FlyBase Gene Report: Dmel\Fkbp59

General Information

Symbol

Dmel\Fkbp59

Species

D. melanogaster

Name

FK506-binding protein 59kD

Annotation Symbol

CG4535

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029174

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Snapshot

FK506-binding protein 59kD (Fkbp59) encodes a peptidylprolyl isomerase involved in the regulation of calcium transport and phototransduction. [Date last reviewed: 2019-09-19]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dFKBP59, l(2)k00424, FKBP59-bp1

Key Links

Genomic Location

Cytogenetic map

30E1-30E1

Sequence location

2L:9,888,005..9,890,119 [+]

Recombination map

2-37

RefSeq locus

NT_033779 REGION:9888005..9890119

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:inaD; FB:FBgn0001263

(Goel et al., 2001)

inferred from physical interaction with FLYBASE:trpl; FB:FBgn0005614

(Goel et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables FK506 binding

inferred from sequence or structural similarity with HGNC:3720

(Goel et al., 2001)

enables peptidyl-prolyl cis-trans isomerase activity

inferred from biological aspect of ancestor with PANTHER:PTN000054102

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in detection of light stimulus involved in visual perception

inferred from physical interaction with FLYBASE:inaD; FB:FBgn0001263

(Goel et al., 2001)

inferred from physical interaction with FLYBASE:trpl; FB:FBgn0005614

(Goel et al., 2001)

involved_in regulation of calcium ion transport

inferred from direct assay

(Goel et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in chaperone-mediated protein folding

inferred from biological aspect of ancestor with PANTHER:PTN000054102

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein peptidyl-prolyl isomerization

inferred from biological aspect of ancestor with PANTHER:PTN000054102

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of inaD signaling complex

inferred from physical interaction with FLYBASE:inaD; FB:FBgn0001263

(Goel et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000054102

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

FK506-BINDING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

FK506-BINDING PROTEINS -: FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Protein Function (UniProtKB)

May have a role in phototransduction; inhibits or prevents Ca(2+) induced stimulation of the trpl ion channel.

(UniProt, Q9VL78)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fkbp59 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fkbp59-RA

FBtr0079872

NM_080156

1494

439

Fkbp59-RB

FBtr0342837

NM_001298855

1587

439

Additional Transcript Data and Comments

Reported size (kB)

1.7 (northern blot)

(Zaffran, 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Fkbp59-PA

FBpp0079468

48.8

439

5.08

NP_524895

AAF52818

Fkbp59-PB

FBpp0309663

48.8

439

5.08

NP_001285784

AHN54298

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

439 aa isoforms: Fkbp59-PA, Fkbp59-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

439 (aa)

(Zaffran, 2000)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with inaD and trpl, and may be part of the inaD signaling complex.

(UniProt, Q9VL78)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fkbp59 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FKBP59_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

crystal cell

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval oenocyte

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

embryonic/larval lymph gland

(Zaffran, 2000)

embryonic stage 13 -- 17

embryonic/larval garland cell

(Zaffran, 2000)

embryonic/larval oenocyte

(Zaffran, 2000)

embryonic stage -- adult stage

(Zaffran, 2000)

Additional Descriptive Data

Fkbp59 transcripts are detected throughout development on northern blots with peaks in early embryos, first and second instar larvae, and adult females. They are detected by in situ hybridization in three glands in embryos. They are detected at stage 13 in garland cell precursors and at stage 15 in the garland cells. Fkbp59 transcripts are detected at stage 13 in the oenocytes and at later stages in the lymph glands.

(Zaffran, 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of inaD signaling complex

inferred from physical interaction with FLYBASE:inaD; FB:FBgn0001263

(Goel et al., 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Fkbp59 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fkbp59

View exonic expression by tissue for Dmel\Fkbp59

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029174

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0029174

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4535-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4535

Flygut - An atlas of the Drosophila adult midgut

FBgn0029174

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Fkbp59

Stages(s) 1-3
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fkbp59

Transgenic constructs containing regulatory region of Fkbp59

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation

Gene not disrupted in

Df(2L)Mdh

(Kania et al., 1995)

Df(2L)N22-3

(BDGP Project Members, 1994-1999)

Df(2L)N22-5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)s1402

(Prokopenko et al., 2000, Zaffran, 2000, BDGP Project Members, 1994-1999)

Gene disrupted in

Df(2L)Exel6025

(Ryder, 2004.4.26)

Df(2L)Exel7043

(Ryder, 2004.4.26)

