FlyBase Gene Report: Dmel\Hml

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Gene: Dmel\Hml

General Information

Symbol

Dmel\Hml

Species

D. melanogaster

Name

Hemolectin

Annotation Symbol

CG7002

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029167

Gene Model Status

Stock Availability

16 publicly available

Gene Summary

Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

CT21553

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:13,846,054..13,860,001 [+]

Recombination map

3-41

RefSeq locus

NT_037436 REGION:13846054..13860001

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein homodimerization activity

inferred from direct assay

(Goto et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR002557, InterPro:IPR036508

(InterPro Project Members, 2004-)

enables extracellular matrix structural constituent

inferred from biological aspect of ancestor with PANTHER:PTN000885756

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in hemolymph coagulation

inferred from mutant phenotype

(Scherfer et al., 2004)

involved_in hemostasis

inferred from mutant phenotype

(Goto et al., 2003)

inferred from expression pattern

(Goto et al., 2001)

involved_in wound healing

inferred from mutant phenotype

(Goto et al., 2003)

NOT involved_in melanization defense response

inferred from mutant phenotype

(Goto et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Goto et al., 2001)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN000885756

(GO Reference Genome Project, 2011-)

located_in extracellular region

inferred from electronic annotation with InterPro:IPR002557

(InterPro Project Members, 2004-)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000885756

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CHITIN BINDING DOMAIN-CONTAINING PROTEINS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CHITIN BINDING DOMAIN-CONTAINING PROTEINS -: Chitin binding domains are found in certain classes of chitin binding proteins and chitin-active enzymes. (Adapted from FBrf0108362.)

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\Hml for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VU94)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0075753

11756

3843

FBtr0333020

11753

3842

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0075495

426.2

3843

5.74

FBpp0305234

426.2

3842

5.74

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hml using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hml_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.88

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

spermatogenesis & adult stage | male

primary spermatocyte

(White-Cooper, 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17

embryonic/larval hemocyte

(Goto et al., 2003)

Comment: no lamellocyte expression observed

(Goto et al., 2003)

embryonic/larval crystal cell | subset

(Goto et al., 2003)

embryonic/larval plasmatocyte | subset

(Goto et al., 2003)

first instar larval stage

embryonic/larval hemocyte

(Goto et al., 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval hemolymph

Comment: component of hemolymph clot

(Scherfer et al., 2004)

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

Additional Descriptive Data

Isolated from a pullout assay for proteins contained in clots from larval hemolymph and identified by mass spec.

(Scherfer et al., 2004)

Staining of firstinstar larvae with a monoclonal antibody against Hml protein showed that this protein is expressed in hemocytes. A GFP report driven by Hml-GAL4 was used to further narrow Hml expression to a subset of larval plasmatocytes and crystal cells. No expression was detected in lamellocytes.

(Goto et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Goto et al., 2001)

Expression Deduced from Reporters

Reporter: P{Hml-GAL4.Δ}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval plasmatocyte

(Reitman et al., 2015, Chen et al., 2014)

embryonic/larval hemocyte

(Arefin et al., 2017, Han et al., 2014, Khadilkar et al., 2014, Mondal et al., 2014)

embryonic/larval crystal cell

(Reitman et al., 2015)

cortical zone of lymph gland primary lobe

(Khadilkar et al., 2014)

larval sessile hemocyte

(Arefin et al., 2017, Mondal et al., 2014)

embryonic/larval lymph gland

(Arefin et al., 2017)

larval stage -- adult stage

(Costa et al., 2009)

first instar larval stage -- adult stage

embryonic/larval plasmatocyte

(Charroux and Royet, 2009)

larval sessile hemocyte

(Charroux and Royet, 2009)

second instar larval stage -- third instar larval stage

embryonic/larval hemocyte

(Sinenko et al., 2009)

lymph gland derived hemocyte

(Sinenko et al., 2009)

cortical zone of lymph gland primary lobe

(Charroux and Royet, 2009, Sinenko et al., 2009)

third instar larval stage

embryonic/larval hemocyte

(Avet-Rochex et al., 2010)

cortical zone of lymph gland primary lobe

(Avet-Rochex et al., 2010)

embryonic/larval hindgut

(Avet-Rochex et al., 2010)

