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Gene Dmel\lva

General Information
Symbol	Dmel\lva	Species	D. melanogaster
Name	lava lamp	Annotation symbol	CG6450
Feature type	protein_coding_gene	FlyBase ID	FBgn0029688
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	lava, lvl
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4A1-4A1	Sequence location	X:3,849,578..3,858,787 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lava lamp is referred to in FlyBase by the symbol Dmel\lva (CG6450, FBgn0029688). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: actin binding; protein binding; microtubule binding. There is experimental evidence that it is involved in the biological process: negative regulation of dendrite morphogenesis; establishment of Golgi localization; cellularization. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Prefoldin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, inseminated spermatheca, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1635954_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of lva. Gene sequence location is X:3849578..3858787.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105
FB2012_01	Sequence features BKN45027 HFA18403 BKN23551
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4A1-4A1   Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lva for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone SD02391 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lva-RC FBtr0070626  NM_080325   8670   2779
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lva-PC   FBpp0070596   315.9   2779   4.52     NP_525064   AAF45910
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142007   AA698308   AA942044   AE014298 AAF45910   AI403430   AI404494   AI405674   AI519706   AI531383   AW941441   AW944235   AY075374   AY118638 AAM50007   BF487583   BF505983   BG633375   BG638949   BG639512   BG639513   BI574031   BI574032   BI581324   BI581999   BI582182   BI586343   BI592221   BI605431   BI609784   BI612805   BI617885   BI635037   BI639678   CO190723   CO262086   CO287249   CO300687   CO307016   CO318266   CO318610   CO333482   CO344690   EC051465   EC052413   EC070566   EC073940   EC078334   EC079997   EC079998   EC086952   EC203554   EC206607   EC218545   EC228323   EC238794   EC253924   EV577063   EY198971   GH773759   GH921256   GH938759
UniProtKB/Swiss-Prot	Q8MSS1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0029688    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0029688 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0029688 expression level Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2413) embryo 02-04hr  (919) embryo 04-06hr  (1459) embryo 06-08hr  (2173) embryo 08-10hr  (2092) embryo 10-12hr  (1545) embryo 12-14hr  (2149) embryo 14-16hr  (2245) embryo 16-18hr  (1932) embryo 18-20hr  (1700) embryo 20-22hr  (1349) embryo 22-24hr  (1367) larva L1  (1476) larva L2  (2100) larva L3 12hr old  (1732) larva L3 puffstage 1-2  (1134) larva L3 puffstage 3-6  (1587) larva L3 puffstage 7-9  (1435) white prepupae new  (1477) white prepupae 12hr  (1159) white prepupae 24hr  (1552) pupae 2d postWPP  (1521) pupae 3d postWPP  (1204) pupae 4d postWPP  (1040) adult male 01day  (1828) adult male 05day  (1951) adult male 30day  (2091) adult female 01day  (1944) adult female 05day  (2602) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2413) embryo 02-04hr    919 embryo 04-06hr  1459 embryo 06-08hr  (2173) embryo 08-10hr  (2092) embryo 10-12hr  (1545) embryo 12-14hr  (2149) embryo 14-16hr  (2245) embryo 16-18hr  (1932) embryo 18-20hr  (1700) embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1  1476 larva L2  (2100) larva L3 12hr old  (1732) larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6  (1587) larva L3 puffstage 7-9  1435 white prepupae new  1477 white prepupae 12hr    1159 white prepupae 24hr  (1552) pupae 2d postWPP  (1521) pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day  (1828) adult male 05day  (1951) adult male 30day  (2091) adult female 01day  (1944) adult female 05day  (2602) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0029688 expression level Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2413) embryo 02-04hr  (919) embryo 04-06hr  (1459) embryo 06-08hr  (2173) embryo 08-10hr  (2092) embryo 10-12hr  (1545) embryo 12-14hr  (2149) embryo 14-16hr  (2245) embryo 16-18hr  (1932) embryo 18-20hr  (1700) embryo 20-22hr  (1349) embryo 22-24hr  (1367) larva L1  (1476) larva L2  (2100) larva L3 12hr old  (1732) larva L3 puffstage 1-2  (1134) larva L3 puffstage 3-6  (1587) larva L3 puffstage 7-9  (1435) white prepupae new  (1477) white prepupae 