FB2025_01 , released February 20, 2025
Gene: Dmel\Cph
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General Information
Symbol
Dmel\Cph
Species
D. melanogaster
Name
Chronophage
Annotation Symbol
CG9650
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029939
Gene Model Status
Current
Stock Availability
75 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
6F10-7A5
Sequence location
Recombination map
1-20
RefSeq locus
NC_004354 REGION:7137723..7241932
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from direct assay
(Fox et al., 2022)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor binding
inferred from sequence or structural similarity with UniProtKB:Q9H165-1
(Fox et al., 2022)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in negative regulation of peptide hormone secretion
inferred from mutant phenotype
(Park et al., 2014)
involved_in neuroblast fate specification
inferred from mutant phenotype
(Fox et al., 2022)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Fox et al., 2022)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001905569
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:Q9H165-2
(Fox et al., 2022)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Cph for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A499JF18)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.40

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.46

Gene model reviewed during 5.50

Stop-codon suppression (UGA) postulated; FBrf0234051.

Gene model reviewed during 6.25

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cph-RG
FBtr0301240
NM_001103429
6154
1209
Cph-RI
FBtr0309030
NM_167121
6934
1207
Cph-RJ
FBtr0339815
NM_132157
5637
1140
Cph-RK
FBtr0474234
NM_001370055
5755
1254
Cph-RL
FBtr0474235
NM_001103430
5755
1213
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cph-PG
FBpp0290458
128.4
1209
5.86
A8JV12
NP_001096899
ABW09351
Cph-PI
FBpp0301059
128.3
1207
5.86
R9PY46
NP_727173
AAN09205
Cph-PJ
FBpp0308848
120.9
1140
5.79
A0A023GPJ3
NP_572385
AAN09204
Cph-PK
FBpp0423187
133.7
1254
6.10
ABW09350
Cph-PL
FBpp0423188
129.0
1213
5.83
ABW09352
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cph using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.41

