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FB2021_03, released June 15, 2021

Gene: Dmel\Pink1

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General Information
Symbol
Dmel\Pink1
Species
D. melanogaster
Name
PTEN-induced putative kinase 1
Annotation Symbol
CG4523
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029891
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dPINK1, Pink

Key Links
Genomic Location
Cytogenetic map
6C6-6C6
Sequence location
X:6,683,798..6,687,302 [+]
Recombination map
1-18
RefSeq locus
NC_004354 REGION:6683798..6687302
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (40 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables ATP-dependent protein binding
inferred from physical interaction with FLYBASE:Mitofilin; FB:FBgn0019960
(Tsai et al., 2018)
enables protein binding
inferred from physical interaction with FLYBASE:Pgam5; FB:FBgn0023517
(Imai et al., 2010)
inferred from physical interaction with FLYBASE:rho-7; FB:FBgn0033672
(Whitworth et al., 2008)
inferred from physical interaction with FLYBASE:Mitofilin; FB:FBgn0019960
(Tsai et al., 2018)
enables protein kinase activity
inferred from direct assay
(Woodroof et al., 2011)
inferred from mutant phenotype
(assigned by UniProt )
(Shiba-Fukushima et al., 2017)
enables protein serine/threonine kinase activity
inferred from direct assay
(assigned by UniProt )
(Pirooznia et al., 2020, Course et al., 2018)
inferred from direct assay
(Tsai et al., 2018, Shiba-Fukushima et al., 2014)
inferred from mutant phenotype
(assigned by UniProt )
(Zhuang et al., 2016)
inferred from mutant phenotype
(Zhang et al., 2019)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000540563
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001121970
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (30 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
involved_in autophagy of mitochondrion
inferred from mutant phenotype
(Ziviani et al., 2010)
involved_in compound eye development
inferred from mutant phenotype
(Wang et al., 2006)
involved_in ectopic germ cell programmed cell death
inferred from mutant phenotype
(Yacobi-Sharon et al., 2013)
involved_in establishment of mitochondrion localization
inferred from mutant phenotype
(Liu et al., 2012)
involved_in establishment of protein localization to mitochondrion
inferred from mutant phenotype
(assigned by UniProt )
(Zhuang et al., 2016)
involved_in intracellular distribution of mitochondria
inferred from mutant phenotype
(assigned by CACAO )
(Liu et al., 2012)
involved_in medium-term memory
inferred from mutant phenotype
(assigned by UniProt )
(Julienne et al., 2017)
involved_in mitochondrial fission
inferred from genetic interaction with FLYBASE:Drp1; FB:FBgn0026479
(Poole et al., 2008, Yang et al., 2008)
inferred from genetic interaction with FLYBASE:Marf; FB:FBgn0029870
(Poole et al., 2008)
inferred from genetic interaction with FLYBASE:Opa1; FB:FBgn0261276
(Poole et al., 2008, Yang et al., 2008)
acts_upstream_of mitochondrion inheritance
inferred from mutant phenotype
(Zhang et al., 2019)
involved_in mitochondrion organization
inferred from mutant phenotype
(Tsai et al., 2018, Shiba-Fukushima et al., 2014, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008, Clark et al., 2006, Park et al., 2006)
inferred from direct assay
(Yang et al., 2006)
inferred from genetic interaction with FLYBASE:Buffy; FB:FBgn0040491
(Park et al., 2006)
involved_in mitochondrion transport along microtubule
inferred from mutant phenotype
(assigned by CACAO )
(Liu et al., 2012)
involved_in negative regulation of cytoplasmic translation
inferred from mutant phenotype
(Zhang et al., 2019)
involved_in negative regulation of mitochondrial fusion
inferred from mutant phenotype
(Ziviani et al., 2010)
involved_in negative regulation of neuron apoptotic process
inferred from direct assay
(Yang et al., 2006)
involved_in negative regulation of programmed cell death
inferred from mutant phenotype
(Wang et al., 2006)
involved_in neuromuscular synaptic transmission
inferred from mutant phenotype
(Morais et al., 2009)
involved_in peptidyl-serine autophosphorylation
inferred from mutant phenotype
(assigned by UniProt )
(Zhuang et al., 2016)
involved_in positive regulation of autophagy of mitochondrion
inferred from mutant phenotype
(assigned by UniProt )
(Zhuang et al., 2016)
inferred from genetic interaction with UniProtKB:Q7KTX7
(assigned by UniProt )
(Zhuang et al., 2016)
involved_in positive regulation of compound eye pigmentation
inferred from mutant phenotype
(assigned by BHF-UCL )
(Venderova et al., 2009)
involved_in positive regulation of locomotor rhythm
inferred from mutant phenotype
(assigned by UniProt )
(Julienne et al., 2017)
involved_in positive regulation of mitochondrial fission
inferred from mutant phenotype
(Ziviani et al., 2010)
involved_in positive regulation of neuronal action potential
inferred from mutant phenotype
(assigned by UniProt )
(Julienne et al., 2017)
involved_in protein phosphorylation
inferred from mutant phenotype
(assigned by UniProt )
(Zhuang et al., 2016)
inferred from direct assay
(Shiba-Fukushima et al., 2014)
involved_in regulation of mitochondrial electron transport, NADH to ubiquinone
inferred from genetic interaction with FLYBASE:no biological data available-42; FB:FBgn0019957
(Morais et al., 2014, Pogson et al., 2014)
involved_in regulation of mitochondrion organization
inferred from mutant phenotype
(Lutz et al., 2009)
involved_in response to oxidative stress
inferred from mutant phenotype
(Wang et al., 2006)
involved_in short-term memory
inferred from mutant phenotype
(assigned by UniProt )
(Julienne et al., 2017)
involved_in sperm mitochondrion organization
inferred from mutant phenotype
(Deng et al., 2008, Clark et al., 2006, Park et al., 2006)
involved_in ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Ziviani et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in autophagy of mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN001121970
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of mitochondrial fission
inferred from biological aspect of ancestor with PANTHER:PTN001121970
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000540563
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of apoptotic process
inferred from biological aspect of ancestor with PANTHER:PTN001121970
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Whitworth et al., 2008)
located_in cytosol
inferred from direct assay
(Tsai et al., 2018)
is_active_in extrinsic component of mitochondrial outer membrane
inferred from direct assay
(Zhang et al., 2019)
located_in mitochondrion
inferred from direct assay
(Tsai et al., 2018, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Clark et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN001121970
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. [Date last reviewed: 2018-10-11]
Gene Group (FlyBase)
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
Summary (Interactive Fly)

promotes mitochondrial fragmentation by targeting core components of the mitochondrial morphogenesis machinery for ubiquitination - negatively regulates mitochondrial fusion - a fruitfly model for Parkinson's disease