(Chen et al., 2014)

Reporter: P{Hml-GAL4.G}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17 -- prepupal stage P1

(Goto et al., 2003)

(Narita et al., 2004, Goto, 2001.12.6)

embryonic/larval hemocyte

(Kester and Nambu, 2011)

larval stage -- adult stage

(Shia et al., 2009)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hml in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hml

View exonic expression by tissue for Dmel\Hml

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029167

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39529/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029167

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029167

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029167

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7002

Flygut - An atlas of the Drosophila adult midgut

FBgn0029167

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hml

Transgenic constructs containing regulatory region of Hml

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

Hml^f03374

viable, with Scer\GAL4^da.G32

Hml^RNAi.UAS

viable, with Scer\GAL4^tin.CΔ4

Hml^GD1292

Sterility

Allele

Hml^f03374

Other Phenotypes

Allele

abnormal immune response | larval stage

Hml^f03374

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (29)

9 of 14

Yes

Yes

9 of 14

Yes

Yes

8 of 14

No

Yes

7 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

5 of 14

No

Yes

5 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

8 of 14

Yes

Yes

7 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

5 of 14

No

Yes

4 of 14

No

Yes

4 of 14

No

Yes

3 of 14

No

No

3 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

Mus musculus (laboratory mouse) (23)

9 of 14

Yes

Yes

8 of 14

No

Yes

8 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

6 of 14

No

Yes

4 of 14

No

Yes

3 of 14

No

Yes

3 of 14

No

Yes

Mmus\9530053A07Rik

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (64)

7 of 13

Yes

Yes

4 of 13

No

Yes

Xtro\LOC100495470

4 of 13

No

Yes

4 of 13

No

Yes

4 of 13

No

Yes

4 of 13

No

Yes

3 of 13

No

Yes

2 of 13

No

Yes

Xtro\LOC100492329

2 of 13

No

Yes

Xtro\LOC100493184

2 of 13

No

Yes

Xtro\LOC100494113

2 of 13

No

Yes

Xtro\LOC100497756

2 of 13

No

Yes

Xtro\LOC116410388

2 of 13

No

Yes

2 of 13

No

Yes

2 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xtro\LOC100485197

1 of 13

No

Yes

Xtro\LOC100485343

1 of 13

No

Yes

Xtro\LOC100485356

1 of 13

No

Yes

Xtro\LOC100485405

1 of 13

No

Yes

Xtro\LOC100490280

1 of 13

No

Yes

Xtro\LOC100493186

1 of 13

No

No

Xtro\LOC100494747

1 of 13

No

Yes

Xtro\LOC100498223

1 of 13

No

Yes

Xtro\LOC100498375

1 of 13

No

Yes

Xtro\LOC100498539

1 of 13

No

Yes

Xtro\LOC101730747

1 of 13

No

Yes

Xtro\LOC101734651

1 of 13

No

Yes

Xtro\LOC105947064

1 of 13

No

Yes

Xtro\LOC108647331

1 of 13

No

Yes

Xtro\LOC108647333

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (33)

8 of 14

Yes

Yes

8 of 14

Yes

Yes

7 of 14

No

Yes

6 of 14

No

Yes

4 of 14

No

Yes

4 of 14

No

Yes

Drer\LOC100329651

3 of 14

No

Yes

2 of 14

No

Yes

Drer\si:ch211-39f2.3

2 of 14

No

Yes

Drer\si:dkey-65b12.6

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\LOC100147849

1 of 14

No

Yes

Drer\LOC100149773

1 of 14

No

Yes

Drer\LOC100332723

1 of 14

No

Yes

Drer\LOC100536949

1 of 14

No

Yes

Drer\LOC101885543

1 of 14

No

Yes

Drer\LOC101885726

1 of 14

No

Yes

Drer\LOC108181583

1 of 14

No

Yes

Drer\LOC108190762

1 of 14

No

Yes

Drer\LOC108190763

1 of 14

No

Yes

Drer\LOC110437733

1 of 14

No

Yes

Drer\LOC110438378

1 of 14

No

Yes

Drer\LOC110439905

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (27)

