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Gene Dmel\Nf-YC

General Information
Symbol	Dmel\Nf-YC	Species	D. melanogaster
Name	Nuclear factor Y-box C	Annotation symbol	CG3075
Feature type	protein_coding_gene	FlyBase ID	FBgn0029905
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	nf-yc
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	6D3-6D3	Sequence location	X:6,712,211..6,714,948 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nuclear factor Y-box C is referred to in FlyBase by the symbol Dmel\Nf-YC (CG3075, FBgn0029905). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process: regulation of smoothened signaling pathway; axon guidance; cellular process; wing disc pattern formation. 14 alleles are reported. The phenotypes of these alleles are annotated with: wing; lamina. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone-fold; Transcription factor CBF/NF-Y/archaeal histone. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1634101_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nf-YC. Gene sequence location is X:6712211..6714948.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA18272 BKN27595
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6D3-6D3   Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nf-YC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nf-YC-RA FBtr0070974  NM_132126   2518   601
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nf-YC-PA   FBpp0070935   64.7   601   9.60     NP_572354   AAF46204
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor CBF/NF-Y/archaeal histone (IPR003958) Histone-fold (IPR009072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202294   AA264311   AE014298 AAF46204   AI404634   AI456503   AI543432   AI546558   BG639790   BI357320   BT001649 AAN71404   CO284875   CO307147   EC087836   EC203563   EV583997   EV595175
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3V9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0029905    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0029905 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0029905 expression level Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6601) embryo 02-04hr  (2370) embryo 04-06hr  (2036) embryo 06-08hr  (1912) embryo 08-10hr  (1481) embryo 10-12hr  (1265) embryo 12-14hr  (915) embryo 14-16hr  (1034) embryo 16-18hr  (738) embryo 18-20hr  (788) embryo 20-22hr  (626) embryo 22-24hr  (545) larva L1  (721) larva L2  (386) larva L3 12hr old  (438) larva L3 puffstage 1-2  (399) larva L3 puffstage 3-6  (606) larva L3 puffstage 7-9  (581) white prepupae new  (621) white prepupae 12hr  (665) white prepupae 24hr  (866) pupae 2d postWPP  (555) pupae 3d postWPP  (342) pupae 4d postWPP  (393) adult male 01day  (416) adult male 05day  (561) adult male 30day  (685) adult female 01day  (2016) adult female 05day  (2942) adult female 30day  (3348) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6601) embryo 02-04hr  (2370) embryo 04-06hr  (2036) embryo 06-08hr  (1912) embryo 08-10hr  1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day  (2016) adult female 05day  (2942) adult female 30day  (3348) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0029905 expression level Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6601) embryo 02-04hr  (2370) embryo 04-06hr  (2036) embryo 06-08hr  (1912) embryo 08-10hr  (1481) embryo 10-12hr  (1265) embryo 12-14hr  (915) embryo 14-16hr  (1034) embryo 16-18hr  (738) embryo 18-20hr  (788) embryo 20-22hr  (626) embryo 22-24hr  (545) larva L1  (721) larva L2  (386) larva L3 12hr old  (438) larva L3 puffstage 1-2  (399) larva L3 puffstage 3-6  (606) larva L3 puffstage 7-9  (581) white prepupae new  (621) white prepupae 12hr  (665) white prepupae 24hr  (866) pupae 2d postWPP  (555) pupae 3d postWPP  (342) pupae 4d postWPP  (393) adult male 01day  (416) adult male 05day  (561) adult male 30day  (685) adult female 01day  (2016) adult female 05day  (2942) adult female 30day  (3348) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6601) embryo 02-04hr  2370 embryo 04-06hr  2036 embryo 06-08hr  1912 embryo 08-10hr  1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day  2016 adult female 05day  (2942) adult female 30day  (3348) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6601 embryo 02-04hr    2370 embryo 04-06hr    2036 embryo 06-08hr    1912 embryo 08-10hr    1481 embryo 10-12hr    1265 embryo 12-14hr    915 embryo 14-16hr    1034 embryo 16-18hr    738 embryo 18-20hr    788 embryo 20-22hr    626 embryo 22-24hr    545 larva L1    721 larva L2    386 larva L3 12hr old    438 larva L3 puffstage 1-2    399 larva L3 puffstage 3-6    606 larva L3 puffstage 7-9    581 white prepupae new    621 white prepupae 12hr    665 white prepupae 24hr    866 pupae 2d postWPP    555 pupae 3d postWPP    342 pupae 4d postWPP    393 adult male 01day    416 adult male 05day    561 adult male 30day    685 adult female 01day    2016 adult female 05day    2942 adult female 30day    3348 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0029905    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0029905 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0029905 expression level Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0029905 expression level Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    63.1 Larval Hindgut    49.3 Larval Malpighian Tubules    46.5 Larval Fat Body    34 Larval Salivary Gland    75.2 Larval Trachea    118.6 Larval Carcass    55.825 Adult Head    46.9 Adult Eye    95.85 Adult Brain    87.8 Adult Thoracic-Abdominal Ganglion    60.4 Adult Crop    70.9 Adult Midgut    46.3 Adult Hindgut    50.3 Adult Malpighian Tubules    46.1 Adult Fat Body    63 Adult Salivary Gland    106.7 Adult Heart    82.375 Adult VirginFemale Spermatheca    69.1 Adult InseminatedFemale Spermatheca    79.6 Adult Ovary    291.8 Adult Testis no informative data Adult Male Accessory Gland    65.7 Adult Carcass    56.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    46.9   NA  Eye    95.85   NA  Brain    87.8   145.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    60.4   NA  Crop    70.9   63.1  Midgut    46.3   49.3  Hindgut    50.3   46.5  Malpighian Tubules    46.1   34  Fat Body    63   75.2  Salivary Gland    106.7   NA  Heart    82.375   118.6  Trachea    NA   NA  VirginFemale Spermatheca    69.1   NA  InseminatedFemale Spermatheca    79.6   NA  Ovary    291.8   NA  Testis    no informative data   NA  Male Accessory Gland    65.7   55.825  Carcass    56.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029905 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3075-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Nf-YCGD4285 lethal | pharate adult stage (with Nf-YC6Df2) Nf-YCΔ96 lethal | pharate adult stage (with Nf-YC40) Nf-YCΔ96 lethal | pharate adult stage (with Nf-YCm607) Nf-YCΔ96 lethal | pharate adult stage (with Nf-YCΔ96) Nf-YC6Df2 Nf-YC40 Nf-YCm607 lethal | pharate adult stage | recessive Nf-YC6Df2 Nf-YC40 lethal | pupal stage (with Nf-YC6Df2) Nf-YCΔ96 lethal | pupal stage (with Nf-YC40) Nf-YCΔ96 lethal | pupal stage (with Nf-YCm607) Nf-YCΔ96 lethal | pupal stage (with Nf-YCΔ96) Nf-YC6Df2 Nf-YC40 Nf-YCm607 lethal | pupal stage | recessive Nf-YC40 Other Phenotypes Allele visible, with Scer\GAL4Bx-MS1096 Nf-YCScer\UAS.cRa Phenotype manifest in Allele axon & photoreceptor cell R7 Nf-YC40 axon & photoreceptor cell R7 | somatic clone Nf-YC40 Nf-YCΔ96 Nf-YCm607 axon & photoreceptor cell R8 Nf-YC40 lamina Nf-YC40 wing, with Scer\GAL4Bx-MS1096 Nf-YCScer\UAS.cRa wing vein | supernumerary, with Scer\GAL471B Nf-YCScer\UAS.cRa wing vein | supernumerary, with Scer\GAL4Bx-MS1096 Nf-YCScer\UAS.cRa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Nf-YC Class Mutagen Stocks Known lesion Nf-YCHP10871 1 -- Nf-YC40 ethyl methanesulfonate 0 Yes Nf-YC6Df2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Nf-YCm607 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Nf-YCunspecified 0 -- Nf-YCΔ96 loss of function allele 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nf-YC Class Mutagen Stocks Known lesion Nf-YCGD4285 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nf-YCC.