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pink1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pink1-RA
FBtr0070956
NM_132112
2859
721
Pink1-RB
FBtr0070957
NM_167083
2779
721
Pink1-RC
FBtr0100413
NM_001031883
2865
721
Pink1-RD
FBtr0100414
NM_001031882
2773
721
Pink1-RE
FBtr0100415
NM_001031881
2864
721
Pink1-RF
FBtr0100416
NM_001031880
3158
721
Pink1-RG
FBtr0100419
NM_001031879
2921
721
Pink1-RH
FBtr0100420
NM_001031878
2894
721
Pink1-RI
FBtr0345295
NM_001298023
2411
721
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pink1-PA
FBpp0070917
80.2
721
8.18
NP_572340
AAN09178
Pink1-PB
FBpp0070918
80.2
721
8.18
NP_727110
AAF46188
Pink1-PC
FBpp0099830
80.2
721
8.18
NP_001027054
AAZ52497
Pink1-PD
FBpp0099831
80.2
721
8.18
NP_001027053
AAZ52498
Pink1-PE
FBpp0099832
80.2
721
8.18
NP_001027052
AAZ52499
Pink1-PF
FBpp0099833
80.2
721
8.18
NP_001027051
AAZ52500
Pink1-PG
FBpp0099835
80.2
721
8.18
NP_001027050
AAZ52501
Pink1-PH
FBpp0099837
80.2
721
8.18
NP_001027049
AAZ52502
Pink1-PI
FBpp0311462
80.2
721
8.18
NP_001284952
AHN59423
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

721 aa isoforms: Pink1-PA, Pink1-PB, Pink1-PC, Pink1-PD, Pink1-PE, Pink1-PF, Pink1-PG, Pink1-PH, Pink1-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pink1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Whitworth et al., 2008)
located_in cytosol
inferred from direct assay
(Tsai et al., 2018)
is_active_in extrinsic component of mitochondrial outer membrane
inferred from direct assay
(Zhang et al., 2019)
located_in mitochondrion
inferred from direct assay
(Tsai et al., 2018, Whitworth et al., 2008)
located_in Nebenkern
inferred from direct assay
(Clark et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pink1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 46 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pink1
Transgenic constructs containing regulatory region of Pink1
Aberrations (Deficiencies and Duplications) ( 1 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4Mef2.PR
lethal - all die before end of second instar larval stage, with Scer\GAL4da.G32
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4da.PU
viable, with Scer\GAL4elav.PU
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
male semi-sterile, with Scer\GAL4Tub.PU
male sterile
sterile
Other Phenotypes
Allele
abnormal cell size | prepupal stage | somatic clone, with Scer\GAL4Act.PU
abnormal flight
abnormal flight, with Scer\GAL4Mhc.PW
abnormal flight | progressive
abnormal flight | recessive
abnormal heat stress response
abnormal jumping
abnormal jumping, with Scer\GAL4Mhc.PU
abnormal locomotor behavior
abnormal locomotor behavior, with Scer\GAL4da.G32
abnormal locomotor behavior | adult stage
abnormal locomotor behavior | adult stage, with Scer\GAL4Ddc.PL
abnormal locomotor behavior | adult stage, with Scer\GAL4Mef2.PR
abnormal locomotor behavior | adult stage | progressive
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4ple.PF
abnormal locomotor behavior | adult stage | recessive
abnormal locomotor behavior | larval stage
abnormal locomotor behavior | progressive
abnormal locomotor rhythm | adult stage
abnormal locomotor rhythm | adult stage | adult stage, with Scer\GAL4tim.PE
abnormal memory | adult stage
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4Ddc.PL
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy, with Scer\GAL4ple.PF
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Scer\GAL4VGlut-OK371
abnormal neuroanatomy | adult stage | dominant
abnormal neuroanatomy | adult stage | progressive
abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4ple.PF
abnormal neuroanatomy | progressive
abnormal neurophysiology
abnormal neurophysiology | adult stage
abnormal neurophysiology | third instar larval stage
abnormal osmotic stress response
abnormal oxidative stress response | adult stage | chemical conditional
abnormal size | adult stage
abnormal size | adult stage, with Scer\GAL4Mef2.PR
abnormal size | third instar larval stage, with Scer\GAL4Cg.PA
abnormal smell perception
abnormal smell perception | adult stage
abnormal visual perception
chemical sensitive
decreased cell number
decreased cell number | adult stage
decreased cell number | adult stage | progressive, with Scer\GAL4ple.PF
flightless
flightless, with Scer\GAL4da.G32
flightless | adult stage
hyperplasia | adult stage
increased cell death
increased cell death, with Scer\GAL4da.G32
increased cell death, with Scer\GAL4Mhc.PW
increased cell death | adult stage
increased cell size, with Scer\GAL4GMR.PF
increased mortality | chemical conditional
majority die during embryonic stage | maternal effect, with Scer\GAL4nos.PU
short lived
short lived, with Scer\GAL4da.G32
short lived, with Scer\GAL4Ddc.PL
short lived, with Scer\GAL4Mhc.PW
short lived, with Scer\GAL4Tub.PU
some die during second instar larval stage, with Scer\GAL4da.G32
visible
visible, with Scer\GAL4elav.PLu
visible, with Scer\GAL4elav-C155
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4Mhc.PW
visible, with Scer\GAL4Tub.PU
visible | adult stage
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4Mhc.PU
visible | progressive
visible | recessive
Phenotype manifest in
Allele
adult antennal lobe
adult brain
adult external thorax
adult somatic muscle
adult thorax
adult thorax | dorsal
adult ventral nerve cord
autophagosome | prepupal stage | somatic clone, with Scer\GAL4Act.PU
axon | adult stage
axon | adult stage, with Scer\GAL4VGlut-OK371
axon | third instar larval stage
bouton
cytoskeleton of presynaptic active zone
dendrite | third instar larval stage
dendritic arborizing neuron
depressor muscle, with Scer\GAL4da.G32
dopamine neuron & adult brain
dopamine neuron & adult brain, with Scer\GAL4Ddc.PL
dopamine neuron & adult brain, with Scer\GAL4elav.PLu
dopaminergic neuron
dopaminergic neuron, with Scer\GAL4ple.PF
dopaminergic neuron | adult stage
dopaminergic neuron | adult stage | decreased number, with Scer\GAL4ple.PF
dopaminergic neuron | progressive
dopaminergic PPL1 neuron
dopaminergic PPL1 neuron | adult stage
dopaminergic PPL1 neuron | progressive
dopaminergic PPM1 neuron
dopaminergic PPM2 neuron
dopaminergic PPM2 neuron | adult stage
dorsal mesothorax
dorso-lateral dopaminergic neuron
egg | maternal effect
egg | maternal effect, with Scer\GAL4nos.PU
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval hypocerebral ganglion | embryonic stage
embryonic/larval hypodermal muscle | third instar larval stage
embryonic/larval motor neuron | larval stage, with Scer\GAL4ple.PF
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4ple.PF
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval somatic muscle | third instar larval stage
embryonic frontal ganglion
endoplasmic reticulum | adult stage
enterocyte | prepupal stage | somatic clone
enterocyte | prepupal stage | somatic clone, with Scer\GAL4Act.PU
eye, with Scer\GAL4elav.PLu
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye | adult stage, with Scer\GAL4GMR.PF
flight muscle
flight muscle, with Scer\GAL4Mhc.PU
indirect flight muscle
indirect flight muscle, with Scer\GAL4da.G32
indirect flight muscle, with Scer\GAL4Mhc.PU
indirect flight muscle, with Scer\GAL4Mhc.PW
indirect flight muscle | adult stage
indirect flight muscle | progressive
interommatidial bristle, with Scer\GAL4GMR.PF
intestinal stem cell | late third instar larval stage | somatic clone, with Scer\GAL4esg.PU
intestinal stem cell | prepupal stage | somatic clone, with Scer\GAL4esg.PU
intestinal stem cell | pupal stage | somatic clone, with Scer\GAL4esg.PU
larval ventral nerve cord | third instar larval stage
l-LNv neuron | adult stage
midgut | late third instar larval stage | somatic clone, with Scer\GAL4esg.PU
midgut | prepupal stage | somatic clone
midgut | prepupal stage | somatic clone, with Scer\GAL4Act.PU
midgut | prepupal stage | somatic clone, with Scer\GAL4esg.PU
midgut | pupal stage | somatic clone, with Scer\GAL4esg.PU
minor mitochondrial derivative
mitochondrial crista
mitochondrial crista, with Scer\GAL4da.G32
mitochondrial crista, with Scer\GAL4Mhc.PW
mitochondrial crista & indirect flight muscle
mitochondrial crista | adult stage
mitochondrial crista | adult stage | progressive
mitochondrial crista | adult stage | progressive, with Scer\GAL4Mef2.PR
mitochondrial crista | third instar larval stage
mitochondrial crista junction | third instar larval stage
mitochondrial derivative
mitochondrial inner membrane & indirect flight muscle
mitochondrial outer membrane
mitochondrial outer membrane & indirect flight muscle
mitochondrion
mitochondrion, with Scer\GAL4Mhc.PU
mitochondrion, with Scer\GAL4Mhc.PW
mitochondrion, with Scer\GAL4nos.PU
mitochondrion (with Df(1)BSC535)
mitochondrion & dopamine neuron & adult brain
mitochondrion & dopaminergic neuron
mitochondrion & dorso-lateral dopaminergic neuron
mitochondrion & dorso-lateral dopaminergic neuron, with Scer\GAL4ple.PF
mitochondrion & indirect flight muscle
mitochondrion | adult stage
mitochondrion | adult stage, with Scer\GAL4Mhc.PU
mitochondrion | adult stage, with Scer\GAL4ple.PF
mitochondrion | adult stage, with Scer\GAL4VGlut-OK371
mitochondrion | adult stage | progressive
mitochondrion | adult stage | progressive, with Scer\GAL4Mef2.PR
mitochondrion | larval stage, with Scer\GAL4ple.PF
mitochondrion | late third instar larval stage | somatic clone, with Scer\GAL4esg.PU
mitochondrion | prepupal stage | somatic clone
mitochondrion | prepupal stage | somatic clone, with Scer\GAL4Act.PU
mitochondrion | prepupal stage | somatic clone, with Scer\GAL4esg.PU
mitochondrion | pupal stage | somatic clone, with Scer\GAL4esg.PU
mitochondrion | third instar larval stage
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
muscle cell | adult stage
myofibril, with Scer\GAL4da.G32
myofibril, with Scer\GAL4Mhc.PW
myofibril & indirect flight muscle
Nebenkern
Nebenkern derivative
neuron
neuropil | adult stage
NMJ bouton
ommatidium, with Scer\GAL4elav.PLu
ommatidium, with Scer\GAL4ey.PU
ommatidium, with Scer\GAL4GMR.PF
ommatidium | adult stage, with Scer\GAL4GMR.PF
ovary, with Scer\GAL4nos.PU
ovary (with Df(1)BSC535)
paraesophageal ganglion | embryonic stage
photoreceptor & neuron, with Scer\GAL4GMR.PF
pigment cell, with Scer\GAL4GMR.PF
rhabdomere | adult stage, with Scer\GAL4GMR.PF
skeletal muscle of thorax
skeletal muscle of thorax | progressive, with Scer\GAL4Mef2.PR
spermatid
spermatid cyst
spermatozoon
synapse | third instar larval stage
synaptic vesicle
testis | adult stage
thorax
wing
wing, with Scer\GAL4da.G32
wing, with Scer\GAL4elav-C155
wing, with Scer\GAL4Mhc.PW
wing, with Scer\GAL4Tub.PU
wing | adult stage
wing | adult stage, with Scer\GAL4Mhc.PU
wing | progressive
wing blade
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PINK1
10 of 15
Yes
Yes
 
