FlyBase Gene Report: Dmel\Pink1

General Information

Symbol

Dmel\Pink1

Species

D. melanogaster

Name

PTEN-induced putative kinase 1

Annotation Symbol

CG4523

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029891

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dPINK1, Pink

Key Links

Genomic Location

Cytogenetic map

6C6-6C6

Sequence location

X:6,683,798..6,687,302 [+]

Recombination map

1-18

RefSeq locus

NC_004354 REGION:6683798..6687302

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (40 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables ATP-dependent protein binding

inferred from physical interaction with FLYBASE:Mitofilin; FB:FBgn0019960

(Tsai et al., 2018)

enables protein binding

inferred from physical interaction with FLYBASE:Pgam5; FB:FBgn0023517

(Imai et al., 2010)

inferred from physical interaction with FLYBASE:rho-7; FB:FBgn0033672

(Whitworth et al., 2008)

inferred from physical interaction with FLYBASE:Mitofilin; FB:FBgn0019960

(Tsai et al., 2018)

enables protein kinase activity

inferred from direct assay

(Woodroof et al., 2011)

inferred from mutant phenotype

(assigned by UniProt )

(Shiba-Fukushima et al., 2017)

enables protein serine/threonine kinase activity

inferred from direct assay

(assigned by UniProt )

(Pirooznia et al., 2020, Course et al., 2018)

inferred from direct assay

(Tsai et al., 2018, Shiba-Fukushima et al., 2014)

inferred from mutant phenotype

(assigned by UniProt )

(Zhuang et al., 2016)

inferred from mutant phenotype

(Zhang et al., 2019)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables protein kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000540563

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001121970

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (30 terms)

Terms Based on Experimental Evidence (29 terms)

CV Term

Evidence

References

involved_in autophagy of mitochondrion

inferred from mutant phenotype

(Ziviani et al., 2010)

involved_in compound eye development

inferred from mutant phenotype

(Wang et al., 2006)

involved_in ectopic germ cell programmed cell death

inferred from mutant phenotype

(Yacobi-Sharon et al., 2013)

involved_in establishment of mitochondrion localization

inferred from mutant phenotype

(Liu et al., 2012)

involved_in establishment of protein localization to mitochondrion

inferred from mutant phenotype

(assigned by UniProt )

(Zhuang et al., 2016)

involved_in intracellular distribution of mitochondria

inferred from mutant phenotype

(assigned by CACAO )

(Liu et al., 2012)

involved_in medium-term memory

inferred from mutant phenotype

(assigned by UniProt )

(Julienne et al., 2017)

involved_in mitochondrial fission

inferred from genetic interaction with FLYBASE:Drp1; FB:FBgn0026479

(Poole et al., 2008, Yang et al., 2008)

inferred from genetic interaction with FLYBASE:Marf; FB:FBgn0029870

(Poole et al., 2008)

inferred from genetic interaction with FLYBASE:Opa1; FB:FBgn0261276

(Poole et al., 2008, Yang et al., 2008)

acts_upstream_of mitochondrion inheritance

inferred from mutant phenotype

(Zhang et al., 2019)

involved_in mitochondrion organization

inferred from mutant phenotype

(Tsai et al., 2018, Shiba-Fukushima et al., 2014, Poole et al., 2008, Yang et al., 2008, Clark et al., 2006, Park et al., 2006)

inferred from direct assay

(Yang et al., 2006)

inferred from genetic interaction with FLYBASE:Buffy; FB:FBgn0040491

(Park et al., 2006)

involved_in mitochondrion transport along microtubule

inferred from mutant phenotype

(assigned by CACAO )

(Liu et al., 2012)

involved_in negative regulation of cytoplasmic translation

inferred from mutant phenotype

(Zhang et al., 2019)

involved_in negative regulation of mitochondrial fusion

inferred from mutant phenotype

(Ziviani et al., 2010)

inferred from genetic interaction with FLYBASE:fzo; FB:FBgn0011596

(Deng et al., 2008)

involved_in negative regulation of neuron apoptotic process

inferred from direct assay

(Yang et al., 2006)

involved_in negative regulation of programmed cell death

inferred from mutant phenotype

(Wang et al., 2006)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Morais et al., 2009)

involved_in peptidyl-serine autophosphorylation

inferred from mutant phenotype

(assigned by UniProt )

(Zhuang et al., 2016)

involved_in positive regulation of autophagy of mitochondrion

inferred from mutant phenotype

(assigned by UniProt )

(Zhuang et al., 2016)

inferred from genetic interaction with UniProtKB:Q7KTX7

(assigned by UniProt )

(Zhuang et al., 2016)

involved_in positive regulation of compound eye pigmentation

inferred from mutant phenotype

(assigned by BHF-UCL )

(Venderova et al., 2009)

involved_in positive regulation of locomotor rhythm

inferred from mutant phenotype

(assigned by UniProt )

(Julienne et al., 2017)

involved_in positive regulation of mitochondrial fission

inferred from mutant phenotype

(Ziviani et al., 2010, Deng et al., 2008)

involved_in positive regulation of neuronal action potential

inferred from mutant phenotype

(assigned by UniProt )

(Julienne et al., 2017)

involved_in protein phosphorylation

inferred from mutant phenotype

(assigned by UniProt )

(Zhuang et al., 2016)

inferred from direct assay

(Shiba-Fukushima et al., 2014)

involved_in regulation of mitochondrial electron transport, NADH to ubiquinone

inferred from genetic interaction with FLYBASE:no biological data available-42; FB:FBgn0019957

(Morais et al., 2014, Pogson et al., 2014)

involved_in regulation of mitochondrion organization

inferred from mutant phenotype

(Lutz et al., 2009)

involved_in response to oxidative stress

inferred from mutant phenotype

(Wang et al., 2006)

involved_in short-term memory

inferred from mutant phenotype

(assigned by UniProt )

(Julienne et al., 2017)

involved_in sperm mitochondrion organization

inferred from mutant phenotype

(Deng et al., 2008, Clark et al., 2006, Park et al., 2006)

involved_in ubiquitin-dependent protein catabolic process

inferred from mutant phenotype

(Ziviani et al., 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in autophagy of mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN001121970

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of mitochondrial fission

inferred from biological aspect of ancestor with PANTHER:PTN001121970

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000540563

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN001121970

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Whitworth et al., 2008)

located_in cytosol

inferred from direct assay

(Tsai et al., 2018)

is_active_in extrinsic component of mitochondrial outer membrane

inferred from direct assay

(Zhang et al., 2019)

located_in mitochondrion

inferred from direct assay

(Tsai et al., 2018, Whitworth et al., 2008)

located_in Nebenkern

inferred from direct assay

(Clark et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN001121970

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q0KHV6)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -: The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.

Protein Function (UniProtKB)

Acts as a serine/threonine-protein kinase (PubMed:16672980, PubMed:18799731, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Exhibits a substrate preference for proline at position P+1 and a general preference at several residues for basic residues such as arginine (By similarity). Also exhibits moderate preferences for a phosphotyrosine at position P-3 and a tryptophan at P-5 (By similarity). Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as park and likely Drp1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:16672980, PubMed:18799731, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:23509287, PubMed:24901221, PubMed:25474007). Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18443288, PubMed:18799731, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:32138754). Mediates the translocation and activation of park at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:24901221, PubMed:20194754, PubMed:18957282, PubMed:18799731, PubMed:25474007, PubMed:27906179). At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains, the Pink1-phosphorylated polyubiquitin then recruits park from the cytosol to the OMM where park is fully activated by phosphorylation at 'Ser-94' by Pink1 (PubMed:24901221, PubMed:20194754, PubMed:18957282, PubMed:18799731, PubMed:25474007, PubMed:27906179). When cellular stress results in irreversible mitochondrial damage, functions with park to promote the clearance of dysfunctional and/or depolarized mitochondria by selective autophagy (mitophagy) (PubMed:16672980, PubMed:16672981, PubMed:20194754, PubMed:18957282, PubMed:23509287, PubMed:25474007). The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria, by phosphorylating and thus promoting the park-dependent degradation of proteins involved in mitochondrial fusion/fission such as Marf, Opa1 and fzo (PubMed:18443288, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:24901221). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:18799731, PubMed:18230723, PubMed:20194754, PubMed:24901221). Also likely to promote mitochondrial fission independently of park and Atg7-mediated mitophagy, via the phosphorylation and activation of Drp1 (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (PubMed:22396657). The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (PubMed:16672980, PubMed:23509287, PubMed:30772175). Involved in mitochondrial biogenesis by promoting the park-dependent ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (PubMed:32138754). Functions with park to promote localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (PubMed:23509287). During oogenesis, phosphorylates and inactivates larp on the membrane of defective mitochondria, thus impairing local translation and mtDNA replication and consequently, reducing transmission of deleterious mtDNA mutations to the mature oocyte (PubMed:30772175).

