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Gene Dmel\Gβ5

General Information
Symbol	Dmel\Gβ5	Species	D. melanogaster
Name	Gβ5	Annotation symbol	CG10763
Feature type	protein_coding_gene	FlyBase ID	FBgn0030011
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	Gβ, Gbeta5
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7D16-7D16	Sequence location	X:8,044,764..8,046,311 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gβ5 is referred to in FlyBase by the symbol Dmel\Gβ5 (CG10763, FBgn0030011). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. It is reported to be involved in the biological process: G-protein coupled receptor signaling pathway. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; G-protein, beta subunit; Guanine nucleotide-binding protein, beta subunit; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop. Comments on Affy2 ProbeSet: ProbeSet 1625454_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gbeta5. Gene sequence location is X:8044764..8046311.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN28311 HFA17754
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D16-7D16   Limits computationally determined from genome sequence between P{EP}Ubc-E2HEP1303 and P{EP}CG1583EP1516&P{EP}CG1583EP325
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gβ5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gβ5-RA FBtr0071189  NM_132224   1548   358
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gβ5-PA   FBpp0071137   39.4   358   5.22     NP_572452   AAF46336
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein, beta subunit (IPR001632) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) Guanine nucleotide-binding protein, beta subunit (IPR016346) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46336   BI573825   BI573826   BI611234   BI629256   BT004841 AAO45197   CO188972   CO300629   CO326579   EC057762   EC085634   EC260116   EL870321   EL870322   GH947135   GH947527   GH960759   GH964829   GH970195   GH979460   GH982958
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3J1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030011    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030011 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030011 expression level Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (835) embryo 02-04hr  104 embryo 04-06hr    69 embryo 06-08hr  (302) embryo 08-10hr  (545) embryo 10-12hr  (1654) embryo 12-14hr  (1238) embryo 14-16hr  (2186) embryo 16-18hr  (2011) embryo 18-20hr  (2209) embryo 20-22hr  (1877) embryo 22-24hr  (1869) larva L1  (2203) larva L2  (672) larva L3 12hr old  (239) larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (273) larva L3 puffstage 7-9  (276) white prepupae new  (295) white prepupae 12hr  (601) white prepupae 24hr  (859) pupae 2d postWPP  (1165) pupae 3d postWPP  (1451) pupae 4d postWPP  (1462) adult male 01day  (1029) adult male 05day  (1081) adult male 30day  (1129) adult female 01day  (902) adult female 05day  (363) adult female 30day  (444) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr  (1654) embryo 12-14hr    1238 embryo 14-16hr  (2186) embryo 16-18hr  (2011) embryo 18-20hr  (2209) embryo 20-22hr  (1877) embryo 22-24hr  (1869) larva L1  (2203) larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP  1451 pupae 4d postWPP  1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030011 expression level Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (835) embryo 02-04hr  104 embryo 04-06hr    69 embryo 06-08hr  (302) embryo 08-10hr  (545) embryo 10-12hr  (1654) embryo 12-14hr  (1238) embryo 14-16hr  (2186) embryo 16-18hr  (2011) embryo 18-20hr  (2209) embryo 20-22hr  (1877) embryo 22-24hr  (1869) larva L1  (2203) larva L2  (672) larva L3 12hr old  (239) larva L3 puffstage 1-2  (195) larva L3 puffstage 3-6  (273) larva L3 puffstage 7-9  (276) white prepupae new  (295) white prepupae 12hr  (601) white prepupae 24hr  (859) pupae 2d postWPP  (1165) pupae 3d postWPP  (1451) pupae 4d postWPP  (1462) adult male 01day  (1029) adult male 05day  (1081) adult male 30day  (1129) adult female 01day  (902) adult female 05day  (363) adult female 30day  (444) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr  1654 embryo 12-14hr    1238 embryo 14-16hr  2186 embryo 16-18hr  2011 embryo 18-20hr  2209 embryo 20-22hr  1877 embryo 22-24hr  1869 larva L1  2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP  1451 pupae 4d postWPP  1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    835 embryo 02-04hr    104 embryo 04-06hr    69 embryo 06-08hr    302 embryo 08-10hr    545 embryo 10-12hr    1654 embryo 12-14hr    1238 embryo 14-16hr    2186 embryo 16-18hr    2011 embryo 18-20hr    2209 embryo 20-22hr    1877 embryo 22-24hr    1869 larva L1    2203 larva L2    672 larva L3 12hr old    239 larva L3 puffstage 1-2    195 larva L3 puffstage 3-6    273 larva L3 puffstage 7-9    276 white prepupae new    295 white prepupae 12hr    601 white prepupae 24hr    859 pupae 2d postWPP    1165 pupae 3d postWPP    1451 pupae 4d postWPP    