9  
Hsap\MIR6084
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pink1
10 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Pink1
5 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (1)
Drer\pink1
9 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pink-1
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\CPK25
1 of 9
Yes
No
Atha\MAPKKK9
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903X1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005022
Drosophila simulans
Dsim\GD24757
Drosophila sechellia
Dsec\GM12513
Drosophila erecta
Dere\GG19606
Drosophila yakuba
Dyak\GE16766
Drosophila ananassae
Dana\GF21424
Drosophila pseudoobscura pseudoobscura
Dpse\GA18232
Drosophila persimilis
Dper\GL13349
Drosophila willistoni
Dwil\GK17835
Drosophila virilis
Dvir\GJ16989
Drosophila mojavensis
Dmoj\Tes31
Drosophila grimshawi
Dgri\GH24718
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915029G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014489
Glossina morsitans
Tsetse fly
Gmor\GMOY002949
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02069
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011594
Anopheles darlingi
American malaria mosquito
Adar\ADAC004838
Anopheles gambiae
Malaria mosquito
Agam\AGAP004315
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009758
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0226 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2754677764
Apis mellifera
Western honey bee
Amel\LOC550929
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14371
Bombus terrestris
Buff-tailed bumblebee
Bter\15204242
Linepithema humile
Argentine ant
Lhum\LH23240
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001bd6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015028
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11495
Tribolium castaneum
Red flour beetle
Tcas\TC013202
Pediculus humanus
Human body louse
Phum\PHUM577390
Cimex lectularius
Bed bug
Clec\CLEC011711
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009661
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08OB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004030
Ixodes scapularis
Black-legged tick
Isca\ISCW002313
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69545.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g04860
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03V6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Gallus gallus
Domestic chicken
Ggal\PINK1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Allele
Disease
Evidence
References
Pink1JF01672
model of  Parkinson's disease 6
CEA
(Zhou et al., 2019)
Pink1dsRNA.UAS.cPa
model of  Parkinson's disease 6
CEC
(Kim et al., 2019)
Pink1B9
model of  Parkinson's disease
CEA
(Tsai et al., 2018, Celardo et al., 2017, Chen et al., 2017, Julienne et al., 2017, Lehmann et al., 2017, Yang et al., 2017, Wang et al., 2016, Zhang et al., 2016, Zhuang et al., 2016, Gao et al., 2015, Zhu et al., 2015, Bingol et al., 2014, Navarro et al., 2014, Poddighe et al., 2014, Wu et al., 2014, Esposito et al., 2013, Kim and Yim, 2013, Poddighe et al., 2013, Song et al., 2013, Vincow et al., 2013, Vos et al., 2013, Liu et al., 2012, Hao et al., 2010, Rana et al., 2010, Morais et al., 2009, Tain et al., 2009, Poole et al., 2008, Park et al., 2006)
model of  testicular cancer
CEA
(Napoletano et al., 2017)
DOES NOT model  Parkinson's disease
CEA with Vps35MH20
(Malik et al., 2015)
CEA with Vps35E42
(Malik et al., 2015)
model of  early-onset Parkinson's disease
CEA
(West et al., 2015)
model of  Parkinson's disease 2
CEC
(Basil et al., 2017)
model of  Parkinson's disease 6
CEC
(von Stockum et al., 2019)
CEA
(Baroli et al., 2019, Wu et al., 2019, Doktór et al., 2018, Liu and Lu, 2010, Tain et al., 2009)
Pink1UAS.Tag:HA
model of  Parkinson's disease 6
CEA
(Min et al., 2015)
Pink15
model of  early-onset Parkinson's disease
CEA
(West et al., 2015)
model of  Hirschsprung's disease
CEA
(Myers et al., 2018)
model of  Parkinson's disease 6
CEA
(Zhang et al., 2017, Tsai et al., 2014)
Pink1UAS.cCa
model of  Parkinson's disease 6
CEA
(Kandul et al., 2016)
Pink1dsRNA.UAS.cWa
model of  Parkinson's disease
CEA
(Wang et al., 2006)
Pink1dsRNA.UAS
model of  Parkinson's disease
CEA
(M'Angale and Staveley, 2017, Yang et al., 2006)
model of  Parkinson's disease 6
CEA
(Doktór et al., 2018, Liu and Lu, 2010)
Pink1VDRC.cUa
model of  Parkinson's disease
CEA
(Fernandes and Rao, 2011)
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
PINK1; PTEN induced kinase 1
model of  Parkinson's disease 6
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 12 )
Allele
Disease
Interaction
References
Pink1B9
model of  Parkinson's disease
is ameliorated by mask10.22
(Zhu et al., 2015)
is ameliorated by maskHMS01045
(Zhu et al., 2015)
is ameliorated by maskEY13048
(Zhu et al., 2015)
is ameliorated by maskKK100529
(Zhu et al., 2015)
is ameliorated by Hsap\BNIP3LUAS.cGa
(Gao et al., 2015)
is exacerbated by ShmtGD8851
(Celardo et al., 2017)
is ameliorated by ShmtUAS.Tag:HA
(Celardo et al., 2017)
is exacerbated by NmdmcKK102478
(Celardo et al., 2017)
is ameliorated by NmdmcUAS.Tag:HA
(Celardo et al., 2017)
is exacerbated by crcKK111018
