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Gene Dmel\CG2076

General Information
Symbol	Dmel\CG2076	Species	D. melanogaster
Name		Annotation symbol	CG2076
Feature type	protein_coding_gene	FlyBase ID	FBgn0030263
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A4-10A4	Sequence location	X:10,984,415..10,986,131 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG2076 (FBgn0030263). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Bax inhibitor 1-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, larval/adult Malpighian tubules, adult heart, adult salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1640185_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG2076. Gene sequence location is X:10984415..10986131.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A4-10A4   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG2076 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG2076-RA FBtr0073428  NM_132453   1319   341
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG2076-PA   FBpp0073284   35.8   341   10.29     NP_572681   AAF47994
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bax inhibitor 1-related (IPR006214)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696403   AE014298 AAF47994   AI062913   AI134506   AI258600   AI293293   AI294962   AI296866   AI389862   AI945419   BE662068   BE979022   BF492229   BF497974   BF503155   BF505211   BG633153   BI351968   BI353045   BI362537   BI606468   BI612134   BI615712   BI629763   BI633843   BI641819   BP557187   BT009945 AAQ22414   CO155515   CO155678   CO176951   CO263033   CO266935   CO285771   CO313858   CO324801   EC057286   EC057663   EC068662   EC069944   EC070687   EC073089   EC082376   EC086332   EC202781   EC207384   EC208137   EC222974   EC263884   EC265704   EV581626
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZ34
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, larval/adult Malpighian tubules, adult heart, adult salivary gland, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut  515.3 Larval Hindgut    408.9 Larval Malpighian Tubules  (640.4) Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass  514.475 Adult Head    423.1 Adult Eye  501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut  (572.7) Adult Hindgut    415.7 Adult Malpighian Tubules  (872.3) Adult Fat Body    338.6 Adult Salivary Gland  (552.4) Adult Heart  (714.25) Adult VirginFemale Spermatheca  539 Adult InseminatedFemale Spermatheca  (559.5) Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass  (670.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut  515.3 Larval Hindgut    408.9 Larval Malpighian Tubules  640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass  514.475 Adult Head    423.1 Adult Eye  501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut  572.7 Adult Hindgut    415.7 Adult Malpighian Tubules  (872.3) Adult Fat Body    338.6 Adult Salivary Gland  552.4 Adult Heart  714.25 Adult VirginFemale Spermatheca  539 Adult InseminatedFemale Spermatheca  559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass  670.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    351.3 Larval Midgut    515.3 Larval Hindgut    408.9 Larval Malpighian Tubules    640.4 Larval Fat Body    277.6 Larval Salivary Gland    388.1 Larval Trachea    292.8 Larval Carcass    514.475 Adult Head    423.1 Adult Eye    501.25 Adult Brain    413.1 Adult Thoracic-Abdominal Ganglion    481.8 Adult Crop    463.1 Adult Midgut    572.7 Adult Hindgut    415.7 Adult Malpighian Tubules    872.3 Adult Fat Body    338.6 Adult Salivary Gland    552.4 Adult Heart    714.25 Adult VirginFemale Spermatheca    539 Adult InseminatedFemale Spermatheca    559.5 Adult Ovary    226.9 Adult Testis    273.3 Adult Male Accessory Gland    254 Adult Carcass    670.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    423.1   NA  Eye    501.25   NA  Brain    413.1   351.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    481.8   NA  Crop    463.1   515.3  Midgut    572.7   408.9  Hindgut    415.7   640.4  Malpighian Tubules    872.3   277.6  Fat Body    338.6   388.1  Salivary Gland    552.4   NA  Heart    714.25   292.8  Trachea    NA   NA  VirginFemale Spermatheca    539   NA  InseminatedFemale Spermatheca    559.5   NA  Ovary    226.9   NA  Testis    273.3   NA  Male Accessory Gland    254   514.475  Carcass    670.