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Gene Dmel\CG1749

General Information
Symbol	Dmel\CG1749	Species	D. melanogaster
Name		Annotation symbol	CG1749
Feature type	protein_coding_gene	FlyBase ID	FBgn0030305
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10B15-10B15	Sequence location	X:11,377,540..11,379,097 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG1749 (FBgn0030305). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Mo-molybdopterin cofactor sulfurase activity. Based on sequence similarity, it is predicted to be involved in the biological process: Mo-molybdopterin cofactor biosynthetic process. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633923_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG1749. Gene sequence location is X:11377540..11379097.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN21313 HFA19775
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10B15-10B15   Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG1749 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG1749-RA FBtr0073505  NM_132494   1447   404
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG1749-PA   FBpp0073354   44.2   404   4.36     NP_572722   AAF48050
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • UBA/THIF-type NAD/FAD binding fold (IPR000594) D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (IPR006140) Molybdenum cofactor biosynthesis, MoeB (IPR009036) NAD(P)-binding domain (IPR016040)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48050   AI061926   AI061932   AI061952   AI063758   AI109093   AI257662   AI259549   AI260480   AI295518   AI296477   AI512872   AY071429 AAL49051   BI164561   BI234794   BI356100   BI357507   BI366373   BI373647   BI375586   BI577377   BI578819   BI579033   CO279502   CO344324   EC085479   EC194373   EC195141   EC209593   EC218267   EC222114   EC237511   EC241855   EC253887   EL872598   EL872599   EL872720   EL872721   EV578451   EV582283   EV582479
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYY3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030305    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030305 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030305 expression level Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4920) embryo 02-04hr  (288) embryo 04-06hr  (222) embryo 06-08hr  (989) embryo 08-10hr  (1870) embryo 10-12hr  (4403) embryo 12-14hr  (2990) embryo 14-16hr  (3538) embryo 16-18hr  (2131) embryo 18-20hr  (1136) embryo 20-22hr  (1136) embryo 22-24hr  (855) larva L1  (2233) larva L2  (5008) larva L3 12hr old  (3546) larva L3 puffstage 1-2  (2560) larva L3 puffstage 3-6  (2447) larva L3 puffstage 7-9  (2511) white prepupae new  (2654) white prepupae 12hr  (1439) white prepupae 24hr  (1885) pupae 2d postWPP  (2375) pupae 3d postWPP  (1015) pupae 4d postWPP  (704) adult male 01day  (1134) adult male 05day  (1306) adult male 30day  (1310) adult female 01day  (2135) adult female 05day  (3746) adult female 30day  (4043) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4920) embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr  (1870) embryo 10-12hr  (4403) embryo 12-14hr  (2990) embryo 14-16hr  (3538) embryo 16-18hr  (2131) embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1  (2233) larva L2  (5008) larva L3 12hr old  (3546) larva L3 puffstage 1-2  (2560) larva L3 puffstage 3-6  (2447) larva L3 puffstage 7-9  (2511) white prepupae new  (2654) white prepupae 12hr  1439 white prepupae 24hr  (1885) pupae 2d postWPP  (2375) pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day  (2135) adult female 05day  (3746) adult female 30day  (4043) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030305 expression level Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4920) embryo 02-04hr  (288) embryo 04-06hr  (222) embryo 06-08hr  (989) embryo 08-10hr  (1870) embryo 10-12hr  (4403) embryo 12-14hr  (2990) embryo 14-16hr  (3538) embryo 16-18hr  (2131) embryo 18-20hr  (1136) embryo 20-22hr  (1136) embryo 22-24hr  (855) larva L1  (2233) larva L2  (5008) larva L3 12hr old  (3546) larva L3 puffstage 1-2  (2560) larva L3 puffstage 3-6  (2447) larva L3 puffstage 7-9  (2511) white prepupae new  (2654) white prepupae 12hr  (1439) white prepupae 24hr  (1885) pupae 2d postWPP  (2375) pupae 3d postWPP  (1015) pupae 4d postWPP  (704) adult male 01day  (1134) adult male 05day  (1306) adult male 30day  (1310) adult female 01day  (2135) adult female 05day  (3746) adult female 30day  (4043) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4920) embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr  1870 embryo 10-12hr  (4403) embryo 12-14hr  (2990) embryo 14-16hr  (3538) embryo 16-18hr  2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1  