1462 adult male 01day    1029 adult male 05day    1081 adult male 30day    1129 adult female 01day    902 adult female 05day    363 adult female 30day    444 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030011    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030011 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030011 expression level Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain  (748.2) Adult Thoracic-Abdominal Ganglion  (547.6) Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030011 expression level Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain  748.2 Adult Thoracic-Abdominal Ganglion  547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut no informative data Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    5.7 Larval Carcass no informative data Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut no informative data Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    224.3   NA  Eye    192.675   NA  Brain    748.2   285.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    547.6   NA  Crop    118.8   no informative data  Midgut    no informative data   38.9  Hindgut    46.2   4.6  Malpighian Tubules    7.8   no informative data  Fat Body    9.7   no informative data  Salivary Gland    8.9   NA  Heart    48.25   5.7  Trachea    NA   NA  VirginFemale Spermatheca    5   NA  InseminatedFemale Spermatheca    5.9   NA  Ovary    24.7   NA  Testis    30.1   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030011 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10763-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gβ5 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Gβ5 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gβ5 Class Mutagen Stocks Known lesion Gβ5JF02941 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gβ5KK108311 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gβ5GD6716 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity with EMBL:U69145 (FlyBase, 1992-)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway non-traceable author statement (Barrett and Roberts, 2001)
Cellular Component
CV term Evidence References
heterotrimeric G-protein complex inferred from sequence or structural similarity with EMBL:U69145 (FlyBase, 1992-) non-traceable author statement (Barrett and Roberts, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gβ5 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030011 DroID - A comprehensive database of gene and protein interactions. • FBgn0030011 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31744
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20976 Dere\GG17982 Dgri\GH24861 Dmoj\GI14411 Dper\GL20190 Dpse\GA10552 Dsec\GM11205 Dsim\GD16125 Dvir\GJ18759 Dwil\GK19916 Dyak\GE17476
Curated drosophilid orthologs	Dpse\GA10552
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010070-PA Aedes aegypti (mosquito) AGAP010318-PA Anopheles gambiae (mosquito) XP_392638.2 Apis mellifera (honey bee) XP_001947420.1 Acyrthosiphon pisum (pea aphid) 230572 Branchiostoma floridae (lancelet) BGIBMGA012592-PA Bombyx mori (silk worm) ENSBTAP00000004896 Bos taurus (bovine) CN16536 Caenorhabditis brenneri (small nematode) CN18656 Caenorhabditis brenneri (small nematode) CBP28820 Caenorhabditis briggsae (nematode) CE17845 Caenorhabditis elegans (worm) ENSCAFP00000023022 Canis familiaris (dog) JA03307 Caenorhabditis japonica (nematode) CPIJ002520 Culex pipens (mosquito) ENSCPOP00000012180 Cavia porcellus (guinea pig) RP04281 Caenorhabditis remanei (nematode) ENSCSAVP00000005736 Ciona savignyi (sedentary tunicate) 171720 Capitella spl (polychaete worm) 205771 Daphnia pulex (daphnia) ENSDARP00000011435 Danio rerio (zebra fish) ENSECAP00000016297 Equus caballus (horse) ENSGACP00000007929 Gymnopilus aculeatus (mushroom) ENSGALP00000007443 Gallus gallus (chicken) 115679 Hypsipyla robusta (cedar shoot borer) ENSP00000261837 Homo sapiens (human) ISCW014555-PA Ixodes scapularis (deer tick) KLLA0D06787g Kluyveromyces lactis (yeast) 162493 Lottia gigantea (owl limpet) ENSMODP00000002374 Monodelphis domestica (gray opossum) ENSMMUP00000022869 Macaca mulatta (rhesus monkey) ENSMUSP00000076155 Mus musculus (house mouse) 244849 Nematostella vectensis (starlet anemone) XP_001606387.1 Nasonia vitripennis (wasp) ENSORLP00000006943 Oryzias latipes (japanese killifish) PHUM004382-PA Pediculus humanus (human body louse) PP00158 Pristionchus pacificus (nematode) ENSPPYP00000007349 Pongo pygmaeus (orangutan) ENSPTRP00000012110 Pan troglodytes (chimpanzee) ENSRNOP00000011963 Rattus norvegicus (norway rat) YOR212W Saccharomyces cerevisiae (budding yeast) Smp_075130 Schistosoma mansoni (trematode parasite) XP_001180944.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975542.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013130 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027895 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14490 LH19323 ISCW014555 FBgn0234941 FBgn0221913 FBgn0205911 FBgn0187761 FBgn0166150 JGI_V11_205771 FBgn0070609 FBgn0157785 FBgn0137163 FBgn0132316 FBgn0110200 FBgn0097981 CPIJ002520 BGIBMGA012592 ACYPI003915 GB16329 AGAP012525 AGAP010318 AAEL010070 PB20884 PHUM371020 GLEAN_08821
