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Gene Dmel\CG12081

General Information
Symbol	Dmel\CG12081	Species	D. melanogaster
Name		Annotation symbol	CG12081
Feature type	protein_coding_gene	FlyBase ID	FBgn0030053
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7F7-7F7	Sequence location	X:8,482,857..8,484,743 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12081 (FBgn0030053). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Kelch repeat type 1; Kelch-type beta propeller. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626154_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12081. Gene sequence location is X:8482857..8484743.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA17802 BKN22411
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7F7-7F7   Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12081 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12081-RA FBtr0071218  NM_132266   1887   403
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12081-PA   FBpp0071164   45.2   403   7.88     NP_572494   AAF46395
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kelch repeat type 1 (IPR006652) Kelch-type beta propeller (IPR015915)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540657   AA950376   AA950991   AE014298 AAF46395   AI135408   AI292903   AI519043   AI519049   AW942562   AY119599 AAM50253   BI166380   BI227985   BI228629   BI235028   BI236050   BI236832   BI238923   BI367223   BI371914   BI371920   BI373910   BI374730   BI566850   BI569218   BI569219   BI589825   BI590070   BI619616   BI636671   BI638374   BI638902   BI638986   BI641427   CA806380   CA806481   CA807056   CO177647   CO178187   CO275781   CO285109   CO285162   CO287369   CO290090   CO298027   CO298842   CO316816   CO322635   CO324388   CO327631   CO327680   CO329203   DN154406   EC062887   EC063312   EC071480   EC078032   EC090169   EC195672   EC195773   EC207740   EC211025   EC223313   EC223536   EC249011   EC252846   EC258093   EV585541   GH738812   GH738963   GH739612   GH739862   GH740159   GH740739   GH740773   GH741109   GH741183   GH742358   GH742363   GH742955   GH743054   GH743296   GH743445   GH743652   GH744069   GH744129   GH744385   GH744966   GH744970   GH745002   GH745152   GH745195   GH745409   GH745615   GH745655   GH745864   GH745883   GH746134   GH746139   GH746215   GH746729   GH747058   GH747251   GH747284   GH747505   GH761763   GH762539   GH762540   GH762593   GH763456   GH763830   GH764071   GH764188   GH764278   GH764428   GH764435   GH764555   GH764598   GH765222   GH765677   GH765755   GH766775   GH766882   GH766975   GH767246   GH767257   GH767261   GH767503   GH767608   GH767668   GH767765   GH768065   GH768201   GH768521   GH768735   GH769618   GH769775
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W3D5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030053    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030053 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030053 expression level Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4282) embryo 02-04hr  (5017) embryo 04-06hr  (1700) embryo 06-08hr  (2914) embryo 08-10hr  (3423) embryo 10-12hr  (3531) embryo 12-14hr  (1900) embryo 14-16hr  (2959) embryo 16-18hr  (2288) embryo 18-20hr  (1949) embryo 20-22hr  (2355) embryo 22-24hr  (1773) larva L1  (891) larva L2  (619) larva L3 12hr old  (1108) larva L3 puffstage 1-2  (1505) larva L3 puffstage 3-6  (2161) larva L3 puffstage 7-9  (2171) white prepupae new  (2042) white prepupae 12hr  (3808) white prepupae 24hr  (2729) pupae 2d postWPP  (1426) pupae 3d postWPP  (868) pupae 4d postWPP  (5672) adult male 01day  (1109) adult male 05day  (1251) adult male 30day  (1309) adult female 01day  (2125) adult female 05day  (1817) adult female 30day  (2004) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4282) embryo 02-04hr  (5017) embryo 04-06hr  (1700) embryo 06-08hr  (2914) embryo 08-10hr  (3423) embryo 10-12hr  (3531) embryo 12-14hr  (1900) embryo 14-16hr  (2959) embryo 16-18hr  (2288) embryo 18-20hr  (1949) embryo 20-22hr  (2355) embryo 22-24hr  (1773) larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2  1505 larva L3 puffstage 3-6  (2161) larva L3 puffstage 7-9  (2171) white prepupae new  (2042) white prepupae 12hr  (3808) white prepupae 24hr  (2729) pupae 2d postWPP  1426 pupae 3d postWPP    868 pupae 4d postWPP  (5672) adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day  (2125) adult female 05day  (1817) adult female 30day  (2004) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030053 expression level Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4282) embryo 02-04hr  (5017) embryo 04-06hr  (1700) embryo 06-08hr  (2914) embryo 08-10hr  (3423) embryo 10-12hr  (3531) embryo 12-14hr  (1900) embryo 14-16hr  (2959) embryo 16-18hr  (2288) embryo 18-20hr  (1949) embryo 20-22hr  (2355) embryo 22-24hr  (1773) larva L1  (891) larva L2  (619) larva L3 12hr old  (1108) larva L3 puffstage 1-2  (1505) larva L3 puffstage 3-6  (2161) larva L3 puffstage 7-9  (2171) white prepupae new  (2042) white prepupae 12hr  (3808) white prepupae 24hr  (2729) pupae 2d postWPP  (1426) pupae 3d postWPP  (868) pupae 4d postWPP  (5672) adult male 01day  (1109) adult male 05day  (1251) adult male 30day  (1309) adult female 01day  (2125) adult female 05day  (1817) adult female 30day  (2004) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4282) embryo 02-04hr  (5017) embryo 04-06hr  1700 embryo 06-08hr  (2914) embryo 08-10hr  (3423) embryo 10-12hr  (3531) embryo 12-14hr  1900 embryo 14-16hr  (2959) embryo 16-18hr  2288 embryo 18-20hr  1949 embryo 20-22hr  2355 embryo 22-24hr  1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2  1505 larva L3 puffstage 3-6  2161 larva L3 puffstage 7-9  2171 white prepupae new  2042 white prepupae 12hr  (3808) white prepupae 24hr  (2729) pupae 2d postWPP  1426 pupae 3d postWPP    868 pupae 4d postWPP  (5672) adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day  2125 adult female 05day  1817 adult female 30day  2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4282 embryo 02-04hr    5017 embryo 04-06hr    1700 embryo 06-08hr    2914 embryo 08-10hr    3423 embryo 10-12hr    3531 embryo 12-14hr    1900 embryo 14-16hr    2959 embryo 16-18hr    2288 embryo 18-20hr    1949 embryo 20-22hr    2355 embryo 22-24hr    1773 larva L1    891 larva L2    619 larva L3 12hr old    1108 larva L3 puffstage 1-2    1505 larva L3 puffstage 3-6    2161 larva L3 puffstage 7-9    2171 white prepupae new    2042 white prepupae 12hr    3808 white prepupae 24hr    2729 pupae 2d postWPP    1426 pupae 3d postWPP    868 pupae 4d postWPP    5672 adult male 01day    1109 adult male 05day    1251 adult male 30day    1309 adult female 01day    2125 adult female 05day    1817 adult female 30day    2004 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030053    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030053 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030053 expression level Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030053 expression level Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    143.95 Larval Midgut    62.1 Larval Hindgut    216.3 Larval Malpighian Tubules    86.9 Larval Fat Body    70.6 Larval Salivary Gland    362.9 Larval Trachea    258.95 Larval Carcass    93.675 Adult Head    59.1 Adult Eye    79.65 Adult Brain    87.2 Adult Thoracic-Abdominal Ganglion    72.9 Adult Crop    58 Adult Midgut    48.8 Adult Hindgut    262.8 Adult Malpighian Tubules    43.1 Adult Fat Body    65.8 Adult Salivary Gland    271.6 Adult Heart    69.475 Adult VirginFemale Spermatheca    66.8 Adult InseminatedFemale Spermatheca    50.7 Adult Ovary    114.1 Adult Testis    55.5 Adult Male Accessory Gland    203.7 Adult Carcass    67.