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Gene Dmel\CG3004

General Information
Symbol	Dmel\CG3004	Species	D. melanogaster
Name		Annotation symbol	CG3004
Feature type	protein_coding_gene	FlyBase ID	FBgn0030142
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	8F1-8F1	Sequence location	X:9,498,187..9,499,999 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG3004 (FBgn0030142). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628483_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3004. Gene sequence location is X:9498187..9499999.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA18262 BKN28778
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 8F1-8F1   Limits computationally determined from genome sequence between P{EP}EP912EP912 and P{EP}nejEP1149&P{EP}nejEP1179
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG3004 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG3004-RA FBtr0071368  NM_132344   1757   313
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG3004-PA   FBpp0071303   35.3   313   7.19     NP_572572   AAF46509
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940854   AA949035   AA949042   AA950349   AE014298 AAF46509   AI516064   AI519632   AW942664   AY061311 AAL28859   BI230755   BI367846   BI483200   BI611683   CK131639   CO187627   CO263720   CO282456   CO289562   CO296698   CO299974   CO329831   EC057632   EC082407   EC087766   EC213098   EC222713   EC250710   GH739867   GH740623   GH741054   GH746240   GH747314   GH763326   GH767657   GH768131   GH769160
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W328
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030142    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030142 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030142 expression level Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2593) embryo 02-04hr  (2285) embryo 04-06hr  (1624) embryo 06-08hr  (2025) embryo 08-10hr  (2457) embryo 10-12hr  (2273) embryo 12-14hr  (1818) embryo 14-16hr  (1468) embryo 16-18hr  (1120) embryo 18-20hr  (881) embryo 20-22hr  (776) embryo 22-24hr  (918) larva L1  (1146) larva L2  (883) larva L3 12hr old  (646) larva L3 puffstage 1-2  (636) larva L3 puffstage 3-6  (961) larva L3 puffstage 7-9  (1149) white prepupae new  (1089) white prepupae 12hr  (1182) white prepupae 24hr  (1221) pupae 2d postWPP  (921) pupae 3d postWPP  (544) pupae 4d postWPP  (551) adult male 01day  (388) adult male 05day  (425) adult male 30day  (433) adult female 01day  (1238) adult female 05day  (1693) adult female 30day  (1748) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2593) embryo 02-04hr  (2285) embryo 04-06hr  (1624) embryo 06-08hr  (2025) embryo 08-10hr  (2457) embryo 10-12hr  (2273) embryo 12-14hr  (1818) embryo 14-16hr  1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day  (1693) adult female 30day  (1748) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030142 expression level Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2593) embryo 02-04hr  (2285) embryo 04-06hr  (1624) embryo 06-08hr  (2025) embryo 08-10hr  (2457) embryo 10-12hr  (2273) embryo 12-14hr  (1818) embryo 14-16hr  (1468) embryo 16-18hr  (1120) embryo 18-20hr  (881) embryo 20-22hr  (776) embryo 22-24hr  (918) larva L1  (1146) larva L2  (883) larva L3 12hr old  (646) larva L3 puffstage 1-2  (636) larva L3 puffstage 3-6  (961) larva L3 puffstage 7-9  (1149) white prepupae new  (1089) white prepupae 12hr  (1182) white prepupae 24hr  (1221) pupae 2d postWPP  (921) pupae 3d postWPP  (544) pupae 4d postWPP  (551) adult male 01day  (388) adult male 05day  (425) adult male 30day  (433) adult female 01day  (1238) adult female 05day  (1693) adult female 30day  (1748) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2593) embryo 02-04hr  2285 embryo 04-06hr  1624 embryo 06-08hr  2025 embryo 08-10hr  2457 embryo 10-12hr  2273 embryo 12-14hr  1818 embryo 14-16hr  1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day  1693 adult female 30day  1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2593 embryo 02-04hr    2285 embryo 04-06hr    1624 embryo 06-08hr    2025 embryo 08-10hr    2457 embryo 10-12hr    2273 embryo 12-14hr    1818 embryo 14-16hr    1468 embryo 16-18hr    1120 embryo 18-20hr    881 embryo 20-22hr    776 embryo 22-24hr    918 larva L1    1146 larva L2    883 larva L3 12hr old    646 larva L3 puffstage 1-2    636 larva L3 puffstage 3-6    961 larva L3 puffstage 7-9    1149 white prepupae new    1089 white prepupae 12hr    1182 white prepupae 24hr    1221 pupae 2d postWPP    921 pupae 3d postWPP    544 pupae 4d postWPP    551 adult male 01day    388 adult male 05day    425 adult male 30day    433 adult female 01day    1238 adult female 05day    1693 adult female 30day    1748 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030142    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030142 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030142 expression level Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030142 expression level Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    392.55 Larval Midgut    119.9 Larval Hindgut    161.3 Larval Malpighian Tubules    126.2 Larval Fat Body    105.9 Larval Salivary Gland    215.6 Larval Trachea    231.225 Larval Carcass    168 Adult Head    86.7 Adult Eye    82.875 Adult Brain    82.4 Adult Thoracic-Abdominal Ganglion    70.7 Adult Crop    164.2 Adult Midgut    108.6 Adult Hindgut    107.8 Adult Malpighian Tubules    118.6 Adult Fat Body    181.8 Adult Salivary Gland    97.8 Adult Heart    115.125 Adult VirginFemale Spermatheca    121.9 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    317.8 Adult Testis    28.4 Adult Male Accessory Gland    136.3 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    86.7   NA  Eye    82.875   NA  Brain    82.4   392.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    70.7   NA  Crop    164.2   119.9  Midgut    108.6   161.3  Hindgut    107.8   126.2  Malpighian Tubules    118.6   105.9  Fat Body    181.8   215.6  Salivary Gland    97.8   NA  Heart    115.125   231.225  Trachea    NA   NA  VirginFemale Spermatheca    121.9   NA  InseminatedFemale Spermatheca    138.1   NA  Ovary    317.8   NA  Testis    28.4   NA  Male Accessory Gland    136.3   168  Carcass    104.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030142 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3004-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG3004GD9976 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG3004 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG3004 Class Mutagen Stocks Known lesion CG3004GD9976 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG3004HMS01350 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3004KK108778 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9976} NA P{KK108778} NA P{TRiP.HMS01350} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a biological process term for this gene. (Based on a review of available data on: 2008-03-26)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity with EMBL:AF051155 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
heterotrimeric G-protein complex inferred from sequence or structural similarity with EMBL:AF051155 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG3004 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58343 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030142 DroID - A comprehensive database of gene and protein interactions. • FBgn0030142 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31903
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22378 Dere\GG18968 Dgri\GH24634 Dmoj\GI15823 Dper\GL20333 Dpse\GA15597 Dsec\GM11356 Dsim\GD16055 Dvir\GJ18676 Dwil\GK25539 Dyak\GE15442
Curated drosophilid orthologs	Dpse\GA15597
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005637-PA Aedes aegypti (mosquito) AGAP001036-PA Anopheles gambiae (mosquito) XP_393223.1 Apis mellifera (honey bee) XP_001947881.1 Acyrthosiphon pisum (pea aphid) At3g18140.1 Arabidopsis thaliana (wall cress) 33407 Batrachochytrium dendrobatidis (chytrid fungus) 119001 Branchiostoma floridae (lancelet) BGIBMGA005290-PA Bombyx mori (silk worm) ENSBTAP00000013104 Bos taurus (bovine) CAL0002120 Candida albicans (a form of yeast) CBP33223 Caenorhabditis briggsae (nematode) CE08097 Caenorhabditis elegans (worm) ENSCAFP00000030885 Canis familiaris (dog) CAGL0H03729g Candida glabrata (haploid yeast) ENSCINP00000009283 Ciona intestinalis (sea squirt) JA01984 Caenorhabditis japonica (nematode) CMH260C Cyanidioschyzon merolae (red alga) cn13102 Cryptococcus neoformans (yeast-like fungus) CPIJ012745 Culex pipens (mosquito) CPIJ012746 Culex pipens (mosquito) ENSCPOP00000001866 Cavia porcellus (guinea pig) 193970 Chlamidomonas reinhardtii (green alga) RP29362 Caenorhabditis remanei (nematode) ENSCSAVP00000007220 Ciona savignyi (sedentary tunicate) 165576 Capitella spl (polychaete worm) DDB0233210 Dictyostelium discoideum (amoeba) DEHA2G10824g Debaryomyces Hansenii (yeast) 205806 Daphnia pulex (daphnia) ENSDARP00000019416 Danio rerio (zebra fish) ENSECAP00000008378 Equus caballus (horse) ENSGACP00000012151 Gymnopilus aculeatus (mushroom) ENSGALP00000009432 Gallus gallus (chicken) GL50803_17353 Giardia lamblia (flagellated protozoan) 106302 Hypsipyla robusta (cedar shoot borer) ENSP00000301724 Homo sapiens (human) ISCW002765-PA Ixodes scapularis (deer tick) KLLA0D04840g Kluyveromyces lactis (yeast) 212084 Lottia gigantea (owl limpet) LmjF19.1010 Leishmania major (virus) 34029 Monocosta brevicollis (choanoflagellate) ENSMODP00000019871 Monodelphis domestica (gray opossum) ENSMMUP00000025274 Macaca mulatta (rhesus monkey) ENSMUSP00000065004 Mus musculus (house mouse) 141896 Nematostella vectensis (starlet anemone) XP_001600522.1 Nasonia vitripennis (wasp) ENSOANP00000003473 Ornithorynchus anatinus (platypus) ENSORLP00000003877 Oryzias latipes (japanese killifish) LOC_Os03g47780.1 Oryza sativa (asian rice) 11363 Ostreococcus tauri (green alga) PHUM001190-PA Pediculus humanus (human body louse) PP24345 Pristionchus pacificus (nematode) 167168 Physcomitrella patens (moss) ENSPPYP00000007913 Pongo pygmaeus (orangutan) 72138 Phytophthora ramorum (sudden oak death pathogen) 109544 Phytophthora sojae (root rot pathogen) 667428 Populus trichocarpa (black cottonwood) ENSPTRP00000013055 Pan troglodytes (chimpanzee) ENSRNOP00000014269 Rattus norvegicus (norway rat) 4886500 Sorghum bicolor (sorghum) YNL006W Saccharomyces cerevisiae (budding yeast) Smp_073560.2 Schistosoma mansoni (trematode parasite) SPBC21B10.05c Schizosaccharomyces pombe (fission yeast) XP_786340.1 Strongylocentrotus purpuratus (purple sea urchin) 21796 Trichoplax adhaerens (metazoa) XP_972979.1 Tribolium castaneum (red flour beetle) Tc00.1047053511295.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015882 Tetraodon nigroviridis (green spotted pufferfish) 4260 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043272 Takifugu rubripes (pufferfish Takifugu) 3700.m00003 Tetrahymena thermophila (ciliate protozoa) 95629.m00058 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000035110 Xenopus tropicalis (frog) YALI0E13530g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14809 NV18576 NV17648 LH21130 ISCW002765 FBgn0233018 FBgn0227498 FBgn0205830 FBgn0187694 FBgn0166299 JGI_V11_205806 FBgn0075614 FBgn0157928 FBgn0138572 FBgn0132090 FBgn0111174 FBgn0099374 CPIJ012745 CPIJ012746 BGIBMGA005290 ACYPI003573 GB19722 AGAP001036 AAEL005637 PHUM097400 GLEAN_12179
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34361 y1 sc* v1; P{TRiP.HMS01350}attP2
VDRC	v101373 P{KK108778}VIE-260B v46556 w1118; P{GD9976}v46556 v46557 w1118; P{GD9976}v46557
Genomic Clones ( 2 )
	BACR18F10 BACR24L02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 34 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23129
Other clones	DPiM_LD23129
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD27777 LD27784 LD28877 LD39285 LD41806 LP12544 RE14787 RE53694 RE66053 RH18061
Other clones	51216 81055 102752 191203 CK01.36B.D4 CK01.91A.H3 EK030935 EK071330 EK089405 EK160527 EK177132 EK214653 EK293959 RP001002132 RP001017061 RP001018364 RP001037486 RP001038961 RP001048208 RP001052210 RP001053260 RP001053746
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030142 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31903
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132344 RefSeq (Proteins) • NP_572572 DDBJ / EMBL / GenBank • AA940854 AAF46509 AAL28859 AW942664 AY061311 Entrez Gene - A searchable database of RefSeq genes. • 31903 UniProtKB/TrEMBL • Q9W328
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat (IPR001680) WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58343 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030142 DroID - A comprehensive database of gene and protein interactions. • FBgn0030142 DRSC - Results from RNAi screens. • FBgn0030142 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030142 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3004-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030142 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31903 InParanoid A subset of ortholog calls from InParanoid. • AAEL005637-PA Aedes aegypti (mosquito) AGAP001036-PA Anopheles gambiae (mosquito) XP_393223.1 Apis mellifera (honey bee) XP_001947881.1 Acyrthosiphon pisum (pea aphid) At3g18140.1 Arabidopsis thaliana (wall cress) 33407 Batrachochytrium dendrobatidis (chytrid fungus) 119001 Branchiostoma floridae (lancelet) BGIBMGA005290-PA Bombyx mori (silk worm) ENSBTAP00000013104 Bos taurus (bovine) CAL0002120 Candida albicans (a form of yeast) CBP33223 Caenorhabditis briggsae (nematode) CE08097 Caenorhabditis elegans (worm) ENSCAFP00000030885 Canis familiaris (dog) CAGL0H03729g Candida glabrata (haploid yeast) ENSCINP00000009283 Ciona intestinalis (sea squirt) JA01984 Caenorhabditis japonica (nematode) CMH260C Cyanidioschyzon merolae (red alga) cn13102 Cryptococcus neoformans (yeast-like fungus) CPIJ012745 Culex pipens (mosquito) CPIJ012746 Culex pipens (mosquito) ENSCPOP00000001866 Cavia porcellus (guinea pig) 193970 Chlamidomonas reinhardtii (green alga) RP29362 Caenorhabditis remanei (nematode) ENSCSAVP00000007220 Ciona savignyi (sedentary tunicate) 165576 Capitella spl (polychaete worm) DDB0233210 Dictyostelium discoideum (amoeba) DEHA2G10824g Debaryomyces Hansenii (yeast) 205806 Daphnia pulex (daphnia) ENSDARP00000019416 Danio rerio (zebra fish) ENSECAP00000008378 Equus caballus (horse) ENSGACP00000012151 Gymnopilus aculeatus (mushroom) ENSGALP00000009432 Gallus gallus (chicken) GL50803_17353 Giardia lamblia (flagellated protozoan) 106302 Hypsipyla robusta (cedar shoot borer) ENSP00000301724 Homo sapiens (human) ISCW002765-PA Ixodes scapularis (deer tick) KLLA0D04840g Kluyveromyces lactis (yeast) 212084 Lottia gigantea (owl limpet) LmjF19.1010 Leishmania major (virus) 34029 Monocosta brevicollis (choanoflagellate) ENSMODP00000019871 Monodelphis domestica (gray opossum) ENSMMUP00000025274 Macaca mulatta (rhesus monkey) ENSMUSP00000065004 Mus musculus (house mouse) 141896 Nematostella vectensis (starlet anemone) XP_001600522.1 Nasonia vitripennis (wasp) ENSOANP00000003473 Ornithorynchus anatinus (platypus) ENSORLP00000003877 Oryzias latipes (japanese killifish) LOC_Os03g47780.1 Oryza sativa (asian rice) 11363 Ostreococcus tauri (green alga) PHUM001190-PA Pediculus humanus (human body louse) PP24345 Pristionchus pacificus (nematode) 167168 Physcomitrella patens (moss) ENSPPYP00000007913 Pongo pygmaeus (orangutan) 72138 Phytophthora ramorum (sudden oak death pathogen) 109544 Phytophthora sojae (root rot pathogen) 667428 Populus trichocarpa (black cottonwood) ENSPTRP00000013055 Pan troglodytes (chimpanzee) ENSRNOP00000014269 Rattus norvegicus (norway rat) 4886500 Sorghum bicolor (sorghum) YNL006W Saccharomyces cerevisiae (budding yeast) Smp_073560.2 Schistosoma mansoni (trematode parasite) SPBC21B10.05c Schizosaccharomyces pombe (fission yeast) XP_786340.1 Strongylocentrotus purpuratus (purple sea urchin) 21796 Trichoplax adhaerens (metazoa) XP_972979.1 Tribolium castaneum (red flour beetle) Tc00.1047053511295.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015882 Tetraodon nigroviridis (green spotted pufferfish) 4260 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043272 Takifugu rubripes (pufferfish Takifugu) 3700.m00003 Tetrahymena thermophila (ciliate protozoa) 95629.m00058 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000035110 Xenopus tropicalis (frog) YALI0E13530g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31903 modMine - Data generated by the modENCODE project. • FBgn0030142 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14809 NV18576 NV17648 LH21130 ISCW002765 FBgn0233018 FBgn0227498 FBgn0205830 FBgn0187694 FBgn0166299 JGI_V11_205806 FBgn0075614 FBgn0157928 FBgn0138572 FBgn0132090 FBgn0111174 FBgn0099374 CPIJ012745 CPIJ012746 BGIBMGA005290 ACYPI003573 GB19722 AGAP001036 AAEL005637 PHUM097400 GLEAN_12179
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG3004 (Wullschleger, 2006, Akdemir et al., 2007, Ayroles et al., 2009, Keleman et al., 2009.8.5, Fernández-Ayala et al., 2010, Ni et al., 2010.12.1)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Ayroles et al., 2009, Nature Genetics 41(3): 299--307 Systems genetics of complex traits in Drosophila melanogaster. [FBrf0206705] Akdemir et al., 2007, Oncogene 26(36): 5184--5193 p53 directs focused genomic responses in Drosophila. [FBrf0202061]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Wullschleger, 2006, Cell 124(3): 471--484 [FBrf0198684]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Mount, 2001.8.14, Intron annotations. Intron annotations. [FBrf0137489]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]