2233 larva L2  (5008) larva L3 12hr old  (3546) larva L3 puffstage 1-2  (2560) larva L3 puffstage 3-6  2447 larva L3 puffstage 7-9  (2511) white prepupae new  (2654) white prepupae 12hr  1439 white prepupae 24hr  1885 pupae 2d postWPP  2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day  2135 adult female 05day  (3746) adult female 30day  (4043) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4920 embryo 02-04hr    288 embryo 04-06hr    222 embryo 06-08hr    989 embryo 08-10hr    1870 embryo 10-12hr    4403 embryo 12-14hr    2990 embryo 14-16hr    3538 embryo 16-18hr    2131 embryo 18-20hr    1136 embryo 20-22hr    1136 embryo 22-24hr    855 larva L1    2233 larva L2    5008 larva L3 12hr old    3546 larva L3 puffstage 1-2    2560 larva L3 puffstage 3-6    2447 larva L3 puffstage 7-9    2511 white prepupae new    2654 white prepupae 12hr    1439 white prepupae 24hr    1885 pupae 2d postWPP    2375 pupae 3d postWPP    1015 pupae 4d postWPP    704 adult male 01day    1134 adult male 05day    1306 adult male 30day    1310 adult female 01day    2135 adult female 05day    3746 adult female 30day    4043 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030305    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030305 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030305 expression level Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland    1208.6 Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland  (1208.6) Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland  (669.3) Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland  (684.8) Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland  (1208.6) Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland    1208.6 Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030305 expression level Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland    1208.6 Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland  (1208.6) Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland  669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland  684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland  1208.6 Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    238.55 Larval Midgut    174.3 Larval Hindgut    223.4 Larval Malpighian Tubules    177.1 Larval Fat Body    328.1 Larval Salivary Gland    1208.6 Larval Trachea    362.125 Larval Carcass    297.25 Adult Head    106.9 Adult Eye    77.175 Adult Brain    75.4 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    114 Adult Midgut    152.1 Adult Hindgut    85.8 Adult Malpighian Tubules    136.1 Adult Fat Body    158.6 Adult Salivary Gland    669.3 Adult Heart    105.175 Adult VirginFemale Spermatheca    298.8 Adult InseminatedFemale Spermatheca    446.2 Adult Ovary    316.4 Adult Testis    66 Adult Male Accessory Gland    684.8 Adult Carcass    110.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    106.9   NA  Eye    77.175   NA  Brain    75.4   238.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    74.6   NA  Crop    114   174.3  Midgut    152.1   223.4  Hindgut    85.8   177.1  Malpighian Tubules    136.1   328.1  Fat Body    158.6   1208.6  Salivary Gland    669.3   NA  Heart    105.175   362.125  Trachea    NA   NA  VirginFemale Spermatheca    298.8   NA  InseminatedFemale Spermatheca    446.2   NA  Ovary    316.4   NA  Testis    66   NA  Male Accessory Gland    684.8   297.25  Carcass    110.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030305 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1749-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG1749 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG1749GD9391 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 CG1749GD9391 visible, with Scer\GAL4pnr-MD237 CG1749GD9391 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG1749GD9391 trichogen cell, with Scer\GAL4pnr-MD237 CG1749GD9391
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG1749 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG1749 Class Mutagen Stocks Known lesion CG1749GD9391 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1749HMS01352 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1749KK101262 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9391} NA P{KK101262} NA P{TRiP.HMS01352} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
cofactor binding inferred from electronic annotation with InterPro:IPR006140 (FlyBase Curators et al., 2004-) Mo-molybdopterin cofactor sulfurase activity inferred from sequence or structural similarity with EMBL:AF102544 (FlyBase, 1992-) nucleotide binding inferred from electronic annotation with InterPro:IPR016040 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor inferred from electronic annotation with InterPro:IPR006140 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
