FlyBase Gene Report: Dmel\Tango10

General Information

Symbol

Dmel\Tango10

Species

D. melanogaster

Name

Transport and Golgi organization 10

Annotation Symbol

CG1841

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030330

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:11,720,245..11,723,854 [+]

Recombination map

1-35

RefSeq locus

NC_004354 REGION:11720245..11723854

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2011-06-28 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in protein secretion

inferred from mutant phenotype

(Bard et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Bard et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tango10 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K187)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tango10-RA

FBtr0073553

NM_132515

3008

587

Tango10-RB

FBtr0073552

NM_167302

3247

587

Tango10-RC

FBtr0332955

NM_001272532

3196

587

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Tango10-PA

FBpp0073398

64.4

587

4.83

NP_572743

AAN09296

Tango10-PB

FBpp0073397

64.4

587

4.83

NP_727555

AAF48083

Tango10-PC

FBpp0305171

64.4

587

4.83

NP_001259461

AGB95304

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

587 aa isoforms: Tango10-PA, Tango10-PB, Tango10-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7K187

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tango10 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Bard et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tango10 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tango10

View exonic expression by tissue for Dmel\Tango10

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030330

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32125/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030330

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030330

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030330

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1841

Flygut - An atlas of the Drosophila adult midgut

FBgn0030330

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Tango10

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tango10

Transgenic constructs containing regulatory region of Tango10

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\BTBD17

11 of 15

Yes

Hsap\LGALS3BP

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\KLHL25

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (8)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Btbd17

11 of 15

Yes

Mmus\Lgals3bp

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Klhl25

1 of 15

Yes

Rattus norvegicus (Norway rat) (7)

Rnor\Btbd17

10 of 13

Yes

Rnor\Lgals3bp

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Klhl25

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\btbd17

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\enc1

1 of 12

Yes

Xtro\klhl25

1 of 12

Yes

Danio rerio (Zebrafish) (15)

Drer\btbd17b

10 of 15

Yes

Drer\btbd17a

8 of 15

Yes

Drer\lgals3bpa

4 of 15

Yes

Drer\lgals3bpb

4 of 15

Yes

Drer\zgc:112492

4 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\enc3

1 of 15

Yes

Drer\klhl25

1 of 15

Yes

Drer\LOC108183378

1 of 15

Yes

Drer\LOC110439351

1 of 15

Yes

Drer\LOC110439355

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\W07A12.4

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\LRB1

1 of 9

Yes

Atha\POB1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BTBD17; BTB domain containing 17

11 of 15

LGALS3BP; galectin 3 binding protein

3 of 15

600626

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58532

DroID - A comprehensive database of gene and protein interactions.

FBgn0030330

MIST (protein-protein) - An integrated Molecular Interaction Database

Tango10

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030330

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-35

Cytogenetic map

10D7-10D8

Sequence location

X:11,720,245..11,723,854 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10D7-10D8

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-35

(FlyBase, 2016)

1-36.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

12775

y¹ w^67c23 P{Mae-UAS.6.11}Tango10^GG01371

57165

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04546}attP40

VDRC

v330206

P{VSH330206}attP40

v103920

P{KK102235}VIE-260B

v318341

PBac{fTRG01283.sfGFP-TVPTBF}VK00033

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (24)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

HL07962

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030330

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030330

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32125

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Tango10 CG1841

(Bard et al., 2006)

Source for database merge of

Additional comments

Other Comments

dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

(Bard et al., 2006)

dsRNA directed against Tango10 inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.

(Bard et al., 2006)

dsRNA has been made from templates generated with primers directed against this gene. RNAi of Tango10 causes a reduction in the arborization of ddaD and ddaE neurons. There is a severe reduction in primary branch outgrowth, lateral branching and lateral branch length. Additionally, there is also inappropriate dendritic routing of ddaE neurons. Additionally, RNAi causes defects in muscle and defects in dendrite morphogenesis.

(Parrish et al., 2006)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32125

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K187

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K187

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K187

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030330

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030330

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32125/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030330

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030330

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030330

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1841

Flygut - An atlas of the Drosophila adult midgut

FBgn0030330

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030330

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32125

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000949

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1841

MARRVEL_MODEL - MARRVEL (model organism gene)

32125

modMine - A data warehouse for the modENCODE project

FBgn0030330

Linkouts

BioGRID - A database of protein and genetic interactions.

58532

DroID - A comprehensive database of gene and protein interactions.

FBgn0030330

DRSC - Results frm RNAi screens

FBgn0030330

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030330

FlyMine - An integrated database for Drosophila genomics

FBgn0030330

MIST (protein-protein) - An integrated Molecular Interaction Database

Tango10

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG1841

(Meadows, 2017.1.11, Frise et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Liu et al., 2008, Bard et al., 2006, Parrish et al., 2006, Giot et al., 2003, Ringrose et al., 2003)

TANGO10

(Bard et al., 2006)

Tango10

(Lee et al., 2021, Sarov et al., 2016, Kwon et al., 2013, Wasbrough et al., 2010)

tango10

(Smibert et al., 2012)

Name Synonyms

Transport and Golgi organization

(Bard et al., 2006)

Transport and Golgi organization 10

Secondary FlyBase IDs

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (28)

The following external sites may use different assemblies or annotations than FlyBase.

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