(Celardo et al., 2017)
is ameliorated by Lrrke03680
(Tain et al., 2009)
is ameliorated by ThorUAS.cMa
(Koh et al., 2012, Tain et al., 2009)
is ameliorated by ParpCH1
(Lehmann et al., 2017)
is ameliorated by Usp30NIG.3016R
(Bingol et al., 2014)
is ameliorated by STUB1UAS.cCa
(Chen et al., 2017)
is ameliorated by parkUAS.cGa
(Pogson et al., 2014, Hao et al., 2010, Poole et al., 2008)
is ameliorated by Drp1Tag:FLAG,Tag:CALI(TC),Tag:HA
(Poole et al., 2008)
is ameliorated by Drp1+t9.4
(Liu et al., 2011, Poole et al., 2008)
is ameliorated by Opa1s3475
(Poole et al., 2008)
is ameliorated by Opa1f02779
(Poole et al., 2008)
is ameliorated by mAcon1MB09176
(Esposito et al., 2013)
is ameliorated by mAcon11
(Esposito et al., 2013)
is ameliorated by GstO2A.UAS
(Kim and Yim, 2013)
is ameliorated by parkUAS.Tag:MYC
(Park et al., 2006)
is ameliorated by Ucp4AUAS.cWa
(Wu et al., 2014)
is ameliorated by dj-1βUAS.cMa
(Hao et al., 2010)
is ameliorated by DJ-1αUAS.cUa
(Hao et al., 2010)
is ameliorated by dj-1βC45A.UAS
(Hao et al., 2010)
is ameliorated by Pink1UAS.cUa
(Hao et al., 2010)
is ameliorated by Hsap\PARK7UAS.cMa
(Hao et al., 2010)
is ameliorated by MiroJF02775
(Liu et al., 2012)
is ameliorated by MiroKK102189
(Liu et al., 2012)
is exacerbated by MiroUAS.cGa
(Liu et al., 2012)
is ameliorated by miltJF03022
(Liu et al., 2012)
is ameliorated by KhcJF01939
(Liu et al., 2012)
is exacerbated by Khc248-2134.UAS.EGFP
(Liu et al., 2012)
is ameliorated by Pink1S519A.GMR.Tag:Mito(Tom20),GFP
(Zhuang et al., 2016)
is ameliorated by Pink1GMR.Tag:Mito(Tom20),GFP
(Zhuang et al., 2016)
is ameliorated by Pink1S346D.KD.GMR.Tag:Mito(Tom20),GFP
(Zhuang et al., 2016)
is ameliorated by Hsap\BNIP3UAS.Tag:HA
(Zhang et al., 2016)
is ameliorated by Hsap\PINK1ΔMTS.UAS.Tag:FLAG
(Tsai et al., 2018)
is ameliorated by MitofilinUAS.Tag:MYC
(Tsai et al., 2018)
is ameliorated by Hsap\PINK1UAS.cTa.Tag:FLAG
(Tsai et al., 2018)
is ameliorated by Sirt1EP2300
(Koh et al., 2012)
is ameliorated by Sirt1UAS.cGa
(Koh et al., 2012)
is ameliorated by foxoUAS.cKd
(Koh et al., 2012)
is ameliorated by Sod2UAS.cUa
(Koh et al., 2012)
is ameliorated by cluUASp.cSa
(Sen et al., 2015)
is ameliorated by Hsap\CLUHUASp.cSa
(Sen et al., 2015)
is ameliorated by Trap1D6
(Kim et al., 2016)
is ameliorated by Trap1EY21851
(Kim et al., 2016)
is ameliorated by MarfKK105681
(Celardo et al., 2016)
is ameliorated by PEKGD5584
(Celardo et al., 2016)
is ameliorated by ND-42UAS.Tag:HA
(Pogson et al., 2014)
is ameliorated by ND-42UAS.cBa
(Pogson et al., 2014)
is ameliorated by ND-42UAS.cMa
(Pogson et al., 2014)
is ameliorated by ND-42SD.UAS
(Morais et al., 2014, Pogson et al., 2014)
is ameliorated by sicilyUAS.cZa
(Pogson et al., 2014)
is ameliorated by ND-42SA.UAS
(Pogson et al., 2014)
is exacerbated by Drp1KG03815
(Fernandes and Rao, 2011)
is exacerbated by heix2
(Vos et al., 2012)
is exacerbated by heixk11403
(Vos et al., 2012)
is exacerbated by heixNP5301
(Vos et al., 2012)
is exacerbated by heix1
(Vos et al., 2012)
is ameliorated by Pgam5NP0568
(Imai et al., 2010)
is ameliorated by Pgam51
(Imai et al., 2010)
is ameliorated by Scer\NDI1UAS.cVa
(Vilain et al., 2012)
is ameliorated by Trap1UAS.cCa
(Costa et al., 2013)
is ameliorated by Hsap\TRAP1UAS.cBa
(Zhang et al., 2013)
is exacerbated by rictorJF01370
(Wu et al., 2013)
is exacerbated by trcK122A+T453A.UAS.L
(Wu et al., 2013)
is ameliorated by Sin1UAS.Tag:FLAG
(Wu et al., 2013)
is ameliorated by trcS292E.UAS.L
(Wu et al., 2013)
is ameliorated by rictorUAS.cHa
(Wu et al., 2013)
is ameliorated by trcL.UAS
(Wu et al., 2013)
is NOT ameliorated by RetMEN2B.UAS
(Klein et al., 2014)
is ameliorated by RetMEN2B.UAS
(Klein et al., 2014)
is ameliorated by RetMEN2B.UAS
(Klein et al., 2014)
is NOT ameliorated by RetMEN2B.UAS
(Klein et al., 2014)
is ameliorated by dnkUAS.cLa
(Tufi et al., 2014)
is ameliorated by TER94UAS.cRa
(Kim et al., 2013)
ameliorates  chromosome 15q11.2 deletion syndrome
modeled by Cyfip85.1
(Kanellopoulos et al., 2020)
model of  Parkinson's disease 6
is ameliorated by Usp8KO
(von Stockum et al., 2019)
is ameliorated by Usp8VDRC.cUa
(von Stockum et al., 2019)
is ameliorated by HtrA2UASp.cTa
(Tain et al., 2009)
is ameliorated by Atg1UAS.cSa
(Liu and Lu, 2010)
is ameliorated by MarfdsRNA.UAS.cUa
(Liu and Lu, 2010)
is exacerbated by S6kTE.UAS
(Liu and Lu, 2010)
is ameliorated by ThorUAS.cMa
(Liu and Lu, 2010)
is ameliorated by parkUAS.Tag:HA
(Liu and Lu, 2010)
is ameliorated by Hsap\AFDNUAS.cBa
(Basil et al., 2017)
Pink1UAS.Tag:HA
ameliorates  neurodegenerative disease
modeled by trpP365
(Huang et al., 2016)
ameliorates  Huntington's disease
modeled by Hsap\HTTQ93.ex1.UAS
(Khalil et al., 2015)
DOES NOT ameliorate  Huntington's disease
modeled by park1, Hsap\HTTQ93.ex1.UAS
(Khalil et al., 2015)
modeled by MarfmiRNA.cUa.UAS, Hsap\HTTQ93.ex1.UAS
(Khalil et al., 2015)
modeled by porink05123, Hsap\HTTQ93.ex1.UAS
(Khalil et al., 2015)
model of  Parkinson's disease 6
is exacerbated by TgA.UAS
(Min et al., 2015)
is ameliorated by TgNIG.7356R
(Min et al., 2015)
Pink15
model of  Parkinson's disease 6
is ameliorated by TER94UAS.cCa
(Zhang et al., 2017)
model of  Parkinson's disease
is ameliorated by Mul1UAS.cYa
