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Gene Dmel\Dlic

General Information
Symbol	Dmel\Dlic	Species	D. melanogaster
Name	Dynein light intermediate chain	Annotation symbol	CG1938
Feature type	protein_coding_gene	FlyBase ID	FBgn0030276
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	DLIC2, l(1)G0065
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10A8-10A8	Sequence location	X:11,048,454..11,058,703 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dynein light intermediate chain is referred to in FlyBase by the symbol Dmel\Dlic (CG1938, FBgn0030276). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled; motor activity. There is experimental evidence that it is involved in the biological process: regulation of dendrite morphogenesis; dendrite morphogenesis; mitosis; mitotic spindle organization; oogenesis; microtubule cytoskeleton organization; axonogenesis; axon cargo transport. 15 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Dynein 1 light intermediate chain; Dynein family light intermediate chain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval trachea, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, larval/adult midgut, adult heart, larval/adult fat body, larval/adult salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638127_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Dlic. Gene sequence location is X:11048434..11057245.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10A8-10A8   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10A11-10A12   (determined by in situ hybridisation) 10B1--2 (determined by in situ hybridisation)   (Peter et al., 2002) 10B1-10B2   (determined by in situ hybridisation) 10A10--12 (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 10B1-10B2   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dlic for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dlic-RA FBtr0073441  NM_132466   2241   493 Dlic-RB FBtr0073444  NM_167276   3371   398 Dlic-RD FBtr0073443  NM_167274   3715   493
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dlic-PA   FBpp0073297   54.5   493   5.87     NP_572694   AAF48011 Dlic-PB   FBpp0073300   44.2   398   6.02     NP_727503   AAN09291 Dlic-PD   FBpp0073299   54.5   493   5.87     NP_727501   AAN09289
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dynein 1 light intermediate chain (IPR008467) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Dynein family light intermediate chain (IPR022780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201764   AA695158   AA698043   AA698267   AA817532   AA978447   AE014298 AAF48011   AE014298 AAN09289   AE014298 AAN09291   AI106661   AI107065   AI108552   AI109528   AI110153   AI403246   AJ426855   AJ426856   AW940227   AY058302 AAL13531   BG632395   BG636066   BG638356   BI228285   BI228836   BI229183   BI229233   BI232930   BI236075   BI362023   BI369542   BI371352   BI485392   BI485424   BI615180   BI617894   BI622347   BI640007   BI641037   BQ102745   BQ103107   CK604705   CK604706   CK604770   CK604771   CK659448   CO156352   CO178790   CO179047   CO185816   CO186666   CO188966   CO190488   CO266054   CO273048   CO274883   CO275231   CO275233   CO276578   CO283255   CO283272   CO289804   CO303027   CO307430   CO309158   CO309681   CO310166   CO312581   CO315830   CO317970   CO319304   CO323232   CO327091   CO327955   CO329204   CO332701   CZ490201   CZ490202   EC057191   EC061485   EC061998   EC063191   EC072138   EC072142   EC076561   EC080858   EC089629   EC090180   EC090539   EC195858   EC199002   EC200961   EC202043   EC202554   EC205303   EC206822   EC207299   EC208850   EC209051   EC213812   EC213973   EC215139   EC215229   EC222381   EC233977   EC234955   EC240721   EC240769   EC243783   EC249449   EC250951   EV579023   GH946566   GH946688   GH947384   GH951150   GH955220   GH956202   GH965932   GH969690   GH976896   GH979978   GH981535   GH983297
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IR93 Q9VZ20
