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Gene Dmel\Men-b

General Information
Symbol	Dmel\Men-b	Species	D. melanogaster
Name	Malic enzyme b	Annotation symbol	CG5889
Feature type	protein_coding_gene	FlyBase ID	FBgn0029155
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	MDH
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97E5-97E5	Sequence location	3R:22,977,384..22,983,325 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Malic enzyme b is referred to in FlyBase by the symbol Dmel\Men-b (CG5889, FBgn0029155). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. Based on sequence similarity, it is predicted to be involved in the biological process: pyruvate metabolic process; malate metabolic process. 16 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Malic enzyme, N-terminal; Malic enzyme, NAD-binding; Malic enzyme, conserved site; Malic oxidoreductase; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult midgut, larval hindgut, larval/adult Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval midgut, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641118_at completely aligns to an exonic region of only a subset of 2 of the 3 FlyBase-annotated transcript isoforms of Mdh. Gene sequence location is 3R:22977384..22983325.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97E5-97E5   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97E-97E     (Farkas, 1999.12.20)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Men-b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Men-b-RA FBtr0085110  NM_143702   3311   617 Men-b-RB FBtr0301707  NM_001170278   2239   621 Men-b-RC FBtr0301708  NM_001170279   2543   624
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Men-b-PA   FBpp0084480   68.6   617   6.69     NP_651959   AAF56674 Men-b-PB   FBpp0290921   69.1   621   6.82     NP_001163749   ACZ95043 Men-b-PC   FBpp0290922   69.5   624   6.82     NP_001163750   ACZ95044
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Malic oxidoreductase (IPR001891) Malic enzyme, N-terminal (IPR012301) Malic enzyme, NAD-binding (IPR012302) Malic enzyme, conserved site (IPR015884) NAD(P)-binding domain (IPR016040) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05889
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698192   AA801548   AE014297 AAF56674   AE014297 ACZ95043   AE014297 ACZ95044   AF171787   AI134602   AI135616   AI238369   AI238496   AI388855   AI520164   AI532840   AI543456   AJ251546 CAB64263   AQ073935   AW940510   AY051465 AAK92889   BF487465   BF494587   BF498591   BF498872   BF499543   BF502247   BF505529   BG634364   BI141929   BI239791   BI240484   BI357539   BI372024   BI487185   BI641336   BP554167   BP554168   CL705873   CO178683   CO180515   CO183366   CO264282   CO268107   CO270969   CO272319   CO278518   CO307301   CO312755   CO313428   CZ467036   CZ467037   CZ477531   CZ477695   CZ480861   EC071816   EC079924   EC197393   EC197580   EC202824   EC203582   EC214319   EC218631   EC221289   EC221323   EC233177   EC237018   EC242500   EC242971   EC248547   EC254096   EV580477   EV593569   EV597226   GH749781   GH751605   GH754144   GH754843   GH755000   GH755287   GH759834   GH770768   GH771134   GH772610   GH775276   GH776124   GH776252   GH776387   GH776491   GH777108   GH780774   GH783970   GH784046   GH784205   GH785138   GH785951   GH786281   GH787277   GH787692   GH790923   GH791186   GH792593   GH794502   GH799067   GH799555   GH806052   GH806419   GH807094   GH807633   GH808027   GH808054   GH808168   GH808376   GH809292   GH809617   GH809775   GH810582   GH814021   GH814438   GH817097   GH818655   GH820090   GH822816   GH823332   GH826119   GH827667   GH828793   GH830298   GH830830   GH832016   GH834168   GH834870   GH836042   GH837883   GH839503   GH839811   GH840440   GH844170   GH847869   GH851320   GH851822   GH852534   GH853623   GH854514   GH858593   GH861159   GH862483   GH862872   GH864886   GH866352   GH870132   GH873111   GH874218   GH875880   GH877545   GH880747   GH880867   GH882495   GH883487   GH884643   GH886237   GH888675   GH890686   GH891494   GH892155   GH892760   GH893658   GH894412   GH895353   GH897139   GH898117   GH898305   GH899511   GH899595   GH899870   GH899907   GH900105   GH901008   GH903776   GH904533   GH905350   GH907358   GH909046   GH912213   GH916373   GH918345   GH918403   GH924420   GH929322   GH930519   GH931549   GH932972   GH933608   GH933769   GH933803   GH935502   GH937315
