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Gene Dmel\Gβ5

General Information
Symbol	Dmel\Gβ5	Species	D. melanogaster
Name	Gβ5	Annotation symbol	CG10763
Feature type	protein_coding_gene	FlyBase ID	FBgn0030011
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	Gβ, Gbeta5
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7D16-7D16	Sequence location	X:8,044,764..8,046,308 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gβ5 is referred to in FlyBase by the symbol Dmel\Gβ5 (CG10763, FBgn0030011). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. It is reported to be involved in the biological process: G-protein coupled receptor signaling pathway. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; G-protein, beta subunit; Guanine nucleotide-binding protein, beta subunit; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop. Comments on Affy2 ProbeSet: ProbeSet 1625454_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gbeta5. Gene sequence location is X:8044764..8046308.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7D16-7D16   Limits computationally determined from genome sequence between P{EP}Ubc-E2HEP1303 and P{EP}CG1583EP1516&P{EP}CG1583EP325
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gβ5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gβ5-RA FBtr0071189  NM_132224   1545   358
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gβ5-PA   FBpp0071137   39.4   358   5.22     NP_572452   AAF46336
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein, beta subunit (IPR001632) WD40 repeat (IPR001680) Guanine nucleotide-binding protein, beta subunit (IPR016346) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF46336   BI573825   BI573826   BI611234   BI629256   BT004841 AAO45197   CO188972   CO300629   CO326579   EC057762   EC085634   EC260116   EL870321   EL870322   GH947135   GH947527   GH960759   GH964829   GH970195   GH979460   GH982958
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3J1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Boto et al., 2010) third segment of antenna   (Boto et al., 2010) maxillary palpus   (Boto et al., 2010)
Additional Descriptive Data
	RT-PCR analysis shows that Gβ5 transcript is expressed in the adult head, third segment of the antenna and maxillary palps. (Boto et al., 2010)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain  (748.2) Adult Thoracic-Abdominal Ganglion  (547.6) Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain  748.2 Adult Thoracic-Abdominal Ganglion  547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.75 Larval Midgut    14 Larval Hindgut    38.9 Larval Malpighian Tubules    4.6 Larval Fat Body    15.8 Larval Salivary Gland    10.6 Larval Trachea    5.7 Larval Carcass    10.975 Adult Head    224.3 Adult Eye    192.675 Adult Brain    748.2 Adult Thoracic-Abdominal Ganglion    547.6 Adult Crop    118.8 Adult Midgut    24.1 Adult Hindgut    46.2 Adult Malpighian Tubules    7.8 Adult Fat Body    9.7 Adult Salivary Gland    8.9 Adult Heart    48.25 Adult VirginFemale Spermatheca    5 Adult InseminatedFemale Spermatheca    5.9 Adult Ovary    24.7 Adult Testis    30.1 Adult Male Accessory Gland    38 Adult Carcass    25.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    224.3   NA  Eye    192.675   NA  Brain    748.2   285.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    547.6   NA  Crop    118.8   no informative data  Midgut    no informative data   38.9  Hindgut    46.2   4.6  Malpighian Tubules    7.8   no informative data  Fat Body    9.7   no informative data  Salivary Gland    8.9   NA  Heart    48.25   5.7  Trachea    NA   NA  VirginFemale Spermatheca    5   NA  InseminatedFemale Spermatheca    5.9   NA  Ovary    24.7   NA  Testis    30.1   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male  (31) head, mated 4-day male    24 head, mated 20-day male  26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male  31 head, mated 4-day male    24 head, mated 20-day male  26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    13 central nervous system, pupae P8    24 head, virgin 1-day female    17 head, virgin 4-day female    16 head, virgin 20-day female    13 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    8 head, mated 1-day male    31 head, mated 4-day male    24 head, mated 20-day male    26 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    4 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr  (29) embryo 16-18hr  (27) embryo 18-20hr  (29) embryo 20-22hr    25 embryo 22-24hr    25 larva L1  (29) larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr  29 embryo 16-18hr  27 embryo 18-20hr  29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1  29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    7 embryo 10-12hr    22 embryo 12-14hr    16 embryo 14-16hr    29 embryo 16-18hr    27 embryo 18-20hr    29 embryo 20-22hr    25 embryo 22-24hr    25 larva L1    29 larva L2    9 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    11 pupae 2d postWPP    15 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    14 adult male 05day    14 adult male 30day    15 adult female 01day    12 adult female 05day    5 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    1 embryonic GM2    2 embryonic Kc167    3 embryonic S1    2 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    6 wing disc ML-DmD8    1 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    5 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • RH17413 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030011 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10763-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gβ5 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Gβ5 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gβ5 Class Mutagen Stocks Known lesion Gβ5JF02941 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gβ5KK108311 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gβ5GD6716 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity with EMBL:U69145 (FlyBase, 1992-)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway non-traceable author statement (Barrett and Roberts, 2001)