(Yun et al., 2014)
Pink1dsRNA.UAS.cWa
model of  Parkinson's disease
is ameliorated by Hsap\SOD1UAS.cPa
(Wang et al., 2006)
is ameliorated by APP-BP1UAS.cKa
(Choo et al., 2012)
Pink1UAS.cTa
ameliorates  Parkinson's disease
modeled by Hsap\SNCAUAS.cFa
(Todd and Staveley, 2008)
Pink1GMR.Tag:Mito(Tom20),GFP
ameliorates  Parkinson's disease
modeled by Pink1B9
(Zhuang et al., 2016)
Pink1S519A.GMR.Tag:Mito(Tom20),GFP
ameliorates  Parkinson's disease
modeled by Pink1B9
(Zhuang et al., 2016)
Pink1S346D.KD.GMR.Tag:Mito(Tom20),GFP
ameliorates  Parkinson's disease
modeled by Pink1B9
(Zhuang et al., 2016)
Pink1dsRNA.UAS
model of  Parkinson's disease
is ameliorated by Hsap\PRKNUAS.cYa
(Yang et al., 2006)
is ameliorated by Hsap\PINK1UAS.cYa
(Yang et al., 2006)
is exacerbated by cluGD13926
(Sen et al., 2015)
is exacerbated by cluKK108024
(Sen et al., 2015)
is exacerbated by rictorJF01370
(Wu et al., 2013)
is ameliorated by trcshort.UAS
(Wu et al., 2013)
is exacerbated by rictorΔ2
(Wu et al., 2013)
is ameliorated by rictorUAS.cHa
(Wu et al., 2013)
is exacerbated by trcK122A+T453A.UAS.L
(Wu et al., 2013)
is ameliorated by trcL.UAS
(Wu et al., 2013)
is ameliorated by trcS292E.UAS.L
(Wu et al., 2013)
is exacerbated by Sin1unspecified
(Wu et al., 2013)
is ameliorated by Sin1UAS.Tag:FLAG
(Wu et al., 2013)
is exacerbated by rictorJF01086
(Wu et al., 2013)
is exacerbated by trcK122A.UAS.L.Tag:FLAG
(Wu et al., 2013)
is ameliorated by trcT453E.UAS.L
(Wu et al., 2013)
is ameliorated by APP-BP1UAS.cKa
(Choo et al., 2012)
ameliorates  amyotrophic lateral sclerosis type 6
modeled by Hsap\FUSWT.UAS.RFP(Unk),Tag:HA
(Chen et al., 2016)
model of  Parkinson's disease 6
is exacerbated by Atg1K38Q.UAS
(Liu and Lu, 2010)
is ameliorated by Atg1UAS.cSa
(Liu and Lu, 2010)
is exacerbated by Atg13NIG.7331R
(Liu and Lu, 2010)
is exacerbated by Atg18aVDRC.cUa
(Liu and Lu, 2010)
is exacerbated by Atg3VDRC.cUa
(Liu and Lu, 2010)
is ameliorated by CatUAS.cUa
(Liu and Lu, 2010)
is ameliorated by GstS1UAS.cUa
(Liu and Lu, 2010)
is ameliorated by MarfdsRNA.UAS.cUa
(Liu and Lu, 2010)
is ameliorated by PHGPxUAS.cUa
(Liu and Lu, 2010)
is ameliorated by RpS9VDRC.cUa
(Liu and Lu, 2010)
is exacerbated by S6kSTDE.UAS
(Liu and Lu, 2010)
is exacerbated by S6kSTDETE.UAS
(Liu and Lu, 2010)
is exacerbated by S6kTE.UAS
(Liu and Lu, 2010)
is exacerbated by S6kUAS.cUa
(Liu and Lu, 2010)
is ameliorated by S6kVDRC.cUa
(Liu and Lu, 2010)
is ameliorated by Sod1UAS.cUa
(Liu and Lu, 2010)
is ameliorated by ThorUAS.cMa
(Liu and Lu, 2010)
is ameliorated by TorWT.UAS.Tag:FLAG
(Liu and Lu, 2010)
is exacerbated by eIF4E1UAS.cRa
(Liu and Lu, 2010)
is ameliorated by parkUAS.Tag:HA
(Liu and Lu, 2010)
Pink1UAS.cYa
exacerbates  amyotrophic lateral sclerosis type 6
modeled by Hsap\FUSP525L.UAS.RFP(Unk),Tag:HA
(Chen et al., 2016)
Pink1VDRC.cUa
model of  Parkinson's disease
is ameliorated by Pi3K21BVDRC.cUa
(Fernandes and Rao, 2011)
is ameliorated by β4GalNAcTA4.1
(Fernandes and Rao, 2011)
Pink1UAS.cUa
ameliorates  Parkinson's disease
modeled by Pink1B9
(Hao et al., 2010)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PINK1; PTEN induced kinase 1
10 of 15
608309
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Pink1
Hsap\PINK1
(Tsai et al., 2018, Morais et al., 2009, Clark et al., 2006, Wang et al., 2006, Yang et al., 2006)
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Pink1
suppressible
AGO1
(Gehrke et al., 2015)
Pink1
suppressible
APP-BP1
(Choo et al., 2012)
Pink1|rictor
suppressible
Atg1
(Wu et al., 2013)
Pink1
enhanceable
Atg1
(Sen et al., 2015)
Pink1|trc
suppressible
Atg1
(Wu et al., 2013)
Pink1
suppressible
Buffy
(M'Angale and Staveley, 2017, Park et al., 2006)
Pink1
enhanceable
Chchd2
(Liu et al., 2020)
Pink1
suppressible
chico
(Imai et al., 2010)
Pink1
enhanceable
clu
(Sen et al., 2015)
Pink1
suppressible
clu
(Sen et al., 2015)
Pink1
enhanceable
crc
(Celardo et al., 2017)
Pink1
suppressible
DCP1
(Gehrke et al., 2015)
Pink1
suppressible
DCP2
(Gehrke et al., 2015)
Pink1
enhanceable
Dhpr
(Zhou et al., 2019)
Pink1
suppressible
DJ-1α
(Hao et al., 2010)
Pink1
suppressible
dj-1β
(Hao et al., 2010)
Pink1
suppressible
dnk
(Tufi et al., 2014)
Pink1
suppressible
Drp1
(Terriente-Felix et al., 2020, Esposito et al., 2013, Vilain et al., 2012, Rival et al., 2011, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008)
Pink1
enhanceable
Drp1
(Park et al., 2009)
Pink1
enhanceable
eIF4G1
(Gehrke et al., 2015)
Pink1
suppressible
Fer3HCH
(Esposito et al., 2013)
Pink1
suppressible
foxo
(Koh et al., 2012)
Pink1
suppressible
fwd
(Terriente-Felix et al., 2020)
Pink1
suppressible
gfzf
(Smith et al., 2019)
Pink1
suppressible
glo
(Gehrke et al., 2015)
Pink1
suppressible
GstO2
(Kim and Yim, 2013)
Pink1
suppressible
gw
(Gehrke et al., 2015)
Pink1
enhanceable
heix
(Vos et al., 2012)
Pink1
suppressible
heix
(Vos et al., 2012)
Pink1
enhanceable
HtrA2
(Whitworth et al., 2008, Yun et al., 2008)
Pink1|park
suppressible
HtrA2
(Whitworth et al., 2008)
Pink1
suppressible
HtrA2
(Tain et al., 2009, Whitworth et al., 2008)
Pink1
suppressible
Keap1
(Imai et al., 2010)
Pink1
enhanceable
Khc
(Liu et al., 2012)
Pink1
suppressible
Khc
(Liu et al., 2012)
Pink1
enhanceable
