FB2025_05 , released December 11, 2025
Gene: Dmel\Ppt1
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General Information
Symbol
Dmel\Ppt1
Species
D. melanogaster
Name
Palmitoyl-protein thioesterase 1
Annotation Symbol
CG12108
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030057
Gene Model Status
Current
Stock Availability
9 publicly available
Enzyme Name (EC)
palmitoyl-protein hydrolase (3.1.2.22)
Gene Summary
Palmitoyl-protein thioesterase 1 (Ppt1) encodes a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
8A2-8A2
Sequence location
Recombination map
1-24
RefSeq locus
NC_004354 REGION:8688627..8690227
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables palmitoyl-(protein) hydrolase activity
inferred from mutant phenotype
(Hickey et al., 2006, Glaser et al., 2003)
inferred from direct assay
(Jones et al., 2014, Bannan et al., 2008)
enables serine hydrolase activity
inferred from high throughput direct assay
(Kumar et al., 2021)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables palmitoyl hydrolase activity
inferred from electronic annotation with InterPro:IPR002472
(InterPro Project Members, 2004-)
enables palmitoyl-(protein) hydrolase activity
inferred from biological aspect of ancestor with PANTHER:PTN000882372
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with MGI:MGI:1298204
(Glaser et al., 2003)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in determination of adult lifespan
inferred from mutant phenotype
(Hickey et al., 2006)
involved_in endocytosis
inferred from direct assay
(Saja et al., 2010)
involved_in neuron fate specification
inferred from mutant phenotype
(Chu-Lagraff et al., 2010)
involved_in positive regulation of synaptic vesicle endocytosis
inferred from mutant phenotype
(Aby et al., 2013)
involved_in regulation of axon guidance
inferred from mutant phenotype
(Chu-Lagraff et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000882372
(GO Reference Genome Project, 2011-)
involved_in nervous system development
inferred from biological aspect of ancestor with PANTHER:PTN000882372
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in lysosome
inferred from direct assay
(Bannan et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in extracellular region
inferred from biological aspect of ancestor with PANTHER:PTN000882371
(GO Reference Genome Project, 2011-)
is_active_in lysosome
inferred from biological aspect of ancestor with PANTHER:PTN000882371
(GO Reference Genome Project, 2011-)
located_in lysosome
inferred from sequence or structural similarity with MGI:MGI:1298204
(Glaser et al., 2003)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the palmitoyl-protein thioesterase family. (Q9W3C7)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
palmitoyl-(protein) hydrolase activity
S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+) (3.1.2.22)
RHEA 19233:
Summaries
Gene Snapshot
Palmitoyl-protein thioesterase 1 (Ppt1) encodes a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PALMITOYL-(PROTEIN) HYDROLASES -
Palmitoyl-(protein) hydrolases are specific for long-chain thioesters of fatty acids and hydrolyze fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
Protein Function (UniProtKB)
Cleaves thioester-linked long fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.
(UniProt, Q9W3C7)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ppt1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W3C7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.02

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ppt1-RA
FBtr0071225
NM_167166
1165
314
Ppt1-RB
FBtr0345985
NM_001298095
1286
314
Additional Transcript Data and Comments
Reported size (kB)

6.7, 4.8, 3.0, 1.5 (northern blot)

(Glaser et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ppt1-PA
FBpp0071170
35.8
314
7.16
Q9W3C7
NP_727284
AAF46403
Ppt1-PB
FBpp0311872
35.8
314
7.16
Q9W3C7
NP_001285024
AHN59495
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

314 aa isoforms: Ppt1-PA, Ppt1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ppt1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.71

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval central nervous system
(Bannan et al., 2008)
organism | ubiquitous
(Chu-Lagraff et al., 2010)
larval stage
larval brain
(Bannan et al., 2008)
third instar larval stage
imaginal disc | ubiquitous
(Chu-Lagraff et al., 2010)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 17

Comment: reference states 0-18 hr AEL

(Glaser et al., 2003)
third instar larval stage
(Glaser et al., 2003)
pupal stage
(Glaser et al., 2003)
adult stage
adult thorax
(Glaser et al., 2003)
testis
(Glaser et al., 2003)
adult head
(Glaser et al., 2003)
ovary
(Glaser et al., 2003)

Comment: expression assayed in cultured cells

(Glaser et al., 2003)
Additional Descriptive Data

Ppt1 exhibits low ubiquitous staining in embryos and third instar imaginal discs.

