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Gene Dmel\CG14434

General Information
Symbol	Dmel\CG14434	Species	D. melanogaster
Name		Annotation symbol	CG14434
Feature type	protein_coding_gene	FlyBase ID	FBgn0029915
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	6D7-6D7	Sequence location	X:6,745,942..6,746,671 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14434 (FBgn0029915). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: CYTH-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631048_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG14434. Gene sequence location is X:6745942..6746671.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6D7-6D7   Limits computationally determined from genome sequence between P{EP}C3GEP1613 and P{EP}EP1388EP1388&P{EP}EP1573
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14434 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14434-RA FBtr0071040  NM_132135   730   187
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14434-PA   FBpp0070999   21.2   187   4.98     NP_572363   AAF46214
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • CYTH-like domain (IPR023577)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA736163   AA802464   AA816717   AE014298 AAF46214   AY118839 AAM50699   BP550835   BP550836   BP552856   BP554735   BP554736   CL527793   CO280249   CO341396   CZ479470   EC073299   EC252181   EV577283   EV585473
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3U9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    468.05 Larval Midgut    53.6 Larval Hindgut    75.1 Larval Malpighian Tubules    53.6 Larval Fat Body    66.5 Larval Salivary Gland    206.7 Larval Trachea    276.425 Larval Carcass    140.325 Adult Head    39.8 Adult Eye    27.625 Adult Brain    44.8 Adult Thoracic-Abdominal Ganglion    61.7 Adult Crop    31.5 Adult Midgut    69.1 Adult Hindgut    37.8 Adult Malpighian Tubules    44.7 Adult Fat Body    44.1 Adult Salivary Gland    47.2 Adult Heart    40.675 Adult VirginFemale Spermatheca    58.1 Adult InseminatedFemale Spermatheca    72.9 Adult Ovary    407.8 Adult Testis    29.5 Adult Male Accessory Gland    159.5 Adult Carcass    34.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    39.8   NA  Eye    27.625   NA  Brain    44.8   468.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    61.7   NA  Crop    31.5   53.6  Midgut    69.1   75.1  Hindgut    37.8   53.6  Malpighian Tubules    no informative data   66.5  Fat Body    44.1   206.7  Salivary Gland    47.2   NA  Heart    40.675   276.425  Trachea    NA   NA  VirginFemale Spermatheca    58.1   NA  InseminatedFemale Spermatheca    72.9   NA  Ovary    407.8   NA  Testis    29.5   NA  Male Accessory Gland    159.5   140.325  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    10 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    2 ovary, virgin 4-day female    25 ovary, mated 4-day female    18 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (73) embryo 04-06hr  (43) embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day  (46) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (71) embryo 02-04hr  (73) embryo 04-06hr  (43) embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day  (46) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    71 embryo 02-04hr    73 embryo 04-06hr    43 embryo 06-08hr    9 embryo 08-10hr    10 embryo 10-12hr    8 embryo 12-14hr    6 embryo 14-16hr    5 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    9 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    18 larva L3 puffstage 7-9    23 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    22 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    3 adult male 05day    3 adult male 30day    3 adult female 01day    25 adult female 05day    46 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    147 tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (71) embryonic 1182-4H  (36) embryonic GM2  26 embryonic Kc167  (28) embryonic S1  (28) embryonic S3  (30) leg disc CME L1  (37) wing disc CME-W2  (37) wing disc ML-DmD8  (49) wing disc ML-DmD9    25 wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  (51) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (45) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (44) CNS ML-DmBG1-c1  (30) CNS ML-DmBG2-c2  (147) tumorous blood cells mbn2  (33) ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2  (147) tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    147 tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    147 tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (71) embryonic 1182-4H  (36) embryonic GM2  26 embryonic Kc167  28 embryonic S1  28 embryonic S3  30 leg disc CME L1  (37) wing disc CME-W2  (37) wing disc ML-DmD8  (49) wing disc ML-DmD9    25 wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  (51) wing disc ML-DmD32    22 haltere disc ML-DmD17-c3  (45) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5  (39) mixed discs ML-DmD4-c1  (44) CNS ML-DmBG1-c1  30 CNS ML-DmBG2-c2  (147) tumorous blood cells mbn2  (33) ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2  (147) tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    71 embryonic 1182-4H    36 embryonic GM2    26 embryonic Kc167    28 embryonic S1    28 embryonic S3    30 leg disc CME L1    37 wing disc CME-W2    37 wing disc ML-DmD8    49 wing disc ML-DmD9    25 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    51 wing disc ML-DmD32    22 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    39 mixed discs ML-DmD4-c1    44 CNS ML-DmBG1-c1    30 CNS ML-DmBG2-c2    147 tumorous blood cells mbn2    33 ovary fGS/OSS    17 ovary OSC    12 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    21 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029915 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14434-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG14434EY05245 viable, with Scer\GAL4pnr-MD237 CG14434GD8323 Sterility Allele fertile CG14434EY05245 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG14434 