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Gene Dmel\Pink1

General Information
Symbol	Dmel\Pink1	Species	D. melanogaster
Name	PTEN-induced putative kinase 1	Annotation symbol	CG4523
Feature type	protein_coding_gene	FlyBase ID	FBgn0029891
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	dPINK1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	6C6-6C6	Sequence location	X:6,577,831..6,581,047 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene PTEN-induced putative kinase 1 is referred to in FlyBase by the symbol Dmel\Pink1 (CG4523, FBgn0029891). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: negative regulation of programmed cell death; mitochondrial fission; sperm mitochondrion organization; negative regulation of neuron apoptosis; compound eye development; response to oxidative stress; regulation of mitochondrion organization; mitochondrion organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; cytoplasmic part; adult; organelle; external compound sense organ; adult segment; intracellular organelle; spermatozoon; elongation stage spermatid. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult Malpighian tubules, adult salivary gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1639403_s_at completely aligns to an exonic region common to each of the 8 FlyBase-annotated transcript isoforms of Pink1. Gene sequence location is X:6577831..6581047.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Truscott et al., 2011, Genes Dev. 25(17): 1820--1834
FB2012_01	Sequence features HFA18361 BKN50980 BKN50507 BKN21256
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6C6-6C6   Limits computationally determined from genome sequence between P{EP}Ctr1AEP1364&P{EP}EP1445 and P{EP}C3GEP1613
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pink1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pink1-RA FBtr0070956  NM_132112   2884   721 Pink1-RB FBtr0070957  NM_167083   2804   721 Pink1-RC FBtr0100413  NM_001031883   2890   721 Pink1-RD FBtr0100414  NM_001031882   2798   721 Pink1-RE FBtr0100415  NM_001031881   2889   721 Pink1-RF FBtr0100416  NM_001031880   2895   721 Pink1-RG FBtr0100419  NM_001031879   2946   721 Pink1-RH FBtr0100420  NM_001031878   2894   721
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pink1-PA   FBpp0070917   80.2   721   8.18     NP_572340   AAN09178 Pink1-PB   FBpp0070918   80.2   721   8.18     NP_727110   AAF46188 Pink1-PC   FBpp0099830   80.2   721   8.18     NP_001027054   AAZ52497 Pink1-PD   FBpp0099831   80.2   721   8.18     NP_001027053   AAZ52498 Pink1-PE   FBpp0099832   80.2   721   8.18     NP_001027052   AAZ52499 Pink1-PF   FBpp0099833   80.2   721   8.18     NP_001027051   AAZ52500 Pink1-PG   FBpp0099835   80.2   721   8.18     NP_001027050   AAZ52501 Pink1-PH   FBpp0099837   80.2   721   8.18     NP_001027049   AAZ52502
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202172   AA391906   AA392391   AA438494   AA438891   AA439257   AA440721   AA539101   AA539307   AA540524   AA803635   AA803937   AA816641   AA817318   AA948872   AA951413   AE014298 AAF46188   AE014298 AAN09178   AE014298 AAZ52497   AE014298 AAZ52498   AE014298 AAZ52499   AE014298 AAZ52500   AE014298 AAZ52501   AE014298 AAZ52502   AI062876   AI063193   AI063872   AI064659   AI107280   AI109002   AI135093   AI135155   AI238971   AI386505   AI387348   AI387506   AI388640   AI389694   AI402595   AI403922   AI455592   AI455926   AI511660   AI511987   AI512156   AI512947   AI515628   AI517409   AI517899   AI520495   AI530879   AI944507   AI945974   AW940799   AY051559 AAK92983   BF485964   BF487277   BG632334   BG633892   BG636182   BG637305   BI166228   BI212421   BI213493   BI213995   BI230810   BI240798   BI242647   BI242987   BI358072   BI364599   BI367462   BI368607   BI369678   BI371463   BI375358   BI482300   