(UniProt, Q0KHV6)

Summary (Interactive Fly)

promotes mitochondrial fragmentation by targeting core components of the mitochondrial morphogenesis machinery for ubiquitination - negatively regulates mitochondrial fusion - a fruitfly model for Parkinson's disease

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pink1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0KHV6)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pink1-RA

FBtr0070956

NM_132112

2859

721

Pink1-RB

FBtr0070957

NM_167083

2779

721

Pink1-RC

FBtr0100413

NM_001031883

2865

721

Pink1-RD

FBtr0100414

NM_001031882

2773

721

Pink1-RE

FBtr0100415

NM_001031881

2864

721

Pink1-RF

FBtr0100416

NM_001031880

3158

721

Pink1-RG

FBtr0100419

NM_001031879

2921

721

Pink1-RH

FBtr0100420

NM_001031878

2894

721

Pink1-RI

FBtr0345295

NM_001298023

2411

721

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Pink1-PA

FBpp0070917

80.2

721

8.18

NP_572340

AAN09178

Pink1-PB

FBpp0070918

80.2

721

8.18

NP_727110

AAF46188

Pink1-PC

FBpp0099830

80.2

721

8.18

NP_001027054

AAZ52497

Pink1-PD

FBpp0099831

80.2

721

8.18

NP_001027053

AAZ52498

Pink1-PE

FBpp0099832

80.2

721

8.18

NP_001027052

AAZ52499

Pink1-PF

FBpp0099833

80.2

721

8.18

NP_001027051

AAZ52500

Pink1-PG

FBpp0099835

80.2

721

8.18

NP_001027050

AAZ52501

Pink1-PH

FBpp0099837

80.2

721

8.18

NP_001027049

AAZ52502

Pink1-PI

FBpp0311462

80.2

721

8.18

NP_001284952

AHN59423

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

721 aa isoforms: Pink1-PA, Pink1-PB, Pink1-PC, Pink1-PD, Pink1-PE, Pink1-PF, Pink1-PG, Pink1-PH, Pink1-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with park (PubMed:19048081). Interacts with rho-7 and HtrA2 (PubMed:19048081).

(UniProt, Q0KHV6)

Post Translational Modification

Proteolytically cleaved (PubMed:19048081). In healthy cells, the precursor is continuously imported into mitochondria where it is proteolytically cleaved into its short form by the mitochondrial rhomboid protease rho-7 (PubMed:19048081). The short form is then released into the cytosol where it rapidly undergoes proteasome-dependent degradation (Probable). In unhealthy cells, when cellular stress conditions lead to the loss of mitochondrial membrane potential, mitochondrial import is impaired leading to the precursor accumulating on the outer mitochondrial membrane (OMM) (PubMed:27906179).

Autophosphorylated on Ser-346, which activates kinase activity (PubMed:25474007, PubMed:27906179). Loss of mitochondrial membrane potential results in the precursor accumulating on the outer mitochondrial membrane (OMM) where it is activated by autophosphorylation at Ser-346 (PubMed:27906179). Autophosphorylation is sufficient and essential for selective recruitment of park to depolarized mitochondria, likely via Pink1-dependent phosphorylation of polyubiquitin chains (PubMed:25474007, PubMed:27906179).

(UniProt, Q0KHV6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q0KHV6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pink1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Whitworth et al., 2008)

located_in cytosol

inferred from direct assay

(Tsai et al., 2018)

is_active_in extrinsic component of mitochondrial outer membrane

inferred from direct assay

(Zhang et al., 2019)

located_in mitochondrion

inferred from direct assay

(Tsai et al., 2018, Whitworth et al., 2008)

located_in Nebenkern

inferred from direct assay

(Clark et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pink1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pink1

View exonic expression by tissue for Dmel\Pink1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029891

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31607/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029891

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029891

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029891

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4523

Flygut - An atlas of the Drosophila adult midgut

FBgn0029891

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 46 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pink1

Transgenic constructs containing regulatory region of Pink1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)Pink1⁹

(Clark et al., 2006)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

lethal, with Scer\GAL4^Mef2.PR

lethal - all die before end of second instar larval stage, with Scer\GAL4^da.G32

Pink1^{dsRNA.UAS.cWa}

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pink1^GD11336

viable, with Scer\GAL4^da.PU

Pink1^UAS.cUa

viable, with Scer\GAL4^elav.PU

Pink1^UAS.Tag:HA

viable, with Scer\GAL4^pnr-MD237

Pink1^GD11336

viable, with Scer\GAL4^tin.CΔ4

Pink1^GD11336

Sterility

Allele

female semi-sterile

Pink1^unspecified

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Pink1^GL00164

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

Pink1^G900

male semi-sterile, with Scer\GAL4^Tub.PU

male sterile

sterile

Pink1⁵

Other Phenotypes

Allele

abnormal cell size | prepupal stage | somatic clone, with Scer\GAL4^Act.PU

Pink1^JF01672

abnormal flight

abnormal flight, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

abnormal flight | progressive

Pink1^B9

abnormal flight | recessive

Pink1^B9

abnormal heat stress response

Pink1^B9

abnormal jumping

Pink1^B9

abnormal jumping, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

abnormal locomotor behavior

Pink1^B9

abnormal locomotor behavior, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

abnormal locomotor behavior | adult stage

Pink1^B9

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ddc.PL

Pink1^dsRNA.UAS

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

Pink1^HMC04160

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

abnormal locomotor behavior | adult stage, with Scer\GAL4^{αTub84B.Switch.PK}

Pink1^HMC04160

abnormal locomotor behavior | adult stage | progressive

Pink1^B9

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^DJ667

Pink1^HMS02204

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^ple.PF

Pink1^HMS01707

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^ple.PU

Pink1^JF01203

abnormal locomotor behavior | adult stage | recessive

Pink1^B9

abnormal locomotor behavior | larval stage

Pink1⁵

abnormal locomotor behavior | progressive

Pink1^B9

abnormal locomotor rhythm | adult stage

Pink1^B9

abnormal locomotor rhythm | adult stage | adult stage, with Scer\GAL4^tim.PE

Pink1^dsRNA.UAS

abnormal memory | adult stage

Pink1^B9

abnormal neuroanatomy

Pink1^B9

abnormal neuroanatomy, with Scer\GAL4^Ddc.PL

Pink1^{dsRNA.UAS.cWa}

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

Pink1^{dsRNA.UAS.cWa}

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

abnormal neuroanatomy, with Scer\GAL4^ple.PF

Pink1^dsRNA.UAS

abnormal neuroanatomy | adult stage

Pink1^B9

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PLu

Pink1^HMC04160

abnormal neuroanatomy | adult stage, with Scer\GAL4^VGlut-OK371

Pink1^UAS.cUa

abnormal neuroanatomy | adult stage | dominant

Pink1⁵

abnormal neuroanatomy | adult stage | progressive

Pink1^B9

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^ple.PF

Pink1^HMS01707

abnormal neuroanatomy | progressive

Pink1⁵

abnormal neurophysiology

Pink1^B9

abnormal neurophysiology | adult stage

Pink1^B9

abnormal neurophysiology | third instar larval stage

Pink1^B9

abnormal osmotic stress response

Pink1⁵

abnormal oxidative stress response | adult stage | chemical conditional

Pink1^B9

abnormal size | adult stage

Pink1^B9

abnormal size | adult stage, with Scer\GAL4^Mef2.PR

Pink1^UAS.cCa

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

Pink1^JF01672

abnormal smell perception

Pink1^B9

abnormal smell perception | adult stage

Pink1^B9

abnormal visual perception

chemical sensitive

Pink1⁵

decreased cell number

Pink1^B9

decreased cell number | adult stage

Pink1^B9

decreased cell number | adult stage, with Scer\GAL4^elav.PLu

Pink1^HMC04160

decreased cell number | adult stage | progressive, with Scer\GAL4^ple.PF

Pink1^HMS01707

flightless

Pink1^B9

flightless, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

flightless | adult stage

Pink1^B9

hyperplasia | adult stage

Pink1^B9

increased cell death

increased cell death, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

increased cell death, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

increased cell death | adult stage

Pink1^B9

increased cell size, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

increased mortality | chemical conditional

Pink1^B9

increased size | adult stage

Pink1^B9

majority die during embryonic stage | maternal effect, with Scer\GAL4^nos.PU

Pink1^{UASp.GFP,Tag:Mito(Tom20)}

short lived

Pink1^B9

short lived, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

short lived, with Scer\GAL4^Ddc.PL

Pink1^dsRNA.UAS

short lived, with Scer\GAL4^elav.PLu

Pink1^HMC04160

short lived, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

short lived, with Scer\GAL4^Tub.PU

Pink1^VDRC.cUa

short lived, with Scer\GAL4^{αTub84B.Switch.PK}

Pink1^HMC04160

some die during second instar larval stage, with Scer\GAL4^da.G32

Pink1^{dsRNA.UAS.cWa}

visible

visible, with Scer\GAL4^elav.PLu

Pink1^{dsRNA.UAS.cWa}

visible, with Scer\GAL4^elav-C155

Pink1^GD11336

visible, with Scer\GAL4^ey.PH

Pink1^UAS.Tag:HA

visible, with Scer\GAL4^ey.PU

Pink1^UAS.Tag:HA

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^GMR.PU

Pink1^UAS.Tag:HA

visible, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

visible, with Scer\GAL4^Tub.PU

Pink1^VDRC.cUa

visible | adult stage

Pink1^B9

visible | adult stage, with Scer\GAL4^GMR.PF

visible | adult stage, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

visible | adult stage, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

visible | adult stage | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

Pink1^HMC04160

visible | progressive

Pink1^B9

visible | recessive

Pink1^B9

Phenotype manifest in

Allele

adult antennal lobe

Pink1^B9

adult brain

Pink1^B9

adult external thorax

Pink1^B9

adult somatic muscle cell

Pink1^B9

adult somatic muscle cell, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

adult thorax

Pink1^B9

adult thorax | dorsal

Pink1⁵

adult ventral nerve cord

Pink1^B9

adult visceral muscle cell, with Scer\GAL4^{αTub84B.Switch.PK}

Pink1^HMC04160

autophagosome | prepupal stage | somatic clone, with Scer\GAL4^Act.PU

Pink1^JF01672

axon | adult stage

Pink1⁵

axon | adult stage, with Scer\GAL4^VGlut-OK371

Pink1^UAS.cUa

axon | third instar larval stage

Pink1⁵

bouton

Pink1^B9

cytoskeleton of presynaptic active zone

Pink1^B9

dendrite | third instar larval stage

Pink1⁵

dendritic arborizing neuron

Pink1^B9

depressor muscle cell, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

dopamine neuron & adult brain

Pink1^B9

dopamine neuron & adult brain, with Scer\GAL4^Ddc.PL

Pink1^{dsRNA.UAS.cWa}

dopamine neuron & adult brain, with Scer\GAL4^elav.PLu

Pink1^{dsRNA.UAS.cWa}

dopaminergic neuron

Pink1^B9

dopaminergic neuron, with Scer\GAL4^ple.PF

Pink1^dsRNA.UAS

dopaminergic neuron | adult stage

Pink1^B9

dopaminergic neuron | adult stage | decreased number, with Scer\GAL4^ple.PF

Pink1^HMS01707

dopaminergic neuron | progressive

Pink1⁵

dopaminergic PPL1 neuron

dopaminergic PPL1 neuron | adult stage

Pink1^B9

dopaminergic PPL1 neuron | decreased number

Pink1^B9

dopaminergic PPL1 neuron | decreased number, with Scer\GAL4^elav.PLu

Pink1^HMC04160

dopaminergic PPL1 neuron | progressive

Pink1^B9

dopaminergic PPM1 neuron

Pink1^B9

dopaminergic PPM1 neuron | decreased number

Pink1^B9

dopaminergic PPM2 neuron

Pink1^B9

dopaminergic PPM2 neuron | adult stage

Pink1^B9

dopaminergic PPM2 neuron | decreased number

Pink1^B9

dorsal medial indirect flight muscle cell | adult stage

Pink1^B9

dorsal mesothorax

Pink1^B9

dorso-lateral dopaminergic neuron

Pink1^B9

egg | maternal effect

Pink1^B9

egg | maternal effect, with Scer\GAL4^nos.PU

Pink1^{UASp.GFP,Tag:Mito(Tom20)}

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

Pink1^JF01672

embryonic/larval hypocerebral ganglion | embryonic stage

Pink1⁵

embryonic/larval hypodermal muscle cell | third instar larval stage

embryonic/larval motor neuron | larval stage, with Scer\GAL4^ple.PF

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^ple.PF

embryonic/larval neuromuscular junction | third instar larval stage

embryonic/larval somatic muscle cell, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

embryonic/larval somatic muscle cell | third instar larval stage

Pink1^B9

embryonic frontal ganglion

Pink1⁵

endoplasmic reticulum | adult stage

Pink1^B9

enterocyte | prepupal stage | somatic clone

Pink1^B9

enterocyte | prepupal stage | somatic clone, with Scer\GAL4^Act.PU

eye, with Scer\GAL4^elav.PLu

Pink1^{dsRNA.UAS.cWa}

eye, with Scer\GAL4^ey.PH

Pink1^UAS.Tag:HA

eye, with Scer\GAL4^ey.PU

Pink1^UAS.Tag:HA

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

Pink1^UAS.Tag:HA

eye | adult stage, with Scer\GAL4^GMR.PF

Pink1^UAS.Tag:HA

flight muscle cell

Pink1^B9

flight muscle cell, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

flight muscle cell | adult stage

Pink1^B9

indirect flight muscle cell

indirect flight muscle cell, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

indirect flight muscle cell, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

indirect flight muscle cell, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

indirect flight muscle cell | adult stage

Pink1^B9

indirect flight muscle cell | progressive

Pink1⁵

interommatidial bristle, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

intestinal stem cell | late third instar larval stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

intestinal stem cell | prepupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

intestinal stem cell | pupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

larval ventral nerve cord | third instar larval stage

Pink1⁵

l-LNv neuron | adult stage

Pink1^B9

lysosome | adult stage | increased number, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

midgut | late third instar larval stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

midgut | prepupal stage | somatic clone

Pink1^B9

midgut | prepupal stage | somatic clone, with Scer\GAL4^Act.PU

midgut | prepupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

midgut | pupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

minor mitochondrial derivative

Pink1⁵

mitochondrial crista

mitochondrial crista, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

mitochondrial crista, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

mitochondrial crista & indirect flight muscle

mitochondrial crista | adult stage

Pink1^B9

mitochondrial crista | adult stage | progressive

Pink1⁵

mitochondrial crista | adult stage | progressive, with Scer\GAL4^Mef2.PR

Pink1^UAS.cCa

mitochondrial crista | third instar larval stage

mitochondrial crista junction | third instar larval stage

Pink1⁵

mitochondrial derivative

Pink1⁵

mitochondrial inner membrane & indirect flight muscle

Pink1^B9

mitochondrial membrane | adult stage

Pink1^B9

mitochondrial outer membrane

Pink1^B9

mitochondrial outer membrane & indirect flight muscle

Pink1^B9

mitochondrion

mitochondrion, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

mitochondrion, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

mitochondrion, with Scer\GAL4^nos.PU

Pink1^{UASp.GFP,Tag:Mito(Tom20)}

mitochondrion (with Df(1)BSC535)

Pink1^B9

mitochondrion & dopamine neuron & adult brain

Pink1^B9

mitochondrion & dopaminergic neuron

Pink1^B9

mitochondrion & dorso-lateral dopaminergic neuron

Pink1^B9

mitochondrion & dorso-lateral dopaminergic neuron, with Scer\GAL4^ple.PF

mitochondrion & indirect flight muscle

Pink1^B9

mitochondrion | adult stage

mitochondrion | adult stage, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

mitochondrion | adult stage, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

mitochondrion | adult stage, with Scer\GAL4^ple.PF

Pink1^HMS01707

mitochondrion | adult stage, with Scer\GAL4^VGlut-OK371

Pink1^UAS.cUa

mitochondrion | adult stage | progressive

Pink1⁵

mitochondrion | adult stage | progressive, with Scer\GAL4^Mef2.PR

Pink1^UAS.cCa

mitochondrion | larval stage, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

mitochondrion | larval stage, with Scer\GAL4^ple.PF

mitochondrion | late third instar larval stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

mitochondrion | prepupal stage | somatic clone

Pink1^B9

mitochondrion | prepupal stage | somatic clone, with Scer\GAL4^Act.PU

mitochondrion | prepupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

mitochondrion | pupal stage | somatic clone, with Scer\GAL4^esg.PU

Pink1^UAS.cCa

mitochondrion | third instar larval stage

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

Pink1^JF01672

muscle cell | adult stage

Pink1^B9

myofibril, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

myofibril, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

myofibril & indirect flight muscle

Nebenkern

Nebenkern derivative

Pink1^unspecified

neuron

Pink1^B9

neuropil | adult stage

Pink1^B9

NMJ bouton

Pink1^B9

ommatidium, with Scer\GAL4^elav.PLu

Pink1^{dsRNA.UAS.cWa}

ommatidium, with Scer\GAL4^ey.PU

Pink1^UAS.Tag:HA

ommatidium, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

ommatidium | adult stage, with Scer\GAL4^GMR.PF

Pink1^UAS.Tag:HA

ovary, with Scer\GAL4^nos.PU

Pink1^{UASp.GFP,Tag:Mito(Tom20)}

ovary (with Df(1)BSC535)

Pink1^B9

paraesophageal ganglion | embryonic stage

Pink1⁵

photoreceptor & neuron, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

pigment cell, with Scer\GAL4^GMR.PF

Pink1^{dsRNA.UAS.cWa}

rhabdomere | adult stage, with Scer\GAL4^GMR.PF

Pink1^HMS01707

somatic muscle cell of thorax

Pink1^B9

somatic muscle cell of thorax | progressive, with Scer\GAL4^Mef2.PR

Pink1^UAS.cCa

spermatid

spermatid cyst

Pink1^unspecified

spermatozoon

Pink1^B9

synapse | third instar larval stage

Pink1⁵

synaptic vesicle

Pink1^B9

testis | adult stage

Pink1^B9

thorax

Pink1^B9

wing

wing, with Scer\GAL4^da.G32

Pink1^dsRNA.UAS

wing, with Scer\GAL4^elav-C155

Pink1^GD11336

wing, with Scer\GAL4^Mef2.PR

Pink1^HMC04160

wing, with Scer\GAL4^Mhc.PW

Pink1^dsRNA.UAS

wing, with Scer\GAL4^Tub.PU

Pink1^VDRC.cUa

wing | adult stage

Pink1^B9

wing | adult stage, with Scer\GAL4^Mhc.PU

Pink1^dsRNA.UAS

wing | progressive

Pink1^B9

wing | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

Pink1^HMC04160

wing blade

Pink1^B9

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PINK1

10 of 15

Yes

Hsap\MIR6084

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pink1

10 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Pink1

5 of 13

Yes

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (1)

Drer\pink1

9 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\pink-1

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\CPK25

1 of 9

Yes

Atha\MAPKKK9

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Parkinson disease 6, early-onset

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 12 )

Allele

Disease

Evidence

References

Pink1^JF01203

model of Parkinson's disease 6

CEA

(Dinh et al., 2021)

Pink1^JF01672

model of Parkinson's disease 6

CEA

(Zhou et al., 2019, Valadas et al., 2018)

Pink1^{dsRNA.UAS.cPa}

model of Parkinson's disease 6

CEC

(Kim et al., 2019)

Pink1^B9

model of Parkinson's disease

model of testicular cancer

CEA

(Napoletano et al., 2017)

DOES NOT model Parkinson's disease

CEA with Vps35^MH20

(Malik et al., 2015)

CEA with Vps35^E42

(Malik et al., 2015)

model of early-onset Parkinson's disease

CEA

(West et al., 2015)

model of Parkinson's disease 2

CEC

(Basil et al., 2017)

model of Parkinson's disease 6

Pink1^UAS.Tag:HA

model of Parkinson's disease 6

CEA

(Min et al., 2015)

Pink1⁵

model of early-onset Parkinson's disease

CEA

(West et al., 2015)

model of Hirschsprung's disease

CEA

(Myers et al., 2018)

model of Parkinson's disease 6

CEA

(Zhang et al., 2017, Tsai et al., 2014)

Pink1^UAS.cCa

model of Parkinson's disease 6

CEA

(Kandul et al., 2016)

Pink1^{dsRNA.UAS.cWa}

model of Parkinson's disease

CEA

(Wang et al., 2006)

Pink1^HMC04160

model of Parkinson's disease 6

CEA

(Gumeni et al., 2021)

Pink1^dsRNA.UAS

model of Parkinson's disease

CEA

(M'Angale and Staveley, 2017, Yang et al., 2006)

model of Parkinson's disease 6

CEA

(Shiba-Fukushima et al., 2020, Wan et al., 2020, Doktór et al., 2018, Liu and Lu, 2010)

Pink1^HMS01707

model of Parkinson's disease 6

CEA

(Liu et al., 2020)

Pink1^VDRC.cUa

model of Parkinson's disease

CEA

(Fernandes and Rao, 2011)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PINK1; PTEN induced kinase 1

model of Parkinson's disease 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 17 )

Allele

Disease

Interaction

References

Pink1^B9

model of Parkinson's disease

is ameliorated by mask^EY13048

(Zhu et al., 2015)

is ameliorated by mask^HMS01045

(Zhu et al., 2015)

is ameliorated by mask^KK100529

(Zhu et al., 2015)

is ameliorated by mask^10.22

(Zhu et al., 2015)

is ameliorated by Hsap\BNIP3L^UAS.cGa

(Gao et al., 2015)

is exacerbated by Shmt^GD8851

(Celardo et al., 2017)

is ameliorated by Shmt^UAS.Tag:HA

(Celardo et al., 2017)

is exacerbated by Nmdmc^KK102478

(Celardo et al., 2017)

is ameliorated by Nmdmc^UAS.Tag:HA

(Celardo et al., 2017)

is exacerbated by crc^KK111018

(Celardo et al., 2017)

is ameliorated by Lrrk^e03680

(Tain et al., 2009)

is ameliorated by Thor^UAS.cMa

(Koh et al., 2012, Tain et al., 2009)

is ameliorated by Parp^CH1

(Lehmann et al., 2017)

is ameliorated by Usp30^NIG.3016R

(Bingol et al., 2014)

is ameliorated by STUB1^UAS.cCa

(Chen et al., 2017)

is ameliorated by park^UAS.cGa

(Pogson et al., 2014, Hao et al., 2010, Poole et al., 2008)

is ameliorated by Drp1^{Tag:FLAG,Tag:CALI(TC),Tag:HA}

(Poole et al., 2008)

is ameliorated by Opa1^s3475

(Poole et al., 2008)

is ameliorated by Drp1^+t9.4

(Liu et al., 2011, Poole et al., 2008)

is ameliorated by Opa1^f02779

(Poole et al., 2008)

is ameliorated by mAcon1^MB09176

(Esposito et al., 2013)

is ameliorated by mAcon1¹

(Esposito et al., 2013)

is ameliorated by GstO2^A.UAS

(Kim and Yim, 2013)

is ameliorated by park^UAS.Tag:MYC

(Park et al., 2006)

is ameliorated by Ucp4A^UAS.cWa

(Wu et al., 2014)

is ameliorated by dj-1β^UAS.cMa

(Hao et al., 2010)

is ameliorated by dj-1β^C45A.UAS

(Hao et al., 2010)

is ameliorated by DJ-1α^UAS.cUa

(Hao et al., 2010)

is ameliorated by Pink1^UAS.cUa

(Hao et al., 2010)

is ameliorated by Hsap\PARK7^UAS.cMa

(Hao et al., 2010)

is ameliorated by Miro^KK102189

(Liu et al., 2012)

is exacerbated by Miro^UAS.cGa

(Liu et al., 2012)

is ameliorated by Miro^JF02775

(Liu et al., 2012)

is ameliorated by milt^JF03022

(Liu et al., 2012)

is ameliorated by Khc^JF01939

(Liu et al., 2012)

is exacerbated by Khc^{248-2134.UAS.EGFP}

(Liu et al., 2012)

is ameliorated by Pink1^{S519A.GMR.Tag:Mito(Tom20),GFP}

(Zhuang et al., 2016)

is ameliorated by Pink1^{S346D.KD.GMR.Tag:Mito(Tom20),GFP}

(Zhuang et al., 2016)

is ameliorated by Pink1^{GMR.Tag:Mito(Tom20),GFP}

(Zhuang et al., 2016)

is ameliorated by Hsap\BNIP3^UAS.Tag:HA

(Zhang et al., 2016)

is ameliorated by Hsap\PINK1^{UAS.cTa.Tag:FLAG}

(Tsai et al., 2018)

is ameliorated by Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

(Tsai et al., 2018)

is ameliorated by Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

is ameliorated by Sirt1^EP2300

(Koh et al., 2012)

is ameliorated by Sod2^UAS.cUa

(Koh et al., 2012)

is ameliorated by foxo^UAS.cKd

(Koh et al., 2012)