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nf-YCC.T:Avic\GFP in vitro construct - coding region fusion 0 Yes Nf-YCN.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nf-YCN.T:Avic\GFP in vitro construct - coding region fusion 0 Yes Nf-YCScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Nf-YCScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes Nf-YCtMa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(1)pod1Δ96 (Morey et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Nf-YC.C.GFP} NA P{UAS-Nf-YC.M} NA P{UAS-Nf-YC.N.GFP} NA characterization construct P{Nf-YCC.T:Avic\GFP} NA P{Nf-YCN.T:Avic\GFP} NA P{Nf-YCtMa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}Nf-YCHP10871 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
contributes_to sequence-specific DNA binding inferred from direct assay (Yoshioka et al., 2007)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Morey et al., 2008) cellular process inferred from mutant phenotype (Boutros et al., 2004) regulation of smoothened signaling pathway inferred from mutant phenotype (Ramos and Mohler, 2006) wing disc pattern formation inferred from mutant phenotype (Ramos and Mohler, 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:AB006181 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:AB006181 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nf-YC allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58107 DroID - A comprehensive database of gene and protein interactions. • FBgn0029905 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31622
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19549 Dere\GG17653 Dgri\GH24525 Dmoj\GI21605 Dper\GL26874 Dpse\GA15909 Dsec\GM12548 Dvir\GJ16544 Dwil\GK10349 Dyak\GE16442
Curated drosophilid orthologs	Dpse\GA15909
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP000441-PA Anopheles gambiae (mosquito) XP_001951583.1 Acyrthosiphon pisum (pea aphid) 123513 Branchiostoma floridae (lancelet) ENSBTAP00000025381 Bos taurus (bovine) ENSCAFP00000004175 Canis familiaris (dog) ENSCINP00000015864 Ciona intestinalis (sea squirt) CPIJ010882 Culex pipens (mosquito) ENSCPOP00000004470 Cavia porcellus (guinea pig) 180137 Capitella spl (polychaete worm) DEHA2D10714g Debaryomyces Hansenii (yeast) ENSECAP00000001526 Equus caballus (horse) ENSGACP00000006420 Gymnopilus aculeatus (mushroom) ENSGALP00000034390 Gallus gallus (chicken) 184852 Hypsipyla robusta (cedar shoot borer) ENSP00000361741 Homo sapiens (human) ENSMMUP00000013656 Macaca mulatta (rhesus monkey) ENSMUSP00000112610 Mus musculus (house mouse) ENSOANP00000019570 Ornithorynchus anatinus (platypus) ENSORLP00000015027 Oryzias latipes (japanese killifish) ENSPPYP00000001715 Pongo pygmaeus (orangutan) 74486 Phytophthora ramorum (sudden oak death pathogen) 558718 Populus trichocarpa (black cottonwood) ENSPTRP00000052465 Pan troglodytes (chimpanzee) ENSRNOP00000053489 Rattus norvegicus (norway rat) Smp_176340 Schistosoma mansoni (trematode parasite) SPBC3B8.02 Schizosaccharomyces pombe (fission yeast) 28000 Trichoplax adhaerens (metazoa) ENSTNIP00000020090 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036419 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000054159 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH19020 ISCW017362 FBgn0212364 FBgn0167485 JGI_V11_46746 FBgn0075925 FBgn0164455 FBgn0164454 FBgn0144334 CPIJ010882 ACYPI003442 GB30092 GB17993 AGAP000441 PHUM204110 GLEAN_09586
