General Information
Symbol
Dmel\hdm
Species
D. melanogaster
Name
hold'em
Annotation Symbol
CG15329
Feature Type
FlyBase ID
FBgn0029977
Gene Model Status
Stock Availability
Gene Snapshot
Hold'em is predicted to be a single-strand DNA binding protein based on the presence of three Oligosaccharide-Binding (OB) folds. It is involved in making meiotic crossovers and in some DNA repair process. [Date last reviewed: 2016-08-18]
Genomic Location
Cytogenetic map
Sequence location
X:7,918,517..7,920,131 [-]
Recombination map
1-21
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the MEIOB family. (Q9W3M9)
Molecular Function (see GO section for details)
Summaries
UniProt Contributed Function Data
Single-stranded DNA-binding protein required for meiosis. May be involved in the resolution of recombination intermediates into crossovers in the meiotic recombination pathway.
(UniProt, Q9W3M9)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\hdm or the JBrowse view of Dmel\hdm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0071133
1461
486
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0071085
54.7
486
7.67
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with mei-9 and Ercc1.
(UniProt, Q9W3M9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hdm using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:mei-9; FB:FBgn0002707
inferred from physical interaction with FLYBASE:Ercc1; FB:FBgn0028434
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001465761
(assigned by GO_Central )
inferred from sequence model
inferred from biological aspect of ancestor with PANTHER:PTN001465761
(assigned by GO_Central )
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001465761
(assigned by GO_Central )
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:mei-9; FB:FBgn0002707
inferred from physical interaction with FLYBASE:Ercc1; FB:FBgn0028434
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:mei-9; FB:FBgn0002707
inferred from physical interaction with FLYBASE:Ercc1; FB:FBgn0028434
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\hdm in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Allele of hdm
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
        0
        --
        Other relevant insertions
        Transgenic Constructs ( 4 )
        For All Alleles Carried on Transgenic Constructs Show
        Transgenic constructs containing/affecting coding region of hdm
        Allele of hdm
        Mutagen
        Associated Transgenic Construct
        Stocks
        Transgenic constructs containing regulatory region of hdm
        Deletions and Duplications ( 0 )
        Summary of Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        Orthologs
        Human Orthologs (via DIOPT v7.1)
        Homo sapiens (Human) (1)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        12 of 15
        Yes
        Yes
        Model Organism Orthologs (via DIOPT v7.1)
        Mus musculus (laboratory mouse) (1)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        12 of 15
        Yes
        Yes
        Rattus norvegicus (Norway rat) (1)
        12 of 13
        Yes
        Yes
        Xenopus tropicalis (Western clawed frog) (1)
        2 of 12
        Yes
        Yes
        Danio rerio (Zebrafish) (0)
        No orthologs reported.
        Caenorhabditis elegans (Nematode, roundworm) (1)
        1 of 15
        Yes
        No
        Arabidopsis thaliana (thale-cress) (2)
        1 of 9
        Yes
        No
        1 of 9
        Yes
        No
        Saccharomyces cerevisiae (Brewer's yeast) (0)
        No orthologs reported.
        Schizosaccharomyces pombe (Fission yeast) (0)
        No orthologs reported.
        Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909V0 )
        Organism
        Common Name
        Gene
        AAA Syntenic Ortholog
        Multiple Dmel Genes in this Orthologous Group
        Drosophila melanogaster
        fruit fly
        Drosophila suzukii
        Spotted wing Drosophila
        Drosophila simulans
        Drosophila sechellia
        Drosophila erecta
        Drosophila yakuba
        Drosophila ananassae
        Drosophila pseudoobscura pseudoobscura
        Drosophila persimilis
        Drosophila willistoni
        Drosophila virilis
        Drosophila mojavensis
        Drosophila grimshawi
        Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150442 )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Musca domestica
        House fly
        Glossina morsitans
        Tsetse fly
        Lucilia cuprina
        Australian sheep blowfly
        Mayetiola destructor
        Hessian fly
        Aedes aegypti
        Yellow fever mosquito
        Anopheles darlingi
        American malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0D0N )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Danaus plexippus
        Monarch butterfly
        Danaus plexippus
        Monarch butterfly
        Apis florea
        Little honeybee
        Apis mellifera
        Western honey bee
        Bombus impatiens
        Common eastern bumble bee
        Bombus terrestris
        Buff-tailed bumblebee
        Linepithema humile
        Argentine ant
        Megachile rotundata
        Alfalfa leafcutting bee
        Nasonia vitripennis
        Parasitic wasp
        Dendroctonus ponderosae
        Mountain pine beetle
        Tribolium castaneum
        Red flour beetle
        Pediculus humanus
        Human body louse
        Rhodnius prolixus
        Kissing bug
        Rhodnius prolixus
        Kissing bug
        Cimex lectularius
        Bed bug
        Acyrthosiphon pisum
        Pea aphid
        Zootermopsis nevadensis
        Nevada dampwood termite
        Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X072B )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Ixodes scapularis
        Black-legged tick
        Stegodyphus mimosarum
        African social velvet spider
        Daphnia pulex
        Water flea
        Daphnia pulex
        Water flea
        Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ICR )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Strongylocentrotus purpuratus
        Purple sea urchin
        Gallus gallus
        Domestic chicken
        Human Disease Model Data
        FlyBase Human Disease Model Reports
          Alleles Reported to Model Human Disease (Disease Ontology)
          Download
          Models ( 0 )
          Allele
          Disease
          Evidence
          References
          Interactions ( 0 )
          Allele
          Disease
          Interaction
          References
          Comments ( 0 )
           
          Human Orthologs (via DIOPT v7.1)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Homo sapiens (Human)
          Gene name
          Score
          OMIM
          OMIM Phenotype
          Complementation?
          Transgene?
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser

          Please look at the Interaction Group reports for full details of the physical interactions
          protein-protein
          Interacting group
          Assay
          References
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement

          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Subunit Structure (UniProtKB)
          Interacts with mei-9 and Ercc1.
          (UniProt, Q9W3M9 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Gene Group - Pathway Membership (FlyBase)
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          X
          Recombination map
          1-21
          Cytogenetic map
          Sequence location
          X:7,918,517..7,920,131 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          7C3-7C3
          Limits computationally determined from genome sequence between P{EP}EP1209 and P{EP}CG10777EP1347&P{EP}CG10777EP1363
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (3)
          Genomic Clones (11)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (1)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of
                Source for database merge of
                Additional comments
                Other Comments
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 19 )
                Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                InterPro - A database of protein families, domains and functional sites
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                Flygut - An atlas of the Drosophila adult midgut
                FlyMine - An integrated database for Drosophila genomics
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Synonyms and Secondary IDs (3)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (28)