3 of 14

Yes

Yes

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP006168

2 of 12

Yes

No

Agam\AgaP_AGAP001176

1 of 12

No

No

Agam\AgaP_AGAP002445

1 of 12

No

No

Agam\AgaP_AGAP006252

1 of 12

No

No

Agam\AgaP_AGAP006253

1 of 12

No

No

Agam\AgaP_AGAP006523

1 of 12

No

No

Agam\AgaP_AGAP006527

1 of 12

No

No

Agam\AgaP_AGAP006581

1 of 12

No

No

Agam\AgaP_AGAP006582

1 of 12

No

No

Agam\AgaP_AGAP006584

1 of 12

No

No

Agam\AgaP_AGAP006585

1 of 12

No

No

Agam\AgaP_AGAP006586

1 of 12

No

No

Agam\AgaP_AGAP006587

1 of 12

No

No

Agam\AgaP_AGAP006589

1 of 12

No

No

Agam\AgaP_AGAP006813

1 of 12

No

No

Agam\AgaP_AGAP009669

1 of 12

No

Yes

Agam\BURS_ANOGA

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (3)

1 of 13

Yes

Yes

1 of 13

Yes

Yes

1 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

1 of 13

Yes

Yes

1 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hml. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

MUC5B; mucin 5B, oligomeric mucus/gel-forming

model of interstitial lung disease 2

IEA

(FlyBase, 2019-)

VWF; von Willebrand factor

model of von Willebrand's disease 2

IEA

(FlyBase, 2019-)

model of von Willebrand's disease 1

IEA

(FlyBase, 2019-)

model of von Willebrand's disease 3

IEA

(FlyBase, 2019-)

model of autosomal recessive nonsyndromic deafness 18B

IEA

(FlyBase, 2019-)

OTOGL; otogelin like

model of autosomal recessive nonsyndromic deafness 84B

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MUC5AC; mucin 5AC, oligomeric mucus/gel-forming

9 of 14

MUC5B; mucin 5B, oligomeric mucus/gel-forming

9 of 14

INTERSTITIAL LUNG DISEASE 2; ILD2

interstitial lung disease 2

VWF; von Willebrand factor

8 of 14

MUC2; mucin 2, oligomeric mucus/gel-forming

7 of 14

MUC6; mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)

6 of 14

6 of 14

DEAFNESS, AUTOSOMAL RECESSIVE 18B; DFNB18B

autosomal recessive nonsyndromic deafness 18B

SSPOP; SCO-spondin, pseudogene

6 of 14

MUC19; mucin 19, oligomeric (gene/pseudogene)

5 of 14

OTOGL; otogelin like

5 of 14

DEAFNESS, AUTOSOMAL RECESSIVE 84B; DFNB84B

autosomal recessive nonsyndromic deafness 84B

FCGBP; Fc gamma binding protein

3 of 14

ZAN; zonadhesin

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Fuwa et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029167

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ECM-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-41

Cytogenetic map

Sequence location

3L:13,846,054..13,860,001 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70C4-70C5

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70C1-70C5

(determined by in situ hybridisation)

(Goto et al., 2001)

70C1-70C5

(Kitagawa, 1999.12.16)

Experimentally Determined Recombination Data

Location

3-41

(FlyBase, 2016)

