l(3)01207, Mkph, MKP
phosphatase - plays a pivotal role in actin dynamic by reactivating the actin depolymerizing factor cofilin
Please see the JBrowse view of Dmel\ssh for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
None of the polypeptides share 100% sequence identity.
Interacts with actin.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ssh using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\ssh in GBrowse 23-86
3-85.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: ssh MAP-kinase-phosphatase
Source for merge of: MAP-kinase-phosphatase CG6238
Source for merge of: l(3)01207 ssh
Source for merge of: ssh Mkph
Source for merge of: MAP-kinase-phosphatase ssh
Source for merge of MAP-kinase-phosphatase ssh was sequence comparison ( date:010405 ).
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
ssh plays a critical role in controlling actin dynamics and thus reactivating cofilin in cellular and developmental contexts.
ssh regulates cytoskeletal reorganization.
Strong mutations in ssh result in larval lethality. Adult escapers of hypomorphic alleles and mitotic clones of strong alleles show kinked and/or branched bristles and wing hairs.
Inactivates rl kinase.
Strong mutations caused larval lethality. Escaper adults of hypomorphic alleles and mitotic clones of strong ones exhibited kinked and/or branched bristles and wing hairs due to disruption of actin bundles.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. ssh gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis.