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Gene Dmel\CG1657

General Information
Symbol	Dmel\CG1657	Species	D. melanogaster
Name		Annotation symbol	CG1657
Feature type	protein_coding_gene	FlyBase ID	FBgn0030286
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10B3-10B3	Sequence location	X:11,219,418..11,228,104 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG1657 (FBgn0030286). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Rab guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of small GTPase mediated signal transduction. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Pre-mRNA-splicing factor 38, C-terminal; Ras GTPase-activating protein; Rho GTPase activation protein; Vacuolar sorting protein 9; Vacuolar sorting protein 9, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, adult Malpighian tubules, adult heart, adult salivary gland, adult ovary, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626575_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG1657. Gene sequence location is X:11219418..11228107.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10B3-10B3   Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG1657 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.42 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG1657-RA FBtr0073448  NM_132476   5830   1712
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG1657-PA   FBpp0073304   191.2   1712   5.53     NP_572704   AAF48024
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ras GTPase-activating protein (IPR001936) Vacuolar sorting protein 9 (IPR003123) Rho GTPase activation protein (IPR008936) Vacuolar sorting protein 9, subgroup (IPR013995) Pre-mRNA-splicing factor 38, C-terminal (IPR024767)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA951098   AA951321   AE014298 AAF48024   AI106929   AI403562   AI404734   AW943082   AY061391 AAL28939   BF492073   BG633333   BG638650   BG641168   BI355851   BI565804   BI590040   CO269979   CO275324   CO291933   CO300243   CO308467   CO310347   CO311396   CO314966   CO322497   CO326537   CO328549   CO330641   CO331848   CO339789   CZ480267   CZ480268   EC063695   EC065512   EC072133   EC087713   EC089103   EC090466   EC220075   EC223519   EC234636   EC235509   EC251034   EC251550   EC256649   EV597409
UniProtKB/Swiss-Prot	Q9VZ08
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult hindgut, adult Malpighian tubules, adult heart, adult salivary gland, adult ovary, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    97.675 Larval Midgut    82.5 Larval Hindgut    67.6 Larval Malpighian Tubules    91.7 Larval Fat Body    25.5 Larval Salivary Gland    20.9 Larval Trachea    60.45 Larval Carcass    28.9 Adult Head    144.6 Adult Eye    243.1 Adult Brain    354.9 Adult Thoracic-Abdominal Ganglion    262.6 Adult Crop    58.7 Adult Midgut    64.1 Adult Hindgut    121.4 Adult Malpighian Tubules    157.9 Adult Fat Body    81.5 Adult Salivary Gland    179.8 Adult Heart    131.375 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    61.5 Adult Ovary    173.2 Adult Testis    28 Adult Male Accessory Gland    192.5 Adult Carcass    145.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    144.6   NA  Eye    243.1   NA  Brain    354.9   97.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    262.6   NA  Crop    58.7   82.5  Midgut    64.1   67.6  Hindgut    121.4   91.7  Malpighian Tubules    157.9   25.5  Fat Body    81.5   20.9  Salivary Gland    179.8   NA  Heart    131.375   60.45  Trachea    NA   NA  VirginFemale Spermatheca    54.3   NA  InseminatedFemale Spermatheca    61.5   NA  Ovary    173.2   NA  Testis    28   NA  Male Accessory Gland    192.5   28.9  Carcass    145.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (27) ovary, mated 4-day female  (28) testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  27 ovary, mated 4-day female  28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    12 central nervous system, pupae P8    13 head, virgin 1-day female    11 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    13 head, mated 4-day female    14 head, mated 20-day female    10 head, mated 1-day male    17 head, mated 4-day male    20 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    7 digestive system, 4-day adult    9 digestive system, 20-day adult    9 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    7 carcass, 1-day adult    10 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    27 ovary, mated 4-day female    28 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day  (31) adult female 05day  (34) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day  31 adult female 05day  (34) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    18 embryo 04-06hr    8 embryo 06-08hr    11 embryo 08-10hr    11 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    14 embryo 16-18hr    18 embryo 18-20hr    24 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    12 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    10 white prepupae 12hr    16 white prepupae 24hr    15 pupae 2d postWPP    13 pupae 3d postWPP    17 pupae 4d postWPP    18 adult male 01day    17 adult male 05day    19 adult male 30day    19 adult female 01day    31 adult female 05day    34 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2    102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2  (102) embryonic Kc167  (27) embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2  (27) ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2  102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2    102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2    102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2  (102) embryonic Kc167  27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2  27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2  102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    16 embryonic 1182-4H    6 embryonic GM2    102 embryonic Kc167    27 embryonic S1    23 embryonic S3    9 leg disc CME L1    13 wing disc CME-W2    8 wing disc ML-DmD8    11 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    14 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    20 tumorous blood cells mbn2    27 ovary fGS/OSS    19 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_26 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1657-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 CG1657GD9179 viable CG1657e02476 Sterility Allele fertile CG1657e02476 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG1657 Class Mutagen Stocks Known lesion CG1657e02476 piggyBac transposase 2 -- CG1657f03945 