3-35.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

30139

w¹¹¹⁸; P{Hml-GAL4.Δ}2

18646

w¹¹¹⁸; PBac{WH}Hml^f03374

30140

w¹¹¹⁸; P{Hml-GAL4.Δ}2, P{UAS-2xEGFP}AH2

30142

w¹¹¹⁸; P{Hml-GAL4.Δ}3, P{UAS-2xEGFP}AH3/MKRS

23381

y¹ w^67c23; Mi{ET1}Hml^MB01940

605154

y^* w^*; TI{2A-QF2}Hml^2A-QF2.RFP-

606648

P{Hml-GAL4.Δ}1, w^*; P{UAS-sfGFP-TurboID-ER}attP40

600218

w^*; P{Hml-GAL4.Δ}2 P{UAS-2xEGFP}AH2; P{He-GAL4.Z}85

v37005

P{GD1292}v37005

v37006

P{GD1292}v37006

v108935

P{KK101608}VIE-260B

v318100

PBac{fTRG00449.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029167

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH24431

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029167

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mutants with reduced levels of Hml protein show a bleeding defect upon injury. This defect is not due to a defect in melanin production or in phenoloxidase activity.

(Goto et al., 2003)

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

(McDonald and Rosbash, 2001)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Hml CG7002

(Kitagawa, 2001.3.22)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG7002

(Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Kanao and Miyachi, 2006, Wertheim et al., 2005, Theopold et al., 2002, Kitagawa, 2001.3.22)

CT21553

(Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Hemolectin

(Dziedziech et al., 2020)

Hml

(Ho et al., 2025, Janssens et al., 2025, Zhang et al., 2025, Goins et al., 2024, Hersperger et al., 2024, Isaacson et al., 2024, Krejčová et al., 2024, Kwon et al., 2024, Pignataro et al., 2024, Salminen et al., 2024, Sutton et al., 2024, Vesala et al., 2024, Chen et al., 2023, Floc'hlay et al., 2023, Hsi et al., 2023, Khalili et al., 2023, Kinoshita et al., 2023, Demir et al., 2022, Green et al., 2022, Gupta et al., 2022, Hultmark and Andó, 2022, Kharrat et al., 2022, Wu et al., 2022, Zhou et al., 2022, Bilder et al., 2021, Cattenoz et al., 2021, Girard et al., 2021, Higareda Alvear et al., 2021, Kramer et al., 2021, Spratford et al., 2021, van de Leemput and Han, 2021, Zhang et al., 2021, Benoit et al., 2020, Cho et al., 2020, Wan et al., 2020, Williams et al., 2020, Barik and Mishra, 2019, Hall et al., 2019, Maitra et al., 2019, Sanchez Bosch et al., 2019, Ariss et al., 2018, Bazzi et al., 2018, Davie et al., 2018, Demir and Marcos, 2018, Gene Disruption Project members, 2018-, Valenza et al., 2018, Yu et al., 2018, Yu et al., 2018, Jansen et al., 2017, Kim et al., 2017, Kline et al., 2017, Alaraby et al., 2016, Mossman et al., 2016, Sarov et al., 2016, Fuwa et al., 2015, Kavi et al., 2015, Bonnay et al., 2014, Choi et al., 2014, Evans et al., 2014, Honti et al., 2014, Salazar-Jaramillo et al., 2014, Taylor et al., 2014, Theopold et al., 2014, Wang et al., 2014, Burra et al., 2013, Kari et al., 2013, Kelsey et al., 2012, Clark et al., 2011, Sinenko et al., 2011, Wertheim et al., 2011, Stofanko et al., 2010, Bartkuhn et al., 2009, Costa et al., 2009, Kanao and Miyachi, 2006, Wertheim et al., 2005, Kitagawa, 1999.12.16)

d-hml

(Goto et al., 2001)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39529

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VU94

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VU94

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029167

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39529/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029167

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029167

FlyMine - An integrated database for Drosophila genomics

FBgn0029167

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7002

MARRVEL_MODEL - MARRVEL (model organism gene)

39529

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029167

DroID - A comprehensive database of gene and protein interactions.

FBgn0029167

DRSC - Results frm RNAi screens

FBgn0029167

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hml_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029167

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029167

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7002

Flygut - An atlas of the Drosophila adult midgut

FBgn0029167

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029167

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012551

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ECM-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (187)