is ameliorated by Sirt1^UAS.cGa

(Koh et al., 2012)

is ameliorated by clu^UASp.cSa

(Sen et al., 2015)

is ameliorated by Hsap\CLUH^UASp.cSa

(Sen et al., 2015)

is ameliorated by Trap1^D6

(Kim et al., 2016)

is ameliorated by Trap1^EY21851

(Kim et al., 2016)

is ameliorated by PEK^GD5584

(Celardo et al., 2016)

is ameliorated by Marf^KK105681

(Celardo et al., 2016)

is ameliorated by ND-42^UAS.Tag:HA

(Pogson et al., 2014)

is ameliorated by ND-42^UAS.cBa

(Pogson et al., 2014)

is ameliorated by ND-42^UAS.cMa

(Pogson et al., 2014)

is ameliorated by ND-42^SD.UAS

(Morais et al., 2014, Pogson et al., 2014)

is ameliorated by ND-42^SA.UAS

(Pogson et al., 2014)

is ameliorated by sicily^UAS.cZa

(Pogson et al., 2014)

is exacerbated by Drp1^KG03815

(Fernandes and Rao, 2011)

is exacerbated by heix^k11403

(Vos et al., 2012)

is exacerbated by heix¹

(Vos et al., 2012)

is exacerbated by heix^NP5301

(Vos et al., 2012)

is exacerbated by heix²

(Vos et al., 2012)

is ameliorated by Pgam5^NP0568

(Imai et al., 2010)

is ameliorated by Pgam5¹

(Imai et al., 2010)

is ameliorated by Scer\NDI1^UAS.cVa

(Vilain et al., 2012)

is ameliorated by Trap1^UAS.cCa

(Costa et al., 2013)

is ameliorated by Hsap\TRAP1^UAS.cBa

(Zhang et al., 2013)

is exacerbated by rictor^JF01370

(Wu et al., 2013)

is exacerbated by trc^{K122A+T453A.UAS.L}

(Wu et al., 2013)

is ameliorated by Sin1^UAS.Tag:FLAG

(Wu et al., 2013)

is ameliorated by trc^S292E.UAS.L

(Wu et al., 2013)

is ameliorated by rictor^UAS.cHa

(Wu et al., 2013)

is ameliorated by trc^L.UAS

(Wu et al., 2013)

is NOT ameliorated by Ret^MEN2B.UAS

(Klein et al., 2014)

is ameliorated by Ret^MEN2B.UAS

(Klein et al., 2014)

is NOT ameliorated by Ret^MEN2B.UAS

(Klein et al., 2014)

is ameliorated by Ret^MEN2B.UAS

(Klein et al., 2014)

is ameliorated by TER94^UAS.cRa

(Kim et al., 2013)

is ameliorated by dnk^UAS.cLa

(Tufi et al., 2014)

ameliorates chromosome 15q11.2 deletion syndrome

modeled by Cyfip^85.1

(Kanellopoulos et al., 2020)

model of Parkinson's disease 6

is ameliorated by PEK^EY09578

(Cui et al., 2020)

is exacerbated by DOR^KO

(Dinh et al., 2021)

is ameliorated by Usp8^KO

(von Stockum et al., 2019)

is ameliorated by Usp8^VDRC.cUa

(von Stockum et al., 2019)

is ameliorated by HtrA2^UASp.cTa

(Tain et al., 2009)

is ameliorated by Atg1^UAS.cSa

(Liu and Lu, 2010)

is ameliorated by Marf^{dsRNA.UAS.cUa}

(Liu and Lu, 2010)

is exacerbated by S6k^TE.UAS

(Liu and Lu, 2010)

is ameliorated by Thor^UAS.cMa

(Liu and Lu, 2010)

is ameliorated by park^UAS.Tag:HA

(Liu and Lu, 2010)

is ameliorated by Hsap\DNM1L^{S616D.UAS.Tag:MYC,Tag:polyHis}

(Han et al., 2020)

is ameliorated by Hsap\DNM1L^{UAS.Tag:MYC,Tag:polyHis}

(Han et al., 2020)

is ameliorated by Drp1^UAS.Tag:HA

(Terriente-Felix et al., 2020)

is ameliorated by fwd^UAS.GFP

(Terriente-Felix et al., 2020)

is ameliorated by AMPKα^TD.UAS

(Ham et al., 2021)

is ameliorated by CG5676^{UAS.ORF.GW.Tag:HA}

(Ham et al., 2021)

is ameliorated by Uch^C93S

(Ham et al., 2021)

is ameliorated by Uch^E8A

(Ham et al., 2021)

is ameliorated by Uch^GD11265

(Ham et al., 2021)

is ameliorated by Uch^KK101723

(Ham et al., 2021)

is ameliorated by Uch^KO

(Ham et al., 2021)

is ameliorated by Uch^V96M

(Ham et al., 2021)

is ameliorated by hiw^ΔN

(Loreto et al., 2020)

is ameliorated by Ret^{UAS.Tag:LOV(VfAU1)}

(Ingles-Prieto et al., 2021)

is ameliorated by porin^JF03251

(Lee et al., 2018)

is ameliorated by Itpr^JF01957

(Lee et al., 2018)

is ameliorated by MCU^HMS01927

(Lee et al., 2018)

is ameliorated by Miro^KK102189

(Lee et al., 2018)

is exacerbated by Miro^UAS.Tag:MYC

(Lee et al., 2018)

is ameliorated by Disc\RFP^{mRFP.Tag:Mito(mAkap1),Tag:ER(yUBC6)}

(Basso et al., 2018)

is exacerbated by Hsap\ZNF746^DM.UAS

(Pirooznia et al., 2020)

is ameliorated by Hsap\AFDN^UAS.cBa

(Basil et al., 2017)

Pink1^UAS.Tag:HA

ameliorates neurodegenerative disease

modeled by trp^P365

(Huang et al., 2016)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

DOES NOT ameliorate Huntington's disease

modeled by park¹, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

modeled by Marf^{miRNA.cUa.UAS}, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

modeled by porin^k05123, Hsap\HTT^Q93.ex1.UAS

(Khalil et al., 2015)

model of Parkinson's disease 6

is exacerbated by Tg^A.UAS

(Min et al., 2015)

is ameliorated by Tg^NIG.7356R

(Min et al., 2015)

ameliorates late onset Parkinson's disease

modeled by Hsap\ZNF746^DM.UAS

(Pirooznia et al., 2020)

Pink1⁵

model of Parkinson's disease 6

is ameliorated by TER94^UAS.cCa

(Zhang et al., 2017)

model of Parkinson's disease

is ameliorated by Mul1^UAS.cYa

(Yun et al., 2014)

Pink1^UAS.cCa

exacerbates neurodegenerative disease

modeled by Tom40^GD5210

(Liu et al., 2018)

Pink1^{dsRNA.UAS.cWa}

model of Parkinson's disease

is ameliorated by Hsap\SOD1^UAS.cPa

(Wang et al., 2006)

is ameliorated by APP-BP1^UAS.cKa

(Choo et al., 2012)

Pink1^UAS.cTa

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Todd and Staveley, 2008)

Pink1^GD11336

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis-2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Pink1^{GMR.Tag:Mito(Tom20),GFP}

ameliorates Parkinson's disease

modeled by Pink1^B9

(Zhuang et al., 2016)

Pink1^{S519A.GMR.Tag:Mito(Tom20),GFP}

ameliorates Parkinson's disease

modeled by Pink1^B9

(Zhuang et al., 2016)

Pink1^{S346D.KD.GMR.Tag:Mito(Tom20),GFP}

ameliorates Parkinson's disease

modeled by Pink1^B9

(Zhuang et al., 2016)

Pink1^HMC04160

model of Parkinson's disease 6

is ameliorated by cnc^UAS.cSa

(Gumeni et al., 2021)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis-2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Pink1^dsRNA.UAS

model of Parkinson's disease

is ameliorated by Hsap\PRKN^UAS.cYa

(Yang et al., 2006)

is ameliorated by Hsap\PINK1^UAS.cYa

(Yang et al., 2006)

is exacerbated by clu^GD13926

(Sen et al., 2015)

is exacerbated by clu^KK108024

(Sen et al., 2015)

is ameliorated by trc^short.UAS

(Wu et al., 2013)

is exacerbated by rictor^JF01370

(Wu et al., 2013)

is exacerbated by rictor^Δ2

(Wu et al., 2013)

is ameliorated by rictor^UAS.cHa

(Wu et al., 2013)

is exacerbated by trc^{K122A+T453A.UAS.L}

(Wu et al., 2013)

is ameliorated by trc^L.UAS

(Wu et al., 2013)

is ameliorated by trc^S292E.UAS.L

(Wu et al., 2013)

is exacerbated by Sin1^unspecified

(Wu et al., 2013)

is ameliorated by Sin1^UAS.Tag:FLAG

(Wu et al., 2013)

is exacerbated by rictor^JF01086

(Wu et al., 2013)

is exacerbated by trc^{K122A.UAS.L.Tag:FLAG}

(Wu et al., 2013)

is ameliorated by trc^T453E.UAS.L

(Wu et al., 2013)

is ameliorated by APP-BP1^UAS.cKa

(Choo et al., 2012)