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult    134 ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3  (38) central nervous system, pupae P8  (29) head, virgin 1-day female  (35) head, virgin 4-day female  (34) head, virgin 20-day female  (45) head, mated 1-day female  (33) head, mated 4-day female  (27) head, mated 20-day female  (42) head, mated 1-day male  (49) head, mated 4-day male  (41) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (56) digestive system, 1-day adult  (61) digestive system, 4-day adult  (50) digestive system, 20-day adult  (71) fat body, larvae L3 wandering    19 fat body, white prepupae  (31) fat body, pupae P8    18 carcass, larvae L3 wandering  (40) carcass, 1-day adult  (66) carcass, 4-day adult  (70) carcass, 20-day adult  (134) ovary, virgin 4-day female  (39) ovary, mated 4-day female  (40) testis, mated 4-day male  (87) accessory gland, mated 4-day male  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult  (134) ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult    134 ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult    134 ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (75) central nervous system, larvae L3  (38) central nervous system, pupae P8  29 head, virgin 1-day female  (35) head, virgin 4-day female  (34) head, virgin 20-day female  (45) head, mated 1-day female  (33) head, mated 4-day female  27 head, mated 20-day female  (42) head, mated 1-day male  (49) head, mated 4-day male  (41) head, mated 20-day male  (67) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (56) digestive system, 1-day adult  (61) digestive system, 4-day adult  (50) digestive system, 20-day adult  (71) fat body, larvae L3 wandering    19 fat body, white prepupae  31 fat body, pupae P8    18 carcass, larvae L3 wandering  (40) carcass, 1-day adult  (66) carcass, 4-day adult  (70) carcass, 20-day adult  (134) ovary, virgin 4-day female  (39) ovary, mated 4-day female  (40) testis, mated 4-day male  (87) accessory gland, mated 4-day male  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult  134 ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    75 central nervous system, larvae L3    38 central nervous system, pupae P8    29 head, virgin 1-day female    35 head, virgin 4-day female    34 head, virgin 20-day female    45 head, mated 1-day female    33 head, mated 4-day female    27 head, mated 20-day female    42 head, mated 1-day male    49 head, mated 4-day male    41 head, mated 20-day male    67 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    56 digestive system, 1-day adult    61 digestive system, 4-day adult    50 digestive system, 20-day adult    71 fat body, larvae L3 wandering    19 fat body, white prepupae    31 fat body, pupae P8    18 carcass, larvae L3 wandering    40 carcass, 1-day adult    66 carcass, 4-day adult    70 carcass, 20-day adult    134 ovary, virgin 4-day female    39 ovary, mated 4-day female    40 testis, mated 4-day male    87 accessory gland, mated 4-day male    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day    114 adult male 05day    127 adult male 30day    186 adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (84) embryo 02-04hr  (57) embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr  (36) embryo 12-14hr  26 embryo 14-16hr  (38) embryo 16-18hr  (34) embryo 18-20hr  (45) embryo 20-22hr  (42) embryo 22-24hr  (38) larva L1  (62) larva L2  (71) larva L3 12hr old  (75) larva L3 puffstage 1-2  (63) larva L3 puffstage 3-6  (62) larva L3 puffstage 7-9  (52) white prepupae new  (43) white prepupae 12hr  (64) white prepupae 24hr  (58) pupae 2d postWPP  (67) pupae 3d postWPP  (62) pupae 4d postWPP  (88) adult male 01day  (114) adult male 05day  (127) adult male 30day  (186) adult female 01day  (85) adult female 05day  (69) adult female 30day  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day  (114) adult male 05day  (127) adult male 30day  (186) adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day    114 adult male 05day    127 adult male 30day    186 adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day    114 adult male 05day    127 adult male 30day    186 adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (84) embryo 02-04hr  (57) embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr  (36) embryo 12-14hr  26 embryo 14-16hr  (38) embryo 16-18hr  (34) embryo 18-20hr  (45) embryo 20-22hr  (42) embryo 22-24hr  (38) larva L1  (62) larva L2  (71) larva L3 12hr old  (75) larva L3 puffstage 1-2  (63) larva L3 puffstage 3-6  (62) larva L3 puffstage 7-9  (52) white prepupae new  (43) white prepupae 12hr  (64) white prepupae 24hr  (58) pupae 2d postWPP  (67) pupae 3d postWPP  (62) pupae 4d postWPP  (88) adult male 01day  (114) adult male 05day  (127) adult male 30day  (186) adult female 01day  (85) adult female 05day  (69) adult female 30day  (74) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day  114 adult male 05day  127 adult male 30day  (186) adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    57 embryo 04-06hr    14 embryo 06-08hr    11 embryo 08-10hr    20 embryo 10-12hr    36 embryo 12-14hr    26 embryo 14-16hr    38 embryo 16-18hr    34 embryo 18-20hr    45 embryo 20-22hr    42 embryo 22-24hr    38 larva L1    62 larva L2    71 larva L3 12hr old    75 larva L3 puffstage 1-2    63 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    52 white prepupae new    43 white prepupae 12hr    64 white prepupae 24hr    58 pupae 2d postWPP    67 pupae 3d postWPP    62 pupae 4d postWPP    88 adult male 01day    114 adult male 05day    127 adult male 30day    186 adult female 01day    85 adult female 05day    69 adult female 30day    74 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    125 embryonic 1182-4H    104 embryonic GM2    189 embryonic Kc167    239 embryonic S1    243 embryonic S3    60 leg disc CME L1    109 wing disc CME-W2    165 wing disc ML-DmD8    159 wing disc ML-DmD9    293 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    153 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    122 eye-antennal disc ML-DmD11    192 antennal disc ML-DmD20-c5    124 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    118 tumorous blood cells mbn2    199 ovary fGS/OSS    99 ovary OSC    252 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4  (125) embryonic 1182-4H  (104) embryonic GM2  (189) embryonic Kc167  (239) embryonic S1  (243) embryonic S3  (60) leg disc CME L1  (109) wing disc CME-W2  (165) wing disc ML-DmD8  (159) wing disc ML-DmD9  (293) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (153) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (122) eye-antennal disc ML-DmD11  (192) antennal disc ML-DmD20-c5  (124) mixed discs ML-DmD4-c1  (93) CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (118) tumorous blood cells mbn2  (199) ovary fGS/OSS  (99) ovary OSC  (252) ovary OSS  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4  (125) embryonic 1182-4H  104 embryonic GM2  (189) embryonic Kc167  (239) embryonic S1  (243) embryonic S3    60 leg disc CME L1  (109) wing disc CME-W2  (165) wing disc ML-DmD8  (159) wing disc ML-DmD9  (293) wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (153) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (122) eye-antennal disc ML-DmD11  (192) antennal disc ML-DmD20-c5  (124) mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (118) tumorous blood cells mbn2  (199) ovary fGS/OSS    99 ovary OSC  (252) ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    125 embryonic 1182-4H    104 embryonic GM2    189 embryonic Kc167    239 embryonic S1    243 embryonic S3    60 leg disc CME L1    109 wing disc CME-W2    165 wing disc ML-DmD8    159 wing disc ML-DmD9    293 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    153 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    122 eye-antennal disc ML-DmD11    192 antennal disc ML-DmD20-c5    124 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    118 tumorous blood cells mbn2    199 ovary fGS/OSS    99 ovary OSC    252 ovary OSS    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    125 embryonic 1182-4H    104 embryonic GM2    189 embryonic Kc167    239 embryonic S1    243 embryonic S3    60 leg disc CME L1    109 wing disc CME-W2    165 wing disc ML-DmD8    159 wing disc ML-DmD9    293 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    153 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    122 eye-antennal disc ML-DmD11    192 antennal disc ML-DmD20-c5    124 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    118 tumorous blood cells mbn2    199 ovary fGS/OSS    99 ovary OSC    252 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4  (125) embryonic 1182-4H  (104) embryonic GM2  (189) embryonic Kc167  (239) embryonic S1  (243) embryonic S3  (60) leg disc CME L1  (109) wing disc CME-W2  (165) wing disc ML-DmD8  (159) wing disc ML-DmD9  (293) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (153) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (122) eye-antennal disc ML-DmD11  (192) antennal disc ML-DmD20-c5  (124) mixed discs ML-DmD4-c1  (93) CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  (118) tumorous blood cells mbn2  (199) ovary fGS/OSS  (99) ovary OSC  (252) ovary OSS  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4  