Lon
(Thomas et al., 2014)
Pink1
suppressible
Lon
(Thomas et al., 2014)
Pink1
suppressible
Lrrk
(Tain et al., 2009)
Pink1
suppressible
mAcon1
(Esposito et al., 2013)
Pink1
suppressible
mAcon1|Drp1
(Esposito et al., 2013)
Pink1
suppressible
Marf
(Celardo et al., 2016, Park et al., 2009, Deng et al., 2008)
Pink1|rictor
suppressible
Marf
(Wu et al., 2013)
Pink1|trc
suppressible
Marf
(Wu et al., 2013)
Pink1
enhanceable
Marf
(Poole et al., 2008)
Pink1
suppressible
mask
(Zhu et al., 2015)
Pink1
suppressible
Mcad
(Course et al., 2018)
Pink1
suppressible
milt
(Liu et al., 2012)
Pink1
suppressible
Miro
(Liu et al., 2012)
Pink1
enhanceable
Miro
(Liu et al., 2012)
Pink1|rictor
suppressible
Miro
(Wu et al., 2013)
Pink1|trc
suppressible
Miro
(Wu et al., 2013)
Pink1
suppressible
Mitofilin
(Tsai et al., 2018)
Pink1
suppressible
Mul1
(Yun et al., 2014)
Pink1
enhanceable
Mul1
(Yun et al., 2014)
Pink1
suppressible
N
(Lee et al., 2013)
Pink1
suppressible
ND-42
(Morais et al., 2014, Pogson et al., 2014)
Pink1
enhanceable
Nmdmc
(Celardo et al., 2017)
Pink1
suppressible
Nmdmc
(Celardo et al., 2017)
Pink1
suppressible
Opa1
(Vilain et al., 2012, Rival et al., 2011, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008)
Pink1
enhanceable
Opa1
(Poole et al., 2008)
Pink1
suppressible
Paris
(Pirooznia et al., 2020)
Pink1
suppressible
park
(Khalil et al., 2015, Zhu et al., 2015, Pogson et al., 2014, Shiba-Fukushima et al., 2014, de Castro et al., 2013, Hao et al., 2010, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Whitworth et al., 2008, Yang et al., 2008, Clark et al., 2006, Park et al., 2006)
Pink1
enhanceable
park
(Sen et al., 2015, Poole et al., 2008, Whitworth et al., 2008)
Pink1
suppressible
Parp
(Lehmann et al., 2017)
Pink1
suppressible
PEK
(Celardo et al., 2016)
Pink1
suppressible
Pgam5
(Imai et al., 2010)
Pink1
enhanceable
Pgam5
(Ishida et al., 2012, Imai et al., 2010)
Pink1
suppressible
Pi3K21B
(Fernandes and Rao, 2011)
Pink1
suppressible
Pop2
(Gehrke et al., 2015)
Pink1
suppressible
pum
(Gehrke et al., 2015)
Pink1
suppressible
ref(2)P
(de Castro et al., 2013)
Pink1
enhanceable
Rel
(Lee et al., 2020)
Pink1
suppressible
Ret
(Klein et al., 2014)
Pink1
enhanceable
rictor
(Wu et al., 2013)
Pink1
suppressible
rictor
(Wu et al., 2013)
Pink1
suppressible
Shmt
(Celardo et al., 2017)
Pink1
enhanceable
Shmt
(Celardo et al., 2017)
Pink1
suppressible
sicily
(Pogson et al., 2014)
Pink1
enhanceable
Sin1
(Wu et al., 2013)
Pink1
suppressible
Sin1
(Wu et al., 2013)
Pink1
suppressible
Sirt1
(Koh et al., 2012)
Pink1
suppressible
Sirt1|foxo
(Koh et al., 2012)
Pink1
suppressible
Sod2
(Koh et al., 2012)
Pink1
suppressible
srl
(Pirooznia et al., 2020)
Pink1
suppressible
STUB1
(Chen et al., 2017)
Pink1
suppressible
TER94
(Kim et al., 2013)
Pink1
suppressible
Tg
(Min et al., 2015)
Pink1
enhanceable
Tg
(Min et al., 2015)
Pink1
suppressible
Thor
(Koh et al., 2012, Tain et al., 2009)
Pink1
enhanceable
Tim8
(Gehrke et al., 2015)
Pink1
enhanceable
Tim13
(Gehrke et al., 2015)
Pink1
enhanceable
Tom7
(Gehrke et al., 2015)
Pink1
enhanceable
Tom20
(Gehrke et al., 2015)
Pink1
suppressible
Tom20
(Gehrke et al., 2015)
Pink1
enhanceable
Tom40
(Gehrke et al., 2015)
Pink1
suppressible
Trap1
(Kim et al., 2016, Costa et al., 2013)
Pink1
suppressible
trc
(Wu et al., 2013)
Pink1
enhanceable
trc
(Wu et al., 2013)
Pink1
suppressible
Ucp4A
(Wu et al., 2014)
Pink1
enhanceable
Ucp4A
(Wu et al., 2014)
Pink1
suppressible
Ucp4B
(Wu et al., 2014)
Pink1
suppressible
Ucp4C
(Wu et al., 2014)
Pink1
suppressible
Usp30
(Bingol et al., 2014)
Pink1
enhanceable
Vps35
(Malik et al., 2015)
Pink1
suppressible
β4GalNAcTA
(Fernandes and Rao, 2011)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Atg1|trp
suppressible
Pink1
(Huang et al., 2016)
Chchd2
enhanceable
Pink1
(Liu et al., 2020)
clu
enhanceable
Pink1
(Sen et al., 2015)
clu
suppressible
Pink1
(Wang et al., 2016)
Dhpr
suppressible
Pink1
(Zhou et al., 2019)
Dhpr
enhanceable
Pink1
(Zhou et al., 2019)
gfzf
suppressible
Pink1
(Smith et al., 2019)
N
suppressible
Pink1|Myc
(Lee et al., 2013)
N
enhanceable
Pink1
(Lee et al., 2013)
N
suppressible
Pink1|Su(H)
(Lee et al., 2013)
Paris
suppressible
Pink1
(Pirooznia et al., 2020)
park
suppressible
Pink1
(Shiba-Fukushima et al., 2014)
park
enhanceable
Pink1
(Sen et al., 2015, Shiba-Fukushima et al., 2014, Fernandes and Rao, 2011)
Pgam5
enhanceable
Pink1
(Ishida et al., 2012)
Ret
suppressible
Pink1
(Klein et al., 2014)
rho-7
suppressible
Pink1
(Whitworth et al., 2008)
rho-7
enhanceable
Pink1
(Whitworth et al., 2008)
Syx17
enhanceable
Pink1
(Liu et al., 2018)
Tg
suppressible
Pink1
(Min et al., 2015)
Tg
enhanceable
Pink1
(Min et al., 2015)
Tom20
suppressible
Pink1
(Gehrke et al., 2015)
Tom40
enhanceable
Pink1
(Liu et al., 2018)
Tom40
suppressible
Pink1
(Liu et al., 2018)
trp
suppressible
Pink1|park
(Huang et al., 2016)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-18
Cytogenetic map
6C6-6C6
Sequence location
X:6,683,798..6,687,302 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
6C6-6C6
Limits computationally determined from genome sequence between P{EP}Ctr1AEP1364&P{EP}EP1445 and P{EP}C3GEP1613
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