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{WT.UAS.RFP(Unk),Tag:HA}

(Chen et al., 2016)

model of Parkinson's disease 6

is exacerbated by Atg1^K38Q.UAS

(Liu and Lu, 2010)

is ameliorated by Atg1^UAS.cSa

(Liu and Lu, 2010)

is exacerbated by Atg13^NIG.7331R

(Liu and Lu, 2010)

is exacerbated by Atg18a^VDRC.cUa

(Liu and Lu, 2010)

is exacerbated by Atg3^VDRC.cUa

(Liu and Lu, 2010)

is ameliorated by Cat^UAS.cUa

(Liu and Lu, 2010)

is ameliorated by GstS1^UAS.cUa

(Liu and Lu, 2010)

is ameliorated by Marf^{dsRNA.UAS.cUa}

(Liu and Lu, 2010)

is ameliorated by PHGPx^UAS.cUa

(Liu and Lu, 2010)

is ameliorated by RpS9^VDRC.cUa

(Liu and Lu, 2010)

is exacerbated by S6k^STDE.UAS

(Liu and Lu, 2010)

is exacerbated by S6k^STDETE.UAS

(Liu and Lu, 2010)

is exacerbated by S6k^TE.UAS

(Liu and Lu, 2010)

is exacerbated by S6k^UAS.cUa

(Liu and Lu, 2010)

is ameliorated by S6k^VDRC.cUa

(Liu and Lu, 2010)

is ameliorated by Sod1^UAS.cUa

(Liu and Lu, 2010)

is ameliorated by Thor^UAS.cMa

(Liu and Lu, 2010)

is ameliorated by Tor^{WT.UAS.Tag:FLAG}

(Liu and Lu, 2010)

is exacerbated by eIF4E1^UAS.cRa

(Liu and Lu, 2010)

is ameliorated by park^UAS.Tag:HA

(Liu and Lu, 2010)

is ameliorated by Fer3HCH^NIG.4349R

(Wan et al., 2020)

is exacerbated by mfrn^NIG.4963R

(Wan et al., 2020)

is ameliorated by mfrn^UAS.cWa

(Wan et al., 2020)

Pink1^UAS.cYa

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{P525L.UAS.RFP(Unk),Tag:HA}

(Chen et al., 2016)

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(Krzystek et al., 2021)

Pink1^KK101205

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis-2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Pink1^HMS01707

model of Parkinson's disease 6

is ameliorated by Chchd2^8-8

(Liu et al., 2020)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cDa

(Sun et al., 2018)

Pink1^VDRC.cUa

model of Parkinson's disease

is ameliorated by β4GalNAcTA^4.1

(Fernandes and Rao, 2011)

is ameliorated by Pi3K21B^VDRC.cUa

(Fernandes and Rao, 2011)

Pink1^UAS.cUa

ameliorates Parkinson's disease

modeled by Pink1^B9

(Hao et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PINK1; PTEN induced kinase 1

10 of 15

608309

PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET; PARK6

Parkinson's disease 6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Pink1

Hsap\PINK1

(Tsai et al., 2018, Morais et al., 2009, Clark et al., 2006, Wang et al., 2006, Yang et al., 2006)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pink1 - Hsap\SNCA

anti bait coimmunoprecipitation, western blot

(Krzystek et al., 2021)

Pink1 - HtrA2

anti tag coimmunoprecipitation, anti tag western blot

(Whitworth et al., 2008)

Pink1 - Mitofilin

pull down, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Tsai et al., 2018)

Pink1 - N

anti tag coimmunoprecipitation, western blot

(Lee et al., 2013)

Pink1 - Pgam5

anti tag coimmunoprecipitation, anti tag western blot

(Imai et al., 2010)

Pink1 - Tom20

anti bait coimmunoprecipitation, western blot

(Gehrke et al., 2015)

Pink1 - clu

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Sen et al., 2015)

Pink1 - larp

enzymatic study, western blot

(Zhang et al., 2019)

Pink1 - park

anti tag coimmunoprecipitation, anti tag western blot

(Sen et al., 2015, Whitworth et al., 2008)

Pink1 - pelo

anti tag coimmunoprecipitation, western blot

(Wu et al., 2018)

Pink1 - rho-7

anti tag coimmunoprecipitation, anti tag western blot

(Whitworth et al., 2008)

RNA-RNA

Physical Interaction

Assay

References

Pink1 - mir-11

quantitative reverse transcription pcr, luminiscence technology

(Truscott et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pink1

suppressible

AGO1

(Gehrke et al., 2015)

suppressible

(Ham et al., 2021)

suppressible

(Choo et al., 2012)

suppressible

(Wu et al., 2013)

suppressible

(Wu et al., 2013)

enhanceable

(Sen et al., 2015)

suppressible

(Ham et al., 2021)

suppressible

(M'Angale and Staveley, 2017, Park et al., 2006)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

enhanceable

(Liu et al., 2020)

suppressible

(Imai et al., 2010)

suppressible

(Sen et al., 2015)

enhanceable

(Sen et al., 2015)

enhanceable

(Maddison et al., 2020)

Pink1

suppressible

(Maddison et al., 2020)

Pink1

suppressible

cnc

(Gumeni et al., 2021)

Pink1

enhanceable

cnc

(Gumeni et al., 2021)

Pink1

suppressible

cnc|ref(2)P

(Gumeni et al., 2021)

Pink1

enhanceable

crc

(Celardo et al., 2017)

Pink1

suppressible

DCP1

(Gehrke et al., 2015)

Pink1

suppressible

DCP2

(Gehrke et al., 2015)

Pink1

enhanceable

Dhpr

(Zhou et al., 2019)

suppressible

(Hao et al., 2010)

suppressible

(Hao et al., 2010)

suppressible

(Tufi et al., 2014)

Pink1

suppressible

DOR

(Dinh et al., 2021)

Pink1

enhanceable

DOR

(Dinh et al., 2021)

Pink1

suppressible

Drp1

(Terriente-Felix et al., 2020, Esposito et al., 2013, Vilain et al., 2012, Rival et al., 2011, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008)

Pink1

enhanceable

Drp1

(Park et al., 2009)

Pink1

enhanceable

eIF4G1

(Gehrke et al., 2015)

Pink1

suppressible

Fer3HCH

(Esposito et al., 2013)

suppressible

(Koh et al., 2012)

suppressible

(Terriente-Felix et al., 2020)

Pink1

suppressible

gfzf

(Smith et al., 2019)

Pink1

suppressible

glo

(Gehrke et al., 2015)

Pink1

suppressible

GstO2

(Kim and Yim, 2013)

Pink1

suppressible

(Gehrke et al., 2015)

suppressible

(Vos et al., 2012)

enhanceable

(Vos et al., 2012)

suppressible

(Tain et al., 2009, Whitworth et al., 2008)

Pink1

enhanceable

HtrA2

(Whitworth et al., 2008, Yun et al., 2008)

Pink1|park

suppressible

HtrA2

(Whitworth et al., 2008)

Pink1

suppressible

Keap1

(Imai et al., 2010)

enhanceable

(Liu et al., 2012)

suppressible

(Liu et al., 2012)

enhanceable

(Thomas et al., 2014)

Pink1

suppressible

Lon

(Thomas et al., 2014)

Pink1

suppressible

Lrrk

(Tain et al., 2009)

Pink1

suppressible

mAcon1

(Esposito et al., 2013)

Pink1

suppressible

mAcon1|Drp1

(Esposito et al., 2013)

Pink1

suppressible

Marf

(Celardo et al., 2016, Park et al., 2009, Deng et al., 2008)

suppressible

(Wu et al., 2013)

suppressible

(Wu et al., 2013)

enhanceable

(Poole et al., 2008)

suppressible

(Zhu et al., 2015)

suppressible

(Course et al., 2018)

suppressible

(Liu et al., 2012)

enhanceable

(Liu et al., 2012)

suppressible

(Wu et al., 2013)

suppressible

(Liu et al., 2012)

suppressible

(Wu et al., 2013)

suppressible

(Tsai et al., 2018)

enhanceable

(Yun et al., 2014)

suppressible

(Yun et al., 2014)

suppressible

(Lee et al., 2013)

