA damage inferred from mutant phenotype (Brachmann et al., 2000) negative regulation of neuron apoptotic process inferred from mutant phenotype (Senoo-Matsuda et al., 2005) neuron homeostasis inferred from genetic interaction with Ank2 (Keller et al., 2011)
Cellular Component
CV term Evidence References
mitochondrial envelope inferred from direct assay (Igaki et al., 2000)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Colussi, 1999.8.17, Meier et al., 2000, Lawen, 2003) traceable author statement (Gorski and Marra, 2002, Richardson and Kumar, 2002, Tittel and Steller, 2000) induction of apoptosis inferred from sequence or structural similarity with NCBI_gi:5802578 (Vernooy et al., 2000) negative regulation of apoptotic process inferred from sequence or structural similarity with UniProtKB:P10415 (Sardiello et al., 2003.6.11) regulation of mitochondrial membrane permeability inferred from sequence or structural similarity with UniProtKB:P10415 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial outer membrane inferred from sequence or structural similarity with UniProtKB:P10415 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
debcl - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) debcl - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) debcl - CG1129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) debcl - CG17494 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) debcl - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) debcl - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions debcl allele Gene References debclGMR.PB BacA\p35 (Brachmann et al., 2000) debclScer\UAS.T:Ivir\HA1 Ark (Colussi et al., 2000) Buffy (Quinn et al., 2003) unspecified th (Colussi et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72808 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029131 DroID - A comprehensive database of gene and protein interactions. • FBgn0029131 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53585
Orthologs
OrthoDB Orthologs (22) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65B21R Dipteran inclusive ortholog search EOG60K87S Insect inclusive ortholog search EOG6DBSB3 Arthropod inclusive ortholog search EOG6NP5KW Metazoa inclusive ortholog search EOG6KT2DQ
Orthologs in Drosophila Species (EOG65B21R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\debcl     Drosophila simulans   Dsim\GD10412 Y   Drosophila sechellia   Dsec\GM20882 Y   Drosophila erecta   Dere\GG23208 Y   Drosophila yakuba   Dyak\GE19062 Y   Drosophila ananassae   Dana\GF11057 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17309 Y   Drosophila persimilis   Dper\GL20359 Y   Drosophila willistoni   Dwil\GK19537 Y   Drosophila virilis   Dvir\GJ21634 Y   Drosophila mojavensis   Dmoj\GI18625 Y   Drosophila grimshawi   Dgri\GH21025 Y
Orthologs in non-Drosophila Dipterans (EOG60K87S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001515   Anopheles gambiae Malaria mosquito  Agam\anob-1   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002200
Orthologs in non-Dipteran Insects (EOG6DBSB3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC411613 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006942 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005643 Y Pediculus humanus Human body louse  Phum\PHUM582920 Y Tribolium castaneum Red flour beetle  Tcas\TC013830 Y
Orthologs in non-Insect Arthropods (EOG6NP5KW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW019088 Y
Orthologs in non-Arthropod Metazoa (EOG6KT2DQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021416gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10412 Drosophila sechellia Dsec\GM20882 Drosophila erecta Dere\GG23208 Drosophila yakuba Dyak\GE19062 Drosophila ananassae Dana\GF11057 Drosophila pseudoobscura pseudoobscura Dpse\GA17309 Drosophila persimilis Dper\GL20359 Drosophila willistoni Dwil\GK19537 Drosophila virilis Dvir\GJ21634 Drosophila mojavensis Dmoj\GI18625 Drosophila grimshawi Dgri\GH21025
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	27342 w1118; debclE26 27341 w1118; debclW105 27083 y1 v1; P{TRiP.JF02429}attP2 27338 w1118; debclE26 BuffyH37 27339 w1118; debclW105 BuffyH37
Harvard	- PBac{RB}debcle00816 - PBac{WH}debclf04864
VDRC	v106669 P{KK100738}VIE-260B v47517 w1118 P{GD1637}v47517 v47515 w1118; P{GD1637}v47515 v47518 w1118; P{GD1637}v47518 v47516 w1118; P{GD1637}v47516/CyO
	More stocks available...