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasmic dynein complex inferred from direct assay (Mische et al., 2008) dynein complex inferred from physical interaction with Dhc64C (Satoh et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval trachea, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, larval/adult midgut, adult heart, larval/adult fat body, larval/adult salivary gland, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut  (612.7) Larval Malpighian Tubules  513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea  (631.95) Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain  520.8 Adult Thoracic-Abdominal Ganglion  (618.8) Adult Crop  528.8 Adult Midgut    273.3 Adult Hindgut  521.2 Adult Malpighian Tubules  (697.9) Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca  502.3 Adult InseminatedFemale Spermatheca  510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut  612.7 Larval Malpighian Tubules  513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea  631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain  520.8 Adult Thoracic-Abdominal Ganglion  618.8 Adult Crop  528.8 Adult Midgut    273.3 Adult Hindgut  521.2 Adult Malpighian Tubules  697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca  502.3 Adult InseminatedFemale Spermatheca  510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    366.675 Larval Midgut    437.5 Larval Hindgut    612.7 Larval Malpighian Tubules    513.6 Larval Fat Body    287.2 Larval Salivary Gland    407.6 Larval Trachea    631.95 Larval Carcass    373.975 Adult Head    260.5 Adult Eye    325 Adult Brain    520.8 Adult Thoracic-Abdominal Ganglion    618.8 Adult Crop    528.8 Adult Midgut    273.3 Adult Hindgut    521.2 Adult Malpighian Tubules    697.9 Adult Fat Body    281.1 Adult Salivary Gland    274 Adult Heart    376.825 Adult VirginFemale Spermatheca    502.3 Adult InseminatedFemale Spermatheca    510.3 Adult Ovary    495 Adult Testis    65.1 Adult Male Accessory Gland    175.9 Adult Carcass    277.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    260.5   NA  Eye    325   NA  Brain    520.8   366.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    618.8   NA  Crop    528.8   437.5  Midgut    273.3   612.7  Hindgut    521.2   513.6  Malpighian Tubules    697.9   287.2  Fat Body    281.1   407.6  Salivary Gland    274   NA  Heart    376.825   631.95  Trachea    NA   NA  VirginFemale Spermatheca    502.3   NA  InseminatedFemale Spermatheca    510.3   NA  Ovary    495   NA  Testis    65.1   NA  Male Accessory Gland    175.9   373.975  Carcass    277.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female    131 ovary, mated 4-day female    140 testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (81) central nervous system, pupae P8  (70) head, virgin 1-day female  (65) head, virgin 4-day female  (65) head, virgin 20-day female  (36) head, mated 1-day female  (62) head, mated 4-day female  (58) head, mated 20-day female  (39) head, mated 1-day male  (66) head, mated 4-day male  (85) head, mated 20-day male  (69) salivary gland, larvae L3 wandering  (28) salivary gland, white prepupae  (78) digestive system, larvae L3 wandering  (70) digestive system, 1-day adult  (51) digestive system, 4-day adult  (63) digestive system, 20-day adult  (47) fat body, larvae L3 wandering  (34) fat body, white prepupae  (52) fat body, pupae P8  (43) carcass, larvae L3 wandering  (58) carcass, 1-day adult  (60) carcass, 4-day adult  (63) carcass, 20-day adult  (52) ovary, virgin 4-day female  (131) ovary, mated 4-day female  (140) testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female  (131) ovary, mated 4-day female  (140) testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female    131 ovary, mated 4-day female    140 testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female    131 ovary, mated 4-day female    140 testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (47) central nervous system, larvae L3  (81) central nervous system, pupae P8  (70) head, virgin 1-day female  (65) head, virgin 4-day female  (65) head, virgin 20-day female  (36) head, mated 1-day female  (62) head, mated 4-day female  (58) head, mated 20-day female  (39) head, mated 1-day male  (66) head, mated 4-day male  (85) head, mated 20-day male  (69) salivary gland, larvae L3 wandering  28 salivary gland, white prepupae  (78) digestive system, larvae L3 wandering  (70) digestive system, 1-day adult  (51) digestive system, 4-day adult  (63) digestive system, 20-day adult  (47) fat body, larvae L3 wandering  (34) fat body, white prepupae  (52) fat body, pupae P8  (43) carcass, larvae L3 wandering  (58) carcass, 1-day adult  (60) carcass, 4-day adult  (63) carcass, 20-day adult  (52) ovary, virgin 4-day female  (131) ovary, mated 4-day female  (140) testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female  131 ovary, mated 