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Gene Dmel\CG12065

General Information
Symbol	Dmel\CG12065	Species	D. melanogaster
Name		Annotation symbol	CG12065
Feature type	protein_coding_gene	FlyBase ID	FBgn0030052
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7F5-7F7	Sequence location	X:8,468,337..8,482,561 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12065 (FBgn0030052). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity. There is experimental evidence that it is involved in the biological process: lateral inhibition. 6 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Nucleoside phosphorylase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1632774_s_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of CG12065. Gene sequence location is X:8468337..8482561.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN24340 HFA17799 HFA17798
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7F5-7F7   Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12065 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12065-RA FBtr0071214  NM_132265   2795   687 CG12065-RB FBtr0071215  NM_167162   2655   687 CG12065-RC FBtr0071216  NM_206662   2657   641 CG12065-RD FBtr0071217  NM_206661   2517   641 CG12065-RE FBtr0300750  NM_001169237   2654   641 CG12065-RF FBtr0300751  NM_001169238   2660   641
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12065-PA   FBpp0071160   76.7   687   8.72     NP_572493   AAF46394 CG12065-PB   FBpp0071161   76.7   687   8.72     NP_727278   AAN09237 CG12065-PC   FBpp0071162   71.2   641   7.44     NP_996385   AAS65291 CG12065-PD   FBpp0071163   71.2   641   7.44     NP_996384   AAS65292 CG12065-PE   FBpp0289974   71.2   641   7.44     NP_001162708   ACZ95243 CG12065-PF   FBpp0289975   71.2   641   7.44     NP_001162709   ACZ95244
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleoside phosphorylase domain (IPR000845)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540470   AE014298 AAF46394   AE014298 AAN09237   AE014298 AAS65291   AE014298 AAS65292   AE014298 ACZ95243   AE014298 ACZ95244   AI239043   AI542509   AW940582   AY119523 AAM50177   BG638210   BI163283   BI164045   BI215371   BI228390   BI228433   BI234734   BI235744   BI355661   BI356062   BI362461   BI483297   BI483784   BI566229   BI569608   BI580018   BI581158   BI581635   BI582526   BI586588   BI605065   BI613889   BI614331   BI615250   BI618361   BI618649   BI618844   BI619106   BI620908   BI623739   BI626753   BI627886   BI629849   BI630929   BI632743   BI634542   BI635488   BI637396   BT023715   CL525914   CO154314   CO155575   CO156055   CO156122   CO156293   CO156537   CO156871   CO177931   CO314454   CO317974   CO335855   CO336545   CO338330   CO344745   EC076814   EC089618   EC195788   EC260710   EC261178   EC261895   EC262540   EC263062   EC266009   EC266582   EC266629   EC266714   EC266808   EC267583   GH943971   GH945076   GH946416   GH952988   GH955359   GH957895   GH960393   GH964024   GH964875   GH974303   GH974670   GH975542   GH981403   GR705800
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MRM6 Q9W3D6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030052    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030052 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030052 expression level Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (811) embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr  (342) embryo 08-10hr  (341) embryo 10-12hr  (973) embryo 12-14hr  (900) embryo 14-16hr  (2531) embryo 16-18hr  (5010) embryo 18-20hr  (7811) embryo 20-22hr  (5120) embryo 22-24hr  (4741) larva L1  (2680) larva L2  (1695) larva L3 12hr old  (1692) larva L3 puffstage 1-2  (1491) larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (1720) white prepupae new  (1473) white prepupae 12hr  (2859) white prepupae 24hr  (964) pupae 2d postWPP  (1720) pupae 3d postWPP  (1809) pupae 4d postWPP  (2416) adult male 01day  (1826) adult male 05day  (1706) adult male 30day  (1932) adult female 01day  (2045) adult female 05day  (1205) adult female 30day  (1325) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr  (2531) embryo 16-18hr  (5010) embryo 18-20hr  (7811) embryo 20-22hr  (5120) embryo 22-24hr  (4741) larva L1  (2680) larva L2  (1695) larva L3 12hr old  (1692) larva L3 puffstage 1-2  1491 larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (1720) white prepupae new  1473 white prepupae 12hr  (2859) white prepupae 24hr    964 pupae 2d postWPP  (1720) pupae 3d postWPP  (1809) pupae 4d postWPP  (2416) adult male 01day  (1826) adult male 05day  (1706) adult male 30day  (1932) adult female 01day  (2045) adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030052 expression level Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (811) embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr  (342) embryo 08-10hr  (341) embryo 10-12hr  (973) embryo 12-14hr  (900) embryo 14-16hr  (2531) embryo 16-18hr  (5010) embryo 18-20hr  (7811) embryo 20-22hr  (5120) embryo 22-24hr  (4741) larva L1  (2680) larva L2  (1695) larva L3 12hr old  (1692) larva L3 puffstage 1-2  (1491) larva L3 puffstage 3-6  (1966) larva L3 puffstage 7-9  (1720) white