12hr  (1159) white prepupae 24hr  (1552) pupae 2d postWPP  (1521) pupae 3d postWPP  (1204) pupae 4d postWPP  (1040) adult male 01day  (1828) adult male 05day  (1951) adult male 30day  (2091) adult female 01day  (1944) adult female 05day  (2602) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2413 embryo 02-04hr    919 embryo 04-06hr  1459 embryo 06-08hr  2173 embryo 08-10hr  2092 embryo 10-12hr  1545 embryo 12-14hr  2149 embryo 14-16hr  2245 embryo 16-18hr  1932 embryo 18-20hr  1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1  1476 larva L2  2100 larva L3 12hr old  1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6  1587 larva L3 puffstage 7-9  1435 white prepupae new  1477 white prepupae 12hr    1159 white prepupae 24hr  1552 pupae 2d postWPP  1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day  1828 adult male 05day  1951 adult male 30day  2091 adult female 01day  1944 adult female 05day  (2602) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2413 embryo 02-04hr    919 embryo 04-06hr    1459 embryo 06-08hr    2173 embryo 08-10hr    2092 embryo 10-12hr    1545 embryo 12-14hr    2149 embryo 14-16hr    2245 embryo 16-18hr    1932 embryo 18-20hr    1700 embryo 20-22hr    1349 embryo 22-24hr    1367 larva L1    1476 larva L2    2100 larva L3 12hr old    1732 larva L3 puffstage 1-2    1134 larva L3 puffstage 3-6    1587 larva L3 puffstage 7-9    1435 white prepupae new    1477 white prepupae 12hr    1159 white prepupae 24hr    1552 pupae 2d postWPP    1521 pupae 3d postWPP    1204 pupae 4d postWPP    1040 adult male 01day    1828 adult male 05day    1951 adult male 30day    2091 adult female 01day    1944 adult female 05day    2602 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0029688    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0029688 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, inseminated spermatheca, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0029688 expression level Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland  520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland  (559.5) Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0029688 expression level Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland  520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland  559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    72.725 Larval Midgut    81.8 Larval Hindgut    105.4 Larval Malpighian Tubules    108.2 Larval Fat Body    80.6 Larval Salivary Gland    520.1 Larval Trachea    90.075 Larval Carcass    72.6 Adult Head    97.2 Adult Eye    113.325 Adult Brain    119.4 Adult Thoracic-Abdominal Ganglion    112.6 Adult Crop    125.5 Adult Midgut    70.1 Adult Hindgut    69.9 Adult Malpighian Tubules    80.3 Adult Fat Body    80.4 Adult Salivary Gland    559.5 Adult Heart    74.3 Adult VirginFemale Spermatheca    82.4 Adult InseminatedFemale Spermatheca    106.4 Adult Ovary    96.6 Adult Testis    37.3 Adult Male Accessory Gland    424 Adult Carcass    85.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    97.2   NA  Eye    113.325   NA  Brain    119.4   72.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    112.6   NA  Crop    125.5   81.8  Midgut    70.1   105.4  Hindgut    69.9   108.2  Malpighian Tubules    80.3   80.6  Fat Body    80.4   520.1  Salivary Gland    559.5   NA  Heart    74.3   90.075  Trachea    NA   NA  VirginFemale Spermatheca    82.4   NA  InseminatedFemale Spermatheca    106.4   NA  Ovary    96.6   NA  Testis    37.3   NA  Male Accessory Gland    424   72.6  Carcass    85.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6450-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 lvaGD11929 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS neuroanatomy defective, with Scer\GAL4477 lvaDN.Scer\UAS Phenotype manifest in Allele dendrite & dendritic arborising neuron, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS dendrite & dendritic arborising neuron, with Scer\GAL4477 lvaDN.Scer\UAS Golgi apparatus & dendritic arborising neuron, with Scer\GAL4109(2)80 lvadsRNA.1.Scer\UAS Golgi apparatus & dendritic arborising neuron, with Scer\GAL4477 lvaDN.Scer\UAS
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of lva Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lva Class Mutagen Stocks Known lesion lvaGD11929 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lvaKK103359 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lva1.T:Sjap\GST in vitro construct - coding region fusion 0 Yes lva3.T:Sjap\GST in vitro construct - coding region fusion 0 Yes lva5.T:Sjap\GST in vitro construct - coding region fusion 0 Yes lvaDN.Scer\UAS in vitro construct - regulatory fusion 0 Yes lvadsRNA.1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes lvadsRNA.2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11929} NA P{KK103359} NA P{UAS-lva.DN} NA P{UAS-lva-RNAi.1} NA P{UAS-lva-RNAi.2} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
