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Gene Dmel\Mkrn1

General Information
Symbol	Dmel\Mkrn1	Species	D. melanogaster
Name	Makorin 1	Annotation symbol	CG7184
Feature type	protein_coding_gene	FlyBase ID	FBgn0029152
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78D5-78D5	Sequence location	3L:21,523,059..21,526,813 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Makorin 1 is referred to in FlyBase by the symbol Dmel\Mkrn1 (CG7184, FBgn0029152). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Putative E3 ubiquitin-protein ligase, makorin-related; Zinc finger, CCCH-type; Zinc finger, RING-type; Zinc finger, RING-type, conserved site; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636847_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Mkrn1. Gene sequence location is 3L:21523059..21526813.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78D5-78D5   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mkrn1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mkrn1-RA FBtr0078383  NM_079965   2884   386 Mkrn1-RB FBtr0078384  NM_168922   2163   386 Mkrn1-RC FBtr0305331  NM_001259938   2229   386
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mkrn1-PA   FBpp0078038   43.8   386   5.35     NP_524704   AAF51740 Mkrn1-PB   FBpp0078039   43.8   386   5.35     NP_730653   AAN12178 Mkrn1-PC   FBpp0293874   43.8   386   5.35     NP_001246867   AFH04538
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571) Zinc finger, RING-type (IPR001841) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, RING/FYVE/PHD-type (IPR013083) Putative E3 ubiquitin-protein ligase, makorin-related (IPR026290)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202244   AA202399   AA202821   AA263322   AA264206   AA390973   AA438369   AA439059   AA439249   AA439921   AA440066   AA440559   AA440639   AA538659   AA538808   AA538894   AA540202   AA540204   AA541068   AA694711   AA696448   AA948863   AA948996   AA950730   AA990835   AE014296 AAF51740   AE014296 AAN12178   AF192788 AAF17491   AF192794 AAF17486   AE014296 AFH04538   AI258228   AI455635   AI456190   AI456909   AI515731   AI516956   AI519805   AI520056   AI532635   AI543475   AW943559   AY058694 AAL13923   BE976588   BF494547   BG638910   BG640588   BI165096   BI166322   BI168691   BI169873   BI170247   BI173390   BI214337   BI215940   BI227809   BI230269   BI230535   BI234331   BI234825   BI235409   BI235615   BI237696   BI237842   BI243139   BI356041   BI356112   BI363507   BI371476   BI371788   BI375419   BI483602   BI484867   BI486026   BI486778   BI566761   BI568885   BI568886   BI568974   BI568975   BI570120   BI570636   BI579331   BI581001   BI581002   BI587536   BI592294   BI592468   BI592473   BI615655   BI616390   BI619592   BI619879   BI622791   BI622792   BI631319   BI637230   BI639152   BP548970   BQ103349   CK086501   CL943652   CO154554   CO186614   CO187009   CO188938   CO278014   CO278872   CO279480   CO282227   CO285476   CO285902   CO286317   CO290858   CO291767   CO297043   CO299614   CO300747   CO301763   CO302224   CO304120   CO309634   CO311051   CO311732   CO317098   CO317208   CO318855   CO320714   CO323861   CO324781   CO328168   EC063400   EC064505   EC066588   EC068861   EC068940   EC072490   EC074717   EC080335   EC080562   EC081369   EC083665   EC085543   EC087741   EC199575   EC199962   EC201024   EC203191   EC211064   EC214443   EC215742   EC224433   EC226951   EC227653   EC230370   EC234519   EC236296   EC236772   EC246946   EC248069   EC249190   EC257735   EC264654   EV596510   EV599996   GH750614   GH753559   GH756208   GH756518   GH772587   GH774129   GH774185   GH774987   GH778116   GH781053   GH781145   GH781613   GH782850   GH783246   GH787281   GH789662   GH790048   GH790547   GH795244   GH799221   GH802096   GH802521   GH803757   GH809485   GH812386   GH812576   GH814661   GH816463   GH816755   GH817063   GH818039   GH819287   GH819393   GH822385   GH823499   GH823506   GH824316   GH826282   GH826342   GH833701   GH835987   GH839377   GH839708   GH841141   GH841302   GH843468   GH847457   GH847516   GH848796   GH849972   GH850388   GH850405   GH851503   GH859446   GH860208   GH860404   GH861902   GH862125   GH868908   GH869767   GH871632   GH871899   GH872836   GH878010   GH879148   GH880131   GH881024   GH881838   GH883610   GH888591   GH889256   GH889277   GH889757   GH890622   GH891111   GH891628   GH896802   GH897072   GH897163   GH898670   GH899712   GH899808   GH901986   GH902184   GH907927   GH907935   GH913756   GH921255   GH921338   GH922006   GH922711   GH927930   GH928537   GH928829   GH928997   GH929010   GH931966   GH934096   GH934568   GH935888   GH940470   Z32465
