potassium channel - negatively regulates nociception - interacts with calmodulin, which acts as a Ca sensor - regulates synaptic excitation in the visual network - postsynapse of the NMJ - contributes to photoreceptor performance by mediating sensitivity control at the first negatively regulates the acquisition of short-term memory
Gene model reviewed during 5.55
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 5.54
Gene model reviewed during 5.56
Stop-codon suppression (UGA) postulated; FBrf0225455.
None of the polypeptides share 100% sequence identity.
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SK using the Feature Mapper tool.
SK protein is strongly expressed in the adult lamina and medulla layers. In the lamina, is localises to the axons of the photoreceptors, the cell body of non-glutamatergic neurons, (possibly L4) and in the presynaptic active zones. In the medulla, it is detected in glutamatergic and non-glutamatergic neurons. Expression seems strongest in medulla layers M4 and M5. In the central brain, SK protein is expressed by the olfactory projection neurons that innervate the mushroom bodies.
GBrowse - Visual display of RNA-Seq signalsView Dmel\SK in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.