BI482838   BI604378   BI619245   BI621885   BI624391   BI627504   BI627519   BP552022   BP552023   CO281991   CO299276   CO331366   EC053827   EC216471   EC245384   EC267161   EL873588   EL873589   GH941609   GH942074   GH942753   GH942945   GH943429   GH943901   GH944120   GH944475   GH944494   GH945052   GH945473   GH945495   GH945512   GH945974   GH946206   GH946238   GH947271   GH947874   GH947918   GH948078   GH948562   GH949068   GH949592   GH949595   GH949736   GH950037   GH950379   GH950549   GH950730   GH950851   GH950907   GH951210   GH951516   GH951782   GH952076   GH952091   GH952785   GH953193   GH953275   GH953339   GH953389   GH953857   GH953887   GH954505   GH954936   GH954937   GH955748   GH956096   GH956310   GH956405   GH956844   GH957119   GH957479   GH957721   GH957866   GH958614   GH958967   GH959600   GH959663   GH959933   GH959940   GH960077   GH960176   GH960441   GH960722   GH960818   GH961288   GH961964   GH962526   GH962642   GH963042   GH963161   GH964627   GH965282   GH965499   GH966207   GH967232   GH967773   GH967870   GH968130   GH968193   GH968498   GH968615   GH968859   GH969613   GH969733   GH969802   GH969836   GH969994   GH970616   GH971948   GH972062   GH972307   GH972337   GH972714   GH973372   GH973564   GH973954   GH975650   GH976999   GH978047   GH978107   GH978879   GH978965   GH979209   GH979957   GH979976   GH980526   GH981530   GH981540   GH982202   GH982463   GH982700   GH982728   GH984171
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961J3 Q0KHV6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0029891    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0029891 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0029891 expression level Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day    12572 adult male 30day    12015 adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6168) embryo 02-04hr  (5139) embryo 04-06hr  (1933) embryo 06-08hr  (1951) embryo 08-10hr  (2331) embryo 10-12hr  (2306) embryo 12-14hr  (1548) embryo 14-16hr  (2467) embryo 16-18hr  (2182) embryo 18-20hr  (2852) embryo 20-22hr  (3511) embryo 22-24hr  (3115) larva L1  (2347) larva L2  (1877) larva L3 12hr old  (2727) larva L3 puffstage 1-2  (4289) larva L3 puffstage 3-6  (5103) larva L3 puffstage 7-9  (3915) white prepupae new  (2807) white prepupae 12hr  (2520) white prepupae 24hr  (2277) pupae 2d postWPP  (2421) pupae 3d postWPP  (3086) pupae 4d postWPP  (5560) adult male 01day  (8391) adult male 05day  (12572) adult male 30day  (12015) adult female 01day  (7324) adult female 05day  (5367) adult female 30day  (5396) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6168) embryo 02-04hr  (5139) embryo 04-06hr  (1933) embryo 06-08hr  (1951) embryo 08-10hr  (2331) embryo 10-12hr  (2306) embryo 12-14hr  (1548) embryo 14-16hr  (2467) embryo 16-18hr  (2182) embryo 18-20hr  (2852) embryo 20-22hr  (3511) embryo 22-24hr  (3115) larva L1  (2347) larva L2  (1877) larva L3 12hr old  (2727) larva L3 puffstage 1-2  (4289) larva L3 puffstage 3-6  (5103) larva L3 puffstage 7-9  (3915) white prepupae new  (2807) white prepupae 12hr  (2520) white prepupae 24hr  (2277) pupae 2d postWPP  (2421) pupae 3d postWPP  (3086) pupae 4d postWPP  (5560) adult male 01day  (8391) adult male 05day  (12572) adult male 30day  (12015) adult female 01day  (7324) adult female 05day  (5367) adult female 30day  (5396) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day  (12572) adult male 30day  (12015) adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day    12572 adult male 30day    12015 adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0029891 expression level Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day    12572 adult male 30day    12015 adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6168) embryo 02-04hr  (5139) embryo 04-06hr  (1933) embryo 06-08hr  (1951) embryo 08-10hr  (2331) embryo 10-12hr  (2306) embryo 12-14hr  (1548) embryo 14-16hr  (2467) embryo 16-18hr  (2182) embryo 18-20hr  (2852) embryo 20-22hr  (3511) embryo 22-24hr  (3115) larva L1  (2347) larva L2  (1877) larva L3 12hr old  (2727) larva L3 puffstage 1-2  (4289) larva L3 puffstage 3-6  (5103) larva L3 puffstage 7-9  (3915) white prepupae new  (2807) white prepupae 12hr  (2520) white prepupae 24hr  (2277) pupae 2d postWPP  (2421) pupae 3d postWPP  (3086) pupae 4d postWPP  (5560) adult male 01day  (8391) adult male 05day  (12572) adult male 30day  (12015) adult female 01day  (7324) adult female 05day  (5367) adult female 30day  (5396) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6168) embryo 02-04hr  (5139) embryo 04-06hr  1933 embryo 06-08hr  1951 embryo 08-10hr  2331 embryo 10-12hr  2306 embryo 12-14hr  1548 embryo 14-16hr  2467 embryo 16-18hr  2182 embryo 18-20hr  (2852) embryo 20-22hr  (3511) embryo 22-24hr  (3115) larva L1  2347 larva L2  1877 larva L3 12hr old  (2727) larva L3 puffstage 1-2  (4289) larva L3 puffstage 3-6  (5103) larva L3 puffstage 7-9  (3915) white prepupae new  (2807) white prepupae 12hr  (2520) white prepupae 24hr  2277 pupae 2d postWPP  2421 pupae 3d postWPP  (3086) pupae 4d postWPP  (5560) adult male 01day  (8391) adult male 05day  (12572) adult male 30day  (12015) adult female 01day  (7324) adult female 05day  (5367) adult female 30day  (5396) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day  12572 adult male 30day  12015 adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6168 embryo 02-04hr    5139 embryo 04-06hr    1933 embryo 06-08hr    1951 embryo 08-10hr    2331 embryo 10-12hr    2306 embryo 12-14hr    1548 embryo 14-16hr    2467 embryo 16-18hr    2182 embryo 18-20hr    2852 embryo 20-22hr    3511 embryo 22-24hr    3115 larva L1    2347 larva L2    1877 larva L3 12hr old    2727 larva L3 puffstage 1-2    4289 larva L3 puffstage 3-6    5103 larva L3 puffstage 7-9    3915 white prepupae new    2807 white prepupae 12hr    2520 white prepupae 24hr    2277 pupae 2d postWPP    2421 pupae 3d postWPP    3086 pupae 4d postWPP    5560 adult male 01day    8391 adult male 05day    12572 adult male 30day    12015 adult female 01day    7324 adult female 05day    5367 adult female 30day    5396 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0029891    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0029891 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult Malpighian tubules, adult salivary gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0029891 expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye  (615) Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop  (609.9) Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules  515.1 Adult Fat Body    279.4 Adult Salivary Gland  (574) Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass  (893.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0029891 expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye  615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop  609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules  515.1 Adult Fat Body    279.4 Adult Salivary Gland  574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass  (893.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    315.9 Larval Hindgut    363.2 Larval Malpighian Tubules    399.7 Larval Fat Body    152.7 Larval Salivary Gland    207.2 Larval Trachea    149.575 Larval Carcass    353.45 Adult Head    469 Adult Eye    615 Adult Brain    327.9 Adult Thoracic-Abdominal Ganglion    436.9 Adult Crop    609.9 Adult Midgut    286.1 Adult Hindgut    494.6 Adult Malpighian Tubules    515.1 Adult Fat Body    279.4 Adult Salivary Gland    574 Adult Heart    362.875 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    223.7 Adult Ovary    231.5 Adult Testis    257.7 Adult Male Accessory Gland    389.6 Adult Carcass    893.