actin binding inferred from direct assay (assigned by UniProtKB) (Sisson et al., 2000) microtubule binding inferred from direct assay (assigned by UniProtKB) (Sisson et al., 2000) protein binding inferred from physical interaction with CLIP-190 (assigned by UniProtKB) (Sisson et al., 2000)
Biological Process
CV term Evidence References
cellularization inferred from mutant phenotype (Papoulas et al., 2005) inferred from mutant phenotype (assigned by UniProtKB) (Sisson et al., 2000) establishment of Golgi localization inferred from mutant phenotype (Papoulas et al., 2005) negative regulation of dendrite morphogenesis inferred from mutant phenotype (Ye et al., 2007)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (assigned by UniProtKB) (Sisson et al., 2000) Golgi apparatus inferred from direct assay (assigned by UniProtKB) (Sisson et al., 2000) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
spectrin binding traceable author statement (Lecuit and Pilot, 2003)
Biological Process
CV term Evidence References
cellularization non-traceable author statement (Tepass et al., 2001) traceable author statement (Lecuit and Pilot, 2003)
Cellular Component
CV term Evidence References
Golgi apparatus non-traceable author statement (Sisson, 2000.11.4) traceable author statement (Lecuit and Pilot, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lva allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57868 DroID - A comprehensive database of gene and protein interactions. • FBgn0029688 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31350
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21903 Dere\GG18567 Dgri\GH24649 Dpse\GA24315 Dsec\GM12709 Dsim\GD16316 Dvir\GJ15883 Dwil\GK10361 Dyak\GE16878
Curated drosophilid orthologs	Drep\lva   Dsim\lva (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007506-PA Aedes aegypti (mosquito) AGAP000035-PA Anopheles gambiae (mosquito) XP_001120525.1 Apis mellifera (honey bee) BGIBMGA000894-PA Bombyx mori (silk worm) CPIJ014522 Culex pipens (mosquito) ENSCPOP00000005772 Cavia porcellus (guinea pig) XP_001604782.1 Nasonia vitripennis (wasp) PHUM000102-PA Pediculus humanus (human body louse) XP_974572.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0234368 FBgn0212376 FBgn0203070 FBgn0187939 FBgn0167645 FBgn0245712 FBgn0154450 FBgn0154449 FBgn0144435 FBgn0144434 FBgn0132105 FBgn0110778 FBgn0098903 CPIJ014522 AGAP000035 AAEL007506 GLEAN_07813
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v106476 P{KK103359}VIE-260B v40382 w1118; P{GD11929}v40382
Genomic Clones ( 1 )
	BACR21M21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL04250 SD02391
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08327 AT22550 GH22864 GH24235 LD26054 RH09861 RH14624 RH18702 RH19860 RH20134 RH26273 RH41777 RH48350 RH71028 SD01829 SD22328
Other clones	54226 77460 147883 166659 172797 214445.52 281673 CK01.19D.E1 CK01.39A.A6 CK01.69B.H3 CK01.99C.E2 CK00115 Dmel_dig_000843_0670_0367 DMG2-chrX.4.054.a.1 EC051465 EC052413 EK049350 EK065323 EK084349 EK179118 EK253135 EK271210 EK273211 EK307046 EP19731 GH25776 LD39389 RH09450 RP003117888 RP003310101 RP003575090 SD01765
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029688 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31350
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "lava lamp" after the apical/basal movements of Golgi bodies marked with an antibody against the lva protein, which resemble the motion of droplets in a lava lamp. (Sisson et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: lva CG6450 (Sisson, 2000.11.4)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) lva is required for cellularisation in embryos. (Sisson et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080325 RefSeq (Proteins) • NP_525064 DDBJ / EMBL / GenBank • AA698308 AAF45910 AAM50007 AI531383 AW941441 AW944235 AY075374 AY118638 Entrez Gene - A searchable database of RefSeq genes. • 31350 UniProtKB/Swiss-Prot • Q8MSS1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin (IPR009053)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57868 DroID - A comprehensive database of gene and protein interactions. • FBgn0029688 DRSC - Results from RNAi screens. • FBgn0029688 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6450-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029688 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31350 