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Gene Dmel\Tango10

General Information
Symbol	Dmel\Tango10	Species	D. melanogaster
Name	Transport and Golgi organization 10	Annotation symbol	CG1841
Feature type	protein_coding_gene	FlyBase ID	FBgn0030330
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10D7-10D8	Sequence location	X:11,614,278..11,617,889 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transport and Golgi organization 10 is referred to in FlyBase by the symbol Dmel\Tango10 (CG1841, FBgn0030330). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; muscle organ development; protein secretion. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BTB/Kelch-associated; BTB/POZ; BTB/POZ fold; BTB/POZ-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1622903_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Tango10. Gene sequence location is X:11614278..11617889.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10D7-10D8
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tango10 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tango10-RA FBtr0073553  NM_132515   3008   587 Tango10-RB FBtr0073552  NM_167302   3247   587 Tango10-RC FBtr0332955  NM_001272532   3198   587
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tango10-PA   FBpp0073398   64.4   587   4.83     NP_572743   AAN09296 Tango10-PB   FBpp0073397   64.4   587   4.83     NP_727555   AAF48083 Tango10-PC   FBpp0305171   64.4   587   4.83     NP_001259461   AGB95304
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ-like (IPR000210) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699215   AA802127   AE014298 AAF48083   AE014298 AAN09296   AE014298 AGB95304   AI512795   AI516425   AI520240   AI531128   AI533308   AI533541   AW942023   AY069304 AAL39449   BI161955   BI161956   BI243152   BI361714   BI366631   BI368070   BI605415   BI627340   BI628895   CK658215   CO269851   CO281873   CO283122   CO283378   CO342539   EC057398   EC082759   EV574879   EV582075
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K187
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytosol inferred from direct assay (Bard et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.875 Larval Midgut    67.3 Larval Hindgut    104.8 Larval Malpighian Tubules    104.5 Larval Fat Body    69.3 Larval Salivary Gland    187.8 Larval Trachea    113.175 Larval Carcass    118.6 Adult Head    116 Adult Eye    109.4 Adult Brain    273.3 Adult Thoracic-Abdominal Ganglion    281.3 Adult Crop    114.6 Adult Midgut    69.8 Adult Hindgut    82.8 Adult Malpighian Tubules    87.4 Adult Fat Body    55.6 Adult Salivary Gland    139.7 Adult Heart    61.1 Adult VirginFemale Spermatheca    70.9 Adult InseminatedFemale Spermatheca    85 Adult Ovary    261 Adult Testis    16.5 Adult Male Accessory Gland    210.5 Adult Carcass    72.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    116   NA  Eye    109.4   NA  Brain    273.3   244.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    281.3   NA  Crop    114.6   67.3  Midgut    69.8   104.8  Hindgut    82.8   104.5  Malpighian Tubules    87.4   69.3  Fat Body    55.6   187.8  Salivary Gland    139.7   NA  Heart    61.1   113.175  Trachea    NA   NA  VirginFemale Spermatheca    70.9   NA  InseminatedFemale Spermatheca    85   NA  Ovary    261   NA  Testis    16.5   NA  Male Accessory Gland    210.5   118.6  Carcass    72.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (46) testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (46) testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    8 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    6 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    7 fat body, pupae P8    14 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    51 ovary, mated 4-day female    46 testis, mated 4-day male    5 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (34) embryo 04-06hr    23 embryo 06-08hr  (27) embryo 08-10hr  26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day  (31) adult female 05day  (40) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (34) embryo 04-06hr    23 embryo 06-08hr  27 embryo 08-10hr  26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day  31 adult female 05day  (40) adult female 30day  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    34 embryo 04-06hr    23 embryo 06-08hr    27 embryo 08-10hr    26 embryo 10-12hr    18 embryo 12-14hr    16 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    11 embryo 22-24hr    10 larva L1    14 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    15 white prepupae 24hr    16 pupae 2d postWPP    13 pupae 3d postWPP    10 pupae 4d postWPP    13 adult male 01day    10 adult male 05day    11 adult male 30day    14 adult female 01day    31 adult female 05day    40 adult female 30day    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    12 embryonic 1182-4H    17 embryonic GM2    16 embryonic Kc167    11 embryonic S1    18 embryonic S3    11 leg disc CME L1    14 wing disc CME-W2    9 wing disc ML-DmD8    14 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    13 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    11 ovary fGS/OSS    19 ovary OSC    10 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (32) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (32) Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    32 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    32 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1841-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tango10 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Tango10 Class Mutagen Stocks Known lesion Tango10GG01371 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tango10 Class Mutagen Stocks Known lesion Tango10KK102235 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tango10GD15013 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tango10T:SV5\V5 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15013} NA P{KK102235} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}Tango10GG01371 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2011-06-28)
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) protein secretion inferred from mutant phenotype (Bard et al., 2006)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (Bard et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tango10 allele Gene References unspecified sens (Parrish et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58532 DroID - A comprehensive database of gene and protein interactions. • FBgn0030330 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32125