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    469   NA  Eye    615   NA  Brain    327.9   142.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    436.9   NA  Crop    609.9   315.9  Midgut    286.1   363.2  Hindgut    494.6   399.7  Malpighian Tubules    515.1   152.7  Fat Body    279.4   207.2  Salivary Gland    574   NA  Heart    362.875   149.575  Trachea    NA   NA  VirginFemale Spermatheca    259.5   NA  InseminatedFemale Spermatheca    223.7   NA  Ovary    231.5   NA  Testis    257.7   NA  Male Accessory Gland    389.6   353.45  Carcass    893.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029891 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4523-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | second instar larval stage, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS.cWa viable Pink15 Pink19 Pink1G900 Pink1unspecified viable, with Scer\GAL4pnr-MD237 Pink1GD11336 Sterility Allele female sterile | partially Pink1unspecified fertile Pink1G900 male sterile Pink15 Pink1unspecified Other Phenotypes Allele chemical sensitive Pink15 flight defective Pink1unspecified flightless Pink1B9 flightless, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS increased cell death, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS increased cell death, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS increased cell size, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa locomotor behavior defective Pink1B9 locomotor behavior defective, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS neuroanatomy defective, with Scer\GAL4Ddc.PL Pink1dsRNA.Scer\UAS.cWa neuroanatomy defective, with Scer\GAL4elav.PLu Pink1dsRNA.Scer\UAS.cWa neuroanatomy defective, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa neuroanatomy defective, with Scer\GAL4ple.PF Pink1dsRNA.Scer\UAS osmotic stress response defective Pink15 short lived Pink1B9 short lived, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS short lived, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS visible Pink15 Pink1B9 Pink1D3 visible, with Scer\GAL4elav.PLu Pink1dsRNA.Scer\UAS.cWa visible, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa visible, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS Phenotype manifest in Allele adult thorax Pink1B9 depressor muscle, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS dopamine neuron & adult brain Pink1B9 dopamine neuron & adult brain, with Scer\GAL4Ddc.PL Pink1dsRNA.Scer\UAS.cWa dopamine neuron & adult brain, with Scer\GAL4elav.PLu Pink1dsRNA.Scer\UAS.cWa dopaminergic neuron, with Scer\GAL4ple.PF Pink1dsRNA.Scer\UAS dopaminergic PPL1 neuron Pink1B9 dopaminergic PPM1 neuron Pink1B9 dopaminergic PPM2 neuron Pink1B9 eye, with Scer\GAL4elav.PLu Pink1dsRNA.Scer\UAS.cWa eye, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa indirect flight muscle Pink1B9 Pink15 indirect flight muscle, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS indirect flight muscle, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS interommatidial bristle, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa minor mitochondrial derivative Pink15 mitochondrial crista Pink1unspecified Pink15 mitochondrial crista, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS mitochondrial crista, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS mitochondrial crista & indirect flight muscle Pink1unspecified Pink15 mitochondrial inner membrane & indirect flight muscle Pink1B9 mitochondrial outer membrane & indirect flight muscle Pink1B9 mitochondrion Pink1B9 Pink1unspecified Pink15 mitochondrion & dopamine neuron & adult brain Pink1B9 mitochondrion & dopaminergic neuron Pink1B9 mitochondrion & dorso-lateral dopaminergic neuron Pink1B9 mitochondrion & dorso-lateral dopaminergic neuron, with Scer\GAL4ple.PF Pink1dsRNA.Scer\UAS Pink1Scer\UAS.cYa mitochondrion & indirect flight muscle Pink1B9 myofibril, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS myofibril, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS myofibril & indirect flight muscle Pink1B9 Pink1unspecified Nebenkern Pink1B9 Pink1unspecified Pink15 Nebenkern derivative Pink1unspecified ommatidium, with Scer\GAL4elav.PLu Pink1dsRNA.Scer\UAS.cWa ommatidium, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa photoreceptor & neuron, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa pigment cell, with Scer\GAL4GMR.PF Pink1dsRNA.Scer\UAS.cWa spermatid cyst Pink1unspecified spermatozoon Pink1B9 wing Pink1D3 Pink1B9 Pink1unspecified Pink15 wing, with Scer\GAL4da.G32 Pink1dsRNA.Scer\UAS wing, with Scer\GAL4Mhc.PW Pink1dsRNA.Scer\UAS
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Pink1 Class Mutagen Stocks Known lesion Pink1B9 loss of function allele P-element activity 1 Yes Pink1G900 P-element activity 1 Yes Pink15 P-element activity 0 Yes Pink19 P-element activity 0 Yes Pink1D3 loss of function allele P-element activity 0 Yes Pink1GE271 0 Yes Pink1RV P-element activity 0 Yes Pink1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pink1 Class Mutagen Stocks Known lesion Pink1GD11336 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pink1JF01203 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pink1JF01672 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pink1+tCa in vitro construct - genomic fragment 0 Yes Pink1dsRNA.Scer\UAS.cWa in vitro construct - RNAi 0 Yes Pink1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Pink1K337R.D479A.D501A.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Pink1KK101205 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Pink1Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes Pink1Scer\UAS.cYa in vitro construct - regulatory fusion 0 Yes Pink1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pink1T:Hsap\MYC in vitro construct - coding region fusion 0 Yes Pink1βTub85D.PC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(1)Pink19 (Clark et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11336} NA P{KK101205} NA P{TRiP.JF01203} NA P{TRiP.JF01672} NA P{UAS-Pink1.dsRNA.Y} NA P{UAS-Pink1.HA.KD} NA P{UAS-Pink1.Y} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Pink1G900 NA P{EP}Pink1GE271 NA miscellaneous insertions P{?EP}Pink1RV NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye development inferred from mutant phenotype (Wang et al., 2006) mitochondrial fission inferred from genetic interaction with Drp1 (Yang et al., 2008, Poole et al., 2008) inferred from genetic interaction with Marf (Poole et al., 2008) inferred from genetic interaction with opa1-like (Yang et al., 2008, Poole et al., 2008) mitochondrion organization inferred from direct assay (Yang et al., 2006) inferred from genetic interaction with Buffy (Park et al., 2006) inferred from mutant phenotype (Park et al., 2006, Clark et al., 2006, Deng et al., 2008, Yang et al., 2008, Poole et al., 2008) negative regulation of neuron apoptosis inferred from direct assay (Yang et al., 2006) negative regulation of programmed cell death inferred from mutant phenotype (Wang et al., 2006) regulation of mitochondrion organization inferred from mutant phenotype (Lutz et al., 2009) response to oxidative stress inferred from mutant phenotype (Wang et al., 2006) sperm mitochondrion organization inferred from mutant phenotype (Park et al., 2006, Clark et al., 2006, Deng et al., 2008)
Cellular Component
CV term Evidence References