Class Mutagen Stocks Known lesion CG14434e01662 piggyBac transposase 1 -- CG14434EY05245 P-element activity 1 -- CG14434NP2582 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14434 Class Mutagen Stocks Known lesion CG14434GD8323 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG14434KK102996 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG14434NIG.14434R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8323} NA P{KK102996} NA P{NIG.14434R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG14434EY05245 NA insertion of enhancer trap binary system P{GawB}CG14434NP2582 No miscellaneous insertions PBac{RB}CG14434e01662 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG14434 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14434 - MFS16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG14434 - Pebp1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14434 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58116 DroID - A comprehensive database of gene and protein interactions. • FBgn0029915 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31632
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6Z8ZGZ Dipteran inclusive ortholog search EOG6C5CTN Insect inclusive ortholog search EOG6WDC89 Arthropod inclusive ortholog search EOG6V9S73 Metazoa inclusive ortholog search EOG6KHFQG
Orthologs in Drosophila Species (EOG6Z8ZGZ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG14434     Drosophila simulans   Dsim\GD24582 Y   Drosophila sechellia   Dsec\GM12544 Y   Drosophila erecta   Dere\GG17648 Y   Drosophila yakuba   Dyak\GE16437 Y   Drosophila ananassae   Dana\GF21413 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12981 Y   Drosophila persimilis   Dper\GL13319 Y   Drosophila willistoni   Dwil\GK25238 Y   Drosophila virilis   Dvir\GJ16999 Y   Drosophila mojavensis   Dmoj\GI15295 Y   Drosophila grimshawi   Dgri\GH24160 Y
Orthologs in non-Drosophila Dipterans (EOG6C5CTN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011200   Anopheles gambiae Malaria mosquito  Agam\AGAP000680   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009805
Orthologs in non-Dipteran Insects (EOG6WDC89)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41588   Apis mellifera Western honey bee  Amel\GB48202   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006707   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15358   Atta cephalotes Leafcutter ant  Acep\ACEP12902   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15793   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12451   Linepithema humile Argentine ant  Lhum\LH22939   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25662   Solenopsis invicta Red fire ant  Sinv\SINV17498   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008695   Bombyx mori Silkmoth  Bmor\BGIBMGA008749   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07076
Orthologs in non-Insect Arthropods (EOG6V9S73)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_93051   Daphnia pulex Water flea  Dpux\JGI_V11_306903   Ixodes scapularis Deer tick  Isca\ISCW019650
Orthologs in non-Arthropod Metazoa (EOG6KHFQG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F35D11.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025303gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24582 Drosophila sechellia Dsec\GM12544 Drosophila erecta Dere\GG17648 Drosophila yakuba Dyak\GE16437 Drosophila ananassae Dana\GF21413 Drosophila pseudoobscura pseudoobscura Dpse\GA12981 Drosophila persimilis Dper\GL13319 Drosophila willistoni Dwil\GK25238 Drosophila virilis Dvir\GJ16999 Drosophila mojavensis Dmoj\GI15295 Drosophila grimshawi Dgri\GH24160
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	16645 y1 w67c23 P{EPgy2}CG14434EY05245
Harvard	- PBac{RB}CG14434e01662
Kyoto	104248 y* w* P{GawB}CG14434NP2582 / FM7c
VDRC	v107085 P{KK102996}VIE-260B v17594 w1118 P{GD8323}v17594 v17595 w1118; P{GD8323}v17595
Genomic Clones ( 2 )
	BACR04D11 BACR48O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM12295
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM05601 LD04824
Other clones	40054 214511.9 Dmel_dig_008456_0662_1616 Dmel_dig_016515_0621_0555 EK153463 EP12360 FGM209D10 FGM221B10 FGM231D12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0029915 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31632
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132135 RefSeq (Proteins) • NP_572363 DDBJ / EMBL / GenBank • AA736163 AAF46214 AAM50699 AY118839 CL527793 CZ479470 Entrez Gene - A searchable database of RefSeq genes. • 31632 UniProtKB/TrEMBL • Q9W3U9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • CYTH-like domain (IPR023577)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58116 DroID - A comprehensive database of gene and protein interactions. • FBgn0029915 DRSC - Results from RNAi screens. • FBgn0029915 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0029915 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14434-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0029915 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31632 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31632 modMine - Data generated by the modENCODE project. • FBgn0029915
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG14434 (Von Ohlen et al., 2012, Negre et al., 2006, Keleman et al., 2009.8.5, Pauli et al., 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Von Ohlen et al., 2012, Infect. Immun. 80(10): 3576--3586 Identification of Critical Host Mitochondrion-Associated Genes during Ehrlichia chaffeensis Infections. [FBrf0219421] Pauli et al., 2010, Curr. Biol. 20(20): 1787--1798 A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. [FBrf0212124] Negre et al., 2006, PLoS Biol. 4(6): e170 Chromosomal distribution of PcG proteins during Drosophila development. [FBrf0191372] Dimova et al., 2003, Genes Dev. 17(18): 2308--2320 Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. [FBrf0162136]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]