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Gene Dmel\CG12121

General Information
Symbol	Dmel\CG12121	Species	D. melanogaster
Name		Annotation symbol	CG12121
Feature type	protein_coding_gene	FlyBase ID	FBgn0030109
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	8D2-8D2	Sequence location	X:9,122,829..9,126,411 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12121 (FBgn0030109). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Transmembrane receptor, eukaryota. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632894_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12121. Gene sequence location is X:9122829..9126411.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8D2-8D2   Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12121 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12121-RA FBtr0071334  NM_132317   2954   738
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12121-PA   FBpp0071269   83.6   738   4.97     NP_572545   AAF46469
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transmembrane receptor, eukaryota (IPR009637)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391578   AA438818   AA439839   AA735181   AA816309   AE014298 AAF46469   AI454999   AI515649   AI518008   AI519700   AY113517 AAM29522   BF496949   BF505241   BG639227   BI213252   BI215012   BI231244   BI352413   BI357733   BI361605   BI365072   BI367354   BI369346   BI370374   BI371588   BI372140   BI372772   BI374211   BI578047   BI578067   BI618466   BP543821   BP543822   BP545611   BP545612   CK130560   CK134335   CK659911   CO178442   CO188993   CO271517   CO273949   CO282058   CO282567   CO288830   CO294190   CO307375   CO311981   CO322187   CO324225   CO336558   EC060541   EC062104   EC071589   EC075248   EC086163   EC204056   EC207262   EC217297   EC223515   EC225423   EC226475   EC230652   EC245404   EC266883   EV575630   EV592757   GH742870   GH745492   GH746037   GH747002   GH747233   GH766651   GH766964   GH768547   GH769796   GH779598   GO254466
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W366
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland    1882.3 Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland  515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland  (1882.3) Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland  (1882.3) Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland    1882.3 Adult Carcass    214.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland    1882.3 Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland  515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland  (1882.3) Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland  (1882.3) Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    321.075 Larval Midgut    152.3 Larval Hindgut    280.9 Larval Malpighian Tubules    361.4 Larval Fat Body    219.5 Larval Salivary Gland    515.1 Larval Trachea    261.325 Larval Carcass    192.425 Adult Head    257.3 Adult Eye    276.675 Adult Brain    313.1 Adult Thoracic-Abdominal Ganglion    359.9 Adult Crop    170.8 Adult Midgut    183.9 Adult Hindgut    247.9 Adult Malpighian Tubules    267.2 Adult Fat Body    251 Adult Salivary Gland    436.2 Adult Heart    211.45 Adult VirginFemale Spermatheca    313.4 Adult InseminatedFemale Spermatheca    333.6 Adult Ovary    370.6 Adult Testis    214.7 Adult Male Accessory Gland    1882.3 Adult Carcass    214.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    257.3   NA  Eye    276.675   NA  Brain    313.1   321.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    359.9   NA  Crop    170.8   152.3  Midgut    183.9   280.9  Hindgut    247.9   361.4  Malpighian Tubules    267.2   219.5  Fat Body    251   515.1  Salivary Gland    436.2   NA  Heart    211.45   261.325  Trachea    NA   NA  VirginFemale Spermatheca    313.4   NA  InseminatedFemale Spermatheca    333.6   NA  Ovary    370.6   NA  Testis    214.7   NA  Male Accessory Gland    1882.3   192.425  Carcass    214.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (32) central nervous system, larvae L3  26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (34) testis, mated 4-day male    20 accessory gland, mated 4-day male  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  32 central nervous system, larvae L3  26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (34) testis, mated 4-day male    20 accessory gland, mated 4-day male  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    32 central nervous system, larvae L3    26 central nervous system, pupae P8    25 head, virgin 1-day female    15 head, virgin 4-day female    14 head, virgin 20-day female    18 head, mated 1-day female    10 head, mated 4-day female    13 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    20 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    13 digestive system, 4-day adult    16 digestive system, 20-day adult    16 fat body, larvae L3 wandering    9 fat body, white prepupae    17 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    10 carcass, 4-day adult    14 carcass, 20-day adult    14 ovary, virgin 4-day female    41 ovary, mated 4-day female    34 testis, mated 