Pink1

suppressible

ND-42

(Morais et al., 2014, Pogson et al., 2014)

Pink1

enhanceable

Nmdmc

(Celardo et al., 2017)

Pink1

suppressible

Nmdmc

(Celardo et al., 2017)

Pink1

suppressible

Opa1

(Vilain et al., 2012, Rival et al., 2011, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008)

Pink1

enhanceable

Opa1

(Poole et al., 2008)

Pink1

suppressible

Paris

(Pirooznia et al., 2020)

Pink1

suppressible

park

(Khalil et al., 2015, Zhu et al., 2015, Pogson et al., 2014, Shiba-Fukushima et al., 2014, de Castro et al., 2013, Hao et al., 2010, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Whitworth et al., 2008, Yang et al., 2008, Clark et al., 2006, Park et al., 2006)

Pink1

enhanceable

park

(Sen et al., 2015, Poole et al., 2008, Whitworth et al., 2008)

Pink1

suppressible

Parp

(Lehmann et al., 2017)

Pink1

suppressible

PEK

(Celardo et al., 2016)

Pink1

suppressible

Pgam5

(Imai et al., 2010)

Pink1

enhanceable

Pgam5

(Ishida et al., 2012, Imai et al., 2010)

Pink1

suppressible

Pi3K21B

(Fernandes and Rao, 2011)

Pink1

suppressible

Pop2

(Gehrke et al., 2015)

Pink1

suppressible

pum

(Gehrke et al., 2015)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

suppressible

(de Castro et al., 2013)

enhanceable

(Lee et al., 2020)

suppressible

(Klein et al., 2014)

enhanceable

(Wu et al., 2013)

suppressible

(Wu et al., 2013)

suppressible

(Celardo et al., 2017)

Pink1

enhanceable

Shmt

(Celardo et al., 2017)

Pink1

suppressible

sicily

(Pogson et al., 2014)

enhanceable

(Wu et al., 2013)

suppressible

(Wu et al., 2013)

suppressible

(Koh et al., 2012)

suppressible

(Koh et al., 2012)

suppressible

(Koh et al., 2012)

suppressible

(Pirooznia et al., 2020)

Pink1

suppressible

STUB1

(Chen et al., 2017)

Pink1

suppressible

TER94

(Kim et al., 2013)

Pink1

enhanceable

(Min et al., 2015)

Pink1

suppressible

(Min et al., 2015)

Pink1

suppressible

Thor

(Koh et al., 2012, Tain et al., 2009)

Pink1

enhanceable

Tim8

(Gehrke et al., 2015)

Pink1

enhanceable

Tim13

(Gehrke et al., 2015)

Pink1

enhanceable

Tom7

(Gehrke et al., 2015)

Pink1

enhanceable

Tom20

(Gehrke et al., 2015)

Pink1

suppressible

Tom20

(Gehrke et al., 2015)

Pink1

enhanceable

Tom40

(Gehrke et al., 2015)

Pink1

suppressible

Trap1

(Kim et al., 2016, Costa et al., 2013)

suppressible

(Wu et al., 2013)

enhanceable

(Wu et al., 2013)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

suppressible

(Ham et al., 2021)

suppressible

(Wu et al., 2014)

enhanceable

(Wu et al., 2014)

suppressible

(Wu et al., 2014)

suppressible

(Wu et al., 2014)

suppressible

(Bingol et al., 2014)

Pink1

enhanceable

Vps35

(Malik et al., 2015)

Pink1

suppressible

β4GalNAcTA

(Fernandes and Rao, 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg1|trp

suppressible

Pink1

(Huang et al., 2016)

enhanceable

(Liu et al., 2020)

enhanceable

(Sen et al., 2015)

suppressible

(Wang et al., 2016)

Dhpr

enhanceable

Pink1

(Zhou et al., 2019)

Dhpr

suppressible

Pink1

(Zhou et al., 2019)

gfzf

suppressible

Pink1

(Smith et al., 2019)

mAcon1

suppressible

Pink1

(Cho et al., 2021)

suppressible

Pink1|Myc

(Lee et al., 2013)

enhanceable

Pink1

(Lee et al., 2013)

suppressible

Pink1|Su(H)

(Lee et al., 2013)

Paris

suppressible

Pink1

(Pirooznia et al., 2020)

park

enhanceable

Pink1

(Sen et al., 2015, Shiba-Fukushima et al., 2014, Fernandes and Rao, 2011)

park

suppressible

Pink1

(Shiba-Fukushima et al., 2014)

Pgam5

enhanceable

Pink1

(Ishida et al., 2012)

Ret

suppressible

Pink1

(Klein et al., 2014)

rho-7

enhanceable

Pink1

(Whitworth et al., 2008)

rho-7

suppressible

Pink1

(Whitworth et al., 2008)

Syx17

enhanceable

Pink1

(Liu et al., 2018)

suppressible

Pink1

(Min et al., 2015)

enhanceable

Pink1

(Min et al., 2015)

Tom20

suppressible

Pink1

(Gehrke et al., 2015)

suppressible

(Liu et al., 2018)

enhanceable

(Liu et al., 2018)

suppressible

(Huang et al., 2016)

External Data

Subunit Structure (UniProtKB)

Interacts with park (PubMed:19048081). Interacts with rho-7 and HtrA2 (PubMed:19048081).

(UniProt, Q0KHV6 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58093

DroID - A comprehensive database of gene and protein interactions.

FBgn0029891

MIST (genetic) - An integrated Molecular Interaction Database

Pink1

MIST (protein-protein) - An integrated Molecular Interaction Database

Pink1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029891

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Pink/Parkin Mediated Mitophagy

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-18

Cytogenetic map

6C6-6C6

Sequence location

X:6,683,798..6,687,302 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6C6-6C6

Limits computationally determined from genome sequence between P{EP}Ctr1A^EP1364&P{EP}EP1445 and P{EP}C3G^EP1613

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-18

(FlyBase, 2016)

1-18.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

51648

w^*; P{UAS-Pink1.C}A

26611

w^* P{EP}Pink1^G900

51649

Pink1⁵/FM7i, P{ActGFP}JMR3

83368

w^*; M{GMR-Pink1.Tom20.GFP}ZH-86Fb

31170

y¹ v¹; P{TRiP.JF01672}attP2

31262

y¹ v¹; P{TRiP.JF01203}attP2

34749

w^* Pink1^B9/FM7i, P{ActGFP}JMR3

83369

w^*; M{GMR-Pink1.S346A.Tom20.GFP}ZH-86Fb

VDRC

v109614

P{KK101205}VIE-260B

v318143

PBac{fTRG00514.sfGFP-TVPTBF}VK00033

v21860

w¹¹¹⁸; P{GD11336}v21860/CyO

v342373

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02307}attP40/CyO-GFP

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (198)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH20931

Other clones

FI19430

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029891

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029891

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31607

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Park et al., 2006, Yang et al., 2006)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Pink1 CG4523

(Clark, 2006.2.28)

Source for database merge of

Source for merge of: CG4523 BEST:GH23468

(Rana, 2004.7.8)

Additional comments

Other Comments

Mutants are viable but sterile. Mutant spermatids form abnormal Nebenkerns and mitochondrial derivatives and subsequently fail to individualize the 64-cell cyst into discrete sperm. Mutants show increased sensitivity to paraquat and hyperoxia and have heldup wings due to degeneration of indirect flight muscle.

(Clark et al., 2006)

Pink1 is required for normal mitochondrial function.

(Clark et al., 2006)

Mutants show a number of degenerative phenotypes which are due to mitochondrial dysfunction.

(Park et al., 2006)

Pink1 plays an important role in regulating energy metabolism and exerts an impact on lifespan.

(Yang et al., 2006)

Pink1 plays a critical role in promoting dopaminergic neuronal function and survival.

(Yang et al., 2006)

Pink1 mutants exhibit age-dependent muscle degeneration characterised by extensive DNA fragmentation, probably indicative of cell death.

(Yang et al., 2006)

Pink1 is required for maintaining proper mitochondria morphology and the integrity of suets of muscle cells and dopaminergic neurons.

(Yang et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31607

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0KHV6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q0KHV6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0KHV6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029891

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029891

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31607/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029891

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029891

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029891

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4523

Flygut - An atlas of the Drosophila adult midgut

FBgn0029891

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029891

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31607

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4523

MARRVEL_MODEL - MARRVEL (model organism gene)

31607

modMine - A data warehouse for the modENCODE project

FBgn0029891

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KHV6

Linkouts

BioGRID - A database of protein and genetic interactions.