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
stomatogastric nervous system primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cph in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 51 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cph
Transgenic constructs containing regulatory region of Cph
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4elav-C155
lethal, with Scer\GAL4en-e16E
lethal, with Scer\GAL4hs.2sev
lethal, with Scer\GAL4sca-4512
lethal | recessive
lethal - all die during embryonic stage
lethal - all die during embryonic stage, with Scer\GAL4Act5C.PI
partially lethal | male limited, with Scer\GAL4Bx-MS1096
partially lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
partially lethal - majority die, with Scer\GAL4BG380
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | larval stage, with Scer\GAL4sca-109-68
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
bang sensitive | adult stage, with Scer\GAL4sca-109-68
decreased cell number | embryonic stage, with Scer\GAL4en-e16E
decreased efficacy of learning | larval stage, with Scer\GAL4sca-109-68
decreased rate of larval locomotory behavior, with Scer\GAL4elav.PLu
decreased rate of larval locomotory behavior, with Scer\GAL4sca-109-68
increased cell number | embryonic stage
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4sca-109-68
eye, with Scer\GAL4ey.PH
interommatidial bristle, with Scer\GAL4GMR.PF
larval DA3 motor neuron | embryonic stage | increased number
larval longitudinal connective, with Scer\GAL4sca-4512
larval ventral nerve cord commissure, with Scer\GAL4sca-4512
ommatidium, with Scer\GAL4GMR.PF
U neuron | decreased number | embryonic stage, with Scer\GAL4en-e16E
U neuron | embryonic stage | increased number
wing, with Scer\GAL4Bx-MS1096
wing | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (38)
Hsap\BCL11A
10 of 14
Yes
Yes
Hsap\BCL11B
10 of 14
Yes
Yes
Hsap\IKZF1
1 of 14
No
No
Hsap\MZF1
1 of 14
No
No
Hsap\RBAK
1 of 14
No
No
Hsap\REPIN1
1 of 14
No
No
Hsap\SALL1
1 of 14
No
No
Hsap\SALL2
1 of 14
No
No
Hsap\SALL3
1 of 14
No
No
Hsap\ZBTB20
1 of 14
No
No
Hsap\ZBTB45
1 of 14
No
Yes
Hsap\ZBTB47
1 of 14
No
No
Hsap\ZKSCAN5
1 of 14
No
No
Hsap\ZNF107
1 of 14
No
No
Hsap\ZNF133
1 of 14
No
No
Hsap\ZNF219
1 of 14
No
Yes
Hsap\ZNF226
1 of 14
No
No
Hsap\ZNF260
1 of 14
No
No
1  
Hsap\ZNF275
1 of 14
No
No
Hsap\ZNF276
1 of 14
No
Yes
Hsap\ZNF296
1 of 14
No
Yes
Hsap\ZNF382
1 of 14
No
No
Hsap\ZNF398
1 of 14
No
No
Hsap\ZNF419
1 of 14
No
Yes
Hsap\ZNF493
1 of 14
No
No
Hsap\ZNF628
1 of 14
No
No
Hsap\ZNF660
1 of 14
No
No
Hsap\ZNF672
1 of 14
No
Yes
Hsap\ZNF691
1 of 14
No
No
Hsap\ZNF692
1 of 14
No
No
Hsap\ZNF717
1 of 14
No
No
Hsap\ZNF768
1 of 14
No
No
Hsap\ZNF771
1 of 14
No
No
Hsap\ZNF773
1 of 14
No
Yes
Hsap\ZNF775
1 of 14
No
No
Hsap\ZNF814
1 of 14
No
No
Hsap\ZNF850
1 of 14
No
No
Hsap\ZSCAN5C
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Bcl11a
10 of 14
Yes
Yes
Rnor\Bcl11b
8 of 14
No
Yes
Rnor\LOC100360380
1 of 14
No
No
Rnor\Sall2
1 of 14
No
No
Rnor\Zfp11
1 of 14
No
No
Rnor\Zfp59
1 of 14
No
No
Rnor\Zfp217
1 of 14
No
Yes
Rnor\Zfp219
1 of 14
No
Yes
Rnor\Zfp296
1 of 14
No
Yes
Rnor\Zfp420
1 of 14
No
No
Rnor\Zfp445
1 of 14
No
Yes
Mus musculus (laboratory mouse) (13)
Mmus\Bcl11b
10 of 14
Yes
Yes
Mmus\Bcl11a
9 of 14
No
Yes
Mmus\Sall2
1 of 14
No
No
Mmus\Zfp11
1 of 14
No
No
Mmus\Zfp58
1 of 14
No
Yes
Mmus\Zfp219
1 of 14
No
Yes
Mmus\Zfp275
1 of 14
No
Yes
Mmus\Zfp296
1 of 14
No
Yes
Mmus\Zfp420
1 of 14
No
No
Mmus\Zfp553
1 of 14
No
No
Mmus\Zfp729a
1 of 14
No
No
Mmus\Zfp945
1 of 14
No
No
Mmus\Zfp948
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\bcl11a
9 of 13
Yes
Yes
Xtro\bcl11b
6 of 13
No
Yes
Xtro\LOC496795
1 of 13
No
No
Xtro\LOC549508
1 of 13
No
No
Xtro\LOC100485124
1 of 13
No
No
Xtro\LOC100493522
1 of 13
No
No
Xtro\LOC101731232
1 of 13
No
No
Xtro\LOC101734390
1 of 13
No
Yes
Xtro\LOC108645295
1 of 13
No
No
Xtro\LOC116411608
1 of 13
No
No
Xtro\LOC116411645
1 of 13
No
No
Xtro\MGC146893
1 of 13
No
No
Xtro\XB5795368
1 of 13
No
No
Xtro\zbtb20
1 of 13
No
Yes
Xtro\zbtb47
1 of 13
No
Yes
Xtro\znf276
1 of 13
No
Yes
Xtro\znf853
1 of 13
No
No
Danio rerio (Zebrafish) (9)
Drer\bcl11aa
9 of 14
Yes
Yes
Drer\bcl11ab
9 of 14
Yes
Yes
Drer\bcl11ba
9 of 14
Yes
Yes
Drer\bcl11bb
9 of 14
Yes
Yes
Drer\znf296
3 of 14
No
Yes
Drer\sall3b
1 of 14
No
No
Drer\zgc:113295
1 of 14
No
No
Drer\znf516
1 of 14
No
No
Drer\znf668
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\bcl-11
7 of 14
Yes
Yes
Cele\ZK177.3
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP002610
11 of 12
Yes
Yes
Agam\AgaP_AGAP002082
1 of 12
No
No
Agam\AgaP_AGAP002083
1 of 12
No
No
Agam\AgaP_AGAP003111
1 of 12
No
No
Agam\AgaP_AGAP004269
1 of 12
No
No
Agam\AgaP_AGAP006544
1 of 12
No
Yes
Agam\AgaP_AGAP008984
1 of 12
No
No
Agam\AgaP_AGAP009010
1 of 12
No
No
Agam\AgaP_AGAP009566
1 of 12
No
No
Agam\AgaP_AGAP011877
1 of 12
No
Yes
Agam\AgaP_AGAP013275
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\AZF1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cph. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (11)
Cf2
1 of 13
CG43347
1 of 13
CTCF
1 of 13
jim
1 of 13
ken
1 of 13
pad
1 of 13
peb
1 of 13
Phs
1 of 13
salm
1 of 13
salr
1 of 13
sqz
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
BCL11B; BCL11 transcription factor B
model of  immunodeficiency 49
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
BCL11A; BCL11 transcription factor A
10 of 14
606557
    BCL11B; BCL11 transcription factor B
    10 of 14
    606558
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Cph - Blos1
    two hybrid array
    (Shokri et al., 2019)
    Cph - GATAe
    two hybrid array
    (Shokri et al., 2019)
    Cph - Hr78
    two hybrid array
    (Shokri et al., 2019)
    Cph - Scm
    two hybrid array
    (Shokri et al., 2019)
    Cph - phol
    two hybrid array
    (Shokri et al., 2019)
    Cph - sage
    two hybrid array
    (Shokri et al., 2019)
    Cph - svp
    two hybrid array
    (Shokri et al., 2019)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Cph
    suppressible
    cas
    (Fox et al., 2022)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Delta
    enhanceable
    Cph
    (Shalaby et al., 2009)
    Delta
    suppressible
    Cph
    (Shalaby et al., 2009)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-20
    Cytogenetic map
    6F10-7A5
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    6F10-7A5
    ; Limits computationally determined from genome sequence between P{EP}inx7EP1641 and P{EP}CG9650EP1340&P{EP}CG9650EP1617
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-20

    (FlyBase, 2016)

    1-20.7

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (75)
    Genomic Clones (46)
    cDNA Clones (114)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Murthy and Nongthomba, 2024)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
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        Nomenclature History
        Source for database identify of

        Source for identity of: Cph CG9650

        (Fox et al., 2022)
        Nomenclature comments
        Etymology

        Named 'Chronophage' (or 'time-eater') for its role in promoting the progression of temporal patterning that generates different neuronal subtypes in the developing nervous system.

        (Fox et al., 2022)
        Synonyms and Secondary IDs (6)
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        External Crossreferences and Linkouts ( 137 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (genetic) - An integrated Molecular Interaction Database
        References (95)