prepupae new  (1473) white prepupae 12hr  (2859) white prepupae 24hr  (964) pupae 2d postWPP  (1720) pupae 3d postWPP  (1809) pupae 4d postWPP  (2416) adult male 01day  (1826) adult male 05day  (1706) adult male 30day  (1932) adult female 01day  (2045) adult female 05day  (1205) adult female 30day  (1325) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr  (2531) embryo 16-18hr  (5010) embryo 18-20hr  (7811) embryo 20-22hr  (5120) embryo 22-24hr  (4741) larva L1  (2680) larva L2  1695 larva L3 12hr old  1692 larva L3 puffstage 1-2  1491 larva L3 puffstage 3-6  1966 larva L3 puffstage 7-9  1720 white prepupae new  1473 white prepupae 12hr  (2859) white prepupae 24hr    964 pupae 2d postWPP  1720 pupae 3d postWPP  1809 pupae 4d postWPP  2416 adult male 01day  1826 adult male 05day  1706 adult male 30day  1932 adult female 01day  2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    811 embryo 02-04hr    78 embryo 04-06hr    79 embryo 06-08hr    342 embryo 08-10hr    341 embryo 10-12hr    973 embryo 12-14hr    900 embryo 14-16hr    2531 embryo 16-18hr    5010 embryo 18-20hr    7811 embryo 20-22hr    5120 embryo 22-24hr    4741 larva L1    2680 larva L2    1695 larva L3 12hr old    1692 larva L3 puffstage 1-2    1491 larva L3 puffstage 3-6    1966 larva L3 puffstage 7-9    1720 white prepupae new    1473 white prepupae 12hr    2859 white prepupae 24hr    964 pupae 2d postWPP    1720 pupae 3d postWPP    1809 pupae 4d postWPP    2416 adult male 01day    1826 adult male 05day    1706 adult male 30day    1932 adult female 01day    2045 adult female 05day    1205 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030052    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030052 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030052 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030052 expression level Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut    43.6 Larval Hindgut    45.7 Larval Malpighian Tubules no informative data Larval Fat Body    1.9 Larval Salivary Gland no informative data Larval Trachea    3.55 Larval Carcass no informative data Adult Head no informative data Adult Eye    4.775 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion    26.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    9.7 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    8.3 Adult Testis    7.8 Adult Male Accessory Gland    6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    4.775   NA  Brain    no informative data   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    26.7   NA  Crop    no informative data   43.6  Midgut    no informative data   45.7  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   1.9  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   3.55  Trachea    NA   NA  VirginFemale Spermatheca    9.7   NA  InseminatedFemale Spermatheca    7.7   NA  Ovary    8.3   NA  Testis    7.8   NA  Male Accessory Gland    6   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030052 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12065-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG12065EY06278 viable, with Scer\GAL4pnr-MD237 CG12065GD6740 Sterility Allele fertile CG12065EY06278 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG12065GD6740 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 CG12065GD6740
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG12065 Class Mutagen Stocks Known lesion CG12065EY06278 P-element activity 1 -- CG12065NP6114 1 -- CG12065GG01508 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12065 Class Mutagen Stocks Known lesion CG12065GD6740 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG12065HMS01111 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12065KK105204 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6740} NA P{KK105204} NA P{TRiP.HMS01111} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG12065EY06278 NA P{Mae-UAS.6.11}CG12065GG01508 NA insertion of enhancer trap binary system P{GawB}CG12065NP6114 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
catalytic activity inferred from electronic annotation with InterPro:IPR000845 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nucleoside metabolic process inferred from electronic annotation with InterPro:IPR000845 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12065 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58257 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030052 DroID - A comprehensive database of gene and protein interactions. • FBgn0030052 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31798
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21835 Dere\GG18262 Dgri\GH12787 Dmoj\GI15229 Dper\GL20347 Dpse\GA11369 Dsec\GM21702 Dsim\GD16908 Dvir\GJ18688 Dwil\GK19925 Dyak\GE15793