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VP20 Q9TVX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary  (660.2) Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary  660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    345.9 Larval Midgut    131.2 Larval Hindgut    222.6 Larval Malpighian Tubules    227.2 Larval Fat Body    107.2 Larval Salivary Gland    188.4 Larval Trachea    132.575 Larval Carcass    163.075 Adult Head    137.3 Adult Eye    56.9 Adult Brain    191.8 Adult Thoracic-Abdominal Ganglion    167.9 Adult Crop    300.6 Adult Midgut    128 Adult Hindgut    178.3 Adult Malpighian Tubules    165.1 Adult Fat Body    165.8 Adult Salivary Gland    165.5 Adult Heart    81.95 Adult VirginFemale Spermatheca    105.2 Adult InseminatedFemale Spermatheca    109.8 Adult Ovary    660.2 Adult Testis    53.5 Adult Male Accessory Gland    144 Adult Carcass    123.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    137.3   NA  Eye    56.9   NA  Brain    191.8   345.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    167.9   NA  Crop    300.6   131.2  Midgut    128   222.6  Hindgut    178.3   227.2  Malpighian Tubules    165.1   107.2  Fat Body    165.8   188.4  Salivary Gland    165.5   NA  Heart    81.95   132.575  Trachea    NA   NA  VirginFemale Spermatheca    105.2   NA  InseminatedFemale Spermatheca    109.8   NA  Ovary    660.2   NA  Testis    53.5   NA  Male Accessory Gland    144   163.075  Carcass    123.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  (79) ovary, mated 4-day female  (45) testis, mated 4-day male  (86) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  (79) ovary, mated 4-day female  (45) testis, mated 4-day male  (86) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    19 central nervous system, pupae P8    25 head, virgin 1-day female    11 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    8 head, mated 4-day female    8 head, mated 20-day female    8 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    9 digestive system, 20-day adult    10 fat body, larvae L3 wandering    2 fat body, white prepupae    11 fat body, pupae P8    16 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    79 ovary, mated 4-day female    45 testis, mated 4-day male    86 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (64) embryo 04-06hr  (30) embryo 06-08hr  (30) embryo 08-10hr  (36) embryo 10-12hr  (28) embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr  (27) larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day  (36) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (64) embryo 04-06hr  30 embryo 06-08hr  30 embryo 08-10hr  (36) embryo 10-12hr  28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr  27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day  (36) adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    64 embryo 04-06hr    30 embryo 06-08hr    30 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    25 embryo 14-16hr    18 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    25 embryo 22-24hr    27 larva L1    7 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    23 white prepupae 24hr    23 pupae 2d postWPP    20 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    19 adult male 05day    21 adult male 30day    17 adult female 01day    16 adult female 05day    36 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (49) Schneider line 2 Sg4  (37) embryonic 1182-4H  (28) embryonic GM2  (43) embryonic Kc167  (34) embryonic S1  (28) embryonic S3  (39) leg disc CME L1    23 wing disc CME-W2  (34) wing disc ML-DmD8    22 wing disc ML-DmD9  (29) wing disc ML-DmD16-c3    24 wing disc ML-DmD21  (37) wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  (43) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (28) CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (30) ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (49) Schneider line 2 Sg4  (37) embryonic 1182-4H  28 embryonic GM2  (43) embryonic Kc167  (34) embryonic S1  28 embryonic S3  (39) leg disc CME L1    23 wing disc CME-W2  (34) wing disc ML-DmD8    22 wing disc ML-DmD9  29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21  (37) wing disc ML-DmD32    24 haltere disc ML-DmD17-c3  (43) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    37 embryonic 1182-4H    28 embryonic GM2    43 embryonic Kc167    34 embryonic S1    28 embryonic S3    39 leg disc CME L1    23 wing disc CME-W2    34 wing disc ML-DmD8    22 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    37 wing disc ML-DmD32    24 haltere disc ML-DmD17-c3    43 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    28 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    30 ovary fGS/OSS    19 ovary OSC    22 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    6 heat shock, 4-day adult    19 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD41384 