Mo-molybdopterin cofactor biosynthetic process inferred from sequence or structural similarity with EMBL:AF102544 (FlyBase, 1992-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR006140 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG1749 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58505 DroID - A comprehensive database of gene and protein interactions. • FBgn0030305 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32094
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23479 Dere\GG18422 Dgri\GH12371 Dmoj\GI14749 Dper\GL19893 Dpse\GA14526 Dsec\GM13085 Dsim\GD17028 Dvir\GJ19153 Dwil\GK10218 Dyak\GE15940
Curated drosophilid orthologs	Dpse\GA14526
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004076-PA Aedes aegypti (mosquito) AGAP009012-PA Anopheles gambiae (mosquito) XP_393259.2 Apis mellifera (honey bee) XP_001952581.1 Acyrthosiphon pisum (pea aphid) At1g05350.1 Arabidopsis thaliana (wall cress) 113714 Branchiostoma floridae (lancelet) 289800 Branchiostoma floridae (lancelet) XP_001898682.1 Brugia malayi (roundworm nematode) BGIBMGA013537-PA Bombyx mori (silk worm) ENSBTAP00000005894 Bos taurus (bovine) CN09424 Caenorhabditis brenneri (small nematode) CN20561 Caenorhabditis brenneri (small nematode) CBP25964 Caenorhabditis briggsae (nematode) CE13096 Caenorhabditis elegans (worm) ENSCAFP00000009594 Canis familiaris (dog) Chro.40221 Cryptosporidium hominis (obligate parasite) ENSCINP00000008729 Ciona intestinalis (sea squirt) JA12767 Caenorhabditis japonica (nematode) cgd4_1960 Cryptosporidium parvum (protozoan parasite) CPIJ009416 Culex pipens (mosquito) ENSCPOP00000008909 Cavia porcellus (guinea pig) 113805 Chlamidomonas reinhardtii (green alga) RP14100 Caenorhabditis remanei (nematode) 152521 Capitella spl (polychaete worm) DDB0232142 Dictyostelium discoideum (amoeba) 222838 Daphnia pulex (daphnia) ENSDARP00000087478 Danio rerio (zebra fish) ENSECAP00000018858 Equus caballus (horse) ENSGACP00000005010 Gymnopilus aculeatus (mushroom) ENSGALP00000019110 Gallus gallus (chicken) GL50803_11436 Giardia lamblia (flagellated protozoan) 108304 Hypsipyla robusta (cedar shoot borer) ENSP00000348565 Homo sapiens (human) ISCW020154-PA Ixodes scapularis (deer tick) 236214 Lottia gigantea (owl limpet) LmjF15.0970 Leishmania major (virus) 14568 Monocosta brevicollis (choanoflagellate) ENSMODP00000014606 Monodelphis domestica (gray opossum) ENSMMUP00000028668 Macaca mulatta (rhesus monkey) ENSMUSP00000035166 Mus musculus (house mouse) 189522 Nematostella vectensis (starlet anemone) XP_001607066.1 Nasonia vitripennis (wasp) ENSOANP00000010819 Ornithorynchus anatinus (platypus) ENSORLP00000012899 Oryzias latipes (japanese killifish) LOC_Os02g30310.1 Oryza sativa (asian rice) PHUM000218-PA Pediculus humanus (human body louse) PP07255 Pristionchus pacificus (nematode) 111718 Physcomitrella patens (moss) ENSPPYP00000015785 Pongo pygmaeus (orangutan) 71148 Phytophthora ramorum (sudden oak death pathogen) 108205 Phytophthora sojae (root rot pathogen) 733616 Populus trichocarpa (black cottonwood) ENSPTRP00000040235 Pan troglodytes (chimpanzee) ENSRNOP00000015240 Rattus norvegicus (norway rat) 144403 Sorghum bicolor (sorghum) Smp_045780 Schistosoma mansoni (trematode parasite) XP_789316.1 Strongylocentrotus purpuratus (purple sea urchin) 54467 Trichoplax adhaerens (metazoa) TA13145 Theileria annulata (apicomplexan parasite) XP_973315.1 Tribolium castaneum (red flour beetle) Tc00.1047053505843.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015741 Tetraodon nigroviridis (green spotted pufferfish) TP02_0433 Theileria parva (parasitic protozoan) ENSTRUP00000045703 Takifugu rubripes (pufferfish Takifugu) 72.m00191 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054036 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15532 NV12987 LH12638 ISCW020154 FBgn0233497 FBgn0212233 FBgn0206298 FBgn0188603 FBgn0168016 FBgn0249687 JGI_V11_222838 FBgn0074554 FBgn0157491 FBgn0137500 FBgn0119850 FBgn0110637 FBgn0100473 CPIJ009416 BGIBMGA013537 ACYPI002123 GB10830 AGAP009012 AAEL004076 PHUM180990 GLEAN_10401
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	34363 y1 sc* v1; P{TRiP.HMS01352}attP2
VDRC	v32937 w1118; P{GD9391}v32937/CyO
Genomic Clones ( 1 )
	BACR07P15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE51892
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03732 GH03801 LD35006 LD35018 LD35054 LD44950 LP02984 LP04361 LP06085 LP09177 LP10403 RE04261 RE30551 RE42147 RE44017 RE60992 RE63444 RE71043 RE72748 RE73004
Other clones	20919 38590 55206 119251 214253.7 CK01.2D.E2 CK01.36A.B10 CK01.58D.G10 CK01.76D.H7 Dmel_dig_002581_0650_1421 Dmel_dig_010819_0665_1498 Dmel_dig_016687_0639_3315 EK134864 EP19048 IP04492 IP04592