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG1657 Class Mutagen Stocks Known lesion CG1657GD9179 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1657HMJ02054 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1657KK105758 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1657NIG.1657R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG1657t12 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9179} NA P{KK105758} NA P{NIG.1657R} NA P{TRiP.HMJ02054} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG1657e02476 NA PBac{WH}CG1657f03945 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from electronic annotation with InterPro:IPR001936 (FlyBase Curators et al., 2004-) Rab guanyl-nucleotide exchange factor activity inferred from sequence or structural similarity with EMBL:AJ001119 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001936 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR001936, InterPro:IPR008936 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG1657 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030286 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32070
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TXCB6 Dipteran inclusive ortholog search EOG605S81 Insect inclusive ortholog search EOG6BVQPK Arthropod inclusive ortholog search EOG63FFBT Metazoa inclusive ortholog search EOG6X6R26
Orthologs in Drosophila Species (EOG6TXCB6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG1657     Drosophila simulans   Dsim\GD17010 Y   Drosophila sechellia   Dsec\GM11467 Y   Drosophila erecta   Dere\GG18402 Y   Drosophila yakuba   Dyak\GE15921 Y   Drosophila ananassae   Dana\GF22592 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14078 Y   Drosophila persimilis   Dper\GL17843     Drosophila persimilis   Dper\GL19858 Y   Drosophila willistoni   Dwil\GK16114 Y   Drosophila virilis   Dvir\GJ19527 Y   Drosophila mojavensis   Dmoj\GI14866 Y   Drosophila grimshawi   Dgri\GH12512 Y
Orthologs in non-Drosophila Dipterans (EOG605S81)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018479
Orthologs in non-Dipteran Insects (EOG6BVQPK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC411806   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007798   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15095   Atta cephalotes Leafcutter ant  Acep\ACEP27094   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16168   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13622   Linepithema humile Argentine ant  Lhum\LH23281   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20193   Solenopsis invicta Red fire ant  Sinv\SINV23495   Acyrthosiphon pisum Pea aphid  Apim\ACYPI060585   Bombyx mori Silkmoth  Bmor\BGIBMGA007938   Bombyx mori Silkmoth  Bmor\BGIBMGA007937   Pediculus humanus Human body louse  Phum\PHUM195360   Tribolium castaneum Red flour beetle  Tcas\TC001026
Orthologs in non-Insect Arthropods (EOG63FFBT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Rapgef6   Ixodes scapularis Deer tick  Isca\ISCW023431   Ixodes scapularis Deer tick  Isca\ISCW023430
Orthologs in non-Arthropod Metazoa (EOG6X6R26)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rme-6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027805gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017037gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004788gn   Danio rerio Zebrafish  Drer\ENSDARG00000089695   Danio rerio Zebrafish  Drer\zgc:92666   Xenopus tropicalis Western clawed frog  Xtro\gapvd1   Gallus gallus Domestic chicken  Ggal\GAPVD1   Mus musculus House mouse  Mmus\Gapvd1   Rattus norvegicus Norway rat  Rnor\Gapvd1   Homo sapiens Human  Hsap\GAPVD1
Human Orthologs (1)
Gene OMIM HGNC Hsap\GAPVD1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17010 Drosophila sechellia Dsec\GM11467 Drosophila erecta Dere\GG18402 Drosophila yakuba Dyak\GE15921 Drosophila ananassae Dana\GF22592 Drosophila pseudoobscura pseudoobscura Dpse\GA14078 Drosophila persimilis Dper\GL19858 Drosophila willistoni Dwil\GK16114 Drosophila virilis Dvir\GJ19527 Drosophila mojavensis Dmoj\GI14866 Drosophila grimshawi Dgri\GH12512
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18058 w1118 PBac{RB}CG1657e02476 42490 y1 v1; P{TRiP.HMJ02054}attP40
Harvard	- PBac{RB}CG1657e02476 - PBac{WH}CG1657f03945
VDRC	v108453 P{KK105758}VIE-260B v19649 w1118; P{GD9179}v19649
Genomic Clones ( 1 )
	BACR28L07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 38 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD31383
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT28947 GH06192 GH23029 GM32590 RH03591 RH63629 SD12442
Other clones	14293 57353 62570 71062 72681 102106 118874 154502 211110 214409.6 274097 CK01.126C.B4 Dmel_neb_011453_0900_1525 EC256649 EK097038 EK117127 EK177718 EK188244 EK198824 EK221302 EK224349 EK238622 EK258329 EK290847 EK295809 EK301837 EP04063 EP09418 GH24549 LD31729
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32070
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132476 RefSeq (Proteins) • NP_572704 DDBJ / EMBL / GenBank • AA951098 AAF48024 AAL28939 AW943082 AY061391 CZ480267 CZ480268 Entrez Gene - A searchable database of RefSeq genes. • 32070 UniProtKB/Swiss-Prot • Q9VZ08
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ras GTPase-activating protein (IPR001936) Vacuolar sorting protein 9 (IPR003123) Rho GTPase activation protein (IPR008936) Vacuolar sorting protein 9, subgroup (IPR013995) Pre-mRNA-splicing factor 38, C-terminal (IPR024767)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030286 DRSC - Results from RNAi screens. • FBgn0030286 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030286 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1657-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030286 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32070 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32070 modMine - Data generated by the modENCODE project. • FBgn0030286
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG1657 (Keleman et al., 2009.8.5, Wasbrough et al., 2010, Ni et al., 2010.12.1, Carney et al., 2006, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Sarpal et al., 2003, Curr. Biol. 13(19): 1687--1696 Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. [FBrf0167402]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Carney et al., 2006, Trends Cell Biol. 16(1): 27--35 Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. [FBrf0220595]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
DNA/RNA sequence record	Thornton, 2005.12.20, GenBank/EMBL/DDBJ: DQ334112 Drosophila miranda CG1657 gene, partial cds. [FBrf0197720]