58093

DroID - A comprehensive database of gene and protein interactions.

FBgn0029891

DRSC - Results frm RNAi screens

FBgn0029891

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029891

FlyMine - An integrated database for Drosophila genomics

FBgn0029891

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

Pink1

MIST (protein-protein) - An integrated Molecular Interaction Database

Pink1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Pink/Parkin Mediated Mitophagy

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

BEST:GH23468

CG4523

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Ferjoux et al., 2007, Altenhein et al., 2006, Clark et al., 2006, Park et al., 2006, Wang et al., 2006, Bier, 2005, Rana, 2004.7.8, Giot et al., 2003, Manning, 2002.11.16, Anholt and Mackay, 2001, Morrison et al., 2000)

PINK

(Wang et al., 2016, Lesnik et al., 2015, Bhandari et al., 2014, Venderova et al., 2009)

PINK-1

(Ohiomokhare et al., 2020)

PINK1

(Bell and Tower, 2021, Ham et al., 2021, Ingles-Prieto et al., 2021, Kim et al., 2021, Kitani-Morii et al., 2021, Kong et al., 2021, Liguori et al., 2021, Shahzad et al., 2021, Tang et al., 2021, Yu and Hyun, 2021, Ayikobua et al., 2020, Chia et al., 2020, Cui et al., 2020, Imai, 2020, Kim et al., 2020, Luckhart and Riehle, 2020, Vajente et al., 2020, Wan et al., 2020, Xu et al., 2020, Baroli et al., 2019, Cai et al., 2019, Dalla Vecchia et al., 2019, Hsieh et al., 2019, Kim et al., 2019, von Stockum et al., 2019, Basso et al., 2018, Course et al., 2018, Dung and Thao, 2018, Himmelberg et al., 2018, Lee et al., 2018, Xiong and Yu, 2018, Meng et al., 2017, Molina-Mateo et al., 2017, Shiba-Fukushima et al., 2017, Yang et al., 2017, Zhang et al., 2017, Zhu et al., 2017, Ding et al., 2016, Kandul et al., 2016, Kim et al., 2016, Li et al., 2016, Voigt et al., 2016, Von Stockum et al., 2016, Wang et al., 2016, Zhang et al., 2016, Gehrke et al., 2015, Khalil et al., 2015, Sen et al., 2015, Vos et al., 2015, West et al., 2015, Hwang et al., 2014, Ivatt et al., 2014, Jansen et al., 2014, Mulakkal et al., 2014, Poddighe et al., 2014, Shiba-Fukushima et al., 2014, Shiba-Fukushima et al., 2014, Thomas et al., 2014, Tsai et al., 2014, Yun et al., 2014, Burchell et al., 2013, Kim and Yim, 2013, Kim et al., 2013, Lenz et al., 2013, Owusu-Ansah et al., 2013, Poddighe et al., 2013, Vincow et al., 2013, Wu et al., 2013, Guo, 2012, Ishida et al., 2012, Koh et al., 2012, Liu et al., 2012, Nezis, 2012, Muñoz-Soriano and Paricio, 2011, Liu and Lu, 2010, Poole et al., 2010, Ziviani et al., 2010, Lutz et al., 2009, Park et al., 2009, Tain et al., 2009, Venderova et al., 2009, Kim et al., 2008, Poole et al., 2008, Lee et al., 2007, Tain et al., 2007, Todd and Staveley, 2007, Tountas and Fortini, 2007, Bier, 2006, Biskup and Moore, 2006, Lin and Beal, 2006, Maricich and Zoghbi, 2006, Pallanck and Greenamyre, 2006, Park et al., 2006, Park et al., 2006, Wang et al., 2006)

Pink

(Lieber et al., 2019, Sênos Demarco et al., 2019, Kutscher and Shaham, 2017, Senyilmaz et al., 2015)

Pink1

(Baek et al., 2021, Schroeder et al., 2021, De Lazzari et al., 2020, Denton et al., 2020, Funk et al., 2020, Gohel et al., 2020, Kanellopoulos et al., 2020, Lee et al., 2020, Lin et al., 2020, Liu et al., 2020, Liu et al., 2020, Loreto et al., 2020, Lu and Guo, 2020, Maddison et al., 2020, Papakyrikos et al., 2020, Qiao and Mao, 2020, Sun et al., 2020, Xia et al., 2020, Zhao et al., 2020, Aryal and Lee, 2019, Bajracharya et al., 2019, Bouska et al., 2019, Gumeni et al., 2019, Manola et al., 2019, Meltzer et al., 2019, Smith et al., 2019, Wu et al., 2019, Yang et al., 2019, Yuan et al., 2019, Zhou et al., 2019, Chakraborty et al., 2018, Hill et al., 2018, Lee et al., 2018, Liu et al., 2018, Solari et al., 2018, Steyaert et al., 2018, Sun et al., 2018, Valadas et al., 2018, Chen et al., 2017, Galluzzi et al., 2017, Kawasaki et al., 2017, Kim et al., 2017, M'Angale and Staveley, 2017, Song et al., 2017, Chen et al., 2016, Kandul et al., 2016, Liu et al., 2016, Sarov et al., 2016, Liu et al., 2015, Mensah et al., 2015, Senyilmaz et al., 2015, West et al., 2015, DeVorkin et al., 2014, Klein et al., 2014, Morais et al., 2014, Mulakkal et al., 2014, Navarro et al., 2014, Sopko et al., 2014, Costa et al., 2013, Yacobi-Sharon et al., 2013, Zhang et al., 2013, Fabian and Brill, 2012, Immonen and Ritchie, 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Pezzulo et al., 2012, Todd and Staveley, 2012, Abdelwahid et al., 2011, Fernandes and Rao, 2011, Liu et al., 2011, Tain et al., 2009, Todd and Staveley, 2008, Yang et al., 2008, Budde, 2006, Yang et al., 2006)

dPINK1

(Dinh et al., 2021, Krzystek et al., 2021, Wu et al., 2018, Gehrke et al., 2015, Min et al., 2015, Shiba-Fukushima et al., 2014, Lee et al., 2013, Song et al., 2013, Huang et al., 2012, Ishida et al., 2012, Liu et al., 2012, Woodroof et al., 2011, Imai et al., 2010, Bier, 2006, Clark et al., 2006, Wang et al., 2006)

dPINk1

(Choo et al., 2012)

dPink1

(Min et al., 2015, Yang et al., 2008, Yang et al., 2008)

pink1

(Banerjee et al., 2021, Han et al., 2021, He et al., 2021, Shen et al., 2021, Tiwari and Mandal, 2021, Vos and Klein, 2021, Rodriguez-Fernandez et al., 2020, Si et al., 2019, Zhang et al., 2019, Shin et al., 2018, Basil et al., 2017, Celardo et al., 2017, Koehler et al., 2017, Lehmann et al., 2017, Napoletano et al., 2017, Celardo et al., 2016, Huang et al., 2016, Spinazzi and De Strooper, 2016, Zhuang et al., 2016, Gao et al., 2015, Lepesant, 2015, Malik et al., 2015, Mensah et al., 2015, Vanhauwaert and Verstreken, 2015, Zhu et al., 2015, Bingol et al., 2014, Pogson et al., 2014, Tufi et al., 2014, Wu et al., 2014, Chan and McQuibban, 2013, Debattisti and Scorrano, 2013, de Castro et al., 2013, Esposito et al., 2013, Frank et al., 2013, Ruan et al., 2013, Vos et al., 2013, Yacobi-Sharon et al., 2013, Fabian and Brill, 2012, Pimenta de Castro et al., 2012, Schmidt et al., 2012, Vilain et al., 2012, Vos et al., 2012, Rival et al., 2011, Rival et al., 2011, Truscott et al., 2011, Hao et al., 2010, Lorbeck et al., 2010, Morais et al., 2009, Deng et al., 2008, Dodson et al., 2008, Whitworth et al., 2008, Whitworth et al., 2008, Yun et al., 2008, Guo et al., 2007, Korey, 2007, Clark et al., 2006)

Name Synonyms

PINK1

(Bolus et al., 2020, van der Merwe et al., 2015)

PTEN induced putative kinase 1

(Todd and Staveley, 2007)

PTEN-Induced Kinase 1

(Bier, 2006)

PTEN-induced Putative Kinase 1

(Song et al., 2013)

PTEN-induced kinase 1

(Owusu-Ansah et al., 2013)

PTEN-induced putative kinase 1