4-day female  140 testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    47 central nervous system, larvae L3    81 central nervous system, pupae P8    70 head, virgin 1-day female    65 head, virgin 4-day female    65 head, virgin 20-day female    36 head, mated 1-day female    62 head, mated 4-day female    58 head, mated 20-day female    39 head, mated 1-day male    66 head, mated 4-day male    85 head, mated 20-day male    69 salivary gland, larvae L3 wandering    28 salivary gland, white prepupae    78 digestive system, larvae L3 wandering    70 digestive system, 1-day adult    51 digestive system, 4-day adult    63 digestive system, 20-day adult    47 fat body, larvae L3 wandering    34 fat body, white prepupae    52 fat body, pupae P8    43 carcass, larvae L3 wandering    58 carcass, 1-day adult    60 carcass, 4-day adult    63 carcass, 20-day adult    52 ovary, virgin 4-day female    131 ovary, mated 4-day female    140 testis, mated 4-day male    9 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr  (28) embryo 14-16hr    25 embryo 16-18hr  (28) embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr  (28) larva L1    22 larva L2  (28) larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (45) white prepupae new  (48) white prepupae 12hr  (45) white prepupae 24hr  (35) pupae 2d postWPP  (27) pupae 3d postWPP    25 pupae 4d postWPP  (28) adult male 01day  (30) adult male 05day  (28) adult male 30day    25 adult female 01day  (44) adult female 05day  (67) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr  28 embryo 14-16hr    25 embryo 16-18hr  28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr  28 larva L1    22 larva L2  28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (45) white prepupae new  (48) white prepupae 12hr  (45) white prepupae 24hr  (35) pupae 2d postWPP  27 pupae 3d postWPP    25 pupae 4d postWPP  28 adult male 01day  30 adult male 05day  28 adult male 30day    25 adult female 01day  (44) adult female 05day  (67) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    17 embryo 04-06hr    7 embryo 06-08hr    14 embryo 08-10hr    19 embryo 10-12hr    24 embryo 12-14hr    28 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    24 embryo 20-22hr    23 embryo 22-24hr    28 larva L1    22 larva L2    28 larva L3 12hr old    25 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    45 white prepupae new    48 white prepupae 12hr    45 white prepupae 24hr    35 pupae 2d postWPP    27 pupae 3d postWPP    25 pupae 4d postWPP    28 adult male 01day    30 adult male 05day    28 adult male 30day    25 adult female 01day    44 adult female 05day    67 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2    109 embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    138 ovary fGS/OSS    30 ovary OSC    113 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (76) Schneider line 2 Sg4  (48) embryonic 1182-4H  (82) embryonic GM2  (109) embryonic Kc167  (97) embryonic S1  (62) embryonic S3  (66) leg disc CME L1  (50) wing disc CME-W2  (73) wing disc ML-DmD8  (45) wing disc ML-DmD9  (82) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21  (42) wing disc ML-DmD32  (75) haltere disc ML-DmD17-c3  (89) eye-antennal disc ML-DmD11  (62) antennal disc ML-DmD20-c5  (50) mixed discs ML-DmD4-c1  (67) CNS ML-DmBG1-c1  (72) CNS ML-DmBG2-c2  (74) tumorous blood cells mbn2  (138) ovary fGS/OSS  (30) ovary OSC  (113) ovary OSS  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2  (109) embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2  (138) ovary fGS/OSS    30 ovary OSC  (113) ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2    109 embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    138 ovary fGS/OSS    30 ovary OSC    113 ovary OSS    54 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2    109 embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    138 ovary fGS/OSS    30 ovary OSC    113 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (76) Schneider line 2 Sg4  (48) embryonic 1182-4H  (82) embryonic GM2  (109) embryonic Kc167  (97) embryonic S1  (62) embryonic S3  (66) leg disc CME L1  (50) wing disc CME-W2  (73) wing disc ML-DmD8  (45) wing disc ML-DmD9  (82) wing disc ML-DmD16-c3  (80) wing disc ML-DmD21  (42) wing disc ML-DmD32  (75) haltere disc ML-DmD17-c3  (89) eye-antennal disc ML-DmD11  (62) antennal disc ML-DmD20-c5  (50) mixed discs ML-DmD4-c1  (67) CNS ML-DmBG1-c1  (72) CNS ML-DmBG2-c2  (74) tumorous blood cells mbn2  (138) ovary fGS/OSS  30 ovary OSC  (113) ovary OSS  (54) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2  109 embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2  138 ovary fGS/OSS    30 ovary OSC  113 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    76 Schneider line 2 Sg4    48 embryonic 1182-4H    82 embryonic GM2    109 embryonic Kc167    97 embryonic S1    62 embryonic S3    66 leg disc CME L1    50 wing disc CME-W2    73 wing disc ML-DmD8    45 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    80 wing disc ML-DmD21    42 wing disc ML-DmD32    75 haltere disc ML-DmD17-c3    89 eye-antennal disc ML-DmD11    62 antennal disc ML-DmD20-c5    50 mixed discs ML-DmD4-c1    67 CNS ML-DmBG1-c1    72 CNS ML-DmBG2-c2    74 tumorous blood cells mbn2    138 ovary fGS/OSS    30 ovary OSC    113 ovary OSS    54 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult    126 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (42) cold shock, 4-day adult  (32) heat shock, 4-day adult  (52) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3  (48) Cadmium 50 mM 48 hrs, 4-day adult  (56) Cadmium 100 mM 48 hrs, 4-day adult  (126) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3  (27) Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3  (66) Ethanol 5% 3 hrs, larvae L3  (53) Ethanol 10% 3 hrs, larvae L3  (29) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult  (126) Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult    126 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult    126 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (42) cold shock, 4-day adult  32 heat shock, 4-day adult  (52) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3  (48) Cadmium 50 mM 48 hrs, 4-day adult  (56) Cadmium 100 mM 48 hrs, 4-day adult  (126) Copper 0.5 mM 12 hrs, larvae L3  (34) Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3  27 Zinc 4.5 mM 48 hrs, 4-day adult  (126) Ethanol 2.5% 3 hrs, larvae L3  (66) Ethanol 5% 3 hrs, larvae L3  (53) Ethanol 10% 3 hrs, larvae L3  29 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (43) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (113) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult  126 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult  (178) Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult  126 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  113 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    42 cold shock, 4-day adult    32 heat shock, 4-day adult    52 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    48 Cadmium 50 mM 48 hrs, 4-day adult    56 Cadmium 100 mM 48 hrs, 4-day adult    126 Copper 0.5 mM 12 hrs, larvae L3    34 Copper 15 mM 48 hrs, 4-day adult    178 Zinc 5 mM 12 hrs, larvae L3    27 Zinc 4.5 mM 48 hrs, 4-day adult    126 Ethanol 2.5% 3 hrs, larvae L3    66 Ethanol 5% 3 hrs, larvae L3    53 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    43 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    113 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH06357 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030276 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1938-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Dlic Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage DlicG0065 DlicG0190 lethal | larval stage | recessive DlicG0065 DlicG0190 lethal | pupal stage, with Scer\GAL4pnr-MD237 DlicGD9681 lethal | recessive DlicG0065 DlicG0190 DlicPG1 lethal | recessive | second instar larval stage Dlic1 Dlic1157 viable Dlicf07409 Sterility Allele fertile Dlicf07409 Other Phenotypes Allele neuroanatomy defective | recessive | somatic clone | third instar larval stage Dlic1 neuroanatomy defective | somatic clone Dlic1157 Phenotype manifest in Allele axon & abdominal dorsal multidendritic neuron ddaC | somatic clone Dlic1157 class IV dendritic arborizing neuron | somatic clone | third instar larval stage Dlic1 dendrite & abdominal dorsal multidendritic neuron ddaC | somatic clone Dlic1157 egg chamber | germline clone Dlicunspecified Golgi apparatus & abdominal dorsal multidendritic neuron ddaC | somatic clone Dlic1157 nurse cell ring canal | germline clone Dlicunspecified oocyte | germline clone Dlicunspecified terminal tracheal cell | somatic clone Dlic1