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	28310 y1 v1; P{TRiP.JF02941}attP2
VDRC	v108261 P{KK108311}VIE-260B
Genomic Clones ( 1 )
	BACR39F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH17413
Other clones	DPiM_RH17413
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH58094
Other clones	57609 214511.18 CK01.48D.C11 EK042610 EK178833 EP04241 IP02418 RH09326 RP004209135 RP004212910 RP004215824 RP004250175 RP004430662 RP004499222 RP004542721
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030011 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31744
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gβ5 CG10763 (Roberts, 2001.3.14)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of Gβ5 in the hh signalling pathway. (Lum, 2003) Mutants show embryonic lethality with no patterning of nervous system defects. (Barrett and Roberts, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132224 RefSeq (Proteins) • NP_572452 DDBJ / EMBL / GenBank • AAF46336 AAO45197 BI611234 BT004841 Entrez Gene - A searchable database of RefSeq genes. • 31744 UniProtKB/TrEMBL • Q9W3J1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein, beta subunit (IPR001632) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) Guanine nucleotide-binding protein, beta subunit (IPR016346) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030011 DroID - A comprehensive database of gene and protein interactions. • FBgn0030011 DRSC - Results from RNAi screens. • FBgn0030011 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030011 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10763-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030011 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31744 InParanoid A subset of ortholog calls from InParanoid. • AAEL010070-PA Aedes aegypti (mosquito) AGAP010318-PA Anopheles gambiae (mosquito) XP_392638.2 Apis mellifera (honey bee) XP_001947420.1 Acyrthosiphon pisum (pea aphid) 230572 Branchiostoma floridae (lancelet) BGIBMGA012592-PA Bombyx mori (silk worm) ENSBTAP00000004896 Bos taurus (bovine) CN16536 Caenorhabditis brenneri (small nematode) CN18656 Caenorhabditis brenneri (small nematode) CBP28820 Caenorhabditis briggsae (nematode) CE17845 Caenorhabditis elegans (worm) ENSCAFP00000023022 Canis familiaris (dog) JA03307 Caenorhabditis japonica (nematode) CPIJ002520 Culex pipens (mosquito) ENSCPOP00000012180 Cavia porcellus (guinea pig) RP04281 Caenorhabditis remanei (nematode) ENSCSAVP00000005736 Ciona savignyi (sedentary tunicate) 171720 Capitella spl (polychaete worm) 205771 Daphnia pulex (daphnia) ENSDARP00000011435 Danio rerio (zebra fish) ENSECAP00000016297 Equus caballus (horse) ENSGACP00000007929 Gymnopilus aculeatus (mushroom) ENSGALP00000007443 Gallus gallus (chicken) 115679 Hypsipyla robusta (cedar shoot borer) ENSP00000261837 Homo sapiens (human) ISCW014555-PA Ixodes scapularis (deer tick) KLLA0D06787g Kluyveromyces lactis (yeast) 162493 Lottia gigantea (owl limpet) ENSMODP00000002374 Monodelphis domestica (gray opossum) ENSMMUP00000022869 Macaca mulatta (rhesus monkey) ENSMUSP00000076155 Mus musculus (house mouse) 244849 Nematostella vectensis (starlet anemone) XP_001606387.1 Nasonia vitripennis (wasp) ENSORLP00000006943 Oryzias latipes (japanese killifish) PHUM004382-PA Pediculus humanus (human body louse) PP00158 Pristionchus pacificus (nematode) ENSPPYP00000007349 Pongo pygmaeus (orangutan) ENSPTRP00000012110 Pan troglodytes (chimpanzee) ENSRNOP00000011963 Rattus norvegicus (norway rat) YOR212W Saccharomyces cerevisiae (budding yeast) Smp_075130 Schistosoma mansoni (trematode parasite) XP_001180944.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975542.1 Tribolium castaneum (red flour beetle) ENSTNIP00000013130 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027895 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31744 modMine - Data generated by the modENCODE project. • FBgn0030011 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14490 LH19323 ISCW014555 FBgn0234941 FBgn0221913 FBgn0205911 FBgn0187761 FBgn0166150 JGI_V11_205771 FBgn0070609 FBgn0157785 FBgn0137163 FBgn0132316 FBgn0110200 FBgn0097981 CPIJ002520 BGIBMGA012592 ACYPI003915 GB16329 AGAP012525 AGAP010318 AAEL010070 PB20884 PHUM371020 GLEAN_08821
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG10763 (Keleman et al., 2009.8.5, Perkins et al., 2009) Gβ (Montell, 2000) Gbeta 5 (Lum, 2003) Gbeta5 (Telonis-Scott et al., 2009, Hazelett et al., 2009) Gbetagamma (Kaltschmidt and Brand, 2002) Gβ (Lee et al., 2004, Yamashita et al., 2005, Mishra et al., 2010) Gβ5 (Stuart et al., 2007, Yi et al., 2008, Mishra et al., 2010)
Name Synonym	Gβ5
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Mishra et al., 2010, Development 137(17): 2895--2904 Pph13 and Orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function. [FBrf0211519] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...