Genomic Clones ( 1 )
	BACR01C10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 34 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01265 IP01389
Other clones	DPiM_IP01389
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16474 GH01665 LD12719 LD15992 RH57557 SD19515 SD20137 SD21643 SD25551
Other clones	214341.9 523439 bs80g01 CK01.118C.C8 Dmel_neb_008595_0680_0347 EK038330 EN03925 RP004178923 RP004197449 RP004214712 RP004214984 RP004244071 RP004253454 RP004253731 RP004263047 RP004329630 RP004479362 RP004488225 RP004502035 RP004512799 RP004544614 UUGC0334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029131 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53585
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: debcl BOK (Bayraktaroglu, 2000.5.24) Source for merge of: debcl CG12397 (FlyBase, 1996-)
Additional comments	Source for merge of debcl CG12397 was sequence comparison (date:000815). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)
Other Comments
	Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) debcl is not essential for normal development. (Sevrioukov et al., 2007) debcl protects neurons from neurodegeneration through the regulation of mitochondrial homeostasis. (Senoo-Matsuda et al., 2005) dsRNA made from templates generated with primers directed against this gene causes a phenotype in S2 cells. The reduced mitochondrial membrane potential and increase in cell death caused by treatment of cells with rotenone or 3-NP is enhanced. Cell death induction by treatment with proteasome inhibitors is likewise enhanced, while cell death induction by tunicamycin is not affected. Additionally, debcl knockdown significantly increases the percentage of mitochondria showing abnormal morphologies in S2 cells with intact nuclei and enhances the reduction of activities of mitochondrial respiratory chain complex I +III (NADH-cytochrome c oxidoreductase) and complex II +III (succinate-cytochrome c oxidoreductase) in S2 cells treated with rotenone or 3-NP. (Senoo-Matsuda et al., 2005) Area matching Drosophila ESTs AI062455 and AA440915. (Davies, 2001.3.15) debcl both induces apoptosis and demonstrates protective activity when death stimuli are introduced. (Brachmann et al., 2000) debcl encodes a pro-apoptotic protein that functions in a caspase-dependent manner. debcl is required for developmental apoptosis in the embryo. (Colussi et al., 2000) debcl appears to promote cell death by inducing both caspase-dependent and independent pathways at the mitochondria. (Igaki et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176098 RefSeq (Proteins) • NP_788278 DDBJ / EMBL / GenBank • AA440915 AAF25955 AAF26289 AAF26841 AAF44324 AAF44714 AAF57365 AAF89165 AAL13478 AB032430 AC007593 AC007624 AF149798 AF178430 AF216752 AF222004 AF228044 AF244352 AI062163 AI062455 AI513093 AX094083 AY058249 BAA89603 CL705920 CZ478657 CZ487445 CZ487446 Entrez Gene - A searchable database of RefSeq genes. • 53585 UniProtKB/TrEMBL • Q7KJ42 Q7KM33 Q9V9C8 Q95U83
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bcl2-like (IPR002475) Blc2 family (IPR026298) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME12397 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01265
Linkouts
	BioGRID - A database of protein and genetic interactions • 72808 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029131 DroID - A comprehensive database of gene and protein interactions. • FBgn0029131 DRSC - Results from RNAi screens. • FBgn0029131 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029131 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33134-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029131 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 53585 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/bcl2-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 53585 modMine - Data generated by the modENCODE project. • FBgn0029131