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VB69 E1JIZ5 E1JIZ4 Q9U1J0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) gonad   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult midgut, larval hindgut, larval/adult Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval midgut, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut    1601.4 Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (629.325) Larval Midgut    419.1 Larval Hindgut  (767.4) Larval Malpighian Tubules  (551.1) Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass  (881.95) Adult Head    327.2 Adult Eye    475.15 Adult Brain  (831.6) Adult Thoracic-Abdominal Ganglion  (939.5) Adult Crop    186.8 Adult Midgut  (1601.4) Adult Hindgut    311.2 Adult Malpighian Tubules  (749.4) Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut  (1601.4) Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut    1601.4 Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut    1601.4 Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  629.325 Larval Midgut    419.1 Larval Hindgut  767.4 Larval Malpighian Tubules  551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass  (881.95) Adult Head    327.2 Adult Eye    475.15 Adult Brain  (831.6) Adult Thoracic-Abdominal Ganglion  (939.5) Adult Crop    186.8 Adult Midgut  (1601.4) Adult Hindgut    311.2 Adult Malpighian Tubules  749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut  1601.4 Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    629.325 Larval Midgut    419.1 Larval Hindgut    767.4 Larval Malpighian Tubules    551.1 Larval Fat Body    49.3 Larval Salivary Gland    421.8 Larval Trachea    124.25 Larval Carcass    881.95 Adult Head    327.2 Adult Eye    475.15 Adult Brain    831.6 Adult Thoracic-Abdominal Ganglion    939.5 Adult Crop    186.8 Adult Midgut    1601.4 Adult Hindgut    311.2 Adult Malpighian Tubules    749.4 Adult Fat Body    48.7 Adult Salivary Gland    273.4 Adult Heart    71.85 Adult VirginFemale Spermatheca    51.9 Adult InseminatedFemale Spermatheca    66.2 Adult Ovary    306.3 Adult Testis    189 Adult Male Accessory Gland    149 Adult Carcass    350.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    327.2   NA  Eye    475.15   NA  Brain    831.6   629.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    939.5   NA  Crop    186.8   419.1  Midgut    1601.4   767.4  Hindgut    311.2   551.1  Malpighian Tubules    749.4   49.3  Fat Body    48.7   421.8  Salivary Gland    273.4   NA  Heart    71.85   124.25  Trachea    NA   NA  VirginFemale Spermatheca    51.9   NA  InseminatedFemale Spermatheca    66.2   NA  Ovary    306.3   NA  Testis    189   NA  Male Accessory Gland    149   881.95  Carcass    350.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    155 head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female    136 head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male    192 head, mated 4-day male    150 head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    105 digestive system, 4-day adult    105 digestive system, 20-day adult    114 fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult    104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3  (32) central nervous system, pupae P8  (64) head, virgin 1-day female  (155) head, virgin 4-day female  (92) head, virgin 20-day female  (45) head, mated 1-day female  (136) head, mated 4-day female  (71) head, mated 20-day female  (46) head, mated 1-day male  (192) head, mated 4-day male  (150) head, mated 20-day male  (99) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  (30) digestive system, 1-day adult  (105) digestive system, 4-day adult  (105) digestive system, 20-day adult  (114) fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult  (104) carcass, 4-day adult  (60) carcass, 20-day adult  (39) ovary, virgin 4-day female  (83) ovary, mated 4-day female  (81) testis, mated 4-day male  (43) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female  (155) head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female  (136) head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male  (192) head, mated 4-day male  (150) head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult  105 digestive system, 4-day adult  105 digestive system, 20-day adult  (114) fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult  104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    155 