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SF9RM Dipteran inclusive ortholog search EOG6Z62X5 Insect inclusive ortholog search EOG6JQ2SW Arthropod inclusive ortholog search EOG68W9H8 Metazoa inclusive ortholog search EOG6FV7T2
Orthologs in Drosophila Species (EOG6SF9RM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tango10     Drosophila simulans   Dsim\GD17043 Y   Drosophila sechellia   Dsec\GM13105 Y   Drosophila erecta   Dere\GG18440 Y   Drosophila yakuba   Dyak\GE15662 Y   Drosophila ananassae   Dana\GF20429 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14924 Y   Drosophila persimilis   Dper\GL15147 Y   Drosophila willistoni   Dwil\GK16315 Y   Drosophila virilis   Dvir\GJ14765 Y   Drosophila mojavensis   Dmoj\GI15326 Y   Drosophila grimshawi   Dgri\GH24387 Y
Orthologs in non-Drosophila Dipterans (EOG6Z62X5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002941   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013883   Anopheles gambiae Malaria mosquito  Agam\AGAP000791   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015109
Orthologs in non-Dipteran Insects (EOG6JQ2SW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44008   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG025004   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21623   Atta cephalotes Leafcutter ant  Acep\ACEP16168   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14620   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13191   Linepithema humile Argentine ant  Lhum\LH12293   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25060   Solenopsis invicta Red fire ant  Sinv\SINV11108   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009799   Bombyx mori Silkmoth  Bmor\BGIBMGA013583   Pediculus humanus Human body louse  Phum\PHUM105200   Tribolium castaneum Red flour beetle  Tcas\TC000949
Orthologs in non-Insect Arthropods (EOG68W9H8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_318599   Ixodes scapularis Deer tick  Isca\ISCW014872
Orthologs in non-Arthropod Metazoa (EOG6FV7T2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:ch211-8c17.9   Danio rerio Zebrafish  Drer\ENSDARG00000074018   Gallus gallus Domestic chicken  Ggal\BTBD17   Mus musculus House mouse  Mmus\Btbd17   Rattus norvegicus Norway rat  Rnor\Btbd17   Homo sapiens Human  Hsap\BTBD17
Human Orthologs (1)
Gene OMIM HGNC Hsap\BTBD17
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17043 Drosophila sechellia Dsec\GM13105 Drosophila erecta Dere\GG18440 Drosophila yakuba Dyak\GE15662 Drosophila ananassae Dana\GF20429 Drosophila pseudoobscura pseudoobscura Dpse\GA14924 Drosophila persimilis Dper\GL15147 Drosophila willistoni Dwil\GK16315 Drosophila virilis Dvir\GJ14765 Drosophila mojavensis Dmoj\GI15326 Drosophila grimshawi Dgri\GH24387
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	12775 y1 w67c23 P{Mae-UAS.6.11}Tango10GG01371
VDRC	v103920 P{KK102235}VIE-260B
Genomic Clones ( 2 )
	BACR29A04 BACR46E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 26 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL07962
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03892 LD40333 LD42286 LD44832 LP14980 RE40716 RE46046 RE52210 RE53980 RH57660 RH68625 RH71014 SD02028 SD05070 SD05404
Other clones	CK01.23C.G4 CK01.129D.E1 Dmel_dig_009416_0702_1686 Dmel_dig_016224_0686_3453 EK096117 EK159001 EK162308 EK162962 EP15101 RE01409
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32125
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tango10 CG1841 (Bard et al., 2006)
Source for database merge of
Additional comments
Other Comments
	dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) dsRNA directed against Tango10 inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation. (Bard et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of Tango10 causes a reduction in the arborization of ddaD and ddaE neurons. There is a severe reduction in primary branch outgrowth, lateral branching and lateral branch length. Additionally, there is also inappropriate dendritic routing of ddaE neurons. Additionally, RNAi causes defects in muscle and defects in dendrite morphogenesis. (Parrish et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132515 NM_167302 NM_001272532 RefSeq (Proteins) • NP_572743 NP_727555 NP_001259461 DDBJ / EMBL / GenBank • AA699215 AAF48083 AAL39449 AAN09296 AGB95304 AW942023 AY069304 Entrez Gene - A searchable database of RefSeq genes. • 32125 UniProtKB/TrEMBL • Q7K187
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ-like (IPR000210) BTB/Kelch-associated (IPR011705) BTB/POZ (IPR013069)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58532 DroID - A comprehensive database of gene and protein interactions. • FBgn0030330 DRSC - Results from RNAi screens. • FBgn0030330 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1841-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32125 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32125 modMine - Data generated by the modENCODE project. • FBgn0030330
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG1841 (Bard et al., 2006, Ringrose et al., 2003, Giot et al., 2003, Parrish et al., 2006, Frise et al., 2010, Liu et al., 2008, Keleman et al., 2009.8.5) TANGO10 (Bard et al., 2006) Tango10 (Wasbrough et al., 2010) tango10 (Smibert et al., 2012)
Name Synonym	Transport and Golgi organization (Bard et al., 2006) Transport and Golgi organization 10
Secondary FlyBase IDs
References ( 20 )
Research paper	Frise et al., 2010, Mol. Syst. Biol. 6: 345 Systematic image-driven analysis of the spatial Drosophila embryonic expression landscape. [FBrf0209738] Liu et al., 2008, Dev. Biol. 313(2): 876--886 Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. [FBrf0203001] Bard et al., 2006, Nature 439(7076): 604--607 Functional genomics reveals genes involved in protein secretion and Golgi organization. [FBrf0191232] Parrish et al., 2006, Genes Dev. 20(7): 820--835 Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. [FBrf0190556] Ringrose et al., 2003, Dev. Cell 5(5): 759--771 Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. [FBrf0167478]
Supplementary material	Smibert et al., 2012, Cell Rep. 1(3): 277--289 Table S1: Full Lists of CNS-Extended and Testis-Shortened 3' UTRs [FBrf0219848] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Bloomington Drosophila Stock Center, 19??-, Bloomington Stock List. Bloomington Stock List. [FBrf0141259]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Find Enzymes, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126664]