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Gene Dmel\CG2186

General Information
Symbol	Dmel\CG2186	Species	D. melanogaster
Name		Annotation symbol	CG2186
Feature type	protein_coding_gene	FlyBase ID	FBgn0030243
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	9F5-9F5	Sequence location	X:10,751,688..10,760,279 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG2186 (FBgn0030243). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630686_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG2186. Gene sequence location is X:10751688..10760279.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 9F5-9F5   Limits computationally determined from genome sequence between P{EP}sesBEP319&P{EP}ImpEP760 and P{EP}EP1321EP1321&P{EP}CG2061EP1537
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG2186 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated DGC clone appears problematic (LD02311): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG2186-RA FBtr0073381  NM_132432   4449   1128 CG2186-RB FBtr0332961  NM_001272504   7117   1128
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG2186-PA   FBpp0073237   122.7   1128   10.18     NP_572660   AAF47967 CG2186-PB   FBpp0305177   122.7   1128   10.18     NP_001259433   AGB95276
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202201   AA202502   AA264484   AA391236   AA392679   AA439477   AA440312   AA820148   AA949052   AA990893   AE014298 AAF47967   AE014298 AGB95276   AI455346   AW941498   BI162388   BI165844   BI166865   BI238945   BI356383   BI635642   BT023500   CL525934   CO177314   CO179499   CO186852   CO196574   CO262763   CO263234   CO267945   CO270589   CO274547   CO278233   CO280543   CO281495   CO285750   CO286555   CO288817   CO288828   CO289798   CO290835   CO302697   CO304959   CO309787   CO323330   CO331106   CO331717   CO339126   CO339358   CO344891   CZ476684   EC051656   EC059260   EC062977   EC072554   EC077874   EC081042   EC082015   EC196254   EC199438   EC209465   EC210714   EC216422   EC217990   EC218012   EC219039   EC219473   EC219600   EC222062   EC226357   EC228098   EC230386   EC230418   EC230889   EC231517   EC237748   EC242185   EC247879   EC255174   EC256367   EC258692
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZ60
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    116.825 Larval Midgut    47.2 Larval Hindgut    60.9 Larval Malpighian Tubules    68.6 Larval Fat Body    46.7 Larval Salivary Gland    100 Larval Trachea    77.625 Larval Carcass    76.275 Adult Head    33.4 Adult Eye    39.025 Adult Brain    41.5 Adult Thoracic-Abdominal Ganglion    33 Adult Crop    67.6 Adult Midgut    64 Adult Hindgut    49.4 Adult Malpighian Tubules    71 Adult Fat Body    59 Adult Salivary Gland    75.9 Adult Heart    56.6 Adult VirginFemale Spermatheca    45.2 Adult InseminatedFemale Spermatheca    52.2 Adult Ovary    412.5 Adult Testis    9.2 Adult Male Accessory Gland    42.1 Adult Carcass    55.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33.4   NA  Eye    39.025   NA  Brain    41.5   116.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    33   NA  Crop    67.6   47.2  Midgut    64   60.9  Hindgut    49.4   68.6  Malpighian Tubules    71   46.7  Fat Body    59   100  Salivary Gland    75.9   NA  Heart    56.6   77.625  Trachea    NA   NA  VirginFemale Spermatheca    45.2   NA  InseminatedFemale Spermatheca    52.2   NA  Ovary    412.5   NA  Testis    9.2   NA  Male Accessory Gland    42.1   76.275  Carcass    55.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    13 head, virgin 4-day female    14 head, virgin 20-day female    8 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    8 head, mated 1-day male    17 head, mated 4-day male    22 head, mated 20-day male    16 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    14 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    18 ovary, mated 4-day female    19 testis, mated 4-day male    2 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (51) embryo 04-06hr  (28) embryo 06-08hr  (30) embryo 08-10hr  (29) embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (51) embryo 04-06hr  28 embryo 06-08hr  30 embryo 08-10hr  29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    51 embryo 04-06hr    28 embryo 06-08hr    30 embryo 08-10hr    29 embryo 10-12hr    22 embryo 12-14hr    18 embryo 14-16hr    24 embryo 16-18hr    18 embryo 18-20hr    13 embryo 20-22hr    25 embryo 22-24hr    16 larva L1    8 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    6 adult male 05day    7 adult male 30day    7 adult female 01day    14 adult female 05day    17 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (35) ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (35) ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    22 embryonic 1182-4H    18 embryonic GM2    20 embryonic Kc167    25 embryonic S1    15 embryonic S3    18 leg disc CME L1    16 wing disc CME-W2    18 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    16 antennal disc ML-DmD20-c5    14 mixed discs ML-DmD4-c1    17 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    35 ovary fGS/OSS    20 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    10 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	BDGP expression data • LD02311 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030243 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2186-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG2186CB05020 CG2186EY07552 Sterility Allele fertile CG2186EY07552 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG2186 Class Mutagen Stocks Known lesion CG2186d09330 P-element activity 1 -- CG2186EY07552 P-element activity 1 -- CG2186CB05020 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG2186 Class Mutagen Stocks Known lesion CG2186HMS01090 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG2186KK111161 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG2186GD9747 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG2186NIG.2186R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)v-L3 (Verni et al., 2004)