1-18

(FlyBase, 2016)

1-18.6

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (15)
Genomic Clones (12)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (198)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Park et al., 2006, Yang et al., 2006)
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Pink1 CG4523

(Clark, 2006.2.28)
Source for database merge of

Source for merge of: CG4523 BEST:GH23468

(Rana, 2004.7.8)
Additional comments
Other Comments

Mutants are viable but sterile. Mutant spermatids form abnormal Nebenkerns and mitochondrial derivatives and subsequently fail to individualize the 64-cell cyst into discrete sperm. Mutants show increased sensitivity to paraquat and hyperoxia and have heldup wings due to degeneration of indirect flight muscle.

(Clark et al., 2006)

Pink1 is required for normal mitochondrial function.

(Clark et al., 2006)

Mutants show a number of degenerative phenotypes which are due to mitochondrial dysfunction.

(Park et al., 2006)

Pink1 plays an important role in regulating energy metabolism and exerts an impact on lifespan.

(Yang et al., 2006)

Pink1 plays a critical role in promoting dopaminergic neuronal function and survival.

(Yang et al., 2006)

Pink1 mutants exhibit age-dependent muscle degeneration characterised by extensive DNA fragmentation, probably indicative of cell death.

(Yang et al., 2006)

Pink1 is required for maintaining proper mitochondria morphology and the integrity of suets of muscle cells and dopaminergic neurons.