InParanoid A subset of ortholog calls from InParanoid. • AAEL007506-PA Aedes aegypti (mosquito) AGAP000035-PA Anopheles gambiae (mosquito) XP_001120525.1 Apis mellifera (honey bee) BGIBMGA000894-PA Bombyx mori (silk worm) CPIJ014522 Culex pipens (mosquito) ENSCPOP00000005772 Cavia porcellus (guinea pig) XP_001604782.1 Nasonia vitripennis (wasp) PHUM000102-PA Pediculus humanus (human body louse) XP_974572.2 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/lavalmp1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31350 modMine - Data generated by the modENCODE project. • FBgn0029688 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0234368 FBgn0212376 FBgn0203070 FBgn0187939 FBgn0167645 FBgn0245712 FBgn0154450 FBgn0154449 FBgn0144435 FBgn0144434 FBgn0132105 FBgn0110778 FBgn0098903 CPIJ014522 AGAP000035 AAEL007506 GLEAN_07813
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	ABP2 (Sisson et al., 2000) CG6450 (Gonzalez et al., 2002, Sisson, 2000.11.4, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Hughes et al., 2008) CG#6450 (Sisson et al., 2000) lava (Mazumdar and Mazumdar, 2002) Lava (Lu and Bilder, 2005, Lee et al., 2009) Lva (Royou et al., 2004, Papoulas et al., 2005, LaLonde et al., 2006, Ataman et al., 2006, Ataman, 2006, Eisman et al., 2006, Finan et al., 2011, Papoulas et al., 2005, Jafar-Nejad et al., 2005, Missirlis et al., 2007, Denef et al., 2008, Januschke et al., 2007, Giansanti et al., 2007, Leibfried et al., 2008, Harris and Tepass, 2008, Blankenship et al., 2007, Kelkar and Dobberstein, 2009, Giansanti et al., 2006, Snee and Macdonald, 2009, Korkut et al., 2009, Polevoy et al., 2009, Robinett et al., 2009, Phillips and Thomas, 2006, Repnikova et al., 2010, Zhou et al., 2011) LVA (Sisson et al., 2001, Nurminsky, 2007, Monzo et al., 2006, Ma et al., 2010) lva (Wang et al., 2007, Quinones-Coello, 2007, Ye et al., 2007, Bakal et al., 2007, Wasbrough et al., 2010) lvl (Akbar et al., 2007) Lvl (Akbar et al., 2009)
Name Synonym	actin-binding protein 2 (Liu, 2010) Lava Lamp (Papoulas et al., 2003, Finger and White, 2002, Papoulas et al., 2005, Sisson et al., 2001, LaLonde et al., 2006, Lu and Bilder, 2005, Ohyama et al., 2007, Eisman et al., 2006, Monzo et al., 2006, Jaekel and Klein, 2006, Denef et al., 2008, Januschke et al., 2007, Phillips and Thomas, 2006, Dasgupta et al., 2009, Liu, 2010, Tanaka et al., 2011) lava lamp (Sisson, 2000.11.4, Sisson et al., 2000, Wilhelm et al., 2005, Singh et al., 2007, Acharya et al., 2008, Szul et al., 2011) Lava-Lamp (Lu and Bilder, 2005, Leibfried et al., 2008) Lava lamp (Langevin et al., 2005, Finan et al., 2011, Papoulas et al., 2005, Lee and Cooley, 2007, Missirlis et al., 2007, Harris and Tepass, 2008, Blankenship et al., 2007, Kelkar and Dobberstein, 2009, Giansanti et al., 2006, Lee et al., 2009, Snee and Macdonald, 2009, Yan et al., 2009, Robinett et al., 2009, Khanna et al., 2010, Jayaram et al., 2008, Mottola et al., 2010) Lavalamp (Korkut et al., 2009) LAVA LAMP (Kim et al., 2010)
Secondary FlyBase IDs
References ( 90 )
Generate a list of	All references relating to this gene ( 90 )
List References by type	Research paper  ( 57 ) Supplementary material  ( 10 ) Review  ( 6 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 9 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 12 )
	Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105 AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. [FBrf0213890] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Szul et al., 2011, Cell. Logist. 1(2): 69--76 The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila. [FBrf0213963] Tanaka et al., 2011, Development 138(12): 2523--2532 Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. [FBrf0213769] Zhou et al., 2011, Development 138(6): 1111--1120 Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. [FBrf0213068] Khanna et al., 2010, BMC Genomics 11(1): 302 Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210923] Kim et al., 2010, J. Cell Biol. 188(5): 717--734 The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. [FBrf0210177] Liu, 2010, J. Genet. Genomics 37(5): 281--296 Intracellular compartmentation of CTP synthase in Drosophila. [FBrf0210909] Ma et al., 2010, Development 137(22): 3775--3784 OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. [FBrf0212194] Mottola et al., 2010, Development 137(14): 2353--2364 A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity. [FBrf0211104] Repnikova et al., 2010, J. Neurosci. 30(18): 6466--6476 Sialyltransferase regulates nervous system function in Drosophila. [FBrf0210736] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...