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Dlic Class Mutagen Stocks Known lesion Dlicf07409 piggyBac transposase 2 -- DlicG0065 P-element activity 2 Yes DlicG0190 P-element activity 2 Yes Dlic1157 ethyl methanesulfonate 0 -- Dlic1 0 -- Dlic2 0 -- DlicPG1 Delta2-3 0 -- Dlicunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dlic Class Mutagen Stocks Known lesion DlicGD9681 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes DlicKK107892 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dlic+tMa in vitro construct - genomic fragment 0 Yes DlicNIG.1938R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes DlicScer\UAS.cSa.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DlicScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes DlicT:Avic\GFP 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;3)DC235 (Popodi et al., 2010-, Venken et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK107892} NA P{NIG.1938R} NA P{UAS-Dlic.EGFP} NA P{UAS-Dlic.GFP.S} NA characterization construct P{Dlic+tMa} NA P{GFP-Dlic} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Dlicf07409 NA insertion of enhancer trap P{lacW}DlicG0065 No P{lacW}DlicG0190 No insertion of enhancer trap binary system P{GawB}DlicPG1 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon cargo transport inferred from mutant phenotype (Zheng et al., 2008) axonogenesis inferred from mutant phenotype (Satoh et al., 2008) dendrite morphogenesis inferred from direct assay (Satoh et al., 2007) inferred from mutant phenotype (Satoh et al., 2007, Satoh et al., 2008) microtubule cytoskeleton organization inferred from mutant phenotype (Zheng et al., 2008) mitosis inferred from mutant phenotype (Ducat et al., 2008) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) oogenesis inferred from mutant phenotype (Mische et al., 2008) regulation of dendrite morphogenesis inferred from mutant phenotype (Zheng et al., 2008)
Cellular Component
CV term Evidence References
cytoplasmic dynein complex inferred from direct assay (Mische et al., 2008) dynein complex inferred from physical interaction with Dhc64C (Satoh et al., 2008)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) motor activity inferred from sequence or structural similarity with UniProtKB:Q90828 (FlyBase, 1992-)
Biological Process
CV term Evidence References
microtubule-based movement inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
cytoplasmic dynein complex inferred from sequence or structural similarity with UniProtKB:Q90828 (FlyBase, 1992-) dynein complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) microtubule associated complex inferred from sequence or structural similarity with UniProtKB:Q90828 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dlic - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - CG10887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - CG8771 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - Dhc64C cosedimentation, western blot, anti bait coimmunoprecipitation (Mische et al., 2008) Dlic - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - Nup358 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - sick anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dlic - sw cosedimentation, western blot, anti bait coimmunoprecipitation (Mische et al., 2008)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dlic allele Gene References unspecified bchs (Simonsen et al., 2007)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030276 DroID - A comprehensive database of gene and protein interactions. • FBgn0030276 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32057
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63XVP7 Dipteran inclusive ortholog search EOG6SQX53 Insect inclusive ortholog search EOG6S4NBD Arthropod inclusive ortholog search EOG6H9W1R Metazoa inclusive ortholog search EOG67169G
Orthologs in Drosophila Species (EOG63XVP7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dlic     Drosophila sechellia   Dsec\GM11463 Y   Drosophila erecta   Dere\GG18397 Y   Drosophila yakuba   Dyak\GE15915 Y   Drosophila ananassae   Dana\GF22587 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15140 Y   Drosophila persimilis   Dper\GL20252 Y   Drosophila willistoni   Dwil\GK16106 Y   Drosophila virilis   Dvir\GJ19525 Y   Drosophila mojavensis   Dmoj\GI14862 Y   Drosophila grimshawi   Dgri\GH12509 Y
Orthologs in non-Drosophila Dipterans (EOG6SQX53)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011019   Anopheles gambiae Malaria mosquito  Agam\AGAP000723   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009946