Not disrupted in	Df(1)v65b (Verni et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9747} NA P{KK111161} NA P{NIG.2186R} NA P{TRiP.HMS01090} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG2186EY07552 NA P{GSV1}C719.2C719.2 NA P{GSV1}EP-1052EP-1052 NA P{Mae-UAS.6.11}GG01554GG01554 NA P{XP}CG2186d09330 NA miscellaneous insertions P{PTT-GB}CG2186CB05020 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG2186 - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG2186 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58434 DroID - A comprehensive database of gene and protein interactions. • FBgn0030243 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32017
Orthologs
OrthoDB Orthologs (9) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PG6M1 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG641P6B Arthropod inclusive ortholog search EOG69P8DD Metazoa inclusive ortholog search EOG6MM185
Orthologs in Drosophila Species (EOG6PG6M1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG2186     Drosophila simulans   Dsim\GD24784 Y   Drosophila erecta   Dere\GG18374 Y   Drosophila yakuba   Dyak\GE17863 Y   Drosophila ananassae   Dana\GF20470 Y   Drosophila willistoni   Dwil\GK25141 Y   Drosophila virilis   Dvir\GJ17035 Y   Drosophila mojavensis   Dmoj\GI16414 Y   Drosophila grimshawi   Dgri\GH24289 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24784 Drosophila sechellia Dsec\GM11439 Drosophila erecta Dere\GG18374 Drosophila yakuba Dyak\GE17863 Drosophila ananassae Dana\GF20470 Drosophila pseudoobscura pseudoobscura Dpse\GA15289 Drosophila persimilis Dper\GL14326 Drosophila willistoni Dwil\GK25141 Drosophila virilis Dvir\GJ17035 Drosophila mojavensis Dmoj\GI16414 Drosophila grimshawi Dgri\GH24289
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17381 y1 w67c23 P{EPgy2}CG2186EY07552 33750 y1 sc* v1; P{TRiP.HMS01090}attP2
Harvard	- P{XP}CG2186d09330
VDRC	v105328 P{KK111161}VIE-260B
Genomic Clones ( 2 )
	BACR26N01 CH223-05O10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29862
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01996 LD08168 LD10612 LD11456 LD14060 LD15244 LD27802 LD34404 RE01723 RE05823 RE07096 RE35320 RE42514 SD17052
Other clones	12919 16709 37950 40510 42319 61187 97050 124188 147159 159559 194659 273596 CK01.37D.F5 CK01.40B.A4 CK01.65B.B4 CK01.76B.B12 CK01.77D.D3 CK01.88A.E4 CK01.88A.H5 CK01.91C.H2 CK01.97A.G11 CK01.102C.D5 CK01.105A.B12 CK01.118A.A4 EC051656 EC255174 EC256367 EC258692 EK006015 EK024116 EK053138 EK059540 EK060614 EK063220 EK069431 EK069450 EK072059 EK075327 EK086315 EK087840 EK089726 EK099402 EK114420 EK129403 EK154315 EK157315 EK184730 EK190226 EK219316 EK246813 EK298030 EK301311 EP00920 EP01660 EP20148 LD02311 LD23617
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030243 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32017
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132432 NM_001272504 RefSeq (Proteins) • NP_572660 NP_001259433 DDBJ / EMBL / GenBank • AA202201 AAF47967 AGB95276 AW941498 CL525934 CZ476684 Entrez Gene - A searchable database of RefSeq genes. • 32017 UniProtKB/TrEMBL • Q9VZ60
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02311
Linkouts
	BioGRID - A database of protein and genetic interactions • 58434 DroID - A comprehensive database of gene and protein interactions. • FBgn0030243 DRSC - Results from RNAi screens. • FBgn0030243 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030243 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2186-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030243 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32017 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32017 modMine - Data generated by the modENCODE project. • FBgn0030243
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG2186 (Buszczak et al., 2007, Molnar et al., 2006, Grieder et al., 2007, Babenko et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Babenko et al., 2009, Dokl. Biochem. Biophys. 424: 27--30 Characteristics of molecular-genetic organization of intercalary heterochromatin band 10A1-2 in X chromosome of Drosophila melanogaster. [FBrf0207731] Buszczak et al., 2007, Genetics 175(3): 1505--1531 The Carnegie protein trap library: A versatile tool for Drosophila developmental studies. [FBrf0200345] Molnar et al., 2006, Genetics 174(3): 1635--1659 A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. [FBrf0195387] Verni et al., 2004, Curr. Biol. 14(17): 1569--1575 Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis. [FBrf0180061]
Supplementary material	Smibert et al., 2012, Cell Rep. 1(3): 277--289 Table S1: Full Lists of CNS-Extended and Testis-Shortened 3' UTRs [FBrf0219848] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Grieder et al., 2007, Genetics 175(4): Supplemental Data. [FBrf0204785] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]