Df(2L)J39

(Kania et al., 1995, BDGP Project Members, 1994-1999)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die during embryonic stage | recessive

partially lethal - majority die | adult stage, with Scer\GAL4^pnr-MD237

Fkbp59^GD11342

viable

Fkbp59^EY03538

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fkbp59^GD11342

viable, with Scer\GAL4^Mef2.PR

Fkbp59^GD11342

viable, with Scer\GAL4^tin.CΔ4

Fkbp59^GD11342

Sterility

Allele

fertile

Fkbp59^EY03538

Other Phenotypes

Allele

some die during embryonic stage | recessive

Phenotype manifest in

Allele

chordotonal organ | lateral

Fkbp59^k00424

crystal cell

fascicle

Fkbp59^k00424

plasmatocyte

Fkbp59^k09010

presumptive embryonic/larval peripheral nervous system

Fkbp59^k00424

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\FKBP4

11 of 15

Yes

Hsap\FKBP5

10 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\STIMATE-MUSTN1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Fkbp4

11 of 15

Yes

Mmus\Fkbp5

10 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (13)

Rnor\Fkbp4

11 of 13

Yes

Rnor\Fkbp5

10 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (14)

Xtro\fkbp4

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\stimate

1 of 12

Yes

Xtro\tmem110l

1 of 12

Yes

Danio rerio (Zebrafish) (16)

Drer\fkbp4

11 of 15

Yes

Drer\fkbp5

10 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-208h16.4

1 of 15

Drer\stimate

1 of 15

Yes

Drer\tmem110l

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\fkb-6

12 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (6)

Atha\ROF1

8 of 9

Yes

Atha\AT5G48570

7 of 9

Yes

Atha\PAS1

3 of 9

Yes

Atha\AT3G55520

2 of 9

Yes

Atha\FKBP13

1 of 9

Atha\TWD1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\FPR1

2 of 15

Yes

Scer\FPR3

2 of 15

Yes

Scer\FPR4

2 of 15

Yes

Scer\FPR2

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\fkh1

1 of 12

Yes

Spom\SPAC27F1.06c

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908F8 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18239

Drosophila persimilis

Dper\GL16626

Drosophila persimilis

Dper\GL18937

Drosophila willistoni

Dwil\GK23813

Drosophila virilis

Dvir\GJ17544

Drosophila mojavensis

Dmoj\GI17716

Drosophila grimshawi

Dgri\GH11297

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506EL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021621

Glossina morsitans

Tsetse fly

Gmor\GMOY002284

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02937

Mayetiola destructor

Hessian fly

Mdes\Mdes005288

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010491

Anopheles darlingi

American malaria mosquito

Adar\ADAC007461

Anopheles gambiae

Malaria mosquito

Agam\AGAP009347

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014691

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03X3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013634

Bombyx mori

Silkmoth

Bmor\BGIBMGA013635

Danaus plexippus

Monarch butterfly

Dple\DPOGS210582-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007164

Apis florea

Little honeybee

Aflo\3847243636

Apis mellifera

Western honey bee

Amel\FKBP59

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17084

Bombus terrestris

Buff-tailed bumblebee

Bter\15203506

Linepithema humile

Argentine ant

Lhum\LH15576

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001996

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007289

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11984

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08405

Pediculus humanus

Human body louse

Phum\PHUM544510

Rhodnius prolixus

Kissing bug

Rpro\RPRC003352

Cimex lectularius

Bed bug

Clec\CLEC012492

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000411

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI080998

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14620

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05L6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011934

Ixodes scapularis

Black-legged tick

Isca\ISCW006566

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72327.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74608.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g07360

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303608

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_204206

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07OA )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fk506bp4

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000014905

Gallus gallus

Domestic chicken

Ggal\FKBP4

Gallus gallus

Domestic chicken

Ggal\FKBP5

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

4 of 10

2 of 10

2 of 10

shu

2 of 10

zda

2 of 10

CG30075

1 of 10

Fkbp14

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

FKBP5; FKBP prolyl isomerase 5

model of endogenous depression

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FKBP4; FKBP prolyl isomerase 4

11 of 15

600611

FKBP5; FKBP prolyl isomerase 5

10 of 15

602623

MAJOR DEPRESSIVE DISORDER; MDD

endogenous depression

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Fkbp59 - AGO3

anti bait coimmunoprecipitation, western blot

(Cappucci et al., 2019)

Fkbp59 - CG30496

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp59 - Prx2540-2

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp59 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp59 - dUTPase

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp59 - fabp

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp59 - inaD

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, two hybrid, anti tag western blot

(Goel et al., 2001)

Fkbp59 - trpl

affinity chromatography technology, western blot, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, anti tag western blot

(Goel et al., 2001)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with inaD and trpl, and may be part of the inaD signaling complex.