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7184-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Mkrn1GD10767 viable Mkrn1EY14602 Sterility Allele fertile Mkrn1EY14602 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Mkrn1 Class Mutagen Stocks Known lesion Mkrn15-HA-1859 1 -- Mkrn1EY14602 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mkrn1 Class Mutagen Stocks Known lesion Mkrn1GD10767 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Mkrn1GL01521 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mkrn1KK105474 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10767} NA P{KK105474} NA P{TRiP.GL01521} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG33289EY00388 NA P{EPgy2}Mkrn1EY14602 NA miscellaneous insertions P{RS5}Mkrn15-HA-1859 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR000571 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR000571, InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mkrn1 - Lam experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mkrn1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68851 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029152 DroID - A comprehensive database of gene and protein interactions. • FBgn0029152 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44131
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JQ4HG Dipteran inclusive ortholog search EOG6BP1MB Insect inclusive ortholog search EOG68GTZS Arthropod inclusive ortholog search EOG6H44K5 Metazoa inclusive ortholog search EOG6P06MS
Orthologs in Drosophila Species (EOG6JQ4HG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mkrn1     Drosophila simulans   Dsim\GD12110 Y   Drosophila sechellia   Dsec\GM22131 Y   Drosophila erecta   Dere\GG13225 Y   Drosophila yakuba   Dyak\GE22322 Y   Drosophila ananassae   Dana\GF10705 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20164 Y   Drosophila persimilis   Dper\GL11888 Y   Drosophila willistoni   Dwil\GK20382 Y   Drosophila virilis   Dvir\GJ13540 Y   Drosophila mojavensis   Dmoj\GI11841 Y   Drosophila grimshawi   Dgri\GH14787 Y
Orthologs in non-Drosophila Dipterans (EOG6BP1MB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007476 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000355 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009814 Y
Orthologs in non-Dipteran Insects (EOG68GTZS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Mkrn1 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007814 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12645 Y Atta cephalotes Leafcutter ant  Acep\ACEP18577 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13115 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13466 Y Linepithema humile Argentine ant  Lhum\LH15004 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19257 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI38515 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI072134 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI27889 Y Tribolium castaneum Red flour beetle  Tcas\TC004145 Y
Orthologs in non-Insect Arthropods (EOG6H44K5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Uba52 Y Ixodes scapularis Deer tick  Isca\ISCW023116 Y Ixodes scapularis Deer tick  Isca\ISCW010382 Y
Orthologs in non-Arthropod Metazoa (EOG6P06MS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y55F3AM.6 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009003gn Y Danio rerio Zebrafish  Drer\ENSDARG00000007630 Y Danio rerio Zebrafish  Drer\mkrn1 Y Xenopus tropicalis Western clawed frog  Xtro\mkrn2 Y Xenopus tropicalis Western clawed frog  Xtro\mkrn1 Y Gallus gallus Domestic chicken  Ggal\MKRN1 Y Gallus gallus Domestic chicken  Ggal\MKRN2 Y Mus musculus House mouse  Mmus\Mkrn2 Y Mus musculus House mouse  Mmus\Mkrn1 Y Mus musculus House mouse  Mmus\Mkrn3 Y Rattus norvegicus Norway rat  Rnor\Mkrn3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000009280 Y Rattus norvegicus Norway rat  Rnor\Mkrn2 Y Homo sapiens Human  Hsap\MKRN1 Y Homo sapiens Human  Hsap\MKRN2 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\MKRN1     Hsap\MKRN2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12110 Drosophila sechellia Dsec\GM22131 Drosophila erecta Dere\GG13225 Drosophila yakuba Dyak\GE22322 Drosophila ananassae Dana\GF10705 Drosophila pseudoobscura pseudoobscura Dpse\GA20164 Drosophila persimilis Dper\GL11888 Drosophila willistoni Dwil\GK20382 Drosophila virilis Dvir\GJ13540 Drosophila mojavensis Dmoj\GI11841 Drosophila grimshawi Dgri\GH14787
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	43178 y1 v1; P{TRiP.GL01521}attP2 20949 y1 w67c23; P{EPgy2}Mkrn1EY14602
Kyoto	125437 w1118; P{RS5}Mkrn15-HA-1859
VDRC	v101694 P{KK105474}VIE-260B v34374 w1118; P{GD10767}v34374 v34373 w1118; P{GD10767}v34373/CyO