Nebenkern inferred from direct assay (Clark et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Manning, 2002.11.16) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pink1 allele Gene References unspecified Buffy (Park et al., 2006) park (Park et al., 2006, Clark et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58093 DroID - A comprehensive database of gene and protein interactions. • FBgn0029891 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31607
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21424 Dere\GG19606 Dgri\GH24718 Dmoj\Tes31 Dper\GL13349 Dpse\GA18232 Dsec\GM12513 Dsim\GD24757 Dvir\GJ16989 Dwil\GK17835 Dyak\GE16766
Curated drosophilid orthologs	Dpse\GA18232
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011594-PA Aedes aegypti (mosquito) AGAP004315-PA Anopheles gambiae (mosquito) XP_623327.1 Apis mellifera (honey bee) XP_001946944.1 Acyrthosiphon pisum (pea aphid) XP_001896214.1 Brugia malayi (roundworm nematode) ENSBTAP00000029455 Bos taurus (bovine) CE28904 Caenorhabditis elegans (worm) ENSCAFP00000022173 Canis familiaris (dog) CMT185C Cyanidioschyzon merolae (red alga) CPIJ009758 Culex pipens (mosquito) RP33660 Caenorhabditis remanei (nematode) 228381 Capitella spl (polychaete worm) ENSDARP00000014981 Danio rerio (zebra fish) ENSDARP00000050156 Danio rerio (zebra fish) ENSECAP00000007281 Equus caballus (horse) ENSGACP00000014990 Gymnopilus aculeatus (mushroom) ENSGALP00000004900 Gallus gallus (chicken) ENSP00000364204 Homo sapiens (human) ENSMODP00000019920 Monodelphis domestica (gray opossum) ENSMMUP00000000169 Macaca mulatta (rhesus monkey) ENSMMUP00000011580 Macaca mulatta (rhesus monkey) ENSMUSP00000030536 Mus musculus (house mouse) XP_001605979.1 Nasonia vitripennis (wasp) ENSOANP00000016490 Ornithorynchus anatinus (platypus) ENSORLP00000020035 Oryzias latipes (japanese killifish) PHUM011084-PA Pediculus humanus (human body louse) ENSPPYP00000002052 Pongo pygmaeus (orangutan) ENSPTRP00000000500 Pan troglodytes (chimpanzee) ENSRNOP00000020820 Rattus norvegicus (norway rat) XP_968367.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015393 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020226 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16312 PB10237 NV16902 LH23240 ISCW002313 FBgn0234259 FBgn0219834 FBgn0204166 FBgn0196078 FBgn0167450 FBgn0078239 FBgn0150955 FBgn0084467 FBgn0132173 FBgn0111808 FBgn0098426 CPIJ009758 ACYPI009661 GB19578 AGAP004315 AAEL011594 PHUM577390 GLEAN_13202
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26611 w* P{EP}Pink1G900 31170 y1 v1; P{TRiP.JF01672}attP2 31262 y1 v1; P{TRiP.JF01203}attP2 34749 w* Pink1B9/FM7i, P{ActGFP}JMR3
VDRC	v21860 w1118; P{GD11336}v21860/CyO
Genomic Clones ( 2 )
	BACR11K20 BACR48O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 197 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20931
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT20070 AT22027 AT29854 GH02231 GH02724 GH02879 GH03977 GH07488 GH12725 GH12801 GH15129 GH16602 GH17854 GH18052 GH19602 GH21843 GH23468 GH28341 GM12312 GM13732 LD02288 LD02995 LD10352 LD11244 LD12403 LD13272 LD13769 LD15589 LD18815 LD18995 LD20235 LD22558 LD27545 LD31861 LD35113 LD35661 LD40673 LD43037 LD43137 LD43578 LD43894 LD45103 LD47527 RE06270 RE15254 RE17514 RE18906 RE19670 RE37726 RE40044 RE40503 RE44742 RE49756 RE53233 RE54609 RE55941 RE58352 RE63143 RE64975 RE65610 RH50238 RH53429 RH63943 RH68840 RH68860 RH69710 SD01636 SD13783 SD15232
