Gene Dmel\NHP2

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General Information

Symbol

Dmel\NHP2

Species

D. melanogaster

Name

NHP2

Annotation symbol

CG5258

Feature type

protein_coding_gene

FlyBase ID

FBgn0029148

Gene Model Status

Current

Stock availability

3 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

70F6-70F6

Sequence location

3L:14,794,428..14,795,268 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene NHP2 is referred to in FlyBase by the symbol Dmel\NHP2 (CG5258, FBgn0029148). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: snoRNA binding; rRNA pseudouridylation guide activity. Based on sequence similarity, it is predicted to be involved in the biological process: rRNA pseudouridine synthesis; rRNA processing. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein L7Ae/L30e/S12e/Gadd45; Ribosomal protein L7Ae/L8/Nhp2 family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, virgin spermatheca, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627111_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of NHP2. Gene sequence location is 3L:14794428..14795268.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70F6-70F6

Limits computationally determined from genome sequence between P{PZ}Mpcp⁰⁰⁵⁶⁴ and P{PZ}l(3)rO220^rO220

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70F-70F

(Renault, 1999.12.17)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\NHP2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

NHP2-RA

FBtr0075698

NM_143708

667

160

NHP2-RB

FBtr0333076

NM_001274920

781

160

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

NHP2-PA

FBpp0075448

17.7

160

8.30

NP_651965

AAF49701

NHP2-PB

FBpp0305289

17.7

160

8.30

NP_001261849

AGB94542

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ribosomal protein L7Ae/L8/Nhp2 family (IPR018492)

Ribosomal protein L7Ae/L30e/S12e/Gadd45 (IPR004038)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9V3U2

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval somatic muscle

(Fisher et al., 2012)

embryonic/larval visceral muscle

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, virgin spermatheca, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		1101.6
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		(804.475)
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		(662)
Larval Trachea		(885.35)
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		(619.7)
Adult Ovary		(1101.6)
Adult Testis		87.8
Adult Male Accessory Gland		(799.3)
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		(1101.6)
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		1101.6
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		1101.6
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		(885.35)
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		(1101.6)
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		1101.6
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		804.475
Larval Midgut		244.2
Larval Hindgut		342.9
Larval Malpighian Tubules		99.4
Larval Fat Body		147.7
Larval Salivary Gland		662
Larval Trachea		885.35
Larval Carcass		512.45
Adult Head		239.3
Adult Eye		145.975
Adult Brain		115.6
Adult Thoracic-Abdominal Ganglion		163.8
Adult Crop		280.4
Adult Midgut		334.1
Adult Hindgut		216.3
Adult Malpighian Tubules		160.1
Adult Fat Body		340.2
Adult Salivary Gland		285.3
Adult Heart		223.8
Adult VirginFemale Spermatheca		384.8
Adult InseminatedFemale Spermatheca		619.7
Adult Ovary		1101.6
Adult Testis		87.8
Adult Male Accessory Gland		799.3
Adult Carcass		252.3
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	239.3
NA	Eye	145.975
NA	Brain	115.6
804.475	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	163.8
NA	Crop	280.4
244.2	Midgut	334.1
342.9	Hindgut	216.3
99.4	Malpighian Tubules	160.1
147.7	Fat Body	340.2
662	Salivary Gland	285.3
NA	Heart	223.8
885.35	Trachea	NA
NA	VirginFemale Spermatheca	384.8
NA	InseminatedFemale Spermatheca	619.7
NA	Ovary	1101.6
NA	Testis	87.8
NA	Male Accessory Gland	799.3
512.45	Carcass	252.3

