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Gene Dmel\p24-1

General Information
Symbol	Dmel\p24-1	Species	D. melanogaster
Name	p24-related-1	Annotation symbol	CG1967
Feature type	protein_coding_gene	FlyBase ID	FBgn0030341
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10F1-10F1	Sequence location	X:11,745,364..11,746,548 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene p24-related-1 is referred to in FlyBase by the symbol Dmel\p24-1 (CG1967, FBgn0030341). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transporter activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: GOLD; P24-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval midgut, larval hindgut, adult Malpighian tubules, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633304_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of p24-1. Gene sequence location is X:11745364..11746548.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA19827 BKN28359
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10F1-10F1   Limits computationally determined from genome sequence between P{EP}EP345&P{EP}EP1409 and P{EP}ATP7EP308
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\p24-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) p24-1-RA FBtr0073604  NM_132526   1104   210
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein p24-1-PA   FBpp0073441   23.5   210   5.25     NP_572754   AAF48102
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GOLD (IPR009038) P24-related (IPR015718)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA951706   AE014298 AAF48102   AI107897   AI108960   AI124275   AI516929   AY071410 AAL49032   BE976447   BI364393   BP548236   BP552332   BP552333   CL868553   CO177189   CO188234   CO188704   CO276787   CO296131   CO312987   EC058147   EC060175   EC078629   EC202567   EC218111   EV582037   EV584568   EV584933
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYT6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   salivary gland body primordium   (Abrams and Andrew, 2005) embryonic stage 13 -- 14   presumptive embryonic salivary gland   (Abrams and Andrew, 2005)
Additional Descriptive Data
Marker for
	embryonic salivary gland salivary gland body primordium
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030341    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030341 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030341 expression level Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4655) embryo 02-04hr  (1071) embryo 04-06hr  (2359) embryo 06-08hr  (5632) embryo 08-10hr  (6458) embryo 10-12hr  (9544) embryo 12-14hr  (6648) embryo 14-16hr  (5227) embryo 16-18hr  (4605) embryo 18-20hr  (4095) embryo 20-22hr  (2612) embryo 22-24hr  (2622) larva L1  (4259) larva L2  (6315) larva L3 12hr old  (4634) larva L3 puffstage 1-2  (5164) larva L3 puffstage 3-6  (4270) larva L3 puffstage 7-9  (4090) white prepupae new  (4175) white prepupae 12hr  (2655) white prepupae 24hr  (3439) pupae 2d postWPP  (3126) pupae 3d postWPP  (2934) pupae 4d postWPP  (2757) adult male 01day  (4419) adult male 05day  (4344) adult male 30day  (4528) adult female 01day  (3841) adult female 05day  (5063) adult female 30day  (5166) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4655) embryo 02-04hr    1071 embryo 04-06hr  (2359) embryo 06-08hr  (5632) embryo 08-10hr  (6458) embryo 10-12hr  (9544) embryo 12-14hr  (6648) embryo 14-16hr  (5227) embryo 16-18hr  (4605) embryo 18-20hr  (4095) embryo 20-22hr  (2612) embryo 22-24hr  (2622) larva L1  (4259) larva L2  (6315) larva L3 12hr old  (4634) larva L3 puffstage 1-2  (5164) larva L3 puffstage 3-6  (4270) larva L3 puffstage 7-9  (4090) white prepupae new  (4175) white prepupae 12hr  (2655) white prepupae 24hr  (3439) pupae 2d postWPP  (3126) pupae 3d postWPP  (2934) pupae 4d postWPP  (2757) adult male 01day  (4419) adult male 05day  (4344) adult male 30day  (4528) adult female 01day  (3841) adult female 05day  (5063) adult female 30day  (5166) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030341 expression level Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4655) embryo 02-04hr  (1071) embryo 04-06hr  (2359) embryo 06-08hr  (5632) embryo 08-10hr  (6458) embryo 10-12hr  (9544) embryo 12-14hr  (6648) embryo 14-16hr  (5227) embryo 16-18hr  (4605) embryo 18-20hr  (4095) embryo 20-22hr  (2612) embryo 22-24hr  (2622) larva L1  (4259) larva L2  (6315) larva L3 12hr old  (4634) larva L3 puffstage 1-2  (5164) larva L3 puffstage 3-6  (4270) larva L3 puffstage 7-9  (4090) white prepupae new  (4175) white prepupae 12hr  (2655) white prepupae 24hr  (3439) pupae 2d postWPP  (3126) pupae 3d postWPP  (2934) pupae 4d postWPP  (2757) adult male 01day  (4419) adult male 05day  (4344) adult male 30day  (4528) adult female 01day  (3841) adult female 05day  (5063) adult female 30day  (5166) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4655) embryo 02-04hr    1071 embryo 04-06hr  2359 embryo 06-08hr  (5632) embryo 08-10hr  (6458) embryo 10-12hr  (9544) embryo 12-14hr  (6648) embryo 14-16hr  (5227) embryo 16-18hr  (4605) embryo 18-20hr  (4095) embryo 20-22hr  (2612) embryo 22-24hr  (2622) larva L1  (4259) larva L2  (6315) larva L3 12hr old  (4634) larva L3 puffstage 1-2  (5164) larva L3 puffstage 3-6  (4270) larva L3 puffstage 7-9  (4090) white prepupae new  (4175) white prepupae 12hr  (2655) white prepupae 24hr  (3439) pupae 2d postWPP  (3126) pupae 3d postWPP  (2934) pupae 4d postWPP  (2757) adult male 01day  (4419) adult male 05day  (4344) adult male 30day  (4528) adult female 01day  (3841) adult female 05day  (5063) adult female 30day  (5166) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4655 embryo 02-04hr    1071 embryo 04-06hr    2359 embryo 06-08hr    5632 embryo 08-10hr    6458 embryo 10-12hr    9544 embryo 12-14hr    6648 embryo 14-16hr    5227 embryo 16-18hr    4605 embryo 18-20hr    4095 embryo 20-22hr    2612 embryo 22-24hr    2622 larva L1    4259 larva L2    6315 larva L3 12hr old    4634 larva L3 puffstage 1-2    5164 larva L3 puffstage 3-6    4270 larva L3 puffstage 7-9    4090 white prepupae new    4175 white prepupae 12hr    2655 white prepupae 24hr    3439 pupae 2d postWPP    3126 pupae 3d postWPP    2934 pupae 4d postWPP    2757 adult male 01day    4419 adult male 05day    4344 adult male 30day    4528 adult female 01day    3841 adult female 05day    5063 adult female 30day    5166 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030341    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030341 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval midgut, larval hindgut, adult Malpighian tubules, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030341 expression level Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland    1342.8 Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland    1096 Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland    1306.1 Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland  (1342.8) Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland  (1096) Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland  (1306.1) Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland  (1342.8) Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland  (1096) Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland  (1306.1) Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland    1342.8 Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland    1096 Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland    1306.1 Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030341 expression level Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland    1342.8 Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland    1096 Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland    1306.1 Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland  (1342.8) Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland  (1096) Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland  (1306.1) Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland  1342.8 Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland  1096 Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland  1306.1 Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    53.275 Larval Midgut    199.1 Larval Hindgut    172.1 Larval Malpighian Tubules    52.8 Larval Fat Body no informative data Larval Salivary Gland    1342.8 Larval Trachea    89.075 Larval Carcass    95.875 Adult Head    64 Adult Eye    55.3 Adult Brain    82.6 Adult Thoracic-Abdominal Ganglion    101.6 Adult Crop    56.5 Adult Midgut    84.7 Adult Hindgut    94.2 Adult Malpighian Tubules    127.1 Adult Fat Body    98.7 Adult Salivary Gland    1096 Adult Heart    76.35 Adult VirginFemale Spermatheca    48.5 Adult InseminatedFemale Spermatheca    62.2 Adult Ovary    72.7 Adult Testis    56 Adult Male Accessory Gland    1306.1 Adult Carcass    201.