(Chu-Lagraff et al., 2010)

Ppt1 transcripts are observed in all stages tested. Steady state transcript levels vary less than 3-fold among tissues analyzed, with the exception of the testis where 5-fold higher levels are observed.

(Glaser et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
enzyme assay or biochemical detection
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 17

Comment: reference states 0-18 hr AEL

(Glaser et al., 2003)
third instar larval stage
(Glaser et al., 2003)
pupal stage
(Glaser et al., 2003)
adult stage
adult head
(Glaser et al., 2003)
testis
(Glaser et al., 2003)
ovary
(Glaser et al., 2003)
adult thorax
(Glaser et al., 2003)

Comment: expression assayed in cultured cells

(Glaser et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Ppt1 enzymatic activity is detected in all tissues examined, with the highest levels in the testis.

(Glaser et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in lysosome
inferred from direct assay
(Bannan et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ppt1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ppt1
Transgenic constructs containing regulatory region of Ppt1
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal, with Scer\GAL4elav.PLu
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male fertile, with Scer\GAL4bam.PU
Other Phenotypes
Allele
abnormal locomotor behavior
abnormal neuroanatomy, with Scer\GAL4Act5C.PI
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy (with Df(1)446-20)
abnormal neuroanatomy (with Ppt1A179T)
abnormal neuroanatomy (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 11 (with Ppt1A179T)
abnormal neuroanatomy | embryonic stage 11 (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 11 | recessive
abnormal neuroanatomy | embryonic stage 12 (with Ppt1A179T)
abnormal neuroanatomy | embryonic stage 12 (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 12 | recessive
abnormal neuroanatomy | embryonic stage 14 (with Df(1)446-20)
abnormal neuroanatomy | embryonic stage 14 (with Ppt1A179T)
abnormal neuroanatomy | embryonic stage 14 (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 14 | recessive
abnormal neuroanatomy | embryonic stage 15 (with Df(1)446-20)
abnormal neuroanatomy | embryonic stage 15 (with Ppt1A179T)
abnormal neuroanatomy | embryonic stage 15 (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 15 | recessive
abnormal neuroanatomy | embryonic stage 16, with eve2xCQ.RC.G4DBD
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4elav.PU
abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4eve.RN2
abnormal neuroanatomy | embryonic stage 16 (with Df(1)446-20)
abnormal neuroanatomy | embryonic stage 16 (with Ppt1A179T)
abnormal neuroanatomy | embryonic stage 16 (with Ppt1S77F)
abnormal neuroanatomy | embryonic stage 16 | recessive
abnormal neuroanatomy | embryonic stage 17, with eve2xCQ.RC.G4DBD
abnormal neuroanatomy | embryonic stage 17, with Scer\GAL4elav.PU
abnormal neuroanatomy | embryonic stage 17, with Scer\GAL4eve.RN2
abnormal neurophysiology
increased cell death, with Scer\GAL4GMR.PF
increased cell death | adult stage | light conditional, with Scer\GAL4GMR.PU
short lived
short lived (with Df(1)446-20)
short lived (with Ppt1A179T)
short lived (with Ppt1S77F)
visible, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
adult brain, with Scer\GAL4Act5C.PI
adult brain (with Df(1)446-20)
adult brain (with Ppt1A179T)
adult brain (with Ppt1S77F)
embryonic/larval neuromuscular junction | third instar larval stage
eye, with Scer\GAL4GMR.PF
eye photoreceptor cell, with Scer\GAL4GMR.PF
ganglion mother cell GMC4-2a | embryonic stage 11
ganglion mother cell GMC4-2a | embryonic stage 11 (with Ppt1A179T)
ganglion mother cell GMC4-2a | embryonic stage 11 (with Ppt1S77F)
ganglion mother cell GMC4-2a | embryonic stage 12
ganglion mother cell GMC4-2a | embryonic stage 12 (with Ppt1A179T)
ganglion mother cell GMC4-2a | embryonic stage 12 (with Ppt1S77F)
garland cell
larval abdominal lch5 neuron | embryonic stage 17
larval DA1 motor neuron | embryonic stage 11 | increased number
larval DA1 motor neuron | embryonic stage 11 | increased number (with Ppt1A179T)
larval DA1 motor neuron | embryonic stage 11 | increased number (with Ppt1S77F)
larval DA1 motor neuron | embryonic stage 12 | increased number