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030305 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32094
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132494 RefSeq (Proteins) • NP_572722 DDBJ / EMBL / GenBank • AAF48050 AAL49051 AY071429 BI366373 Entrez Gene - A searchable database of RefSeq genes. • 32094 UniProtKB/TrEMBL • Q9VYY3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • UBA/THIF-type NAD/FAD binding fold (IPR000594) D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (IPR006140) Molybdenum cofactor biosynthesis, MoeB (IPR009036) NAD(P)-binding domain (IPR016040)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58505 DroID - A comprehensive database of gene and protein interactions. • FBgn0030305 DRSC - Results from RNAi screens. • FBgn0030305 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030305 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1749-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030305 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32094 InParanoid A subset of ortholog calls from InParanoid. • AAEL004076-PA Aedes aegypti (mosquito) AGAP009012-PA Anopheles gambiae (mosquito) XP_393259.2 Apis mellifera (honey bee) XP_001952581.1 Acyrthosiphon pisum (pea aphid) At1g05350.1 Arabidopsis thaliana (wall cress) 113714 Branchiostoma floridae (lancelet) 289800 Branchiostoma floridae (lancelet) XP_001898682.1 Brugia malayi (roundworm nematode) BGIBMGA013537-PA Bombyx mori (silk worm) ENSBTAP00000005894 Bos taurus (bovine) CN09424 Caenorhabditis brenneri (small nematode) CN20561 Caenorhabditis brenneri (small nematode) CBP25964 Caenorhabditis briggsae (nematode) CE13096 Caenorhabditis elegans (worm) ENSCAFP00000009594 Canis familiaris (dog) Chro.40221 Cryptosporidium hominis (obligate parasite) ENSCINP00000008729 Ciona intestinalis (sea squirt) JA12767 Caenorhabditis japonica (nematode) cgd4_1960 Cryptosporidium parvum (protozoan parasite) CPIJ009416 Culex pipens (mosquito) ENSCPOP00000008909 Cavia porcellus (guinea pig) 113805 Chlamidomonas reinhardtii (green alga) RP14100 Caenorhabditis remanei (nematode) 152521 Capitella spl (polychaete worm) DDB0232142 Dictyostelium discoideum (amoeba) 222838 Daphnia pulex (daphnia) ENSDARP00000087478 Danio rerio (zebra fish) ENSECAP00000018858 Equus caballus (horse) ENSGACP00000005010 Gymnopilus aculeatus (mushroom) ENSGALP00000019110 Gallus gallus (chicken) GL50803_11436 Giardia lamblia (flagellated protozoan) 108304 Hypsipyla robusta (cedar shoot borer) ENSP00000348565 Homo sapiens (human) ISCW020154-PA Ixodes scapularis (deer tick) 236214 Lottia gigantea (owl limpet) LmjF15.0970 Leishmania major (virus) 14568 Monocosta brevicollis (choanoflagellate) ENSMODP00000014606 Monodelphis domestica (gray opossum) ENSMMUP00000028668 Macaca mulatta (rhesus monkey) ENSMUSP00000035166 Mus musculus (house mouse) 189522 Nematostella vectensis (starlet anemone) XP_001607066.1 Nasonia vitripennis (wasp) ENSOANP00000010819 Ornithorynchus anatinus (platypus) ENSORLP00000012899 Oryzias latipes (japanese killifish) LOC_Os02g30310.1 Oryza sativa (asian rice) PHUM000218-PA Pediculus humanus (human body louse) PP07255 Pristionchus pacificus (nematode) 111718 Physcomitrella patens (moss) ENSPPYP00000015785 Pongo pygmaeus (orangutan) 71148 Phytophthora ramorum (sudden oak death pathogen) 108205 Phytophthora sojae (root rot pathogen) 733616 Populus trichocarpa (black cottonwood) ENSPTRP00000040235 Pan troglodytes (chimpanzee) ENSRNOP00000015240 Rattus norvegicus (norway rat) 144403 Sorghum bicolor (sorghum) Smp_045780 Schistosoma mansoni (trematode parasite) XP_789316.1 Strongylocentrotus purpuratus (purple sea urchin) 54467 Trichoplax adhaerens (metazoa) TA13145 Theileria annulata (apicomplexan parasite) XP_973315.1 Tribolium castaneum (red flour beetle) Tc00.1047053505843.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000015741 Tetraodon nigroviridis (green spotted pufferfish) TP02_0433 Theileria parva (parasitic protozoan) ENSTRUP00000045703 Takifugu rubripes (pufferfish Takifugu) 72.m00191 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054036 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32094 modMine - Data generated by the modENCODE project. • FBgn0030305 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15532 NV12987 LH12638 ISCW020154 FBgn0233497 FBgn0212233 FBgn0206298 FBgn0188603 FBgn0168016 FBgn0249687 JGI_V11_222838 FBgn0074554 FBgn0157491 FBgn0137500 FBgn0119850 FBgn0110637 FBgn0100473 CPIJ009416 BGIBMGA013537 ACYPI002123 GB10830 AGAP009012 AAEL004076 PHUM180990 GLEAN_10401
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG1749 (Ni et al., 2010.12.1, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]