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Gene Dmel\CG12730

General Information
Symbol	Dmel\CG12730	Species	D. melanogaster
Name		Annotation symbol	CG12730
Feature type	protein_coding_gene	FlyBase ID	FBgn0029771
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	5A2-5A2	Sequence location	X:5,411,294..5,412,803 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12730 (FBgn0029771). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Marvel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631315_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12730. Gene sequence location is X:5411294..5412803.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN31056 HFA17885 BKN46106
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5A2-5A2   Limits computationally determined from genome sequence between P{EP}CG3249EP1400 and P{EP}Tre1EP496
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12730 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12730-RA FBtr0070780  NM_132000   1238   148
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12730-PA   FBpp0070746   16.3   148   8.80     NP_572228   AAF46040
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Marvel (IPR008253)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46040   AY069764 AAL39909   BI161993   BI161994   BI361715   BI365118   BI640186   BP546219   CO186047   CO338661   CO343132   EC229199   EC252381   EC264423   FD586024   FD587111   FD587275   GH739626   GH740840   GH740995   GH743375   GH744096   GH745327   GH746434   GH746640   GH761796   GH761875   GH764851   GH765350   GH765520   GH765898   GH766569   GH779542   GO254588
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4B6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0029771    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0029771 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0029771 expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr  (797) embryo 04-06hr  (954) embryo 06-08hr  (860) embryo 08-10hr  (910) embryo 10-12hr  (1989) embryo 12-14hr  (2546) embryo 14-16hr  (2482) embryo 16-18hr  (2969) embryo 18-20hr  (2908) embryo 20-22hr  (924) embryo 22-24hr  (1119) larva L1  (601) larva L2  (763) larva L3 12hr old  (554) larva L3 puffstage 1-2  (892) larva L3 puffstage 3-6  (1059) larva L3 puffstage 7-9  (1271) white prepupae new  (1356) white prepupae 12hr  (1622) white prepupae 24hr  (1412) pupae 2d postWPP  (1642) pupae 3d postWPP  (1873) pupae 4d postWPP  (2471) adult male 01day  (1193) adult male 05day  (1106) adult male 30day  (1097) adult female 01day  (838) adult female 05day  (341) adult female 30day  (394) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr  (1989) embryo 12-14hr  (2546) embryo 14-16hr  (2482) embryo 16-18hr  (2969) embryo 18-20hr  (2908) embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr  (1622) white prepupae 24hr  1412 pupae 2d postWPP  (1642) pupae 3d postWPP  (1873) pupae 4d postWPP  (2471) adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0029771 expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr  (797) embryo 04-06hr  (954) embryo 06-08hr  (860) embryo 08-10hr  (910) embryo 10-12hr  (1989) embryo 12-14hr  (2546) embryo 14-16hr  (2482) embryo 16-18hr  (2969) embryo 18-20hr  (2908) embryo 20-22hr  (924) embryo 22-24hr  (1119) larva L1  (601) larva L2  (763) larva L3 12hr old  (554) larva L3 puffstage 1-2  (892) larva L3 puffstage 3-6  (1059) larva L3 puffstage 7-9  (1271) white prepupae new  (1356) white prepupae 12hr  (1622) white prepupae 24hr  (1412) pupae 2d postWPP  (1642) pupae 3d postWPP  (1873) pupae 4d postWPP  (2471) adult male 01day  (1193) adult male 05day  (1106) adult male 30day  (1097) adult female 01day  (838) adult female 05day  (341) adult female 30day  (394) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr  1989 embryo 12-14hr  (2546) embryo 14-16hr  (2482) embryo 16-18hr  (2969) embryo 18-20hr  (2908) embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr  1622 white prepupae 24hr  1412 pupae 2d postWPP  1642 pupae 3d postWPP  1873 pupae 4d postWPP  2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    797 embryo 04-06hr    954 embryo 06-08hr    860 embryo 08-10hr    910 embryo 10-12hr    1989 embryo 12-14hr    2546 embryo 14-16hr    2482 embryo 16-18hr    2969 embryo 18-20hr    2908 embryo 20-22hr    924 embryo 22-24hr    1119 larva L1    601 larva L2    763 larva L3 12hr old    554 larva L3 puffstage 1-2    892 larva L3 puffstage 3-6    1059 larva L3 puffstage 7-9    1271 white prepupae new    1356 white prepupae 12hr    1622 white prepupae 24hr    1412 pupae 2d postWPP    1642 pupae 3d postWPP    1873 pupae 4d postWPP    2471 adult male 01day    1193 adult male 05day    1106 adult male 30day    1097 adult female 01day    838 adult female 05day    341 adult female 30day    394 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0029771    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0029771 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0029771 expression level Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain  (557.4) Adult Thoracic-Abdominal Ganglion  (666.4) Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0029771 expression level Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain  557.4 Adult Thoracic-Abdominal Ganglion  666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    148.35 Larval Midgut    295.3 Larval Hindgut    235.4 Larval Malpighian Tubules    135.1 Larval Fat Body    25.3 Larval Salivary Gland    279 Larval Trachea    142.975 Larval Carcass    154.875 Adult Head    361.5 Adult Eye    186.775 Adult Brain    557.4 Adult Thoracic-Abdominal Ganglion    666.4 Adult Crop    288.6 Adult Midgut    308.8 Adult Hindgut    360.4 Adult Malpighian Tubules    416.6 Adult Fat Body    140.7 Adult Salivary Gland    342.5 Adult Heart    330.475 Adult VirginFemale Spermatheca    184.3 Adult InseminatedFemale Spermatheca    229.2 Adult Ovary    18 Adult Testis    56.5 Adult Male Accessory Gland    213.1 Adult Carcass    236.