Other clones	43941 272843 572899 bs03c12 bs19a04 EC053827 EK159260 EK174961 EK299412 FGM216B10 GH06623 IP13660 RP004017709 RP004028729 RP004048467 RP004052363 RP004057913 RP004065450 RP004070389 RP004079874 RP004082237 RP004085108 RP004092002 RP004106085 RP004106121 RP004113167 RP004122611 RP004123173 RP004130621 RP004131297 RP004132250 RP004133460 RP004139838 RP004148752 RP004148892 RP004153666 RP004163900 RP004165323 RP004166236 RP004167594 RP004168533 RP004174697 RP004175866 RP004177544 RP004183588 RP004183721 RP004183796 RP004189915 RP004197199 RP004201010 RP004201814 RP004203949 RP004204075 RP004210636 RP004217818 RP004218104 RP004220838 RP004221548 RP004223573 RP004224494 RP004224738 RP004229714 RP004230350 RP004230389 RP004230565 RP004230994 RP004235044 RP004240330 RP004240470 RP004240984 RP004244922 RP004245671 RP004245676 RP004246157 RP004250359 RP004252571 RP004254318 RP004256679 RP004256829 RP004258438 RP004259672 RP004263812 RP004264721 RP004264918 RP004304956 RP004338238 RP004372800 RP004379486 RP004382743 RP004393202 RP004399013 RP004399480 RP004403404 RP004405168 RP004424895 RP004432595 RP004435851 RP004436476 RP004437437 RP004438556 RP004449441 RP004451836 RP004454085 RP004458621 RP004459304 RP004461673 RP004463460 RP004470030 RP004482976 RP004491732 RP004493977 RP004501857 RP004516888 RP004518971 RP004522326 RP004522779 RP004529202 RP004536319 RP004541687 RP004543737 RP004544984 RP004548310 RP004549611 RP004551339 RP004551800 RP004553878 RP004555469
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029891 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31607
Antibody Information
	polyclonal (Yang et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pink1 CG4523 (Clark, 2006.2.28)
Source for database merge of	Source for merge of: CG4523 BEST:GH23468 (Rana, 2004.7.8)
Additional comments
Other Comments
	Mutants are viable but sterile. Mutant spermatids form abnormal Nebenkerns and mitochondrial derivatives and subsequently fail to individualize the 64-cell cyst into discrete sperm. Mutants show increased sensitivity to paraquat and hyperoxia and have heldup wings due to degeneration of indirect flight muscle. (Clark et al., 2006) Pink1 is required for normal mitochondrial function. (Clark et al., 2006) Mutants show a number of degenerative phenotypes which are due to mitochondrial dysfunction. (Park et al., 2006) Pink1 plays an important role in regulating energy metabolism and exerts an impact on lifespan. (Yang et al., 2006) Pink1 plays a critical role in promoting dopaminergic neuronal function and survival. (Yang et al., 2006) Pink1 mutants exhibit age-dependent muscle degeneration characterised by extensive DNA fragmentation, probably indicative of cell death. (Yang et al., 2006) Pink1 is required for maintaining proper mitochondria morphology and the integrity of suets of muscle cells and dopaminergic neurons. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132112 NM_167083 NM_001031878 NM_001031879 NM_001031880 NM_001031881 NM_001031882 NM_001031883 RefSeq (Proteins) • NP_572340 NP_727110 NP_001027049 NP_001027050 NP_001027051 NP_001027052 NP_001027053 NP_001027054 DDBJ / EMBL / GenBank • AAF46188 AAF46188.1 AAK92983 AAN09178 AAN09178.1 AAZ52497 AAZ52498 AAZ52499 AAZ52500 AAZ52501 AAZ52502 AI389694 AI403922 AI944507 AI945974 AW940799 AY051559 Entrez Gene - A searchable database of RefSeq genes. • 31607 UniProtKB/TrEMBL • Q0KHV6 Q961J3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58093 DroID - A comprehensive database of gene and protein interactions. • FBgn0029891 DRSC - Results from RNAi screens. • FBgn0029891 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029891 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4523-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029891 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31607 InParanoid A subset of ortholog calls from InParanoid. • AAEL011594-PA Aedes aegypti (mosquito) AGAP004315-PA Anopheles gambiae (mosquito) XP_623327.1 Apis mellifera (honey bee) XP_001946944.1 Acyrthosiphon pisum (pea aphid) XP_001896214.1 Brugia malayi (roundworm nematode) ENSBTAP00000029455 Bos taurus (bovine) CE28904 Caenorhabditis elegans (worm) ENSCAFP00000022173 Canis familiaris (dog) CMT185C Cyanidioschyzon merolae (red alga) CPIJ009758 Culex pipens (mosquito) RP33660 Caenorhabditis remanei (nematode) 228381 Capitella spl (polychaete