FlyBase Gene Report: Dmel\Or1a

General Information

Symbol

Dmel\Or1a

Species

D. melanogaster

Name

Odorant receptor 1a

Annotation Symbol

CG17885

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029521

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Odorant receptor 1a (Or1a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Key Links

Genomic Location

Cytogenetic map

1A2-1A2

Sequence location

X:315,123..316,566 [+]

Recombination map

1-0

RefSeq locus

NC_004354 REGION:315123..316566

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables olfactory receptor activity

inferred from direct assay

(assigned by UniProt )

(Hoare et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables odorant binding

inferred from sequence or structural similarity with FLYBASE:Or43b; FB:FBgn0026393

(FlyBase Curators, 2008--)

enables olfactory receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000474402

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception of smell

inferred from direct assay

(Hoare et al., 2011)

involved_in olfactory behavior

inferred from mutant phenotype

(Fishilevich et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception of smell

inferred from biological aspect of ancestor with PANTHER:PTN000474402

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in dendrite membrane

inferred from sequence or structural similarity with FLYBASE:Or22a; FB:FBgn0026398

(FlyBase Curators, 2008--)

located_in integral component of membrane

inferred from biological aspect of ancestor with PANTHER:PTN000474402

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000474402

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ODORANT RECEPTORS

Protein Family (UniProt)

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily. (Q9W5G6)

Protein Signatures (InterPro)

Olfactory receptor, insect

Summaries

Gene Snapshot

Odorant receptor 1a (Or1a) encodes a multi-transmembrane chemoreceptor that mediates response to volatile chemicals. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

ODORANT RECEPTORS -: Insect odorant receptors (ORs) are a family of chemoreceptors activated by volatile chemicals. ORs form heteromeric complexes, believed to function as non-selective cation channels, comprising an OR and the co-receptor Orco. ORs are expressed in the dendrites of subsets of olfactory neurons in the antenna and maxillary palp. (Adapted from FBrf0168007 and FBrf0220463).

Protein Function (UniProtKB)

Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanal, heptanal, and 2-heptanone.

(UniProt, Q9W5G6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Or1a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Or1a-RA

FBtr0070070

NM_080290

1188

392

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Or1a-PA

FBpp0070069

45.0

392

8.01

NP_525029

AAF45495

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).

(UniProt, Q9W5G6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Olfactory receptor, insect

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

AE014298 / AAF45495

UniProt

Q9W5G6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Or1a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Or1a_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Or1a-GAL4.F}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval olfactory receptor neuron Or1a

(Masuda-Nakagawa et al., 2009)

larval antennal lobe glomerulus 1a

(Masuda-Nakagawa et al., 2009)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Or1a in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Or1a

View exonic expression by tissue for Dmel\Or1a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0029521

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17885-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0029521

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Or1a

Transgenic constructs containing regulatory region of Or1a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Or1a^GD708

viable, with Scer\GAL4^Mef2.PR

Or1a^GD708

viable, with Scer\GAL4^pnr-MD237

Or1a^GD708

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (0)

No records found.

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (0)

No records found.

Rattus norvegicus (Norway rat) (0)

No records found.

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (0)

No records found.

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909HA )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\Or1a

Drosophila persimilis

Dper\GL20372

Drosophila willistoni

Dwil\GK24993

Drosophila virilis

Dvir\GJ19501

Drosophila mojavensis

Dmoj\GI14836

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505MX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17024738

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08HG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR015589

Strigamia maritima

European centipede

Smar\SMAR015531

Ixodes scapularis

Black-legged tick

Isca\ISCW011649

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01070

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00780

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00870

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00650

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01100

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01120

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00260

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g04833

Tetranychus urticae

Two-spotted spider mite

Turt\tetur485g00010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur19g01190

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g01440

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01180

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00850

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01270

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01220

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01110

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g00440

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01380

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01340

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01200

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01360

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01310

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00960

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01280

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01080

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00930

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01160

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01250

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00810

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01060

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00860

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01150

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01130

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g01680

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01350

Tetranychus urticae

Two-spotted spider mite

Turt\tetur19g01180

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01370

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00910

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01170

Tetranychus urticae

Two-spotted spider mite

Turt\tetur142g00030

Tetranychus urticae

Two-spotted spider mite

Turt\tetur142g00010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01090

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00830

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00820

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01190

Tetranychus urticae

Two-spotted spider mite

Turt\tetur27g00860

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01140

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01210

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01230

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (59)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).

(UniProt, Q9W5G6 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029521

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0

Cytogenetic map

1A2-1A2

Sequence location

X:315,123..316,566 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1A2-1A2

Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0

(FlyBase, 2016)

1-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

9949

w^*; P{Or1a-GAL4.F}28.2

53926

y¹ v¹; P{TRiP.HMJ21271}attP40

9950

w^*; Bl¹/SM1; P{Or1a-GAL4.F}28.6/TM6B, Tb¹

VDRC

v108333

P{KK106725}VIE-260B

v44184

w¹¹¹⁸; P{GD708}v44184

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029521

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

30978

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Or1a CG17885

(Warr and Vosshall, 2000.5.19)

Source for database merge of

Additional comments

Other Comments

Or1a is necessary for larval chemotaxis to the odour (E)-2-hexenal, but is sufficient only in concert with another olfactory sensory neuron.

(Fishilevich et al., 2005)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 17 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

30978

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF45495

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W5G6

Other crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Or1a_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0029521

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

30978

InterPro - A database of protein families, domains and functional sites

Olfactory receptor, insect

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG17885

modMine - A data warehouse for the modENCODE project

FBgn0029521

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029521

DRSC - Results frm RNAi screens

FBgn0029521

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0029521

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG17885-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029521

FlyMine - An integrated database for Drosophila genomics

FBgn0029521

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

1A.1

(Warr and Vosshall, 2000.5.19)

(Masuda-Nakagawa et al., 2009, Vogt et al., 2002)

CG17885

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

DOR68

(Warr and Vosshall, 2000.5.19)

OR1a

(Störtkuhl and Fiala, 2011, Stocker, 2006)

Or1a

(Chepurwar et al., 2019, Si et al., 2019, Japanese National Institute of Genetics, 2012.5.21, Hoare et al., 2011, Galizia et al., 2010, Robertson, 2009, Zhou et al., 2009, Kreher et al., 2008, McBride et al., 2007, Stocker, 2006, Robertson et al., 2003)

Name Synonyms

Odorant receptor 1a

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

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