(UniProt, Q9VL78 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029174

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

47762

MIST (protein-protein) - An integrated Molecular Interaction Database

FKBP59

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-37

Cytogenetic map

30E1-30E1

Sequence location

2L:9,888,005..9,890,119 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30E1-30E1

Limits computationally determined from genome sequence between P{lacW}zf30C^k02506&P{EP}und^EP424 and P{lacW}l(2)k06416^k06416&P{lacW}sop^k04603

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

30D3-30D4

(Zaffran, 1999.6.28)

30D1-30D2

(Prokopenko, 1999.8.5, Prokopenko, 1999.8.5)

30D3-30D4

(determined by in situ hybridisation)

(Spradling et al., 1999)

30D1-30D2

30D3--4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-37

(FlyBase, 2016)

2-32.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Bloomington

28349

y¹ v¹; P{TRiP.JF02985}attP2

63375

w¹¹¹⁸; PBac{IT.GAL4}Fkbp59^0520-G4/CyO

19999

y¹ w^67c23; P{EPgy2}Fkbp59^EY03538

10848

y¹ w^67c23; P{lacW}Fkbp59^k09010/CyO

35612

y¹ sc^* v¹ sev²¹; P{TRiP.GL00453}attP2

68132

y¹ sc^* v¹ sev²¹; P{TOE.GS00529}attP40

Kyoto

102155

y¹ w^67c23 ; P{lacW}Fkbp59^k00424 / CyO

111255

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}Fkbp59^k09010 P{neoFRT}40A/CyO y⁺

VDRC

v21862

w¹¹¹⁸; P{GD11342}v21862

v21863

w¹¹¹⁸; P{GD11342}v21863

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (204)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD47530

Other clones

DPiM_LD47530

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029174

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029174

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

47762

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Fkbp59 FKBP59

(FlyBase, 2009-)

Source for database merge of

Source for merge of: FKBP59-bp1 CG4535

(Bayraktaroglu, 2000.8.7)

Source for merge of: FKBP59 l(2)k00424

(Prokopenko et al., 2000)

Source for merge of: FKBP59 anon-WO0118547.161

(FlyBase, 1996-)

Additional comments

Source for merge of FKBP59 anon-WO0118547.161 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Area matching Drosophila EST AA695850. This EST overlaps ESTS AA698310 and has sequence similarity to Rabbit FKB4 protein. Probable intron in gene represented by EST AA695850.

(Davies, 2001.3.15)

FKBP59 protein binds to both inaD and trpl proteins, both in vitro and in vivo. FKBP59 inhibits trpl-mediated Ca²⁺ influx in fura-2 assays in Sf9 cells.

(Goel et al., 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47762

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VL78

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2J5E8

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029174

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029174

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FKBP59_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4535

Flygut - An atlas of the Drosophila adult midgut

FBgn0029174

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

47762

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008405

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4535

modMine - A data warehouse for the modENCODE project

FBgn0029174

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0029174

DroID - A comprehensive database of gene and protein interactions.

FBgn0029174

DRSC - Results frm RNAi screens

FBgn0029174

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0029174

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4535-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029174

FlyMine - An integrated database for Drosophila genomics

FBgn0029174

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

47762

MIST (protein-protein) - An integrated Molecular Interaction Database

FKBP59

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG4535

(Ghartey-Kwansah et al., 2018, Hosono et al., 2015, Ni et al., 2011.7.19, Perkins et al., 2009, Nakahara et al., 2005)

FKBP59

(Lopez-Gonzalez et al., 2019, Olson et al., 2019, Ghartey-Kwansah et al., 2018, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Luck et al., 2014, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Pak et al., 2012, Preall et al., 2012, Holland et al., 2011, Yamamoto et al., 2009.2.25, Neal et al., 2006)

FKBP59-bp1

(Prokopenko et al., 2000)

Fkbp59

(Hall et al., 2019)

anon-WO0118547.161

dFKBP4

(Mordes et al., 2018)

dFKBP59

(Sanokawa-Akakura et al., 2010, Goel et al., 2001, Zaffran, 2000)

fkbp59

(Li et al., 2015)

l(2)k00424

(Prokopenko et al., 2000, Kania et al., 1995)

l(2)k09010

Name Synonyms

FK506-binding protein 59kD

FK506-binding protein FKBP59

Secondary FlyBase IDs

FBgn0015990
FBgn0022021
FBgn0032152
FBgn0062203

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (75)

The following external sites may use different assemblies or annotations than FlyBase.

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