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	21893 w1118 P{EPg}Nf-YCHP10871
VDRC	v41034 w1118; P{GD4285}v41034
Genomic Clones ( 2 )
	BACR04D11 BACR48O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 13 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE43755
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24420 LD02446 LD07549 LD36545 SD10176
Other clones	103778 148144 Dmel_dig_014148_0716_0847 Dmel_neb_013889_0641_2103 EK167150 EK253732 SD06336
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029905 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31622
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nf-YC CG3075 (Yoshioka et al., 2007)
Source for database merge of
Additional comments	FlyBase curator comment: Correspondence with author Morey confirmed that 'NF-YC' = 'CG3075'. (Morey et al., 2007)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132126 RefSeq (Proteins) • NP_572354 DDBJ / EMBL / GenBank • AAF46204 AAN71404 BI357320 BT001649 Entrez Gene - A searchable database of RefSeq genes. • 31622 UniProtKB/TrEMBL • Q9W3V9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor CBF/NF-Y/archaeal histone (IPR003958) Histone-fold (IPR009072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58107 DroID - A comprehensive database of gene and protein interactions. • FBgn0029905 DRSC - Results from RNAi screens. • FBgn0029905 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029905 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3075-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029905 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31622 InParanoid A subset of ortholog calls from InParanoid. • AGAP000441-PA Anopheles gambiae (mosquito) XP_001951583.1 Acyrthosiphon pisum (pea aphid) 123513 Branchiostoma floridae (lancelet) ENSBTAP00000025381 Bos taurus (bovine) ENSCAFP00000004175 Canis familiaris (dog) ENSCINP00000015864 Ciona intestinalis (sea squirt) CPIJ010882 Culex pipens (mosquito) ENSCPOP00000004470 Cavia porcellus (guinea pig) 180137 Capitella spl (polychaete worm) DEHA2D10714g Debaryomyces Hansenii (yeast) ENSECAP00000001526 Equus caballus (horse) ENSGACP00000006420 Gymnopilus aculeatus (mushroom) ENSGALP00000034390 Gallus gallus (chicken) 184852 Hypsipyla robusta (cedar shoot borer) ENSP00000361741 Homo sapiens (human) ENSMMUP00000013656 Macaca mulatta (rhesus monkey) ENSMUSP00000112610 Mus musculus (house mouse) ENSOANP00000019570 Ornithorynchus anatinus (platypus) ENSORLP00000015027 Oryzias latipes (japanese killifish) ENSPPYP00000001715 Pongo pygmaeus (orangutan) 74486 Phytophthora ramorum (sudden oak death pathogen) 558718 Populus trichocarpa (black cottonwood) ENSPTRP00000052465 Pan troglodytes (chimpanzee) ENSRNOP00000053489 Rattus norvegicus (norway rat) Smp_176340 Schistosoma mansoni (trematode parasite) SPBC3B8.02 Schizosaccharomyces pombe (fission yeast) 28000 Trichoplax adhaerens (metazoa) ENSTNIP00000020090 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036419 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000054159 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31622 modMine - Data generated by the modENCODE project. • FBgn0029905 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH19020 ISCW017362 FBgn0212364 FBgn0167485 JGI_V11_46746 FBgn0075925 FBgn0164455 FBgn0164454 FBgn0144334 CPIJ010882 ACYPI003442 GB30092 GB17993 AGAP000441 PHUM204110 GLEAN_09586
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG3075 (Yoshioka et al., 2007, Ramos and Mohler, 2006, Suyari et al., 2009, Morey et al., 2008, Pospisilik et al., 2010) nf-yc (Ramos and Mohler, 2006) NF-YC (Morey et al., 2007, Yoshioka et al., 2007, Morey et al., 2008, Suyari et al., 2009, Morey et al., 2008) Nf-YC
Name Synonym	CG3075   NF-YC-like (Aoyagi and Wassarman, 2000) Nuclear factor Y-box C   nuclear factor Y-box C (Yoshioka et al., 2007)
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...