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    64   NA  Eye    55.3   NA  Brain    82.6   53.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    101.6   NA  Crop    56.5   199.1  Midgut    84.7   172.1  Hindgut    94.2   52.8  Malpighian Tubules    127.1   no informative data  Fat Body    98.7   1342.8  Salivary Gland    1096   NA  Heart    76.35   89.075  Trachea    NA   NA  VirginFemale Spermatheca    48.5   NA  InseminatedFemale Spermatheca    62.2   NA  Ovary    72.7   NA  Testis    56   NA  Male Accessory Gland    1306.1   95.875  Carcass    201.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030341 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1967-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for p24-1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 p24-1GD3321 lethal, with Scer\GAL4pnr-MD237 p24-1GD3321 viable p24-1EY12314 Sterility Allele fertile p24-1EY12314 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 p24-1GD3321 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 p24-1GD3321 ganglion mother cell | larval stage, with Scer\GAL41407 p24-1GD3321
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of p24-1 Class Mutagen Stocks Known lesion p24-1EY12314 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of p24-1 Class Mutagen Stocks Known lesion p24-1GD3321 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes p24-1KK108359 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6243 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{p24-1.lacZ} No P{p24-1-lacZ.CrebAmut} No UAS construct P{GD3321} NA P{KK108359} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}p24-1EY12314 NA miscellaneous insertions P{SUPor-P}KG09084 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
transporter activity inferred from sequence or structural similarity (Liang and Biggin, 1998)
Biological Process
CV term Evidence References
post-Golgi vesicle-mediated transport inferred from sequence or structural similarity with EMBL:AJ132270 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
coated vesicle inferred from sequence or structural similarity with EMBL:AJ132270 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR009038 (FlyBase Curators et al., 2004-) transport vesicle inferred from sequence or structural similarity (Liang and Biggin, 1998)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions p24-1 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030341 DroID - A comprehensive database of gene and protein interactions. • FBgn0030341 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32140
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19411 Dere\GG18829 Dgri\GH11947 Dmoj\GI15363 Dper\GL20350 Dpse\GA15160 Dsec\GM13040 Dsim\GD15965 Dvir\GJ16789 Dwil\GK10123 Dyak\GE17592
Curated drosophilid orthologs	Dpse\GA15160
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011755-PA Aedes aegypti (mosquito) AGAP000949-PA Anopheles gambiae (mosquito) XP_393052.2 Apis mellifera (honey bee) XP_001943186.1 Acyrthosiphon pisum (pea aphid) 13905 Batrachochytrium dendrobatidis (chytrid fungus) 59191 Branchiostoma floridae (lancelet) BGIBMGA006508-PA Bombyx mori (silk worm) ENSBTAP00000046390 Bos taurus (bovine) CAL0005932 Candida albicans (a form of yeast) CN15473 Caenorhabditis brenneri (small nematode) CBP03036 Caenorhabditis briggsae (nematode) CE11306 Caenorhabditis elegans (worm) ENSCAFP00000020614 Canis familiaris (dog) ENSCINP00000003864 Ciona intestinalis (sea squirt) JA07939 Caenorhabditis japonica (nematode) CPIJ009436 Culex pipens (mosquito) ENSCPOP00000019663 Cavia porcellus (guinea pig) RP21213 Caenorhabditis remanei (nematode) ENSCSAVP00000009068 Ciona savignyi (sedentary tunicate) 19779 Capitella spl (polychaete worm) DEHA2C05632g Debaryomyces Hansenii (yeast) 307415 Daphnia pulex (daphnia) ENSDARP00000067665 Danio rerio (zebra fish) ENSECAP00000010672 Equus caballus (horse) XP_656857 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009929 Gymnopilus aculeatus (mushroom) ENSGALP00000013449 Gallus gallus (chicken) 157751 Hypsipyla robusta (cedar shoot borer) ENSP00000299705 Homo sapiens (human) ISCW007906-PA Ixodes scapularis (deer tick) 172331 Lottia gigantea (owl limpet) 29319 Monocosta brevicollis (choanoflagellate) ENSMODP00000024244 Monodelphis domestica (gray opossum) ENSMMUP00000021247 Macaca mulatta (rhesus monkey) ENSMUSP00000043660 Mus musculus (house mouse) ENSMUSP00000058723 Mus musculus (house mouse) 165644 Nematostella vectensis (starlet anemone) XP_001599743.1 Nasonia vitripennis (wasp) ENSOANP00000016815 Ornithorynchus anatinus (platypus) ENSORLP00000006268 Oryzias latipes (japanese killifish) PHUM000258-PA Pediculus humanus (human body louse) PP27606 Pristionchus pacificus (nematode) ENSPPYP00000007613 Pongo pygmaeus (orangutan) ENSPTRP00000012574 Pan troglodytes (chimpanzee) ENSRNOP00000004942 Rattus norvegicus (norway rat) ENSRNOP00000018603 Rattus norvegicus (norway rat) Smp_154960.3 Schistosoma mansoni (trematode parasite) SPAC17A5.08 Schizosaccharomyces pombe (fission yeast) XP_001178424.1 Strongylocentrotus purpuratus (purple sea urchin) 38242 Trichoplax adhaerens (metazoa) XP_969755.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005774 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000030224 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000040594 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12298 NV18501 LH20756 ISCW007906 FBgn0235048 FBgn0212138 FBgn0203968 FBgn0187613 FBgn0167971 JGI_V11_307415 FBgn0075185 FBgn0157945 FBgn0138112 FBgn0119426 FBgn0111037 FBgn0096420 CPIJ009436 BGIBMGA006508 ACYPI006570 ACYPI003651 GB17348 AGAP000949 AAEL011755 PHUM412770 GLEAN_11294
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	20733 y1 w67c23 P{EPgy2}p24-1EY12314
VDRC	v100594 P{KK108359}VIE-260B v12196 w1118; P{GD3321}v12196
Genomic Clones ( 2 )
	BACR12H01 BACR46E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE49489
Other clones	DPiM_RE49489
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05778 GH07445 GH27533 LD32378
Other clones	613 105656 178081 AI124275 bs50f11 CK01.49B.E10 CK01.67A.G1 Dmel_dig_009048_0655_1535 Dmel_dig_017255_0649_3229 Dmel_dig_017590_0652_3191 EK038601 EK041549 EK052725 EK122047 EK212802 EK230862 FGH125D12 FGM218B07
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030341 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32140
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: p24-1 CG1967 (Abrams and Andrew, 2005)
Source for database merge of	Source for merge of: CG1967 anon-EST:Liang-1.45 (FlyBase, 1996-)
Additional comments	Source for merge of CG1967 anon-EST:Liang-1.45 was sequence comparison (date:030722). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132526 RefSeq (Proteins) • NP_572754 DDBJ / EMBL / GenBank • AAF48102 AAL49032 AI124275 AY071410 BI364393 CL868553 Entrez Gene - A searchable database of RefSeq genes. • 32140 UniProtKB/TrEMBL • Q9VYT6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GOLD (IPR009038) P24-related (IPR015718)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030341 DroID - A comprehensive database of gene and protein interactions. • FBgn0030341 DRSC - Results from RNAi screens. • FBgn0030341 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030341 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1967-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030341 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32140 InParanoid A subset of ortholog calls from InParanoid. • AAEL011755-PA Aedes aegypti (mosquito) AGAP000949-PA Anopheles gambiae (mosquito) XP_393052.2 Apis mellifera (honey bee) XP_001943186.1 Acyrthosiphon pisum (pea aphid) 13905 Batrachochytrium dendrobatidis (chytrid fungus) 59191 Branchiostoma floridae (lancelet) BGIBMGA006508-PA Bombyx mori (silk worm) ENSBTAP00000046390 Bos taurus (bovine) CAL0005932 Candida albicans (a form of yeast) CN15473 Caenorhabditis brenneri (small nematode) CBP03036 Caenorhabditis briggsae (nematode) CE11306 Caenorhabditis elegans (worm) ENSCAFP00000020614 