head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female    136 head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male    192 head, mated 4-day male    150 head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    105 digestive system, 4-day adult    105 digestive system, 20-day adult    114 fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult    104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    155 head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female    136 head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male    192 head, mated 4-day male    150 head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    105 digestive system, 4-day adult    105 digestive system, 20-day adult    114 fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult    104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3  32 central nervous system, pupae P8  (64) head, virgin 1-day female  (155) head, virgin 4-day female  (92) head, virgin 20-day female  (45) head, mated 1-day female  (136) head, mated 4-day female  (71) head, mated 20-day female  (46) head, mated 1-day male  (192) head, mated 4-day male  (150) head, mated 20-day male  (99) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering  30 digestive system, 1-day adult  (105) digestive system, 4-day adult  (105) digestive system, 20-day adult  (114) fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult  (104) carcass, 4-day adult  (60) carcass, 20-day adult  (39) ovary, virgin 4-day female  (83) ovary, mated 4-day female  (81) testis, mated 4-day male  (43) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female  (155) head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female  136 head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male  (192) head, mated 4-day male  (150) head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult  105 digestive system, 4-day adult  105 digestive system, 20-day adult  114 fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult  104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    32 central nervous system, pupae P8    64 head, virgin 1-day female    155 head, virgin 4-day female    92 head, virgin 20-day female    45 head, mated 1-day female    136 head, mated 4-day female    71 head, mated 20-day female    46 head, mated 1-day male    192 head, mated 4-day male    150 head, mated 20-day male    99 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    30 digestive system, 1-day adult    105 digestive system, 4-day adult    105 digestive system, 20-day adult    114 fat body, larvae L3 wandering    1 fat body, white prepupae    8 fat body, pupae P8    12 carcass, larvae L3 wandering    19 carcass, 1-day adult    104 carcass, 4-day adult    60 carcass, 20-day adult    39 ovary, virgin 4-day female    83 ovary, mated 4-day female    81 testis, mated 4-day male    43 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr    103 larva L1    116 larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP    273 adult male 01day    120 adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49) embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr  (29) embryo 20-22hr  (98) embryo 22-24hr  (103) larva L1  (116) larva L2  (68) larva L3 12hr old  (76) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP  (67) pupae 4d postWPP  (273) adult male 01day  (120) adult male 05day  (76) adult male 30day  (57) adult female 01day  (96) adult female 05day  (46) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr  103 larva L1  (116) larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP  (273) adult male 01day  (120) adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr    103 larva L1    116 larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP    273 adult male 01day    120 adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr    103 larva L1    116 larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP    273 adult male 01day    120 adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (49) embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr  29 embryo 20-22hr  (98) embryo 22-24hr  (103) larva L1  (116) larva L2  (68) larva L3 12hr old  (76) larva L3 puffstage 1-2  (45) larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP  (67) pupae 4d postWPP  (273) adult male 01day  (120) adult male 05day  (76) adult male 30day  (57) adult female 01day  (96) adult female 05day  (46) adult female 30day  (44) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr  103 larva L1  116 larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP  (273) adult male 01day  120 adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    49 embryo 02-04hr    4 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    6 embryo 16-18hr    11 embryo 18-20hr    29 embryo 20-22hr    98 embryo 22-24hr    103 larva L1    116 larva L2    68 larva L3 12hr old    76 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    25 white prepupae new    18 white prepupae 12hr    23 white prepupae 24hr    19 pupae 2d postWPP    24 pupae 3d postWPP    67 pupae 4d postWPP    273 adult male 01day    120 adult male 05day    76 adult male 30day    57 adult female 01day    96 adult female 05day    46 adult female 30day    44 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2    392 embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    125 ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4  (60) embryonic 1182-4H  (85) embryonic GM2  (392) embryonic Kc167  (77) embryonic S1  (53) embryonic S3  (39) leg disc CME L1  (66) wing disc CME-W2  (68) wing disc ML-DmD8  (42) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (32) wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (103) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2  (125) ovary fGS/OSS    22 ovary OSC  (50) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2  (392) embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11  103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2  101 tumorous blood cells mbn2  (125) ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2    392 embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    125 ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2    392 embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    125 ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4  (60) embryonic 1182-4H  (85) embryonic GM2  (392) embryonic Kc167  (77) embryonic S1  (53) embryonic S3  (39) leg disc CME L1  (66) wing disc CME-W2  (68) wing disc ML-DmD8  (42) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (103) antennal disc ML-DmD20-c5  (33) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (101) tumorous blood cells mbn2  (125) ovary fGS/OSS    22 ovary OSC  (50) ovary OSS  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2  (392) embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11  103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2  101 tumorous blood cells mbn2  125 ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    60 embryonic 1182-4H    85 embryonic GM2    392 embryonic Kc167    77 embryonic S1    53 embryonic S3    39 leg disc CME L1    66 wing disc CME-W2    68 wing disc ML-DmD8    42 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    22 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    103 antennal disc ML-DmD20-c5    33 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    101 tumorous blood cells mbn2    125 ovary fGS/OSS    22 ovary OSC    50 ovary OSS    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult    101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult    25 heat shock, 4-day adult  (59) Cadmium 50 mM 6 hrs, larvae L3  (52) Cadmium 50 mM 12 hrs, larvae L3  (58) Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  (72) Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult  (88) Zinc 5 mM 12 hrs, larvae L3  (76) Zinc 4.5 mM 48 hrs, 4-day adult  (101) Ethanol 2.5% 3 hrs, larvae L3  (57) Ethanol 5% 3 hrs, larvae L3  (71) Ethanol 10% 3 hrs, larvae L3  (75) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (57) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (95) Caffeine 25 mg/ml 48 hrs, 4-day adult  (50) Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (90) Rotenone 2 μg 12 hrs, larvae L3  (77) Rotenone 8 μg 12 hrs, larvae L3  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult  101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult    101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult    101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (39) cold shock, 4-day adult    25 heat shock, 4-day adult  (59) Cadmium 50 mM 6 hrs, larvae L3  (52) Cadmium 50 mM 12 hrs, larvae L3  (58) Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  (72) Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult  (88) Zinc 5 mM 12 hrs, larvae L3  (76) Zinc 4.5 mM 48 hrs, 4-day adult  (101) Ethanol 2.5% 3 hrs, larvae L3  (57) Ethanol 5% 3 hrs, larvae