125 embryonic 1182-4H  104 embryonic GM2  (189) embryonic Kc167  (239) embryonic S1  (243) embryonic S3    60 leg disc CME L1  109 wing disc CME-W2  (165) wing disc ML-DmD8  (159) wing disc ML-DmD9  (293) wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (153) wing disc ML-DmD32  142 haltere disc ML-DmD17-c3  122 eye-antennal disc ML-DmD11  (192) antennal disc ML-DmD20-c5  124 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1  (162) CNS ML-DmBG2-c2  118 tumorous blood cells mbn2  (199) ovary fGS/OSS    99 ovary OSC  (252) ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    125 embryonic 1182-4H    104 embryonic GM2    189 embryonic Kc167    239 embryonic S1    243 embryonic S3    60 leg disc CME L1    109 wing disc CME-W2    165 wing disc ML-DmD8    159 wing disc ML-DmD9    293 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    153 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    122 eye-antennal disc ML-DmD11    192 antennal disc ML-DmD20-c5    124 mixed discs ML-DmD4-c1    93 CNS ML-DmBG1-c1    162 CNS ML-DmBG2-c2    118 tumorous blood cells mbn2    199 ovary fGS/OSS    99 ovary OSC    252 ovary OSS    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3    106 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult    22 heat shock, 4-day adult  (79) Cadmium 50 mM 6 hrs, larvae L3  (95) Cadmium 50 mM 12 hrs, larvae L3  (52) Cadmium 50 mM 48 hrs, 4-day adult  (76) Cadmium 100 mM 48 hrs, 4-day adult  (80) Copper 0.5 mM 12 hrs, larvae L3  (66) Copper 15 mM 48 hrs, 4-day adult  (50) Zinc 5 mM 12 hrs, larvae L3  (43) Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3  (77) Ethanol 5% 3 hrs, larvae L3  (79) Ethanol 10% 3 hrs, larvae L3  (87) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (77) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (60) Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3  (81) Rotenone 8 μg 12 hrs, larvae L3  (106) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3  106 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3    106 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3    106 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult    22 heat shock, 4-day adult  (79) Cadmium 50 mM 6 hrs, larvae L3  (95) Cadmium 50 mM 12 hrs, larvae L3  (52) Cadmium 50 mM 48 hrs, 4-day adult  (76) Cadmium 100 mM 48 hrs, 4-day adult  (80) Copper 0.5 mM 12 hrs, larvae L3  (66) Copper 15 mM 48 hrs, 4-day adult  (50) Zinc 5 mM 12 hrs, larvae L3  (43) Zinc 4.5 mM 48 hrs, 4-day adult  (39) Ethanol 2.5% 3 hrs, larvae L3  (77) Ethanol 5% 3 hrs, larvae L3  (79) Ethanol 10% 3 hrs, larvae L3  (87) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (77) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (72) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (60) Paraquat 10 mM 48 hrs, 4-day adult  (135) Rotenone 2 μg 12 hrs, larvae L3  (81) Rotenone 8 μg 12 hrs, larvae L3  (106) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult  135 Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3  106 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    22 heat shock, 4-day adult    79 Cadmium 50 mM 6 hrs, larvae L3    95 Cadmium 50 mM 12 hrs, larvae L3    52 Cadmium 50 mM 48 hrs, 4-day adult    76 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    66 Copper 15 mM 48 hrs, 4-day adult    50 Zinc 5 mM 12 hrs, larvae L3    43 Zinc 4.5 mM 48 hrs, 4-day adult    39 Ethanol 2.5% 3 hrs, larvae L3    77 Ethanol 5% 3 hrs, larvae L3    79 Ethanol 10% 3 hrs, larvae L3    87 Caffeine 1.5 mg/ml 4 hrs, larvae L3    77 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    72 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    60 Paraquat 10 mM 48 hrs, 4-day adult    135 Rotenone 2 μg 12 hrs, larvae L3    81 Rotenone 8 μg 12 hrs, larvae L3    106 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RH72958 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030263 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2076-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG2076e02315 viable, with Scer\GAL4pnr-MD237 CG2076GD3308 Sterility Allele fertile CG2076e02315 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG2076 Class Mutagen Stocks Known lesion CG2076e02315 piggyBac transposase 2 -- CG2076ΔM11 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG2076 Class Mutagen Stocks Known lesion CG2076GD16580 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG2076GD3308 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG2076NIG.2076R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(1)VagoΔM11 (Deddouche et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3308} NA P{GD16580} NA P{NIG.2076R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG2076e02315 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG2076 - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG2076 - nonA-l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG2076 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58456 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030263 DroID - A comprehensive database of gene and protein interactions. • FBgn0030263 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32041
