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Gene Dmel\SK

General Information
Symbol	Dmel\SK	Species	D. melanogaster
Name	small conductance calcium-activated potassium channel	Annotation symbol	CG10706
Feature type	protein_coding_gene	FlyBase ID	FBgn0029761
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	dSK
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	4F5-4F9	Sequence location	X:5,234,269..5,298,760 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene small conductance calcium-activated potassium channel is referred to in FlyBase by the symbol Dmel\SK (CG10706, FBgn0029761). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: photoreceptor activity; small conductance calcium-activated potassium channel activity. There is experimental evidence that it is involved in the biological process: regulation of membrane potential in photoreceptor cell. 25 alleles are reported. The phenotype of these alleles is annotated with: photoreceptor cell. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Calmodulin-binding domain; Ion transport 2; Potassium channel, calcium-activated, SK. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, adult heart. Gene sequence location is X:5234269..5298760.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 4F5-4F9   Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249EP1400
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\SK for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.45 3' UTR contains an ORF that is conserved among close Drosophila species (potential peptide 194 aa in length; possible stop-codon suppression).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) SK-RH FBtr0300467  NM_167032   3729   524 SK-RI FBtr0301949  NM_167030   3723   522 SK-RJ FBtr0301950  NM_167031   3556   812 SK-RK FBtr0301951  NM_167029   4813   927 SK-RL FBtr0301952  NM_080339   3885   576 SK-RM FBtr0301953  NM_206631   8417   927 SK-RN FBtr0301954  NM_001103415   3484   685 SK-RO FBtr0331602  NM_001272322   4946   960 SK-RP FBtr0331603  NM_001272323   8051   979 SK-RQ FBtr0331604  NM_001272324   4768   928
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein SK-PH   FBpp0289694   59.5   524   9.77     NP_726989   AAF46027 SK-PI   FBpp0291161   59.4   522   9.53     NP_726987   AAN09137 SK-PJ   FBpp0291162   88.6   812   9.63     NP_726988   AAF46029 SK-PK   FBpp0291163   101.9   927   9.34     NP_726986   AAN09136 SK-PL   FBpp0291164   65.1   576   9.63     NP_525078   AAF46030 SK-PM   FBpp0291165   101.8   927   9.47     NP_996354   AAS65264 SK-PN   FBpp0291166   76.6   685   9.77     NP_001096885   ABX11900 SK-PO   FBpp0303992   105.5   960   9.78     NP_001259251   AGB95097 SK-PP   FBpp0303993   107.2   979   9.63     NP_001259252   AGB95098 SK-PQ   FBpp0303994   101.8   928   9.55     NP_001259253   AGB95099
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Potassium channel, calcium-activated, SK (IPR015449) Calmodulin-binding domain (IPR004178) Ion transport 2 (IPR013099)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141418   AA694895   AA696754   AE014298 AAF46027   AE014298 AAF46029   AE014298 AAF46030   AE014298 AAN09136   AE014298 AAN09137   AE014298 AAS65264   AE014298 ABX11900   AE014298 AGB95097   AE014298 AGB95098   AE014298 AGB95099   AI062158   AI063755   AI063784   AI386549   AW940034   AW941148   AW941821   AY095016 AAM11344   AY119457 AAM50111   AY119529 AAM50183   AY157147 AAN71717   AY157148 AAN71718   BE977248   BG632124   BG637547   BH023731   BI163401   BI591830   BI615871   BI616332   BP557102   BP557103   BT029108   CK135496   CO153000   CO155460   CO184501   CO187344   CO187524   CO196392   CO266896   CO271086   CO277580   CO279049   CO280607   CO284811   CO284989   CO285628   CO294418   CO294786   CO296768   CO306166   CO310367   CO319323   CO325141   CO326108   CO327921   CO340738   CO344533   CZ471839   CZ472621   CZ473300   CZ474002   CZ476582   CZ476966   CZ477808   CZ483874   CZ490190   CZ490670   CZ490671   EC062885   EC066179   EC076605   EC080760   EC087017   EC088785   EC200162   EC203515   EC205702   EC210497   EC211176   EC215709   EC225118   EC228655   EC231916   EC239111   EC244337   EC245237   EC258539   EL874825   EL874826   EL874955   EL874956
UniProtKB/Swiss-Prot	Q7KVW5
UniProtKB/TrEMBL	Q8T3J7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   adult brain | restricted   (Abou Tayoun et al., 2011) lamina | restricted   • axon (Abou Tayoun et al., 2011) lamina | restricted   • presynaptic active zone (Abou Tayoun et al., 2011) lamina | restricted   • cell body (Abou Tayoun et al., 2011) medulla | restricted   (Abou Tayoun et al., 2011) retina | faint & restricted   (Abou Tayoun et al., 2011) antennal lobe projection neuron | subset   (Abou Tayoun et al., 2011)
Additional Descriptive Data