larval DA1 motor neuron | embryonic stage 12 | increased number (with Ppt1A179T)
larval DA1 motor neuron | embryonic stage 12 | increased number (with Ppt1S77F)
larval DA1 motor neuron | embryonic stage 16
larval longitudinal connective | embryonic stage 16
larval longitudinal connective | embryonic stage 17
larval midline neuron | ectopic | embryonic stage 16
larval midline neuron | ectopic | embryonic stage 17
larval RP2 motor neuron | embryonic stage 11 (with Ppt1A179T)
larval RP2 motor neuron | embryonic stage 11 (with Ppt1S77F)
larval RP2 motor neuron | embryonic stage 11 | increased number
larval RP2 motor neuron | embryonic stage 12 (with Ppt1A179T)
larval RP2 motor neuron | embryonic stage 12 (with Ppt1S77F)
larval RP2 motor neuron | embryonic stage 12 | increased number
larval RP2 motor neuron | embryonic stage 14
larval RP2 motor neuron | embryonic stage 14 (with Df(1)446-20)
larval RP2 motor neuron | embryonic stage 14 (with Ppt1A179T)
larval RP2 motor neuron | embryonic stage 14 (with Ppt1S77F)
larval RP2 motor neuron | embryonic stage 15
larval RP2 motor neuron | embryonic stage 15 (with Df(1)446-20)
larval RP2 motor neuron | embryonic stage 15 (with Ppt1A179T)
larval RP2 motor neuron | embryonic stage 15 (with Ppt1S77F)
larval RP2 motor neuron | embryonic stage 16
larval RP2 motor neuron | embryonic stage 16 (with Df(1)446-20)
larval RP2 motor neuron | embryonic stage 16 (with Ppt1A179T)
larval RP2 motor neuron | embryonic stage 16 (with Ppt1S77F)
ommatidium, with Scer\GAL4GMR.PU
ommatidium | adult stage | light conditional
ommatidium | adult stage | light conditional, with Scer\GAL4GMR.PU
pCC neuron | embryonic stage 11 | increased number
pCC neuron | embryonic stage 11 | increased number (with Ppt1A179T)
pCC neuron | embryonic stage 11 | increased number (with Ppt1S77F)
pCC neuron | embryonic stage 12 | increased number
pCC neuron | embryonic stage 12 | increased number (with Ppt1A179T)
pCC neuron | embryonic stage 12 | increased number (with Ppt1S77F)
pCC neuron | embryonic stage 16
retina | adult stage | light conditional, with Scer\GAL4GMR.PU
rhabdomere | adult stage | decreased number | light conditional
rhabdomere | adult stage | decreased number | light conditional, with Scer\GAL4GMR.PU
rhabdomere of eye photoreceptor cell, with Scer\GAL4GMR.PF
RP2sib neuron | embryonic stage 11 (with Ppt1A179T)
RP2sib neuron | embryonic stage 11 (with Ppt1S77F)
RP2sib neuron | embryonic stage 11 | increased number
RP2sib neuron | embryonic stage 12 (with Ppt1A179T)
RP2sib neuron | embryonic stage 12 (with Ppt1S77F)
RP2sib neuron | embryonic stage 12 | increased number
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\PPT1
13 of 14
Yes
Yes
1  
Hsap\PPT2
4 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Ppt1
14 of 14
Yes
Yes
Rnor\Ppt2
4 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Ppt1
14 of 14
Yes
Yes
Mmus\Ppt2
4 of 14
No
No
Mmus\9530002B09Rik
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ppt1
8 of 13
Yes
Yes
Xtro\ppt2
3 of 13
No
No
Xtro\krt78.8
1 of 13
No
Yes
Danio rerio (Zebrafish) (6)
Drer\ppt1
14 of 14
Yes
Yes
Drer\ppt2a.1
4 of 14
No
No
Drer\ppt2a.4
4 of 14
No
No
Drer\ppt2a.3
3 of 14
No
No
Drer\ppt2b
3 of 14
No
No
Drer\ppt2a.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ppt-1
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP001058
12 of 12
Yes
Yes
Agam\AgaP_AGAP009695
4 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\AT3G60340
13 of 13
Yes
Yes
Atha\AT4G17470
12 of 13
No
Yes
Atha\AT4G17480
12 of 13
No
Yes
Atha\AT4G17483
12 of 13
No
Yes
Atha\AT5G47330
12 of 13
No
Yes
Atha\AT5G47340
12 of 13
No
Yes
Atha\AT5G47350
12 of 13
No
Yes
Atha\AT1G10740
1 of 13
No
Yes
Atha\AT1G23330
1 of 13
No
Yes
Atha\AT5G17670
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\LDH1
1 of 13
Yes
Yes
Scer\TGL2
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\pdf1
8 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ppt1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
Ppt2
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 5 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
PPT1; palmitoyl-protein thioesterase 1
model of  neuronal ceroid lipofuscinosis 1
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PPT1; palmitoyl-protein thioesterase 1
13 of 14
600722
 
PPT2; palmitoyl-protein thioesterase 2
4 of 14
603298
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Ppt1
      enhanceable
      bchs
      (Buff et al., 2007)
      Ppt1
      suppressible
      Cisd
      (Jones et al., 2014)
      Ppt1
      suppressible
      Cln3
      (Jones et al., 2014)
      Ppt1
      enhanceable
      Cln3
      (Jones et al., 2014)
      Ppt1
      enhanceable
      Csk
      (Saja et al., 2010)
      Ppt1
      enhanceable
      EndoA
      (Buff et al., 2007)
      Ppt1
      enhanceable
      faf
      (Buff et al., 2007)
      Ppt1
      suppressible
      Fas2
      (Buff et al., 2007)
      Ppt1
      enhanceable
      foi
      (Saja et al., 2010)
      Ppt1
      enhanceable
      Frl
      (Buff et al., 2007)
      Ppt1
      enhanceable
      fs(1)N
      (Buff et al., 2007)
      Ppt1
      suppressible
      fs(1)N
      (Buff et al., 2007)
      Ppt1
      suppressible
      gbb
      (Saja et al., 2010)
      Ppt1
      suppressible
      Hsc70-3
      (Buff et al., 2007)
      Ppt1
      enhanceable
      Imp
      (Saja et al., 2010)
      Ppt1
      suppressible
      IntS8
      (Buff et al., 2007)
      Ppt1
      enhanceable
      Jarid2
      (Buff et al., 2007)
      Ppt1
      suppressible
      kay
      (Buff et al., 2007)
      Ppt1
      suppressible
      m
      (Buff et al., 2007)
      Ppt1
      suppressible
      MESR4
      (Buff et al., 2007)
      Ppt1
      enhanceable
      Mrp4
      (Buff et al., 2007)
      Ppt1
      enhanceable
      msn
      (Buff et al., 2007)
      Ppt1
      enhanceable
      mys
      (Buff et al., 2007)
      Ppt1
      enhanceable
      Naa60
      (Buff et al., 2007)
      Ppt1
      enhanceable
      Pisd
      (Buff et al., 2007)
      Ppt1
      suppressible
      sax
      (Saja et al., 2010, Buff et al., 2007)
      Ppt1
      enhanceable
      sax
      (Saja et al., 2010)
      Ppt1
      enhanceable
      shi
      (Saja et al., 2010)
      Ppt1
      suppressible
      stnA
      (Buff et al., 2007)
      Ppt1
      suppressible
      Sumo
      (Saja et al., 2010)
      Ppt1
      suppressible
      Syt1
      (Buff et al., 2007)
      Ppt1
      enhanceable
      tsg
      (Saja et al., 2010)
      Ppt1
      suppressible
      UbcE2H
      (Buff et al., 2007)
      Ppt1
      suppressible
      Usp12-46
      (Buff et al., 2007)
      Ppt1
      enhanceable
      zip
      (Saja et al., 2010)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Pisd
      enhanceable
      Ppt1
      (Midorikawa et al., 2010)
      shi
      enhanceable
      Ppt1
      (Aby et al., 2013)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-24
      Cytogenetic map
      8A2-8A2
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      8A2-8A2
      Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      1-24

      (FlyBase, 2016)

      1-24.4

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (9)
      Genomic Clones (14)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (27)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments
          Relationship to Other Genes
          Source for database merge of
          Additional comments

          FlyBase curator comment: the insertion in the "f08013" Exelixis line (PBac{WH}Ogg1f08013) was originally assigned to the Ppt1 gene in FBrf0179797, resulting in the "Ppt1f08013" (FBal0159995) allele. However, FBrf0184340 shows that the insertion is actually within Ogg1.

          (Bloomington Drosophila Stock Center, 2004.11.6)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (9)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
          References (63)