(Yang et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

(Kiger et al., 2003)
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 66 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB
EMBL-EBI Single Cell Expression Atlas
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (19)
Reported As
Symbol Synonym
BEST:GH23468
CG4523
(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Ferjoux et al., 2007, Altenhein et al., 2006, Clark et al., 2006, Park et al., 2006, Wang et al., 2006, Bier, 2005, Rana, 2004.7.8, Giot et al., 2003, Manning, 2002.11.16, Anholt and Mackay, 2001, Morrison et al., 2000)
PINK
(Wang et al., 2016, Lesnik et al., 2015, Bhandari et al., 2014, Venderova et al., 2009)
PINK-1
(Ohiomokhare et al., 2020)
PINK1
(Yu and Hyun, 2021, Ayikobua et al., 2020, Cui et al., 2020, Imai, 2020, Kim et al., 2020, Luckhart and Riehle, 2020, Vajente et al., 2020, Wan et al., 2020, Xu et al., 2020, Baroli et al., 2019, Cai et al., 2019, Dalla Vecchia et al., 2019, Hsieh et al., 2019, Kim et al., 2019, von Stockum et al., 2019, Basso et al., 2018, Course et al., 2018, Dung and Thao, 2018, Himmelberg et al., 2018, Lee et al., 2018, Xiong and Yu, 2018, Meng et al., 2017, Molina-Mateo et al., 2017, Shiba-Fukushima et al., 2017, Yang et al., 2017, Zhang et al., 2017, Zhu et al., 2017, Ding et al., 2016, Kandul et al., 2016, Kim et al., 2016, Li et al., 2016, Voigt et al., 2016, Von Stockum et al., 2016, Wang et al., 2016, Zhang et al., 2016, Gehrke et al., 2015, Khalil et al., 2015, Sen et al., 2015, Vos et al., 2015, West et al., 2015, Hwang et al., 2014, Ivatt et al., 2014, Jansen et al., 2014, Mulakkal et al., 2014, Poddighe et al., 2014, Shiba-Fukushima et al., 2014, Shiba-Fukushima et al., 2014, Thomas et al., 2014, Tsai et al., 2014, Yun et al., 2014, Burchell et al., 2013, Kim and Yim, 2013, Kim et al., 2013, Lenz et al., 2013, Owusu-Ansah et al., 2013, Poddighe et al., 2013, Vincow et al., 2013, Wu et al., 2013, Guo, 2012, Ishida et al., 2012, Koh et al., 2012, Liu et al., 2012, Nezis, 2012, Muñoz-Soriano and Paricio, 2011, Liu and Lu, 2010, Poole et al., 2010, Ziviani et al., 2010, Lutz et al., 2009, Park et al., 2009, Tain et al., 2009, Venderova et al., 2009, Kim et al., 2008, Poole et al., 2008, Lee et al., 2007, Tain et al., 2007, Todd and Staveley, 2007, Tountas and Fortini, 2007, Bier, 2006, Biskup and Moore, 2006, Lin and Beal, 2006, Maricich and Zoghbi, 2006, Pallanck and Greenamyre, 2006, Park et al., 2006, Park et al., 2006, Wang et al., 2006)
Pink
(Lieber et al., 2019, Sênos Demarco et al., 2019, Kutscher and Shaham, 2017, Senyilmaz et al., 2015)
Pink1
(Baek et al., 2021, De Lazzari et al., 2020, Kanellopoulos et al., 2020, Lee et al., 2020, Lin et al., 2020, Liu et al., 2020, Liu et al., 2020, Lu and Guo, 2020, Maddison et al., 2020, Papakyrikos et al., 2020, Qiao and Mao, 2020, Sun et al., 2020, Xia et al., 2020, Zhao et al., 2020, Aryal and Lee, 2019, Bajracharya et al., 2019, Bouska et al., 2019, Gumeni et al., 2019, Manola et al., 2019, Meltzer et al., 2019, Smith et al., 2019, Wu et al., 2019, Yang et al., 2019, Yuan et al., 2019, Zhou et al., 2019, Chakraborty et al., 2018, Hill et al., 2018, Lee et al., 2018, Liu et al., 2018, Solari et al., 2018, Steyaert et al., 2018, Sun et al., 2018, Valadas et al., 2018, Chen et al., 2017, Galluzzi et al., 2017, Kawasaki et al., 2017, Kim et al., 2017, M'Angale and Staveley, 2017, Song et al., 2017, Chen et al., 2016, Kandul et al., 2016, Liu et al., 2016, Sarov et al., 2016, Liu et al., 2015, Mensah et al., 2015, Senyilmaz et al., 2015, West et al., 2015, DeVorkin et al., 2014, Klein et al., 2014, Morais et al., 2014, Mulakkal et al., 2014, Navarro et al., 2014, Sopko et al., 2014, Costa et al., 2013, Yacobi-Sharon et al., 2013, Zhang et al., 2013, Fabian and Brill, 2012, Immonen and Ritchie, 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Pezzulo et al., 2012, Todd and Staveley, 2012, Abdelwahid et al., 2011, Fernandes and Rao, 2011, Liu et al., 2011, Tain et al., 2009, Todd and Staveley, 2008, Yang et al., 2008, Budde, 2006, Yang et al., 2006)
dPINK1
(Dinh et al., 2021, Wu et al., 2018, Gehrke et al., 2015, Min et al., 2015, Shiba-Fukushima et al., 2014, Lee et al., 2013, Song et al., 2013, Huang et al., 2012, Ishida et al., 2012, Liu et al., 2012, Woodroof et al., 2011, Imai et al., 2010, Bier, 2006, Clark et al., 2006, Wang et al., 2006)
dPINk1
(Choo et al., 2012)
dPink1
(Min et al., 2015, Yang et al., 2008, Yang et al., 2008)
pink1
(Han et al., 2021, Si et al., 2019, Zhang et al., 2019, Shin et al., 2018, Basil et al., 2017, Celardo et al., 2017, Koehler et al., 2017, Lehmann et al., 2017, Napoletano et al., 2017, Celardo et al., 2016, Huang et al., 2016, Spinazzi and De Strooper, 2016, Zhuang et al., 2016, Gao et al., 2015, Lepesant, 2015, Malik et al., 2015, Mensah et al., 2015, Vanhauwaert and Verstreken, 2015, Zhu et al., 2015, Bingol et al., 2014, Pogson et al., 2014, Tufi et al., 2014, Wu et al., 2014, Chan and McQuibban, 2013, Debattisti and Scorrano, 2013, de Castro et al., 2013, Esposito et al., 2013, Frank et al., 2013, Ruan et al., 2013, Vos et al., 2013, Yacobi-Sharon et al., 2013, Fabian and Brill, 2012, Pimenta de Castro et al., 2012, Schmidt et al., 2012, Vilain et al., 2012, Vos et al., 2012, Rival et al., 2011, Rival et al., 2011, Truscott et al., 2011, Hao et al., 2010, Lorbeck et al., 2010, Morais et al., 2009, Deng et al., 2008, Dodson et al., 2008, Whitworth et al., 2008, Whitworth et al., 2008, Yun et al., 2008, Guo et al., 2007, Korey, 2007, Clark et al., 2006)
Name Synonyms
PINK1
(van der Merwe et al., 2015)
PTEN induced putative kinase 1
(Todd and Staveley, 2007)
PTEN-Induced Kinase 1
(Bier, 2006)
PTEN-induced Putative Kinase 1
(Song et al., 2013)
PTEN-induced kinase 1
(Owusu-Ansah et al., 2013)
PTEN-induced putative kinase 1
(Khalil et al., 2015, Mensah et al., 2015, Chan and McQuibban, 2013, Kim et al., 2013, Kim et al., 2008, Park et al., 2006)
Pink1
(Clark, 2006.2.28)
Pten-induced kinase 1(PINK1)
(Lu and Guo, 2020)
phosphatase and tensin homolog-induced putative kinase 1
(Vincow et al., 2013)
pink
(Xu et al., 2016)
Secondary FlyBase IDs
  • FBgn0046284
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (286)