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    59.1   NA  Eye    79.65   NA  Brain    87.2   143.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    72.9   NA  Crop    58   62.1  Midgut    48.8   216.3  Hindgut    262.8   86.9  Malpighian Tubules    43.1   70.6  Fat Body    65.8   362.9  Salivary Gland    271.6   NA  Heart    69.475   258.95  Trachea    NA   NA  VirginFemale Spermatheca    66.8   NA  InseminatedFemale Spermatheca    50.7   NA  Ovary    114.1   NA  Testis    55.5   NA  Male Accessory Gland    203.7   93.675  Carcass    67.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12081-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG12081GD7473 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG12081 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12081 Class Mutagen Stocks Known lesion CG12081GD7473 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG12081KK102345 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7473} NA P{KK102345} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12081 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58258 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030053 DroID - A comprehensive database of gene and protein interactions. • FBgn0030053 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31799
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22299 Dere\GG18263 Dgri\GH24899 Dmoj\GI15073 Dper\GL22550 Dpse\GA11382 Dsec\GM21713 Dsim\GD16909 Dvir\GJ18879 Dwil\GK20037 Dyak\GE15794
Curated drosophilid orthologs	Dpse\GA11382   Dsim\CG12081 (Montchamp-Moreau et al., 2006)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006525-PA Aedes aegypti (mosquito) AGAP009495-PA Anopheles gambiae (mosquito) XP_001947955.1 Acyrthosiphon pisum (pea aphid) At5g48180.1 Arabidopsis thaliana (wall cress) 279592 Branchiostoma floridae (lancelet) XP_001895672.1 Brugia malayi (roundworm nematode) BGIBMGA010565-PA Bombyx mori (silk worm) ENSBTAP00000016944 Bos taurus (bovine) CN06047 Caenorhabditis brenneri (small nematode) CN22638 Caenorhabditis brenneri (small nematode) CBP01282 Caenorhabditis briggsae (nematode) CE20848 Caenorhabditis elegans (worm) ENSCAFP00000002575 Canis familiaris (dog) JA15505 Caenorhabditis japonica (nematode) CMB072C Cyanidioschyzon merolae (red alga) CPIJ002439 Culex pipens (mosquito) ENSCPOP00000021083 Cavia porcellus (guinea pig) 119172 Chlamidomonas reinhardtii (green alga) RP05922 Caenorhabditis remanei (nematode) ENSCSAVP00000019497 Ciona savignyi (sedentary tunicate) 2628 Capitella spl (polychaete worm) DDB0204082 Dictyostelium discoideum (amoeba) 301972 Daphnia pulex (daphnia) ENSDARP00000058270 Danio rerio (zebra fish) ENSECAP00000005006 Equus caballus (horse) ENSGACP00000005442 Gymnopilus aculeatus (mushroom) ENSGALP00000013895 Gallus gallus (chicken) GL50803_6072 Giardia lamblia (flagellated protozoan) 68539 Hypsipyla robusta (cedar shoot borer) ENSP00000377656 Homo sapiens (human) ISCW014630-PA Ixodes scapularis (deer tick) 205828 Lottia gigantea (owl limpet) LmjF24.2090 Leishmania major (virus) ENSMODP00000030434 Monodelphis domestica (gray opossum) ENSMMUP00000001035 Macaca mulatta (rhesus monkey) ENSMUSP00000071743 Mus musculus (house mouse) 99370 Nematostella vectensis (starlet anemone) ENSOANP00000013440 Ornithorynchus anatinus (platypus) ENSORLP00000016070 Oryzias latipes (japanese killifish) LOC_Os12g35560.1 Oryza sativa (asian rice) PP17879 Pristionchus pacificus (nematode) 112656 Physcomitrella patens (moss) ENSPPYP00000018596 Pongo pygmaeus (orangutan) 77579 Phytophthora ramorum (sudden oak death pathogen) 128248 Phytophthora sojae (root rot pathogen) 772767 Populus trichocarpa (black cottonwood) ENSPTRP00000056214 Pan troglodytes (chimpanzee) ENSRNOP00000023979 Rattus norvegicus (norway rat) 147674 Sorghum bicolor (sorghum) XP_001189761.1 Strongylocentrotus purpuratus (purple sea urchin) 2707 Trichoplax adhaerens (metazoa) XP_974196.2 Tribolium castaneum (red flour beetle) Tc00.1047053511071.