L3  (71) Ethanol 10% 3 hrs, larvae L3  (75) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (57) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (95) Caffeine 25 mg/ml 48 hrs, 4-day adult  (50) Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (90) Rotenone 2 μg 12 hrs, larvae L3  (77) Rotenone 8 μg 12 hrs, larvae L3  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult  101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    39 cold shock, 4-day adult    25 heat shock, 4-day adult    59 Cadmium 50 mM 6 hrs, larvae L3    52 Cadmium 50 mM 12 hrs, larvae L3    58 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    72 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    88 Zinc 5 mM 12 hrs, larvae L3    76 Zinc 4.5 mM 48 hrs, 4-day adult    101 Ethanol 2.5% 3 hrs, larvae L3    57 Ethanol 5% 3 hrs, larvae L3    71 Ethanol 10% 3 hrs, larvae L3    75 Caffeine 1.5 mg/ml 4 hrs, larvae L3    57 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    95 Caffeine 25 mg/ml 48 hrs, 4-day adult    50 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    90 Rotenone 2 μg 12 hrs, larvae L3    77 Rotenone 8 μg 12 hrs, larvae L3    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH13437 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029155 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5889-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Men-b Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Men-bCB04968 Men-bEY01197 viable, with Scer\GAL4pnr-MD237 Men-bGD11796 Sterility Allele fertile Men-bEY01197 Phenotype manifest in Allele
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Men-b Class Mutagen Stocks Known lesion Men-bd11068 P-element activity 2 -- Men-bc01276 piggyBac transposase 1 -- Men-bCB-5364-3 1 -- Men-be03094 piggyBac transposase 1 -- Men-bEY01197 P-element activity 1 -- Men-bKG02266 1 -- Men-bCB04968 P-element activity 0 Yes Men-bd11379 P-element activity 0 -- Men-bEP3349 P-element activity 0 -- Men-bEP470 0 -- Men-bGS8066 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Men-b Class Mutagen Stocks Known lesion Men-bGD11796 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Men-bGL00415 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Men-bKK108789 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Men-bGD16408 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Men-bNIG.5889R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6207 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.5889R} NA P{TRiP.GL00415} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG6051EP3089 NA P{EP}Men-bEP470 NA P{EP}Men-bEP3349 NA P{EPgy2}Men-bEY01197 NA P{GSV3}Men-bGS8066 NA P{XP}Men-bd11068 NA P{XP}Men-bd11379 NA miscellaneous insertions P{PTT-GB}Men-bCB04968 NA P{PTT-GB}YB0142 NA P{RS3}Men-bCB-5364-3 NA P{SUPor-P}Men-bKG02266 NA PBac{PB}Men-bc01276 NA PBac{RB}Men-be03094 NA insertion of enhancer trap P{luc-sniffer}3-80 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity inferred from sequence or structural similarity with UniProtKB:Q16798 (FlyBase, 1992-, Sardiello et al., 2003.6.11) non-traceable author statement (Farkas, 1999.12.20) malate dehydrogenase (oxaloacetate-decarboxylating) activity inferred from electronic annotation with InterPro:IPR001891 (FlyBase Curators et al., 2004-) metal ion binding inferred from electronic annotation with InterPro:IPR015884 (FlyBase Curators et al., 2004-) NAD binding inferred from electronic annotation with InterPro:IPR012302 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
malate metabolic process inferred from sequence or structural similarity with UniProtKB:Q16798 (Sardiello et al., 2003.6.11) oxidation-reduction process inferred from electronic annotation with InterPro:IPR001891, InterPro:IPR012301, InterPro:IPR012302, InterPro:IPR015884 (FlyBase Curators et al., 2004-) pyruvate metabolic process inferred from sequence or structural similarity with UniProtKB:Q16798 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with UniProtKB:Q16798 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Men-b allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68727 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029155 DroID - A comprehensive database of gene and protein interactions. • FBgn0029155 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43936
Orthologs