worm) ENSDARP00000014981 Danio rerio (zebra fish) ENSDARP00000050156 Danio rerio (zebra fish) ENSECAP00000007281 Equus caballus (horse) ENSGACP00000014990 Gymnopilus aculeatus (mushroom) ENSGALP00000004900 Gallus gallus (chicken) ENSP00000364204 Homo sapiens (human) ENSMODP00000019920 Monodelphis domestica (gray opossum) ENSMMUP00000000169 Macaca mulatta (rhesus monkey) ENSMMUP00000011580 Macaca mulatta (rhesus monkey) ENSMUSP00000030536 Mus musculus (house mouse) XP_001605979.1 Nasonia vitripennis (wasp) ENSOANP00000016490 Ornithorynchus anatinus (platypus) ENSORLP00000020035 Oryzias latipes (japanese killifish) PHUM011084-PA Pediculus humanus (human body louse) ENSPPYP00000002052 Pongo pygmaeus (orangutan) ENSPTRP00000000500 Pan troglodytes (chimpanzee) ENSRNOP00000020820 Rattus norvegicus (norway rat) XP_968367.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015393 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020226 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31607 modMine - Data generated by the modENCODE project. • FBgn0029891 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16312 PB10237 NV16902 LH23240 ISCW002313 FBgn0234259 FBgn0219834 FBgn0204166 FBgn0196078 FBgn0167450 FBgn0078239 FBgn0150955 FBgn0084467 FBgn0132173 FBgn0111808 FBgn0098426 CPIJ009758 ACYPI009661 GB19578 AGAP004315 AAEL011594 PHUM577390 GLEAN_13202
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BEST:GH23468   CG4523 (Bier, 2005, Morrison et al., 2000, Manning, 2002.11.16, Anholt and Mackay, 2001, Rana, 2004.7.8, Giot et al., 2003, Park et al., 2006, Altenhein et al., 2006, Clark et al., 2006, Wang et al., 2006, Ni et al., 2008, Keleman et al., 2009.8.5) dPINK1 (Clark et al., 2006, Wang et al., 2006, Bier, 2006, Imai et al., 2010) dPink1 (Yang et al., 2008, Yang et al., 2008) PINK (Venderova et al., 2009) Pink1 (Budde, 2006, Yang et al., 2008, Tain et al., 2009, Yang et al., 2006, Todd and Staveley, 2008) PINK1 (Pallanck and Greenamyre, 2006, Park et al., 2006, Todd and Staveley, 2007, Biskup, 2006, Wang et al., 2006, Tain et al., 2007, Lin and Beal, 2006, Tountas and Fortini, 2007, Maricich and Zoghbi, 2006, Kim et al., 2008, Bier, 2006, Poole et al., 2008, Venderova et al., 2009, Park et al., 2009, Tain et al., 2009, Lutz et al., 2009, Poole et al., 2010, Ziviani et al., 2010, Lee et al., 2007) pink1 (Guo et al., 2007, Clark et al., 2006, Korey, 2007, Hao et al., 2010, Rival et al., 2011, Rival et al., 2011, Truscott et al., 2011, Whitworth et al., 2008, Dodson et al., 2008, Yun et al., 2008, Deng et al., 2008, Lorbeck et al., 2010, Whitworth et al., 2008)
Name Synonym	Pink1 (Clark, 2006.2.28) PTEN-Induced Kinase 1 (Bier, 2006) PTEN-induced putative kinase 1 (Park et al., 2006, Kim et al., 2008) PTEN induced putative kinase 1 (Todd and Staveley, 2007)
Secondary FlyBase IDs
	FBgn0046284
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 6 ) Review  ( 7 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Conference report  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Rival et al., 2011, EMBO Rep. 12(3): 223--230 Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. [FBrf0213174] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Hao et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(21): 9747--9752 DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. [FBrf0210895] Imai et al., 2010, PLoS Genet. 6(12): e1001229 The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila. [FBrf0212500] Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Poole et al., 2010, PLoS ONE 5(4): e10054 The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. [FBrf0210539] Ziviani et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(11): 5018--5023 Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin. [FBrf0210308] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...