Synonyms & Secondary IDs ( 38 )
Reported As
Symbol Synonym	bcl-2 (Brun et al., 2002) Bcl-2 (Keller et al., 2011) BG1 (Zhou, 2000.1.6) Bok (Tittel and Steller, 2000) BOK (Bayraktaroglu, 2000.5.24, ) Bok(Debcl) (Lanave et al., 2004) borg1/debcl (Ortega et al., 2005) CG12397 (Brody et al., 2002, Richardson, 2001.4.10, Brody, 2000.9.6, ) CG33134 (Wagner et al., 2009, Perkins et al., 2009.3.31, Carrera et al., 2008, Keleman et al., 2009.8.5) dBOK (Van Hoof and Goris, 2003) Dbok (Gorski and Marra, 2002, Zhang et al., 2000) DBok (Zhang et al., 2000, Sevrioukov et al., 2007) dbok (Vernooy et al., 2000) dBok (Kornbluth and White, 2005, Tsubouchi et al., 2009) dbok/debcl (Brun et al., 2002) dBorg01 (Gorski and Marra, 2002) dBorg1 (Jassim et al., 2001, Sevrioukov et al., 2007) dBorg-1 (Brachmann and Cagan, 2001, Vernooy et al., 2000, Brachmann et al., 2000, Kornbluth and White, 2005) dborg1 (Brachmann, 2000.3.10) dBORG-1/DROB-1/DEBCL/dBOK (Meier et al., 2000) dBrog-1 (Tsubouchi et al., 2009) debc1 (Blanco et al., 2010) Debcl (Quinn et al., 2003, Gorski and Marra, 2002, Colussi et al., 2000, Chen and Abrams, 2000, Kuranaga and Miura, 2007, Kornbluth and White, 2005, Galindo et al., 2009, Copeland et al., 2007, Martin et al., 2007, Tsubouchi et al., 2009, Shim et al., 2009) DEBCL (Buszczak and Cooley, 2000, Doumanis et al., 2007) debcl (Monserrate et al., 2007, Colussi et al., 2000, Hoskins et al., 2005, Peterson et al., 2007, Luo et al., 2011, Sevrioukov et al., 2007, Rendina et al., 2010, Liu and Lehmann, 2008, Wagner et al., 2009, Cao et al., 2007, Hou et al., 2008, Carrera et al., 2008, Tsubouchi et al., 2009, Wu et al., 2010, Park et al., 2010, Terhzaz et al., 2010, Grusche et al., 2011, Keller et al., 2011, Japanese National Institute of Genetics, 2012.5.21) debcl/Borg1 (Purves et al., 2005, Burr et al., 2005) Debcl/dBorg-1/dBok/Drob-1 (Galindo and Abrams, 2007) Debcl/dBorg-1/dRob-1 (Richardson and Kumar, 2002) Debcl/Drob-1/dBorg-1/dBok (Danial and Korsmeyer, 2004) debok (Brun et al., 2001) Drob-1 (Senoo-Matsuda et al., 2004, Igaki et al., 2002, Gorski and Marra, 2002, Chen and Abrams, 2000, Igaki, 1999.9.14, Igaki et al., 2000, Senoo-Matsuda et al., 2005, Sevrioukov et al., 2007, Kornbluth and White, 2005, Kang and Ryoo, 2009) drob-1 (Brun et al., 2001, Vernooy et al., 2000, Tsubouchi et al., 2009) Drob-1/Debcl/dBORG-1 (Baehrecke, 2000) Drob-1/Debcl/dBorg-1/dBok (Igaki and Miura, 2004) Drob-1/Debcl/dBorg-1/DBok (Vernooy et al., 2000)
Name Synonym	Bcl-2 (Keller et al., 2011) death executioner Bcl-2 homologue (Colussi et al., 2000) death inducing Bcl-2-like protein (Colussi et al., 2000) deborg (Brun et al., 2001)
Secondary FlyBase IDs
	FBgn0029509 FBgn0033080 FBgn0053134
References ( 101 )
Generate a list of	All references relating to this gene ( 101 )
List References by type	Research paper  ( 38 ) Supplementary material  ( 7 ) Review  ( 18 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) DNA/RNA sequence record  ( 7 ) Stock list  ( 1 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Keller et al., 2011, Neuron 72(5): 760--775 Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. [FBrf0216904] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Tanner et al., 2011, Development 138(2): 327--338 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...