Curated drosophilid orthologs	Dpse\GA11369   Dsim\GD16908 (Montchamp-Moreau, 2005.6.20)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012246-PA Aedes aegypti (mosquito) AGAP000321-PA Anopheles gambiae (mosquito) XP_001121278.1 Apis mellifera (honey bee) XP_001946833.1 Acyrthosiphon pisum (pea aphid) CN08250 Caenorhabditis brenneri (small nematode) CBP03803 Caenorhabditis briggsae (nematode) CE29974 Caenorhabditis elegans (worm) JA16246 Caenorhabditis japonica (nematode) CPIJ000676 Culex pipens (mosquito) RP46096 Caenorhabditis remanei (nematode) 151003 Capitella spl (polychaete worm) 66107 Daphnia pulex (daphnia) 172421 Hypsipyla robusta (cedar shoot borer) ISCW004091-PA Ixodes scapularis (deer tick) 128403 Lottia gigantea (owl limpet) XP_001605800.1 Nasonia vitripennis (wasp) PHUM001343-PA Pediculus humanus (human body louse) PP17996 Pristionchus pacificus (nematode) Smp_068070 Schistosoma mansoni (trematode parasite) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15067 NV13475 LH14173 ISCW004091 FBgn0233358 FBgn0221922 FBgn0205841 FBgn0084063 FBgn0176581 JGI_V11_66107 FBgn0071423 FBgn0157942 FBgn0137978 FBgn0120266 FBgn0110478 FBgn0098835 CPIJ000676 BGIBMGA012507 BGIBMGA012506 ACYPI007438 GB30343 GB11422 AGAP000321 AAEL012246 PHUM244860 GLEAN_00967
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	17357 y1 w67c23 P{EPgy2}CG12065EY06278 34636 y1 sc* v1; P{TRiP.HMS01111}attP2
Kyoto	105134 y* w* P{GawB}CG12065NP6114 / FM7c
VDRC	v104144 P{KK105204}VIE-260B v31120 w1118; P{GD6740}v31120 v31121 w1118; P{GD6740}v31121
Genomic Clones ( 2 )
	BACR17J10 BACR40O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 84 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH15213 GH20002
Other clones	DPiM_GH15213
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM31795 RE02638 RE03615 RE21754 RE25928 RE25976 RE30482 RE31665 RE42092 RE47020 RE66169 RE66727 RE74139 RH01711 RH18492 RH19162 RH20758 RH26658 RH35421 RH38722 RH43148 RH43681 RH44838 RH48991 RH49527 RH49771 RH50077 RH52167 RH56071 RH58772 RH60273 RH67805 RH69354 RH70581 SD08853 SD16856 SD19404 SD26606
Other clones	117529 165268 214223.19 523427 525016 525813 527098 527164 528027 528328 542800 557970 571282 CK01.68B.F7 EK054724 EK236534 EK269930 EN03911 EN06346 EN07252 EN07364 EN07761 EN08247 EN09455 EN11347 EN12737 EN16519 EP19826 LD19967 MB6-CG12065-RB RP004048257 RP004099687 RP004136864 RP004220181 RP004232182 RP004233557 RP004244063 RP004340080 RP004359164 RP004366729 RP004498154 RP004508814 RP004546104
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030052 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31798
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132265 NM_167162 NM_206661 NM_206662 NM_001169237 NM_001169238 RefSeq (Proteins) • NP_572493 NP_727278 NP_996384 NP_996385 NP_001162708 NP_001162709 DDBJ / EMBL / GenBank • AAF46394 AAM50177 AAN09237 AAS65291 AAS65292 ACZ95243 ACZ95244 AI239043 AW940582 AY119523 CL525914 Entrez Gene - A searchable database of RefSeq genes. • 31798 UniProtKB/TrEMBL • Q8MRM6 Q9W3D6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleoside phosphorylase domain (IPR000845)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58257 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030052 DroID - A comprehensive database of gene and protein interactions. • FBgn0030052 DRSC - Results from RNAi screens. • FBgn0030052 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030052 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12065-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030052 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31798 InParanoid A subset of ortholog calls from InParanoid. • AAEL012246-PA Aedes aegypti (mosquito) AGAP000321-PA Anopheles gambiae (mosquito) XP_001121278.1 Apis mellifera (honey bee) XP_001946833.1 Acyrthosiphon pisum (pea aphid) CN08250 Caenorhabditis brenneri (small nematode) CBP03803 Caenorhabditis briggsae (nematode) CE29974 Caenorhabditis elegans (worm) JA16246 Caenorhabditis japonica (nematode) CPIJ000676 Culex pipens (mosquito) RP46096 Caenorhabditis remanei (nematode) 151003 Capitella spl (polychaete worm) 66107 Daphnia pulex (daphnia) 172421 Hypsipyla robusta (cedar shoot borer) ISCW004091-PA Ixodes scapularis (deer tick) 128403 Lottia gigantea (owl limpet) XP_001605800.1 Nasonia vitripennis (wasp) PHUM001343-PA Pediculus humanus (human body louse) PP17996 Pristionchus pacificus (nematode) Smp_068070 Schistosoma mansoni (trematode parasite) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31798 modMine - Data generated by the modENCODE project. • FBgn0030052 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15067 NV13475 LH14173 ISCW004091 FBgn0233358 FBgn0221922 FBgn0205841 FBgn0084063 FBgn0176581 JGI_V11_66107 FBgn0071423 FBgn0157942 FBgn0137978 FBgn0120266 FBgn0110478 FBgn0098835 CPIJ000676 BGIBMGA012507 BGIBMGA012506 ACYPI007438 GB30343 GB11422 AGAP000321 AAEL012246 PHUM244860 GLEAN_00967
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12065 (Derome et al., 2008, Straub et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Derome et al., 2008, Mol. Biol. Evol. 25(2): 409--416 Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans. [FBrf0204227] Straub et al., 2008, PLoS Genet. 4(12): e1000302 The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex. [FBrf0206582] Asha et al., 2003, Genetics 163(1): 203--215 Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
DNA/RNA sequence record	Montchamp-Moreau, 2005.6.20, GenBank/EMBL/DDBJ: AM040168 Drosophila simulans partial mRNA for cg12065 protein. [FBrf0196799]