Genomic Clones ( 2 )
	BACR03O18 BACR26P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 254 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41384
Other clones	DPiM_LD41384
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03217 GH27566 GM01370 GM07706 LD02369 LD02695 LD03153 LD06488 LD07850 LD09760 LD12630 LD13505 LD13760 LD14625 LD15145 LD15376 LD15485 LD18240 LD18423 LD18543 LD19610 LD19612 LD20855 LD27532 LD27723 LD30835 LD34753 LD35165 LD36058 LD37075 LD38678 LD39595 LD39992 LP01365 RE04911 RE06414 RE08947 RE09536 RE11178 RE11640 RE14232 RE16296 RE20114 RE22718 RE25066 RE30021 RE30576 RE31250 RE31509 RE33972 RE34154 RE40696 RE42067 RE42170 RE48333 RE58374 RE58774 RE63223 RE66519 RE68034 RE69392 RE70242 RE73348 RH02375 RH02916 RH05403 RH09942 RH10163 RH10168 RH28235 RH36501 RH45354 RH46325 RH50657 RH51011 RH54713 RH54714 RH60873 SD04213 SD10243 SD11711 SD19181 SD21624
Other clones	15517 20999 44654 50219 54127 55602 56393 65165 67008 70389 70937 76301 81818 83937 100612 102046 102445 120997 122262 144970 162940 162955 173982 181219 214569.46 523872 bs53d11 CK01.23D.A8 CK01.26C.H6 CK01.39B.F6 CK01.78C.H7 CK01.80C.C12 Dmel_neb_010135_0924_3090 Dmel_neb_010792_0879_2874 EK021536 EK025248 EK042508 EK061132 EK062442 EK075408 EK128509 EK131944 EK134632 EK159847 EK169052 EK175935 EK179322 EK182116 EK183701 EK191717 EK194828 EK198134 EK215805 EK218662 EK223230 EK226027 EK243760 EK267122 EK267333 EK274525 EK287429 EN04345 EP08664 FGM002H06 RH01036 RH01161 RH01219 RP003003674 RP003016967 RP003050527 RP003074972 RP003077319 RP003079675 RP003120572 RP003127813 RP003130159 RP003130522 RP003134898 RP003135012 RP003137606 RP003146122 RP003148424 RP003149643 RP003151464 RP003159303 RP003179156 RP003182799 RP003183142 RP003184535 RP003194102 RP003198201 RP003215250 RP003216196 RP003219923 RP003229964 RP003243911 RP003245563 RP003250368 RP003256423 RP003260681 RP003260998 RP003267662 RP003268800 RP003276437 RP003285412 RP003289602 RP003292694 RP003293098 RP003295943 RP003296822 RP003301888 RP003304815 RP003309158 RP003310097 RP003317695 RP003330727 RP003337797 RP003346381 RP003370617 RP003387222 RP003405693 RP003414675 RP003420781 RP003427161 RP003430106 RP003433912 RP003434178 RP003434317 RP003443302 RP003449892 RP003456469 RP003469216 RP003471916 RP003480239 RP003484766 RP003490988 RP003498865 RP003510168 RP003514667 RP003528433 RP003540123 RP003541281 RP003544322 RP003549160 RP003554322 RP003556789 RP003560695 RP003567848 RP003575793 RP003578462 RP003579183 RP003584749 RP003609950 RP003629177 RP003635752 RP003638565 RP003650910 RP003656004 RP003658060 RP003658296 RP003662419 RP003665085 RP003672461 RP003673662 RP003675190 RP003675876 RP003676361 RP003682935 UUGC0752
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44131
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mkrn1 CG7184 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079965 NM_168922 NM_001259938 RefSeq (Proteins) • NP_524704 NP_730653 NP_001246867 DDBJ / EMBL / GenBank • AA202244 AAF17486 AAF17491 AAF51740 AAL13923 AAN12178 AF192788 AF192794 AFH04538 AI515731 AW943559 AY058694 CL943652 Z32465 Entrez Gene - A searchable database of RefSeq genes. • 44131 UniProtKB/TrEMBL • Q9TVX6 Q9VP20
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, CCCH-type (IPR000571) Zinc finger, RING-type (IPR001841) Zinc finger, RING-type, conserved site (IPR017907) Zinc finger, RING/FYVE/PHD-type (IPR013083) Putative E3 ubiquitin-protein ligase, makorin-related (IPR026290) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD41384
Linkouts
	BioGRID - A database of protein and genetic interactions • 68851 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029152 DroID - A comprehensive database of gene and protein interactions. • FBgn0029152 DRSC - Results from RNAi screens. • FBgn0029152 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7184-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44131 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44131 modMine - Data generated by the modENCODE project. • FBgn0029152
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG7184 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1) MKRN1 (Gray et al., 2000) Mkrn1
Name Synonym	Makorin 1
Secondary FlyBase IDs
	FBgn0037095
References ( 17 )
Research paper	Gray et al., 2000, Genomics 66(1): 76--86 The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. [FBrf0129194]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] Bayraktaroglu, 2000.8.7, Matches of the nc3 class to CGs. Matches of the nc3 class to CGs. [FBrf0129568] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
DNA/RNA sequence record	Gray, 1999.10.7, GenBank/EMBL/DDBJ: AF192794 Drosophila melanogaster makorin 1 (Mkrn1) gene, complete cds. [FBrf0124526]