Canis familiaris (dog) ENSCINP00000003864 Ciona intestinalis (sea squirt) JA07939 Caenorhabditis japonica (nematode) CPIJ009436 Culex pipens (mosquito) ENSCPOP00000019663 Cavia porcellus (guinea pig) RP21213 Caenorhabditis remanei (nematode) ENSCSAVP00000009068 Ciona savignyi (sedentary tunicate) 19779 Capitella spl (polychaete worm) DEHA2C05632g Debaryomyces Hansenii (yeast) 307415 Daphnia pulex (daphnia) ENSDARP00000067665 Danio rerio (zebra fish) ENSECAP00000010672 Equus caballus (horse) XP_656857 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000009929 Gymnopilus aculeatus (mushroom) ENSGALP00000013449 Gallus gallus (chicken) 157751 Hypsipyla robusta (cedar shoot borer) ENSP00000299705 Homo sapiens (human) ISCW007906-PA Ixodes scapularis (deer tick) 172331 Lottia gigantea (owl limpet) 29319 Monocosta brevicollis (choanoflagellate) ENSMODP00000024244 Monodelphis domestica (gray opossum) ENSMMUP00000021247 Macaca mulatta (rhesus monkey) ENSMUSP00000043660 Mus musculus (house mouse) ENSMUSP00000058723 Mus musculus (house mouse) 165644 Nematostella vectensis (starlet anemone) XP_001599743.1 Nasonia vitripennis (wasp) ENSOANP00000016815 Ornithorynchus anatinus (platypus) ENSORLP00000006268 Oryzias latipes (japanese killifish) PHUM000258-PA Pediculus humanus (human body louse) PP27606 Pristionchus pacificus (nematode) ENSPPYP00000007613 Pongo pygmaeus (orangutan) ENSPTRP00000012574 Pan troglodytes (chimpanzee) ENSRNOP00000004942 Rattus norvegicus (norway rat) ENSRNOP00000018603 Rattus norvegicus (norway rat) Smp_154960.3 Schistosoma mansoni (trematode parasite) SPAC17A5.08 Schizosaccharomyces pombe (fission yeast) XP_001178424.1 Strongylocentrotus purpuratus (purple sea urchin) 38242 Trichoplax adhaerens (metazoa) XP_969755.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005774 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000030224 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000040594 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32140 modMine - Data generated by the modENCODE project. • FBgn0030341 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12298 NV18501 LH20756 ISCW007906 FBgn0235048 FBgn0212138 FBgn0203968 FBgn0187613 FBgn0167971 JGI_V11_307415 FBgn0075185 FBgn0157945 FBgn0138112 FBgn0119426 FBgn0111037 FBgn0096420 CPIJ009436 BGIBMGA006508 ACYPI006570 ACYPI003651 GB17348 AGAP000949 AAEL011755 PHUM412770 GLEAN_11294 REDfly - A database of transcriptional regulatory elements. • FBgn0030341
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	anon-EST:Liang-1.45   CG1967 (Carney and Taylor, 2003, Carney and Bowen, 2004, Biggin, 1999.2.5, FlyBase, 1996-, Giot et al., 2003, Boltz et al., 2007, Vinci et al., 2008, Keleman et al., 2009.8.5) clone 1.45 (Liang and Biggin, 1998) p24 (Boltz et al., 2007) p24-1   p24.1 (Fox et al., 2010)
Name Synonym	p24-related-1 (Abrams and Andrew, 2005)
Secondary FlyBase IDs
	FBgn0025988
References ( 20 )
Research paper	Fox et al., 2010, J. Cell Biol. 191(3): 479--492 The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. [FBrf0212217] Vinci et al., 2008, PLoS ONE 3(8): e2883 Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. [FBrf0205755] Boltz et al., 2007, Dev. Dynamics 236(2): 544--555 Drosophila melanogaster p24 genes have developmental, tissue-specific, and sex-specific expression patterns and functions. [FBrf0195392] Abrams and Andrew, 2005, Development 132(12): 2743--2758 CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. [FBrf0187447] Carney and Taylor, 2003, Genetics 164(1): 173--186 logjam encodes a predicted EMP24/GP25 protein that is required for Drosophila oviposition behavior. [FBrf0158991] Liang and Biggin, 1998, Development 125(22): 4471--4482 Eve and ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in Drosophila. [FBrf0105875]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Carney and Bowen, 2004, Biol. Cell 96(4): 271--278 p24 proteins, intracellular trafficking, and behavior: Drosophila melanogaster provides insights and opportunities. [FBrf0174396]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Biggin, 1999.2.5, Some "homology" questions. Some "homology" questions. [FBrf0106226]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]