OrthoDB Orthologs (64) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG680JG7 Dipteran inclusive ortholog search EOG6BCDW4 Insect inclusive ortholog search EOG6MGR3H Arthropod inclusive ortholog search EOG62280W Metazoa inclusive ortholog search EOG6WX4BP
Orthologs in Drosophila Species (EOG680JG7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Men-b     Drosophila sechellia   Dsec\GM10372 Y   Drosophila erecta   Dere\GG11530 Y   Drosophila yakuba   Dyak\GE23720 Y   Drosophila ananassae   Dana\GF23280 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19206 Y   Drosophila persimilis   Dper\GL23904 Y   Drosophila willistoni   Dwil\GK11883 Y   Drosophila virilis   Dvir\GJ22862 Y   Drosophila mojavensis   Dmoj\GI23201 Y   Drosophila grimshawi   Dgri\GH17523     Drosophila grimshawi   Dgri\GH20613
Orthologs in non-Drosophila Dipterans (EOG6BCDW4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001091   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001073   Anopheles gambiae Malaria mosquito  Agam\AGAP004159   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009607   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009608
Orthologs in non-Dipteran Insects (EOG6MGR3H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Mdh Y Apis mellifera Western honey bee  Amel\GB55096 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013704 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000998 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24246 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13121 Y Atta cephalotes Leafcutter ant  Acep\ACEP11951 Y Atta cephalotes Leafcutter ant  Acep\ACEP12304 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18596 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19448 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21922 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20630 Y Linepithema humile Argentine ant  Lhum\LH23125 Y Linepithema humile Argentine ant  Lhum\LH13502 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13772 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24701 Y Solenopsis invicta Red fire ant  Sinv\SINV22127 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004126 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006059 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006419 Y Pediculus humanus Human body louse  Phum\PHUM268250 Y Tribolium castaneum Red flour beetle  Tcas\TC005232 Y Tribolium castaneum Red flour beetle  Tcas\TC005233 Y
Orthologs in non-Insect Arthropods (EOG62280W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_304467 Y Ixodes scapularis Deer tick  Isca\ISCW011260 Y
Orthologs in non-Arthropod Metazoa (EOG6WX4BP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\men-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018110gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006048gn Y Danio rerio Zebrafish  Drer\ENSDARG00000086961 Y Danio rerio Zebrafish  Drer\me1 Y Danio rerio Zebrafish  Drer\me3 Y Danio rerio Zebrafish  Drer\me2 Y Danio rerio Zebrafish  Drer\me2 Y Xenopus tropicalis Western clawed frog  Xtro\me2 Y Xenopus tropicalis Western clawed frog  Xtro\me3 Y Xenopus tropicalis Western clawed frog  Xtro\me1 Y Gallus gallus Domestic chicken  Ggal\ME1 Y Gallus gallus Domestic chicken  Ggal\ME3 Y Mus musculus House mouse  Mmus\Me2 Y Mus musculus House mouse  Mmus\Me3 Y Mus musculus House mouse  Mmus\Me1 Y Rattus norvegicus Norway rat  Rnor\Me3 Y Rattus norvegicus Norway rat  Rnor\Me2 Y Rattus norvegicus Norway rat  Rnor\Me1 Y Homo sapiens Human  Hsap\ME3 Y Homo sapiens Human  Hsap\ME2 Y Homo sapiens Human  Hsap\ME1 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\ME3     Hsap\ME2     Hsap\ME1
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM10372 Drosophila erecta Dere\GG11530 Drosophila yakuba Dyak\GE23720 Drosophila ananassae Dana\GF23280 Drosophila pseudoobscura pseudoobscura Dpse\GA19206 Drosophila persimilis Dper\GL23904 Drosophila willistoni Dwil\GK11883 Drosophila virilis Dvir\GJ22862 Drosophila mojavensis Dmoj\GI23201
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	20110 y1 w67c23; P{EPgy2}Men-bEY01197 35486 y1 sc* v1; P{TRiP.GL00415}attP2 19342 w1118; P{XP}Men-bd11068/TM6B, Tb1 13198 y1 w67c23; ry506 P{SUPor-P}Men-bKG02266
Harvard	- P{XP}Men-bd11068 - PBac{PB}Men-bc01276 - PBac{RB}Men-be03094
Kyoto	123589 w1118; P{RS3}Men-bCB-5364-3
VDRC	v100812 P{KK108789}VIE-260B v27535 w1118; P{GD11796}v27535 v27533 w1118; P{GD11796}v27533/TM3
Genomic Clones ( 1 )