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511903.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016423 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001572 Takifugu rubripes (pufferfish Takifugu) 3830.m00530 Tetrahymena thermophila (ciliate protozoa) 82316.m00013 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001241 Xenopus tropicalis (frog) YALI0F06094g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW014630 FBgn0233359 FBgn0222034 FBgn0206025 FBgn0189295 FBgn0176592 JGI_V11_301972 FBgn0071436 FBgn0160141 FBgn0137824 FBgn0137823 FBgn0132354 FBgn0110479 FBgn0099297 CPIJ002439 BGIBMGA010565 ACYPI005099 ACYPI003495 AGAP009495 AAEL006525 GLEAN_08474
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v106693 P{KK102345}VIE-260B v31642 w1118; P{GD7473}v31642 v31643 w1118; P{GD7473}v31643
Genomic Clones ( 1 )
	BACR40O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 133 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD20420
Other clones	DPiM_LD20420
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH13138 GH15933 LD28912 LD31193 LD38161 LD38173 RE06492 RE25381 RE26231 RE30824 RE32040 RE32953 RE35290 RE52937 RE58942 RE58948 RE61362 RE62402 RH03321 RH03633 RH36614 RH50686 SD18442 SD20649 SD21306 SD21405 SD24752
Other clones	47016 59913 59929 62799 65833 121991 162306 190112 214277.21 214531.16 CK01.66D.G10 CK01.69C.F12 CK01.93C.A10 CK01.144A.F3 Dmel_dig_015053_0654_2258 EK053959 EK055654 EK065654 EK073033 EK118622 EK168234 EK168410 EK171144 EK173952 EK188537 EK193455 EK242117 EK265949 EK292242 EP07747 EP07847 ESG013a.E21.1_D11 ESG013c.E21_D12 ESG016a.E21_D03 RH01362 RP01163 RP001000451 RP001002400 RP001004725 RP001006262 RP001008555 RP001009004 RP001010038 RP001010190 RP001010756 RP001011534 RP001012726 RP001013086 RP001013701 RP001015011 RP001017058 RP001017488 RP001017838 RP001020835 RP001021987 RP001022664 RP001023423 RP001023708 RP001025608 RP001025915 RP001026088 RP001026313 RP001027851 RP001030921 RP001033879 RP001034007 RP001034410 RP001035225 RP001038714 RP001039559 RP001040509 RP001040731 RP001041281 RP001041395 RP001041692 RP001043470 RP001043542 RP001043906 RP001044190 RP001045373 RP001045565 RP001045979 RP001047909 RP001048030 RP001048585 RP001048822 RP001049069 RP001049298 RP001050109 RP001050227 RP001050523 RP001050876 RP001051605 RP001052008 RP001052053 RP001052148 RP001052325 RP001052462 RP001052957 RP001053007 RP001053087 RP001053531 RP001054031 RP001055990
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31799
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132266 RefSeq (Proteins) • NP_572494 DDBJ / EMBL / GenBank • AA540657 AAF46395 AAM50253 AW942562 AY119599 Entrez Gene - A searchable database of RefSeq genes. • 31799 UniProtKB/TrEMBL • Q9W3D5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Kelch repeat type 1 (IPR006652) Kelch-type beta propeller (IPR015915)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58258 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030053 DroID - A comprehensive database of gene and protein interactions. • FBgn0030053 DRSC - Results from RNAi screens. • FBgn0030053 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12081-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31799 InParanoid A subset of ortholog calls from InParanoid. • AAEL006525-PA Aedes aegypti (mosquito) AGAP009495-PA Anopheles gambiae (mosquito) XP_001947955.1 Acyrthosiphon pisum (pea aphid) At5g48180.1 Arabidopsis thaliana (wall cress) 279592 Branchiostoma floridae (lancelet) XP_001895672.1 Brugia malayi (roundworm nematode) BGIBMGA010565-PA Bombyx mori (silk worm) ENSBTAP00000016944 Bos taurus (bovine) CN06047 Caenorhabditis brenneri (small nematode) CN22638 Caenorhabditis brenneri (small nematode) CBP01282 Caenorhabditis briggsae (nematode) CE20848 Caenorhabditis elegans (worm) ENSCAFP00000002575 Canis familiaris (dog) JA15505 Caenorhabditis japonica (nematode) CMB072C Cyanidioschyzon merolae (red alga) CPIJ002439 Culex pipens (mosquito) ENSCPOP00000021083 Cavia porcellus (guinea pig) 119172 Chlamidomonas reinhardtii (green alga) RP05922 Caenorhabditis remanei (nematode) ENSCSAVP00000019497 Ciona savignyi (sedentary tunicate) 2628 Capitella spl (polychaete worm) DDB0204082 Dictyostelium discoideum (amoeba) 301972 Daphnia pulex (daphnia) ENSDARP00000058270 Danio rerio (zebra fish) ENSECAP00000005006 Equus caballus (horse) ENSGACP00000005442 Gymnopilus aculeatus (mushroom) ENSGALP00000013895 Gallus gallus (chicken) GL50803_6072 Giardia lamblia (flagellated protozoan) 68539 Hypsipyla robusta (cedar shoot borer) ENSP00000377656 Homo sapiens (human) ISCW014630-PA Ixodes scapularis (deer tick) 205828 Lottia gigantea (owl limpet) LmjF24.2090 Leishmania major (virus) ENSMODP00000030434 Monodelphis domestica (gray opossum) ENSMMUP00000001035 Macaca mulatta (rhesus monkey) ENSMUSP00000071743 Mus musculus (house mouse) 99370 Nematostella vectensis (starlet anemone) ENSOANP00000013440 Ornithorynchus anatinus (platypus) ENSORLP00000016070 Oryzias latipes (japanese killifish) LOC_Os12g35560.1 Oryza sativa (asian rice) PP17879 Pristionchus pacificus (nematode) 112656 Physcomitrella patens (moss) ENSPPYP00000018596 Pongo pygmaeus (orangutan) 77579 Phytophthora ramorum (sudden oak death pathogen) 128248 Phytophthora sojae (root rot pathogen) 772767 Populus trichocarpa (black cottonwood) ENSPTRP00000056214 Pan troglodytes (chimpanzee) ENSRNOP00000023979 Rattus norvegicus (norway rat) 147674 Sorghum bicolor (sorghum) XP_001189761.1 Strongylocentrotus purpuratus (purple sea urchin) 2707 Trichoplax adhaerens (metazoa) XP_974196.2 Tribolium castaneum (red flour beetle) Tc00.1047053511071.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511903.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016423 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000001572 Takifugu rubripes (pufferfish Takifugu) 3830.m00530 Tetrahymena thermophila (ciliate protozoa) 82316.m00013 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000001241 Xenopus tropicalis (frog) YALI0F06094g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31799 modMine - Data generated by the modENCODE project. • FBgn0030053 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW014630 FBgn0233359 FBgn0222034 FBgn0206025 FBgn0189295 FBgn0176592 JGI_V11_301972 FBgn0071436 FBgn0160141 FBgn0137824 FBgn0137823 FBgn0132354 FBgn0110479 FBgn0099297 CPIJ002439 BGIBMGA010565 ACYPI005099 ACYPI003495 AGAP009495 AAEL006525 GLEAN_08474
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12081 (Straub et al., 2008, Keleman et al., 2009.8.5, Bandyopadhyay et al., 2006)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Straub et al., 2008, PLoS Genet. 4(12): e1000302 The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex. [FBrf0206582] Bandyopadhyay et al., 2006, Genome Res. 16(3): 428--435 Systematic identification of functional orthologs based on protein network comparison. [FBrf0190794] Montchamp-Moreau et al., 2006, Genetics 174(3): 1365--1371 Organization of the sex-ratio meiotic drive region in Drosophila simulans. [FBrf0192398]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]