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    361.5   NA  Eye    186.775   NA  Brain    557.4   148.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    666.4   NA  Crop    288.6   295.3  Midgut    308.8   235.4  Hindgut    360.4   135.1  Malpighian Tubules    416.6   25.3  Fat Body    140.7   279  Salivary Gland    342.5   NA  Heart    330.475   142.975  Trachea    NA   NA  VirginFemale Spermatheca    184.3   NA  InseminatedFemale Spermatheca    229.2   NA  Ovary    18   NA  Testis    56.5   NA  Male Accessory Gland    213.1   154.875  Carcass    236.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029771 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12730-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG12730 Class Mutagen Stocks Known lesion CG12730KG03180 P-element activity 1 -- CG12730MI01031 1 -- CG12730GG01188 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12730 Class Mutagen Stocks Known lesion CG12730GD3992 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG12730KK111056 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6235 (Ryder, 2004.4.26, Erclik et al., 2008) Df(1)Vsx2B1 (Erclik et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3992} NA P{KK111056} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG12730MI01031 NA P{SUPor-P}CG12730KG03180 NA insertion of mobile activating element P{Mae-UAS.6.11}CG12730GG01188 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR008253 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12730 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57972 DroID - A comprehensive database of gene and protein interactions. • FBgn0029771 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31466
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21088 Dere\GG18767 Dgri\GH24760 Dmoj\GI15794 Dper\GL16442 Dpse\GA11776 Dsec\GM12417 Dsim\GD16736 Dvir\GJ18647 Dwil\GK10128 Dyak\GE16411
Curated drosophilid orthologs	Dpse\GA11776
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008497-PA Aedes aegypti (mosquito) AGAP009132-PA Anopheles gambiae (mosquito) XP_392549.1 Apis mellifera (honey bee) CPIJ000755 Culex pipens (mosquito) XP_001601882.1 Nasonia vitripennis (wasp) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233938 FBgn0212143 FBgn0205801 FBgn0188324 FBgn0167354 FBgn0071825 FBgn0154046 FBgn0138543 FBgn0132215 FBgn0110975 FBgn0098093
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	13004 y1 P{SUPor-P}CG12730KG03180 34143 y1 w* Mi{MIC}CG12730MI01031
Genomic Clones ( 1 )
	BACR07P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE01432
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE46047 RE50348 SD22991
Other clones	214415.53 572894 CK01.15B.A8 EK015436 EN17336 EP16150 FGH104A12 RM02883 RM03083 RM03183 RP01087 RP01407 RP001004937 RP001008796 RP001009318 RP001009398 RP001014892 RP001015101 RP001018290 RP001019590 RP001034584 RP001040168 RP001044365 RP001046288 RP001048353 RP001050450 RP001054741
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029771 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31466
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG12730 BcDNA:RE01432 (FlyBase, 1996-)
Additional comments	Source for merge of CG16756 BcDNA:RH17440 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132000 RefSeq (Proteins) • NP_572228 DDBJ / EMBL / GenBank • AAF46040 AAL39909 AY069764 BI161993 BI161994 Entrez Gene - A searchable database of RefSeq genes. • 31466 UniProtKB/TrEMBL • Q9W4B6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Marvel (IPR008253)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57972 DroID - A comprehensive database of gene and protein interactions. • FBgn0029771 DRSC - Results from RNAi screens. • FBgn0029771 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029771 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12730-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029771 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31466 InParanoid A subset of ortholog calls from InParanoid. • AAEL008497-PA Aedes aegypti (mosquito) AGAP009132-PA Anopheles gambiae (mosquito) XP_392549.1 Apis mellifera (honey bee) CPIJ000755 Culex pipens (mosquito) XP_001601882.1 Nasonia vitripennis (wasp) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31466 modMine - Data generated by the modENCODE project. • FBgn0029771 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233938 FBgn0212143 FBgn0205801 FBgn0188324 FBgn0167354 FBgn0071825 FBgn0154046 FBgn0138543 FBgn0132215 FBgn0110975 FBgn0098093
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:RE01432   CG12730 (Erclik et al., 2008, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0047186
References ( 13 )
Research paper	Erclik et al., 2008, Curr. Biol. 18(17): 1278--1287 Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. [FBrf0207154] Gonzalez-Aguero et al., 2005, Gene 345(2): 213--224 Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. [FBrf0187577]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]