	BACR21O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 181 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13437
Other clones	AF171787 DPiM_GH13437
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03274 AT07770 AT13030 AT13282 AT14118 AT17918 AT22268 AT30551 GH12113 GH14402 GH14548 GH19891 HL03917 HL06637 LD40227 RE36377 RE37336 RE44053 RE57151 RE70704 SD04473 SD10212 SD15906 SD24566
Other clones	8251 17776 30415 30803 105045 107316 108521 119332 148592 214409.21 CK01.18B.F7 CK01.72B.A8 CK01.99A.F8 CK01.118D.G2 CK01.132D.E1 CK01.167C.A6 Dmel_dig_007380_0658_2255 Dmel_neb_000879_0864_3700 Dmel_neb_011234_0646_2656 EC01990 EC25590 EK057336 EK090157 EK101217 EK106727 EK130251 EK138415 EK229918 EK232923 EK254320 FGM228D05 RP003004022 RP003010316 RP003015228 RP003018972 RP003020750 RP003021604 RP003023120 RP003023127 RP003025028 RP003031119 RP003035099 RP003035526 RP003042125 RP003046322 RP003050946 RP003057029 RP003059240 RP003061458 RP003064050 RP003076672 RP003077315 RP003080364 RP003083593 RP003085218 RP003086859 RP003098152 RP003099667 RP003102804 RP003115127 RP003120914 RP003123914 RP003133174 RP003148033 RP003153267 RP003156826 RP003164090 RP003167635 RP003180983 RP003183050 RP003183452 RP003184637 RP003186501 RP003186603 RP003190428 RP003192259 RP003200165 RP003200183 RP003208421 RP003208633 RP003213618 RP003214401 RP003214656 RP003226871 RP003246157 RP003259208 RP003268351 RP003269481 RP003269601 RP003271494 RP003287028 RP003299016 RP003320461 RP003323096 RP003326949 RP003330197 RP003343888 RP003351343 RP003355179 RP003357294 RP003360560 RP003360984 RP003366237 RP003377760 RP003381987 RP003384949 RP003396504 RP003409110 RP003419414 RP003420004 RP003429777 RP003429861 RP003438419 RP003441490 RP003443249 RP003444585 RP003447711 RP003451166 RP003455596 RP003457982 RP003463633 RP003468691 RP003478778 RP003484206 RP003488038 RP003490244 RP003498137 RP003500599 RP003507178 RP003509157 RP003512465 RP003514114 RP003517918 RP003518220 RP003523101 RP003532824 RP003541443 RP003542850 RP003546880 RP003556625 RP003579416 RP003591242 RP003597065 RP003598140 RP003603987 RP003617015 RP003620509 RP003626173 RP003627392 RP003631309 RP003645451 RP003647182 RP003675773 RP003682616
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029155 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43936
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Men-b Mdh (FlyBase, 2009-)
Source for database merge of	Source for merge of: Mdh anon-EST:Posey79 (Ashburner, 2004.6.30) Source for merge of: Mdh CG5889 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143702 NM_001170278 NM_001170279 RefSeq (Proteins) • NP_651959 NP_001163749 NP_001163750 DDBJ / EMBL / GenBank • AAF56674 AAK92889 ACZ95043 ACZ95044 AF171787 AI135616 AJ251546 AQ073935 AW940510 AY051465 CAB64263 CL705873 CZ467036 CZ467037 CZ477531 CZ477695 CZ480861 Entrez Gene - A searchable database of RefSeq genes. • 43936 UniProtKB/TrEMBL • E1JIZ4 E1JIZ5 Q9U1J0 Q9VB69
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Malic oxidoreductase (IPR001891) Malic enzyme, N-terminal (IPR012301) Malic enzyme, NAD-binding (IPR012302) Malic enzyme, conserved site (IPR015884) NAD(P)-binding domain (IPR016040) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05889 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH13437
Linkouts
	BioGRID - A database of protein and genetic interactions • 68727 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0029155 DroID - A comprehensive database of gene and protein interactions. • FBgn0029155 DRSC - Results from RNAi screens. • FBgn0029155 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029155 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5889-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029155 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43936 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43936 modMine - Data generated by the modENCODE project. • FBgn0029155
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	anon-EST:Posey79   CG5889 (Ashburner, 2004.6.30, Stempfl et al., 2002, Quinones-Coello, 2007, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Cammarato et al., 2011) MDH (Farkas, 1999.12.20) Mdh (Gregory et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007) Men-b (Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Malic DH (Arking et al., 2000) Malic enzyme b   Mdh (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0027671 FBgn0039493
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...