	SK protein is strongly expressed in the adult lamina and medulla layers. In the lamina, is localises to the axons of the photoreceptors, the cell body of non-glutamatergic neurons, (possibly L4) and in the presynaptic active zones. In the medulla, it is detected in glutamatergic and non-glutamatergic neurons. Expression seems strongest in medulla layers M4 and M5. In the central brain, SK protein is expressed by the olfactory projection neurons that innervate the mushroom bodies. (Abou Tayoun et al., 2011)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
integral to membrane inferred from direct assay (Abou Tayoun et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8    135 head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8  (135) head, virgin 1-day female  (69) head, virgin 4-day female  (75) head, virgin 20-day female    24 head, mated 1-day female  (68) head, mated 4-day female  (58) head, mated 20-day female  (27) head, mated 1-day male  (77) head, mated 4-day male  (89) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8  (135) head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8    135 head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8    135 head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8  (135) head, virgin 1-day female  (69) head, virgin 4-day female  (75) head, virgin 20-day female    24 head, mated 1-day female  (68) head, mated 4-day female  (58) head, mated 20-day female  27 head, mated 1-day male  (77) head, mated 4-day male  (89) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8  135 head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    24 central nervous system, pupae P8    135 head, virgin 1-day female    69 head, virgin 4-day female    75 head, virgin 20-day female    24 head, mated 1-day female    68 head, mated 4-day female    58 head, mated 20-day female    27 head, mated 1-day male    77 head, mated 4-day male    89 head, mated 20-day male    60 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    15 carcass, larvae L3 wandering    6 carcass, 1-day adult    10 carcass, 4-day adult    11 carcass, 20-day adult    5 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    5 embryo 18-20hr    4 embryo 20-22hr    5 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    4 white prepupae 24hr    3 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC  (61) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC  (61) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    61 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    6 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    10 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_14 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • GM01744 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12732-RA;CG10706-RC;CG10706-RA;CT36054
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable SK1 SKf07979 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW SKGD3233 SKGD12601 SKKK107699 viable, with Scer\GAL4pnr-MD237 SKGD3233 SKGD7812 SKGD7813 SKGD12601 Sterility Allele fertile SK1 SKf07979 Other Phenotypes Allele neurophysiology defective SK1 neurophysiology defective, with Scer\GAL4GMR.long SKDN.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele photoreceptor cell SK1 photoreceptor cell, with Scer\GAL4GMR.long SKDN.Scer\UAS.T:Hsap\MYC
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of SK Class Mutagen Stocks Known lesion SKf07979 piggyBac transposase 2 -- SKBG01378 P-element activity 1 -- SKd00844 P-element activity 1 -- SKd02105 P-element activity 1 -- SKd03336 P-element activity 1 -- SKd11567 P-element activity 1 -- SKf01403 piggyBac transposase 1 -- SKf07382 piggyBac transposase 1 -- SKMB03486 1 -- SK1 FLPase 0 Yes SKd01523 0 -- SKd04568 P-element activity 0 -- SKd04662 0 -- SKd09146 P-element activity 0 -- SKd09830 P-element activity 0 -- SKGG01575 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of SK Class Mutagen Stocks Known lesion SKGD3233 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SKGD7812 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes SKGD12601 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SKGD7813 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SKJF02571 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SKKK107699 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SKDN.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes SKNIG.10706R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SKScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3233} NA P{GD7813} NA P{GD12601} NA P{KK107699} NA P{NIG.10706R} NA P{TRiP.JF02571} NA P{UAS-SK.DN.myc} NA P{UAS-SK.myc} NA characterization construct P{GD7812} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}SKBG01378 NA PBac{WH}SKf01403 NA PBac{WH}SKf07382 NA PBac{WH}SKf07979 NA insertion of mobile activating element P{Mae-UAS.6.11}SKGG01575 NA P{XP}SKd00844 NA P{XP}SKd01523 NA P{XP}SKd02105 NA P{XP}SKd03336 NA P{XP}SKd04568 NA P{XP}SKd04662 NA P{XP}SKd09146 NA P{XP}SKd09830 NA P{XP}SKd11567 NA insertion of enhancer trap binary system Mi{ET1}SKMB03486 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