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(30)
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		(43)
ovary, mated 4-day female		(35)
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		(43)
ovary, mated 4-day female		(35)
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		30
central nervous system, larvae L3		23
central nervous system, pupae P8		8
head, virgin 1-day female		7
head, virgin 4-day female		10
head, virgin 20-day female		9
head, mated 1-day female		7
head, mated 4-day female		21
head, mated 20-day female		6
head, mated 1-day male		3
head, mated 4-day male		10
head, mated 20-day male		11
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		3
digestive system, larvae L3 wandering		10
digestive system, 1-day adult		12
digestive system, 4-day adult		22
digestive system, 20-day adult		15
fat body, larvae L3 wandering		1
fat body, white prepupae		4
fat body, pupae P8		16
carcass, larvae L3 wandering		22
carcass, 1-day adult		6
carcass, 4-day adult		17
carcass, 20-day adult		7
ovary, virgin 4-day female		43
ovary, mated 4-day female		35
testis, mated 4-day male		11
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		170
embryo 06-08hr		221
embryo 08-10hr		240
embryo 10-12hr		231
embryo 12-14hr		150
embryo 14-16hr		130
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		125
embryo 22-24hr		105
larva L1		275
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(70)
embryo 02-04hr		(101)
embryo 04-06hr		(170)
embryo 06-08hr		(221)
embryo 08-10hr		(240)
embryo 10-12hr		(231)
embryo 12-14hr		(150)
embryo 14-16hr		(130)
embryo 16-18hr		(91)
embryo 18-20hr		(57)
embryo 20-22hr		(125)
embryo 22-24hr		(105)
larva L1		(275)
larva L2		(107)
larva L3 12hr old		(62)
larva L3 puffstage 1-2		(29)
larva L3 puffstage 3-6		(33)
larva L3 puffstage 7-9		(40)
white prepupae new		(32)
white prepupae 12hr		(34)
white prepupae 24hr		(29)
pupae 2d postWPP		(31)
pupae 3d postWPP		16
pupae 4d postWPP		(29)
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		(104)
adult female 05day		(99)
adult female 30day		(102)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		(170)
embryo 06-08hr		(221)
embryo 08-10hr		(240)
embryo 10-12hr		(231)
embryo 12-14hr		(150)
embryo 14-16hr		(130)
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		(125)
embryo 22-24hr		105
larva L1		(275)
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		170
embryo 06-08hr		221
embryo 08-10hr		240
embryo 10-12hr		231
embryo 12-14hr		150
embryo 14-16hr		130
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		125
embryo 22-24hr		105
larva L1		275
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		170
embryo 06-08hr		221
embryo 08-10hr		240
embryo 10-12hr		231
embryo 12-14hr		150
embryo 14-16hr		130
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		125
embryo 22-24hr		105
larva L1		275
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(70)
embryo 02-04hr		(101)
embryo 04-06hr		(170)
embryo 06-08hr		(221)
embryo 08-10hr		(240)
embryo 10-12hr		(231)
embryo 12-14hr		(150)
embryo 14-16hr		(130)
embryo 16-18hr		(91)
embryo 18-20hr		(57)
embryo 20-22hr		(125)
embryo 22-24hr		(105)
larva L1		(275)
larva L2		(107)
larva L3 12hr old		(62)
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		(33)
larva L3 puffstage 7-9		(40)
white prepupae new		32
white prepupae 12hr		(34)
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		(104)
adult female 05day		(99)
adult female 30day		(102)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		(170)
embryo 06-08hr		(221)
embryo 08-10hr		(240)
embryo 10-12hr		(231)
embryo 12-14hr		(150)
embryo 14-16hr		130
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		125
embryo 22-24hr		105
larva L1		(275)
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		101
embryo 04-06hr		170
embryo 06-08hr		221
embryo 08-10hr		240
embryo 10-12hr		231
embryo 12-14hr		150
embryo 14-16hr		130
embryo 16-18hr		91
embryo 18-20hr		57
embryo 20-22hr		125
embryo 22-24hr		105
larva L1		275
larva L2		107
larva L3 12hr old		62
larva L3 puffstage 1-2		29
larva L3 puffstage 3-6		33
larva L3 puffstage 7-9		40
white prepupae new		32
white prepupae 12hr		34
white prepupae 24hr		29
pupae 2d postWPP		31
pupae 3d postWPP		16
pupae 4d postWPP		29
adult male 01day		12
adult male 05day		13
adult male 30day		17
adult female 01day		104
adult female 05day		99
adult female 30day		102
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		145
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		139