4-day male    20 accessory gland, mated 4-day male    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (53) embryo 02-04hr  (72) embryo 04-06hr  (49) embryo 06-08hr  (54) embryo 08-10hr  (55) embryo 10-12hr  (41) embryo 12-14hr  (42) embryo 14-16hr  (36) embryo 16-18hr  (31) embryo 18-20hr    18 embryo 20-22hr  (31) embryo 22-24hr  (30) larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  26 white prepupae new  (28) white prepupae 12hr  26 white prepupae 24hr  (30) pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day  (31) adult male 30day  (32) adult female 01day    23 adult female 05day  (35) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (53) embryo 02-04hr  (72) embryo 04-06hr  (49) embryo 06-08hr  (54) embryo 08-10hr  (55) embryo 10-12hr  (41) embryo 12-14hr  (42) embryo 14-16hr  (36) embryo 16-18hr  31 embryo 18-20hr    18 embryo 20-22hr  31 embryo 22-24hr  30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  26 white prepupae new  28 white prepupae 12hr  26 white prepupae 24hr  30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day  31 adult male 30day  32 adult female 01day    23 adult female 05day  (35) adult female 30day  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    53 embryo 02-04hr    72 embryo 04-06hr    49 embryo 06-08hr    54 embryo 08-10hr    55 embryo 10-12hr    41 embryo 12-14hr    42 embryo 14-16hr    36 embryo 16-18hr    31 embryo 18-20hr    18 embryo 20-22hr    31 embryo 22-24hr    30 larva L1    22 larva L2    21 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    28 white prepupae 12hr    26 white prepupae 24hr    30 pupae 2d postWPP    23 pupae 3d postWPP    17 pupae 4d postWPP    15 adult male 01day    23 adult male 05day    31 adult male 30day    32 adult female 01day    23 adult female 05day    35 adult female 30day    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (53) Schneider line 2 Sg4  (39) embryonic 1182-4H  (61) embryonic GM2  (80) embryonic Kc167  (47) embryonic S1  (51) embryonic S3  (36) leg disc CME L1  (41) wing disc CME-W2  (36) wing disc ML-DmD8  (41) wing disc ML-DmD9  (59) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21    16 wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  (28) mixed discs ML-DmD4-c1  (42) CNS ML-DmBG1-c1  (48) CNS ML-DmBG2-c2  (62) tumorous blood cells mbn2  (65) ovary fGS/OSS    19 ovary OSC  (28) ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (53) Schneider line 2 Sg4  (39) embryonic 1182-4H  (61) embryonic GM2  (80) embryonic Kc167  (47) embryonic S1  (51) embryonic S3  (36) leg disc CME L1  (41) wing disc CME-W2  (36) wing disc ML-DmD8  (41) wing disc ML-DmD9  (59) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21    16 wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (41) antennal disc ML-DmD20-c5  28 mixed discs ML-DmD4-c1  (42) CNS ML-DmBG1-c1  (48) CNS ML-DmBG2-c2  (62) tumorous blood cells mbn2  (65) ovary fGS/OSS    19 ovary OSC  28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    39 embryonic 1182-4H    61 embryonic GM2    80 embryonic Kc167    47 embryonic S1    51 embryonic S3    36 leg disc CME L1    41 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    59 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    16 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    41 antennal disc ML-DmD20-c5    28 mixed discs ML-DmD4-c1    42 CNS ML-DmBG1-c1    48 CNS ML-DmBG2-c2    62 tumorous blood cells mbn2    65 ovary fGS/OSS    19 ovary OSC    28 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    17 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    25 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030109 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12121-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG12121 Class Mutagen Stocks Known lesion CG12121G1121 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12121 Class Mutagen Stocks Known lesion CG12121KK101631 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12121GD3292 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3292} NA P{KK101631} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG12121G1121 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR009637 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG12121 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG18178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - Cg25C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - eIF-4B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - mRpS33 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - schlank anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG12121 - vkg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12121 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58319 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030109 DroID - A comprehensive database of gene and protein interactions. • FBgn0030109 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31866
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6K0R70 Dipteran inclusive ortholog search EOG6KH338 Insect inclusive ortholog search EOG62V7BT Arthropod inclusive ortholog search EOG6M0CH6 Metazoa inclusive ortholog search EOG6GBM0N
Orthologs in Drosophila Species (EOG6K0R70)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG12121     Drosophila simulans   Dsim\GD16074 Y   Drosophila sechellia   Dsec\GM22360 Y   Drosophila erecta   Dere\GG18990 Y   Drosophila yakuba   Dyak\GE15463 Y   Drosophila ananassae   Dana\GF19098 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28126 Y   Drosophila persimilis   Dper\GL18285 Y   Drosophila willistoni   Dwil\GK25796 Y   Drosophila virilis   Dvir\GJ18803 Y   Drosophila mojavensis   Dmoj\GI14468 Y   Drosophila grimshawi   Dgri\GH12704 Y
Orthologs in non-Drosophila Dipterans (EOG6KH338)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012257   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012256   Anopheles gambiae Malaria mosquito  Agam\AGAP000913   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017826
Orthologs in non-Dipteran Insects (EOG62V7BT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC725576   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000972   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11239   Atta cephalotes Leafcutter ant  Acep\ACEP18195   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13415   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14932   Linepithema humile Argentine ant  Lhum\LH18518   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18693   Solenopsis invicta Red fire ant  Sinv\SINV15829   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008978   Bombyx mori Silkmoth  Bmor\BGIBMGA001998   Pediculus humanus Human body louse  Phum\PHUM564450   Tribolium castaneum Red flour beetle  Tcas\TC002527
Orthologs in non-Insect Arthropods (EOG6M0CH6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_199743   Daphnia pulex Water flea  Dpux\JGI_V11_226872   Ixodes scapularis Deer tick  Isca\ISCW018766   Ixodes scapularis Deer tick  Isca\ISCW018770
Orthologs in non-Arthropod Metazoa (EOG6GBM0N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C15H9.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008986gn   Danio rerio Zebrafish  Drer\gpr107   Xenopus tropicalis Western clawed frog  Xtro\gpr107   Gallus gallus Domestic chicken  Ggal\GPR107   Mus musculus House mouse  Mmus\Gpr108   Mus musculus House mouse  Mmus\Gpr107   Rattus norvegicus Norway rat  Rnor\Gpr107   Homo sapiens Human  Hsap\GPR107   Homo sapiens Human  Hsap\GPR108
Human Orthologs (2)
Gene OMIM HGNC Hsap\GPR107     Hsap\GPR108
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16074 Drosophila sechellia Dsec\GM22360 Drosophila erecta Dere\GG18990 Drosophila yakuba Dyak\GE15463 Drosophila ananassae Dana\GF19098 Drosophila pseudoobscura pseudoobscura Dpse\GA28126 Drosophila persimilis Dper\GL18285 Drosophila willistoni Dwil\GK25796 Drosophila virilis Dvir\GJ18803 Drosophila mojavensis Dmoj\GI14468 Drosophila grimshawi Dgri\GH12704
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	33538 w* P{EP}CG12121G1121
VDRC	v103605 P{KK101631}VIE-260B
Genomic Clones ( 1 )
	BACR30C13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE59932
Other clones	DPiM_RE59932
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07427 GM19155 LD01178 LD01542 LD02853 LD10593 LD13175 LD14515 LD37404 LD39383 LP18043 RE18617 RE20482 RE21192 RE44282 RE45894 RE50292 RE53106 RE55493 RE56870 RE59021 RE61745 RE71844 RE71865 RH49312
Other clones	11847 44248 45063 62500 64829 73948 104043 149405 162065 557985 AT10967 CK01.6D.F5 CK01.71C.G1 CK01.88A.E8 CK01.168D.A10 Dmel_dig_016829_0581_2917 Dmel_neb_009794_0587_0582 EK042719 EK056719 EK069452 EK103733 EK112717 EK159435 EK160732 EK187512 EK193022 EK206301 EK227553 EK254448 EN12752 FGC022E12 FGC032C04 LD47552 RE58511 RP01335 RP001012754 RP001014320 RP001038114 RP001040073 RP001043448 RP001043634 RP001049733 RP001050594 RP001051065 RP001054171
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030109 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31866
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132317 RefSeq (Proteins) • NP_572545 DDBJ / EMBL / GenBank • AAF46469 AAM29522 AY113517 BI372772 Entrez Gene - A searchable database of RefSeq genes. • 31866 UniProtKB/TrEMBL • Q9W366
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transmembrane receptor, eukaryota (IPR009637)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58319 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030109 DroID - A comprehensive database of gene and protein interactions. • FBgn0030109 DRSC - Results from RNAi screens. • FBgn0030109 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030109 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12121-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030109 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31866 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31866 modMine - Data generated by the modENCODE project. • FBgn0030109
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12121 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 11 )
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	Bellen, 2010.12.8, BDGP_2010_1209.GenExel.xml BDGP_2010_1209.GenExel.xml [FBrf0212439] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]