promotes mitochondrial fragmentation by targeting core components of the mitochondrial morphogenesis machinery for ubiquitination - negatively regulates mitochondrial fusion - a fruitfly model for Parkinson's disease
Gene model reviewed during 5.52
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pink1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pink1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutants are viable but sterile. Mutant spermatids form abnormal Nebenkerns and mitochondrial derivatives and subsequently fail to individualize the 64-cell cyst into discrete sperm. Mutants show increased sensitivity to paraquat and hyperoxia and have heldup wings due to degeneration of indirect flight muscle.
Mutants show a number of degenerative phenotypes which are due to mitochondrial dysfunction.
Pink1 plays an important role in regulating energy metabolism and exerts an impact on lifespan.
Pink1 plays a critical role in promoting dopaminergic neuronal function and survival.
Pink1 mutants exhibit age-dependent muscle degeneration characterised by extensive DNA fragmentation, probably indicative of cell death.
Pink1 is required for maintaining proper mitochondria morphology and the integrity of suets of muscle cells and dopaminergic neurons.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.