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		131
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(79)
Schneider line 2 Sg4		(145)
embryonic 1182-4H		(40)
embryonic GM2		(42)
embryonic Kc167		(139)
embryonic S1		(38)
embryonic S3		(83)
leg disc CME L1		(81)
wing disc CME-W2		(131)
wing disc ML-DmD8		(61)
wing disc ML-DmD9		(49)
wing disc ML-DmD16-c3		(59)
wing disc ML-DmD21		(99)
wing disc ML-DmD32		(44)
haltere disc ML-DmD17-c3		(71)
eye-antennal disc ML-DmD11		(38)
antennal disc ML-DmD20-c5		(66)
mixed discs ML-DmD4-c1		(63)
CNS ML-DmBG1-c1		(88)
CNS ML-DmBG2-c2		(63)
tumorous blood cells mbn2		(88)
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		(145)
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		(139)
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		(131)
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		145
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		139
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		131
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		145
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		139
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		131
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(79)
Schneider line 2 Sg4		(145)
embryonic 1182-4H		(40)
embryonic GM2		(42)
embryonic Kc167		(139)
embryonic S1		(38)
embryonic S3		(83)
leg disc CME L1		(81)
wing disc CME-W2		(131)
wing disc ML-DmD8		(61)
wing disc ML-DmD9		(49)
wing disc ML-DmD16-c3		(59)
wing disc ML-DmD21		(99)
wing disc ML-DmD32		(44)
haltere disc ML-DmD17-c3		(71)
eye-antennal disc ML-DmD11		(38)
antennal disc ML-DmD20-c5		(66)
mixed discs ML-DmD4-c1		(63)
CNS ML-DmBG1-c1		(88)
CNS ML-DmBG2-c2		(63)
tumorous blood cells mbn2		(88)
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		(145)
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		139
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		131
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		79
Schneider line 2 Sg4		145
embryonic 1182-4H		40
embryonic GM2		42
embryonic Kc167		139
embryonic S1		38
embryonic S3		83
leg disc CME L1		81
wing disc CME-W2		131
wing disc ML-DmD8		61
wing disc ML-DmD9		49
wing disc ML-DmD16-c3		59
wing disc ML-DmD21		99
wing disc ML-DmD32		44
haltere disc ML-DmD17-c3		71
eye-antennal disc ML-DmD11		38
antennal disc ML-DmD20-c5		66
mixed discs ML-DmD4-c1		63
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		63
tumorous blood cells mbn2		88
ovary fGS/OSS		23
ovary OSC		24
ovary OSS		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		(40)
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		(31)
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		(36)
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		(31)
Rotenone 2 μg 12 hrs, larvae L3		(33)
Rotenone 8 μg 12 hrs, larvae L3		(34)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		(40)
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		(36)
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		(33)
Rotenone 8 μg 12 hrs, larvae L3		(34)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		12
cold shock, 4-day adult		8
heat shock, 4-day adult		40
Cadmium 50 mM 6 hrs, larvae L3		23
Cadmium 50 mM 12 hrs, larvae L3		25
Cadmium 50 mM 48 hrs, 4-day adult		31
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		12
Copper 15 mM 48 hrs, 4-day adult		26
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		36
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		23
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		20
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		26
Paraquat 10 mM 48 hrs, 4-day adult		31
Rotenone 2 μg 12 hrs, larvae L3		33
Rotenone 8 μg 12 hrs, larvae L3		34
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RH66170

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0029148

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG5258-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for NHP2

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

NHP2^GD13496

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

NHP2^GD13496

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

NHP2^GD13496

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of NHP2	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of NHP2	Mutagen	Stocks	Known lesion
NHP2^GD13496	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
NHP2^GL01315	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
NHP2^3.5	in vitro construct	0	Yes
NHP2^NIG.5258R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes