Gene Dmel\CG2972

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General Information

Symbol

Dmel\CG2972

Species

D. melanogaster

Name

Annotation symbol

CG2972

Feature type

protein_coding_gene

FlyBase ID

FBgn0030177

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

9B1-9B1

Sequence location

X:9,977,187..9,979,083 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG2972 (FBgn0030177). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: D-site 20S pre-rRNA nuclease; Nin one binding (NOB1) Zn-ribbon-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1633322_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG2972. Gene sequence location is X:9977187..9979083.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9B1-9B1

Limits computationally determined from genome sequence between P{EP}nej^EP1149&P{EP}nej^EP1179 and P{EP}α-Man-I^EP1628&P{EP}α-Man-I^EP1307

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG2972 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.39

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG2972-RA

FBtr0071430

NM_132375

1630

472

CG2972-RB

FBtr0340473

1838

472

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG2972-PA

FBpp0071365

53.8

472

4.56

NP_572603

AAF46553

CG2972-PB

FBpp0309414

53.8

472

4.56

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nin one binding (NOB1) Zn-ribbon-like (IPR014881)

D-site 20S pre-rRNA nuclease (IPR017117)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9W2Y4

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult male accessory gland.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		103.675
Larval Midgut		52.7
Larval Hindgut		88.8
Larval Malpighian Tubules		44.4
Larval Fat Body		41.9
Larval Salivary Gland		91.9
Larval Trachea		89.9
Larval Carcass		74.275
Adult Head		51.1
Adult Eye		40.15
Adult Brain		36.4
Adult Thoracic-Abdominal Ganglion		40
Adult Crop		64.2
Adult Midgut		45.1
Adult Hindgut		54.4
Adult Malpighian Tubules		71.8
Adult Fat Body		97.7
Adult Salivary Gland		66
Adult Heart		48.625
Adult VirginFemale Spermatheca		68
Adult InseminatedFemale Spermatheca		89.5
Adult Ovary		222.1
Adult Testis		43.6
Adult Male Accessory Gland		116.1
Adult Carcass		52
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	51.1
NA	Eye	40.15
NA	Brain	36.4
103.675	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	40
NA	Crop	64.2
52.7	Midgut	45.1
88.8	Hindgut	54.4
44.4	Malpighian Tubules	71.8
41.9	Fat Body	97.7
91.9	Salivary Gland	66
NA	Heart	48.625
89.9	Trachea	NA
NA	VirginFemale Spermatheca	68
NA	InseminatedFemale Spermatheca	89.5
NA	Ovary	222.1
NA	Testis	43.6
NA	Male Accessory Gland	116.1
74.275	Carcass	52

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		(37)
ovary, mated 4-day female		(36)
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		(37)
ovary, mated 4-day female		(36)
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		16
central nervous system, larvae L3		11
central nervous system, pupae P8		6
head, virgin 1-day female		5
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		9
head, mated 20-day female		6
head, mated 1-day male		4
head, mated 4-day male		7
head, mated 20-day male		6
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		2
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		6
digestive system, 4-day adult		10
digestive system, 20-day adult		5
fat body, larvae L3 wandering		2
fat body, white prepupae		4
fat body, pupae P8		4
carcass, larvae L3 wandering		13
carcass, 1-day adult		4
carcass, 4-day adult		9
carcass, 20-day adult		6
ovary, virgin 4-day female		37
ovary, mated 4-day female		36
testis, mated 4-day male		11
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(54)
embryo 02-04hr		25
embryo 04-06hr		(32)
embryo 06-08hr		(42)
embryo 08-10hr		(41)
embryo 10-12hr		(48)
embryo 12-14hr		(30)
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		(41)
embryo 22-24hr		(33)
larva L1		(62)
larva L2		(33)
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		(38)
adult female 05day		(48)
adult female 30day		(52)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(54)
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		(42)
embryo 08-10hr		(41)
embryo 10-12hr		(48)
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		(41)
embryo 22-24hr		(33)
larva L1		(62)
larva L2		(33)
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		(38)
adult female 05day		(48)
adult female 30day		(52)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		54
embryo 02-04hr		25
embryo 04-06hr		32
embryo 06-08hr		42
embryo 08-10hr		41
embryo 10-12hr		48
embryo 12-14hr		30
embryo 14-16hr		26
embryo 16-18hr		19
embryo 18-20hr		20
embryo 20-22hr		41
embryo 22-24hr		33
larva L1		62
larva L2		33
larva L3 12hr old		21
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		12
white prepupae new		12
white prepupae 12hr		10
white prepupae 24hr		12
pupae 2d postWPP		12
pupae 3d postWPP		8
pupae 4d postWPP		9
adult male 01day		9
adult male 05day		11
adult male 30day		10
adult female 01day		38
adult female 05day		48
adult female 30day		52
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(70)
Schneider line 2 Sg4		(29)
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		(28)
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		(27)
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		(27)
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(70)
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		70
Schneider line 2 Sg4		29
embryonic 1182-4H		24
embryonic GM2		21
embryonic Kc167		16
embryonic S1		17
embryonic S3		24
leg disc CME L1		26
wing disc CME-W2		15
wing disc ML-DmD8		18
wing disc ML-DmD9		24
wing disc ML-DmD16-c3		28
wing disc ML-DmD21		25
wing disc ML-DmD32		24
haltere disc ML-DmD17-c3		20
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		19
mixed discs ML-DmD4-c1		27
CNS ML-DmBG1-c1		23
CNS ML-DmBG2-c2		17
tumorous blood cells mbn2		27
ovary fGS/OSS		12
ovary OSC		12
ovary OSS		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		(28)
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		(27)
Paraquat 10 mM 48 hrs, 4-day adult		(27)
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		11
cold shock, 4-day adult		10
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		7
Cadmium 50 mM 48 hrs, 4-day adult		19
Cadmium 100 mM 48 hrs, 4-day adult		22
Copper 0.5 mM 12 hrs, larvae L3		8
Copper 15 mM 48 hrs, 4-day adult		9
Zinc 5 mM 12 hrs, larvae L3		7
Zinc 4.5 mM 48 hrs, 4-day adult		10
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		5
Ethanol 10% 3 hrs, larvae L3		9
Caffeine 1.5 mg/ml 4 hrs, larvae L3		4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		23
Caffeine 25 mg/ml 48 hrs, 4-day adult		13
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		10
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0030177

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG2972-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal

CG2972^GD9870

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

CG2972^GD9870

Other Phenotypes

Allele

neuroanatomy defective | larval stage

CG2972^GD9870

visible, with Scer\GAL4^pnr-MD237

CG2972^GD9870

Phenotype manifest in

Allele

ganglion mother cell | larval stage

CG2972^GD9870

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CG2972^GD9870

trichogen cell, with Scer\GAL4^pnr-MD237

CG2972^GD9870

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG2972	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG2972	Mutagen	Stocks	Known lesion
CG2972^GD9870	in vitro construct - RNAi in vitro construct - regulatory fusion	3	Yes
CG2972^KK108208	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG2972^NIG.2972R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD9870}

P{KK108208}

P{NIG.2972R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 1 unique term )

Terms Based on Experimental Evidence ( 1 term )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

neurogenesis

inferred from mutant phenotype

(Neumüller et al., 2011)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

CG2972 - CG3530

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

CG2972 - Dsor1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

CG2972 - Optix

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

CG2972 - Rab5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

CG2972 - capu

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG2972 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

58378

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0030177

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

31943

Orthologs

OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6K6GQ8

Dipteran inclusive ortholog search

EOG6KD6VQ

Insect inclusive ortholog search

EOG6VT4SV

Arthropod inclusive ortholog search

EOG6RBP16

Metazoa inclusive ortholog search

EOG6XSZHR

Orthologs in Drosophila Species (EOG6K6GQ8)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15547

Drosophila persimilis

Dper\GL16393

Drosophila persimilis

Dper\GL16394

Drosophila willistoni

Dwil\GK25644

Drosophila virilis

Dvir\GJ18597

Drosophila mojavensis

Dmoj\GI10936

Drosophila grimshawi

Dgri\GH12205

Orthologs in non-Drosophila Dipterans (EOG6KD6VQ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005628

Anopheles gambiae

Malaria mosquito

Agam\AGAP004064

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012739

Orthologs in non-Dipteran Insects (EOG6VT4SV)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC727288

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007374

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH25656

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH25655

Atta cephalotes

Leafcutter ant

Acep\ACEP14814

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO22157

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL20788

Linepithema humile

Argentine ant

Lhum\LH22344

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB22894

Solenopsis invicta

Red fire ant

Sinv\SINV22362

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000645

Bombyx mori

Silkmoth

Bmor\BGIBMGA007192

Pediculus humanus

Human body louse

Phum\PHUM626370

Tribolium castaneum

Red flour beetle

Tcas\TC013384

Orthologs in non-Insect Arthropods (EOG6RBP16)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_301213

Ixodes scapularis

Deer tick

Isca\ISCW022111

Orthologs in non-Arthropod Metazoa (EOG6XSZHR)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y54E10BR.4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_014794gn

Danio rerio

Zebrafish

Drer\wu:fc27e05

Xenopus tropicalis

Western clawed frog

Xtro\nob1

Gallus gallus

Domestic chicken

Ggal\NOB1

Mus musculus

House mouse

Mmus\Nob1

Rattus norvegicus

Norway rat

Rnor\Nob1

Homo sapiens

Human

Hsap\NOB1

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\NOB1

AAA Orthologs (9) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15547

Drosophila willistoni

Dwil\GK25644

Drosophila virilis

Dvir\GJ18597

Drosophila mojavensis

Dmoj\GI10936

Drosophila grimshawi

Dgri\GH12205

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

VDRC

v104991

P{KK108208}VIE-260B

v20961

w¹¹¹⁸ P{GD9870}v20961

v48771

w¹¹¹⁸; P{GD9870}v48771

v48772

w¹¹¹⁸; P{GD9870}v48772

Genomic Clones ( 1 )

BACR07L06

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 12 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD17927

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0030177

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

31943

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_132375

RefSeq (Proteins)

•

NP_572603

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

31943

UniProtKB/TrEMBL

•

Q9W2Y4

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nin one binding (NOB1) Zn-ribbon-like (IPR014881)

D-site 20S pre-rRNA nuclease (IPR017117)

Linkouts

BioGRID - A database of protein and genetic interactions

•

58378

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0030177

DRSC - Results from RNAi screens.

•

FBgn0030177

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0030177

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG2972-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0030177

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

31943

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

31943

modMine - Data generated by the modENCODE project.

•

FBgn0030177

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG2972

(Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 11 )

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
Neumüller et al., 2011, Cell Stem Cell 8(5):: Supplemental Table S1. [FBrf0214431]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project: DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]