Orthologs in non-Dipteran Insects (EOG6S4NBD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47599   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003752   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17907   Atta cephalotes Leafcutter ant  Acep\ACEP12779   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12533   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14339   Linepithema humile Argentine ant  Lhum\LH23755   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21837   Solenopsis invicta Red fire ant  Sinv\SINV10864   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007007   Bombyx mori Silkmoth  Bmor\BGIBMGA006121   Bombyx mori Silkmoth  Bmor\BGIBMGA006122   Pediculus humanus Human body louse  Phum\PHUM250150   Tribolium castaneum Red flour beetle  Tcas\TC013201
Orthologs in non-Insect Arthropods (EOG6H9W1R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_192640   Ixodes scapularis Deer tick  Isca\ISCW016470
Orthologs in non-Arthropod Metazoa (EOG67169G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\dli-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013768gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015909gn   Danio rerio Zebrafish  Drer\dync1li1   Danio rerio Zebrafish  Drer\dync1li2   Xenopus tropicalis Western clawed frog  Xtro\dync1li2   Xenopus tropicalis Western clawed frog  Xtro\dync1li1   Gallus gallus Domestic chicken  Ggal\DYNC1LI1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000014354   Gallus gallus Domestic chicken  Ggal\DYNC1LI2   Gallus gallus Domestic chicken  Ggal\ENSGALG00000022206   Mus musculus House mouse  Mmus\ENSMUSG00000032435   Mus musculus House mouse  Mmus\Dync1li2   Rattus norvegicus Norway rat  Rnor\Dync1li2   Rattus norvegicus Norway rat  Rnor\Dync1li1   Homo sapiens Human  Hsap\DYNC1LI2   Homo sapiens Human  Hsap\DYNC1LI1
Human Orthologs (2)
Gene OMIM HGNC Hsap\DYNC1LI2     Hsap\DYNC1LI1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM11463 Drosophila erecta Dere\GG18397 Drosophila yakuba Dyak\GE15915 Drosophila ananassae Dana\GF22587 Drosophila pseudoobscura pseudoobscura Dpse\GA15140 Drosophila persimilis Dper\GL20252 Drosophila willistoni Dwil\GK16106 Drosophila virilis Dvir\GJ19525 Drosophila mojavensis Dmoj\GI14862 Drosophila grimshawi Dgri\GH12509
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	19075 w1118 PBac{WH}Dlicf07409 11696 w67c23 P{lacW}DlicG0065/FM7c 11951 w67c23 P{lacW}DlicG0190/FM7c
Harvard	- PBac{WH}Dlicf07409
Kyoto	111861 w67c23 P{lacW}DlicG0190 P{neoFRT}19A/FM7c; P{ey-FLP.N}5 111778 y1 w* P{lacW}DlicG0065 P{neoFRT}19A/FM7c; P{ey-FLP.N}5
VDRC	v101340 P{KK107892}VIE-260B v41686 w1118; P{GD9681}v41686
Genomic Clones ( 1 )
	BACR26J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06357
Other clones	DPiM_GH06357
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06732 GH08750 GH09639 GH22647 GM02331 HL03672 HL04075 LD04970 LD30603 LP17219 RE25785 RE26483 RE26913 RE26971 RE29080 RE32071 RE46474 RE55754 RE58226 RE68710 RE68744 RH44741 RH48360 RH54194 SD13655 SD22757 SD24109
Other clones	600 9687 14363 14429 34497 34687 43356 43392 43559 61771 64329 67860 97911 104628 105521 106102 106687 149216 157214 159685 165430 190242 272736 273769 277129 CK01.10C.D8 CK01.22B.E8 CK01.24C.E2 CK01.52C.G4 CK01.59D.E6 CK01.72D.D10 CK01.74A.G4 CK01.142C.B4 Dmel_dig_011601_0661_2650 EK012648 EK022049 EK042558 EK048351 EK057547 EK058258 EK072107 EK109349 EK115838 EK116828 EK116832 EK121455 EK144817 EK162718 EK162741 EK185411 EK190014 EK218907 EK220632 EK229341 EK254551 EK260459 EK262638 EK269924 EK277606 EK292244 EK304248 EN07909 EP05736 EP08325 GH07739 LD23320 RP004083414 RP004100969 RP004162389 RP004209639 RP004211146 RP004217891 RP004218536 RP004230916 RP004245623 RP004307594 RP004437944 RP004486017 UT01390 UT01437 UUGC0129 UUGC0505
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030276 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32057
Antibody Information
	monoclonal (Mische et al., 2008)
Other Information
Discoverer
Etymology
	The name "dandelion clock" refers to the "bushy" dendritic arbor phenotype of homozygous "Dlic[1]" mutant neurons. (Satoh et al., 2008)
Identification
	In a genetic screen to identify genes that affect dendritic morphology. (Satoh et al., 2007)
Relationship to Other Genes
Source for database identity of	Source for identity of: Dlic2 CG1938 (Goldstein and Gunawardena, 2000)