Orthologs
OrthoDB Orthologs (2) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JT0SP Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6JT0SP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG2076     Drosophila simulans   Dsim\GD17005
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM11453 Drosophila erecta Dere\GG18387 Drosophila yakuba Dyak\GE15904 Drosophila ananassae Dana\GF20290 Drosophila pseudoobscura pseudoobscura Dpse\GA28022 Drosophila persimilis Dper\GL18256 Drosophila willistoni Dwil\GK19984 Drosophila virilis Dvir\GJ15635 Drosophila mojavensis Dmoj\GI16063 Drosophila grimshawi Dgri\GH17920
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18038 w1118 PBac{RB}CG2076e02315
Harvard	- PBac{RB}CG2076e02315
VDRC	v5537 w1118 P{GD3308}v5537 v50221 w1118; P{GD16580}v50221
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH72958
Other clones	DPiM_RH72958
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07390 AT12317 AT19069 AT29129 GH02287 GH11989 GH16454 GM07613 GM17042 GM21985 LP01831 LP08457 LP10974 RE47125 RH40539 RH45437 RH58673 SD25453 SD28017
Other clones	36854 55072 66950 108109 291253 292154 bs12f08 bs19g05 bs85g01 CK01.11B.B1 CK01.13D.H6 CK01.39A.H5 CK01.77D.D6 CK01.77D.E6 CK01.103D.A10 CK01.110B.D12 Dmel_dig_002216_0627_0535 EK051730 EK060651 EK087133 EK147961 EK194857 EK234191 EN06231 EN06543 FGM307G12 GH21149
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030263 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32041
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The CG1287 gene may have been derived from the CG2076 gene by retroposition. (Dai et al., 2006)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132453 RefSeq (Proteins) • NP_572681 DDBJ / EMBL / GenBank • AAF47994 AAQ22414 AI062913 AI389862 AI945419 BE662068 BG633153 BI606468 BT009945 Entrez Gene - A searchable database of RefSeq genes. • 32041 UniProtKB/TrEMBL • Q9VZ34
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bax inhibitor 1-related (IPR006214) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH72958
Linkouts
	BioGRID - A database of protein and genetic interactions • 58456 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030263 DroID - A comprehensive database of gene and protein interactions. • FBgn0030263 DRSC - Results from RNAi screens. • FBgn0030263 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030263 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2076-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030263 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32041 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32041 modMine - Data generated by the modENCODE project. • FBgn0030263
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG2076 (Dai et al., 2006, Vatolina et al., 2011, Nelson et al., 2005, Deddouche et al., 2008, Babenko et al., 2009, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Díaz-Castillo and Ranz, 2012, Mol. Biol. Evol. 29(9): 2105--2108 Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. [FBrf0219274] Vatolina et al., 2011, PLoS ONE 6(10): e25960 Identical Functional Organization of Nonpolytene and Polytene Chromosomes in Drosophila melanogaster. [FBrf0216448] Babenko et al., 2009, Dokl. Biochem. Biophys. 424: 27--30 Characteristics of molecular-genetic organization of intercalary heterochromatin band 10A1-2 in X chromosome of Drosophila melanogaster. [FBrf0207731] Deddouche et al., 2008, Nat. Immunol. 9(12): 1425--1432 The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. [FBrf0206193] Dai et al., 2006, Gene 385: 96--102 Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. [FBrf0194437] Nelson et al., 2005, Cell Death Differ. 12(8): 1115--1123 Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. [FBrf0187248] Zou et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97(25): 13726--13731 Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. [FBrf0131436]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]