photoreceptor activity inferred from direct assay (Abou Tayoun et al., 2011) small conductance calcium-activated potassium channel activity inferred from direct assay (Abou Tayoun et al., 2011)
Biological Process
CV term Evidence References
potassium ion transport inferred from mutant phenotype (Abou Tayoun et al., 2011) regulation of membrane potential in photoreceptor cell inferred from direct assay (Abou Tayoun et al., 2011)
Cellular Component
CV term Evidence References
integral to membrane inferred from direct assay (Abou Tayoun et al., 2011)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
calcium-activated potassium channel activity inferred from sequence or structural similarity with EMBL:U69882 (FlyBase, 1992-) calmodulin binding inferred from electronic annotation with InterPro:IPR004178 (FlyBase Curators et al., 2004-) small conductance calcium-activated potassium channel activity inferred from sequence or structural similarity (Nolazco et al., 2001) inferred from sequence or structural similarity with UniProtKB:P70604 (assigned by UniProtKB) (UniProtKB Project Members, 2007.4.3)
Biological Process
CV term Evidence References
potassium ion transport inferred from sequence or structural similarity with UniProtKB:P70604 (assigned by UniProtKB) (UniProtKB Project Members, 2007.4.3)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:P70604 (assigned by UniProtKB) (UniProtKB Project Members, 2007.4.3)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Stapleton et al., 2006, Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions SK allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0029761 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31456
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG651F94 Dipteran inclusive ortholog search EOG61VKB1 Insect inclusive ortholog search EOG65DVJR Arthropod inclusive ortholog search EOG60GB66 Metazoa inclusive ortholog search EOG6QK4JH
Orthologs in Drosophila Species (EOG651F94)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\SK     Drosophila simulans   Dsim\GD16728     Drosophila sechellia   Dsec\GM12409     Drosophila erecta   Dere\GG18757 Y   Drosophila yakuba   Dyak\GE16400     Drosophila ananassae   Dana\GF21340     Drosophila pseudoobscura pseudoobscura   Dpse\GA23696 Y   Drosophila persimilis   Dper\GL14684 Y   Drosophila willistoni   Dwil\GK10057 Y   Drosophila virilis   Dvir\GJ14781     Drosophila mojavensis   Dmoj\GI11078 Y   Drosophila grimshawi   Dgri\GH24618 Y
Orthologs in non-Drosophila Dipterans (EOG61VKB1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006455   Anopheles gambiae Malaria mosquito  Agam\AGAP010503   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008777
Orthologs in non-Dipteran Insects (EOG65DVJR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45070   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019432   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16441   Atta cephalotes Leafcutter ant  Acep\ACEP10845   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19035   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13281   Linepithema humile Argentine ant  Lhum\LH19453   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12691   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12693   Solenopsis invicta Red fire ant  Sinv\SINV16664   Solenopsis invicta Red fire ant  Sinv\SINV16669   Acyrthosiphon pisum Pea aphid  Apim\ACYPI082960   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006843   Bombyx mori Silkmoth  Bmor\BGIBMGA001530   Pediculus humanus Human body louse  Phum\PHUM307630   Tribolium castaneum Red flour beetle  Tcas\TC014196
Orthologs in non-Insect Arthropods (EOG60GB66)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_94428   Daphnia pulex Water flea  Dpux\Olfr1299   Ixodes scapularis Deer tick  Isca\ISCW011573
Orthologs in non-Arthropod Metazoa (EOG6QK4JH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\kcnl-1   Caenorhabditis elegans Nematode  Cele\kcnl-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014406gn   Danio rerio Zebrafish  Drer\si:dkey-76p7.5   Danio rerio Zebrafish  Drer\si:rp71-39b20.3   Danio rerio Zebrafish  Drer\kcnn1   Danio rerio Zebrafish  Drer\ENSDARG00000019753   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033200   Xenopus tropicalis Western clawed frog  Xtro\kcnn1   Xenopus tropicalis Western clawed frog  Xtro\kcnn2   Gallus gallus Domestic chicken  Ggal\KCNN2   Mus musculus House mouse  Mmus\ENSMUSG00000002908   Mus musculus House mouse  Mmus\Kcnn3   Mus musculus House mouse  Mmus\Kcnn2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029264   Rattus norvegicus Norway rat  Rnor\Kcnn2   Rattus norvegicus Norway rat  Rnor\Kcnn3   Homo sapiens Human  Hsap\KCNN2   Homo sapiens Human  Hsap\ENSG00000105642   Homo sapiens Human  Hsap\ENSG00000143603