Cellular Component
CV term Evidence References
heterotrimeric G-protein complex inferred from sequence or structural similarity with EMBL:U69145 (FlyBase, 1992-) non-traceable author statement (Barrett and Roberts, 2001)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gβ5 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gβ5 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030011 DroID - A comprehensive database of gene and protein interactions. • FBgn0030011 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31744 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W3J1
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B5PR4 Dipteran inclusive ortholog search EOG6229TC Insect inclusive ortholog search EOG61RNQN Arthropod inclusive ortholog search EOG6QV9TM Metazoa inclusive ortholog search EOG63C0GQ
Orthologs in Drosophila Species (EOG6B5PR4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gβ5     Drosophila simulans   Dsim\GD16125 Y   Drosophila sechellia   Dsec\GM11205 Y   Drosophila erecta   Dere\GG17982 Y   Drosophila yakuba   Dyak\GE17476 Y   Drosophila ananassae   Dana\GF20976 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10552 Y   Drosophila persimilis   Dper\GL20190 Y   Drosophila willistoni   Dwil\GK19916 Y   Drosophila virilis   Dvir\GJ18759 Y   Drosophila mojavensis   Dmoj\GI14411 Y   Drosophila grimshawi   Dgri\GH24861 Y
Orthologs in non-Drosophila Dipterans (EOG6229TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010070   Anopheles gambiae Malaria mosquito  Agam\AGAP012525   Anopheles gambiae Malaria mosquito  Agam\AGAP010318   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002520
Orthologs in non-Dipteran Insects (EOG61RNQN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Gbeta5   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009611   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25509   Atta cephalotes Leafcutter ant  Acep\ACEP13245   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19270   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17629   Linepithema humile Argentine ant  Lhum\LH19323   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20884   Solenopsis invicta Red fire ant  Sinv\SINV10645   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003915   Bombyx mori Silkmoth  Bmor\BGIBMGA012592   Pediculus humanus Human body louse  Phum\PHUM371020   Tribolium castaneum Red flour beetle  Tcas\TC008821
Orthologs in non-Insect Arthropods (EOG6QV9TM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ppfr-4   Ixodes scapularis Deer tick  Isca\ISCW014555
Orthologs in non-Arthropod Metazoa (EOG63C0GQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gpb-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027826gn   Danio rerio Zebrafish  Drer\gnb5a   Danio rerio Zebrafish  Drer\gnb5b   Xenopus tropicalis Western clawed frog  Xtro\gnb5   Gallus gallus Domestic chicken  Ggal\GNB5   Mus musculus House mouse  Mmus\Gnb5   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008926   Homo sapiens Human  Hsap\GNB5
Human Orthologs (1)
Gene OMIM HGNC Hsap\GNB5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16125 Drosophila sechellia Dsec\GM11205 Drosophila erecta Dere\GG17982 Drosophila yakuba Dyak\GE17476 Drosophila ananassae Dana\GF20976 Drosophila pseudoobscura pseudoobscura Dpse\GA10552 Drosophila persimilis Dper\GL20190 Drosophila willistoni Dwil\GK19916 Drosophila virilis Dvir\GJ18759 Drosophila mojavensis Dmoj\GI14411 Drosophila grimshawi Dgri\GH24861
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	28310 y1 v1; P{TRiP.JF02941}attP2
VDRC	v108261 P{KK108311}VIE-260B
Genomic Clones ( 1 )
	BACR39F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH17413
Other clones	DPiM_RH17413
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH58094
Other clones	57609 214511.18 CK01.48D.C11 EK042610 EK178833 EP04241 IP02418 RH09326 RP004209135 RP004212910 RP004215824 RP004250175 RP004430662 RP004499222 RP004542721
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030011 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31744
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gβ5 CG10763 (Roberts, 2001.3.14)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of Gβ5 in the hh signalling pathway. (Lum, 2003) Mutants show embryonic lethality with no patterning of nervous system defects. (Barrett and Roberts, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132224 RefSeq (Proteins) • NP_572452 DDBJ / EMBL / GenBank • AAF46336 AAO45197 BI611234 BT004841 Entrez Gene - A searchable database of RefSeq genes. • 31744 UniProtKB/TrEMBL • Q9W3J1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein, beta subunit (IPR001632) WD40 repeat (IPR001680) Guanine nucleotide-binding protein, beta subunit (IPR016346) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH17413
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030011 DroID - A comprehensive database of gene and protein interactions. • FBgn0030011 DRSC - Results from RNAi screens. • FBgn0030011 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030011 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10763-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030011 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31744 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31744 modMine - Data generated by the modENCODE project. • FBgn0030011 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W3J1
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG10763 (Boto et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009) Gβ5 (Boto et al., 2010) Gβ (Montell, 2000) Gbeta 5 (Lum, 2003) Gbeta5 (Telonis-Scott et al., 2009, Hazelett et al., 2009) Gbetagamma (Kaltschmidt and Brand, 2002) Gβ (Lee et al., 2004, Yamashita et al., 2005, Mishra et al., 2010) Gβ5 (Stuart et al., 2007, Boto et al., 2010, Yi et al., 2008, Mishra et al., 2010)
Name Synonym	Gβ5
Secondary FlyBase IDs
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...