Source for database merge of	Source for merge of: Dlic2 l(1)G0065 l(1)G0190 (Peter et al., 2002)
Additional comments
Other Comments
	Dlic is required for polarised dendritic transport and uniform microtubule orientation in axons. (Zheng et al., 2008) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes spindle pole detachment when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Mutants in dlic form smaller dendritic receptor fields. Terminals of major branches keep extending without further branching and some of pre-existing side branches retract; in contrast, the proximal region becomes bushy over time. (Satoh et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132466 NM_167274 NM_167276 RefSeq (Proteins) • NP_572694 NP_727501 NP_727503 DDBJ / EMBL / GenBank • AAF48011 AAL13531 AAN09288 AAN09289 AAN09291 AI107065 AJ426855 AJ426856 AW940227 AY058302 CZ490201 CZ490202 Entrez Gene - A searchable database of RefSeq genes. • 32057 UniProtKB/TrEMBL • Q8IR93 Q9VZ20
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dynein 1 light intermediate chain (IPR008467) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Dynein family light intermediate chain (IPR022780) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH06357
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030276 DroID - A comprehensive database of gene and protein interactions. • FBgn0030276 DRSC - Results from RNAi screens. • FBgn0030276 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030276 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1938-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030276 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32057 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32057 modMine - Data generated by the modENCODE project. • FBgn0030276
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG1938 (Bourbon et al., 2002, Goldstein and Gunawardena, 2000, Legube et al., 2006, Goshima et al., 2007, Satoh et al., 2008, Mische et al., 2008, Ducat et al., 2008, Keleman et al., 2009.8.5) dlic (Satoh et al., 2007, Schottenfeld-Roames and Ghabrial, 2012, Satoh et al., 2008, Lloyd et al., 2012) DLIC (Pandey et al., 2007) D-LIC (Pandey et al., 2007) Dlic (Mische et al., 2008, Popodi et al., 2010-, Liu et al., 2011, Venken et al., 2010, Amrute-Nayak and Bullock, 2012, Zhao et al., 2012) DLIC2 (Goldstein and Gunawardena, 2000, Emre et al., 2011) dlic2 (Simonsen et al., 2007, Zheng et al., 2008, Satoh et al., 2008) Dlic2 (Goshima et al., 2007, Moussian et al., 2005, Japanese National Institute of Genetics, 2012.5.21) l(1)G0065 (Schaefer et al., 1999.8.12, Schaefer et al., 1999.6.15, ) l(1)G0190 (Schaefer et al., 1999.8.12, )
Name Synonym	dandelion clock (Satoh et al., 2007, Satoh et al., 2008) Dlic2   DyneinLC (Simonsen et al., 2007) Dynein light intermediate chain (Schottenfeld-Roames and Ghabrial, 2012, Ducat et al., 2008, ) dynein light intermediate chain (Pandey et al., 2007, Liu et al., 2011) dynein light interme- diate chain (Zhao et al., 2012) dynein light intermediate chain 2 (Zheng et al., 2008)
Secondary FlyBase IDs
	FBgn0027319 FBgn0028346
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Amrute-Nayak and Bullock, 2012, Nat. Cell Biol. 14(4): 416--423 Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. [FBrf0217933] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Lloyd et al., 2012, Neuron 74(2): 344--360 The p150(Glued) CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. [FBrf0218160] Schottenfeld-Roames and Ghabrial, 2012, Nat. Cell Biol. 14(4): 386--393 Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth. [FBrf0217936] Zhao et al., 2012, Science 336(6084): 999--1003 Growing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axis. [FBrf0218447] Ambegaokar and Jackson, 2011, Hum. Mol. Genet. 20(24): 4947--4977 Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. [FBrf0217690] Emre et al., 2011, J. Cell Sci. 124(10): 1664--1671 A mitotic role for Mad1 beyond the spindle checkpoint. [FBrf0213557] Liu et al., 2011, J. Neurosci. 31(6): 2052--2063 Drosophila Acyl-CoA Synthetase Long-Chain Family Member 4 Regulates Axonal Transport of Synaptic Vesicles and Is Required for Synaptic Development and Transmission. [FBrf0212968] Otani et al., 2011, Dev. Cell 20(2): 219--232 IKKɛ Regulates Cell Elongation through Recycling Endosome Shuttling. [FBrf0212985] Show all research papers ...