Human Orthologs (3)
Gene OMIM HGNC Hsap\KCNN2     Hsap\ENSG00000105642     Hsap\ENSG00000143603
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG18757 Drosophila pseudoobscura pseudoobscura Dpse\GA23696 Drosophila persimilis Dper\GL14684 Drosophila willistoni Dwil\GK10057 Drosophila mojavensis Dmoj\GI11078 Drosophila grimshawi Dgri\GH24618
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Harvard	- P{XP}SKd00844 - P{XP}SKd02105 - P{XP}SKd03336 - P{XP}SKd11567 - PBac{WH}SKf01403 - PBac{WH}SKf07382 - PBac{WH}SKf07979
VDRC	v103985 P{KK107699}VIE-260B v24597 w1118; P{GD7812}v24597 v24601 w1118; P{GD7813}v24601 v28155 w1118; P{GD12601}v28155 v7052 w1118; P{GD3233}v7052/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR01M22 BACR18K05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01258 GH16664 GM01744 IP14812
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03762 RE02783 RH07620 RH45755 RH46247 RH49548
Other clones	31171 37172 41502 52324 56853 59916 78428 99150 106759 145597 147320 150143 173430 176527 214499.53 bs61e03 CK01.53C.C6 CK01.115B.B2 CK01.115B.D2 CK01.133B.H7 CK01711 EC28183 EK004028 EK028408 EK030206 EK101932 EK125545 EK133352 EK147860 EK154446 EK166858 EK167815 EK169715 EK195701 EK206908 EK207649 EK215123 EK221347 EK250416 EK277637 EN01055 EN06105 EP03241 EP08252 EP11238 EP19445 FGM307D01 GH03729 GM08336 IP14912 IP15012
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31456
Antibody Information
	polyclonal (Abou Tayoun et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: SK BcDNA:GM01744 (FlyBase, 1996-) Source for merge of: SK CG10706 CG4179 (McCaman, 2001.3.12) Source for merge of: SK CG12733 (FlyBase, 1996-)
Additional comments	Source for merge of SK CG12733 was a shared cDNA (date:010720). (FlyBase, 1996-) Source for merge of SK BcDNA:GM01744 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080339 NM_167029 NM_167030 NM_167031 NM_167032 NM_206631 NM_001103415 NM_001272322 NM_001272323 NM_001272324 RefSeq (Proteins) • NP_525078 NP_726986 NP_726987 NP_726988 NP_726989 NP_996354 NP_001096885 NP_001259251 NP_001259252 NP_001259253 DDBJ / EMBL / GenBank • AA694895 AAF46027 AAF46029 AAF46030 AAM11344 AAM50111 AAM50183 AAN09136 AAN09137 AAN71717 AAN71718 AAS65264 ABX11900 AGB95097 AGB95098 AGB95099 AI062158 AI386549 AW940034 AW941148 AW941821 AY095016 AY119457 AY119529 AY157147 AY157148 BH023731 CZ471839 CZ472621 CZ473300 CZ474002 CZ476582 CZ476966 CZ477808 CZ483874 CZ490190 CZ490670 CZ490671 Entrez Gene - A searchable database of RefSeq genes. • 31456 UniProtKB/Swiss-Prot • Q7KVW5 UniProtKB/TrEMBL • Q8T3J7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Potassium channel, calcium-activated, SK (IPR015449) Calmodulin-binding domain (IPR004178) Ion transport 2 (IPR013099) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM01744
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0029761 DRSC - Results from RNAi screens. • FBgn0029761 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12732-RA;CG10706-RC;CG10706-RA;CT36054 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31456 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31456 modMine - Data generated by the modENCODE project. • FBgn0029761
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BcDNA:GM01744   CG4179 (Wang et al., 2004) CG10706 (Wang et al., 2004, Keleman et al., 2009.8.5, Chang et al., 2008, Tsubouchi et al., 2012, Qurashi et al., 2012) CG12733   dSK (Nolazco et al., 2001, Abou Tayoun et al., 2011, Abou Tayoun et al., 2012) SK (Stapleton et al., 2006, UniProtKB Project Members, 2007.4.3, Aerts et al., 2007, Chang et al., 2008, Junion et al., 2007, Perkins et al., 2009.8.10, Glazov et al., 2005, Buffin and Gho, 2010, Sénatore et al., 2010, Blow et al., 2005, Tsubouchi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Qurashi et al., 2012, McCormack, 2003)
Name Synonym	small conductance calcium-activated potassium channel (Nolazco et al., 2001, Chang et al., 2008, Glazov et al., 2005, Buffin and Gho, 2010, Tsubouchi et al., 2012)
Secondary FlyBase IDs
	FBgn0029758 FBgn0029760 FBgn0062493
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) Protein sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Abou Tayoun et al., 2012, PLoS ONE 7(4): e34665 Roles of the Drosophila SK Channel (dSK) in Courtship Memory. [FBrf0218023] Qurashi et al., 2012, Hum. Mol. Genet. 21(9): 2068--2075 Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. [FBrf0217893] Abou Tayoun et al., 2011, J. Neurosci. 31(39): 13897--13910 The Drosophila SK Channel (dSK) Contributes to Photoreceptor Performance by Mediating Sensitivity Control at the First Visual Network. [FBrf0216279] Show all research papers ...