FlyBase Gene Report: Dmel\ATP7

General Information

Symbol

Dmel\ATP7

Species

D. melanogaster

Name

ATP7

Annotation Symbol

CG1886

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030343

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

P-type Cu(+) transporter (7.2.2.8)

P-type Cu(2+) transporter (7.2.2.9)

Gene Summary

ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DmATP7, lincRNA.S9122

Key Links

Genomic Location

Cytogenetic map

10F1-10F2

Sequence location

X:11,855,022..11,864,754 [+]

Recombination map

1-37

RefSeq locus

NC_004354 REGION:11855022..11864754

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (21 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables copper ion transmembrane transporter activity

inferred from mutant phenotype

(Southon et al., 2004)

Terms Based on Predictions or Assertions (8 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR001757

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR001757

(InterPro Project Members, 2004-)

enables ATPase-coupled monoatomic cation transmembrane transporter activity

inferred from electronic annotation with InterPro:IPR027256

(InterPro Project Members, 2004-)

enables copper ion binding

inferred from biological aspect of ancestor with PANTHER:PTN000642961

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006122

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P35670

(Southon et al., 2004)

enables metal ion binding

inferred from electronic annotation with InterPro:IPR006121, InterPro:IPR017969, InterPro:IPR036163

(InterPro Project Members, 2004-)

enables nucleotide binding

inferred from electronic annotation with InterPro:IPR023299

(InterPro Project Members, 2004-)

enables P-type divalent copper transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000642961

(GO Reference Genome Project, 2011-)

enables P-type monovalent copper transporter activity

inferred from sequence or structural similarity with UniProtKB:Q04656

(Gene Ontology Curators, 2002-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in adult chitin-containing cuticle pigmentation

inferred from mutant phenotype

(Norgate et al., 2006)

involved_in copper ion import across plasma membrane

inferred from mutant phenotype

(Bahadorani et al., 2010)

involved_in developmental pigmentation

inferred from mutant phenotype

(Norgate et al., 2006)

involved_in intracellular copper ion homeostasis

inferred from mutant phenotype

(Southon et al., 2004)

involved_in larval development

inferred from mutant phenotype

(Norgate et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in copper ion export

inferred from biological aspect of ancestor with PANTHER:PTN008451426

(GO Reference Genome Project, 2011-)

involved_in copper ion import

inferred from biological aspect of ancestor with PANTHER:PTN001185001

(GO Reference Genome Project, 2011-)

involved_in intracellular copper ion homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN008451426

(GO Reference Genome Project, 2011-)

involved_in monoatomic cation transport

inferred from electronic annotation with InterPro:IPR027256

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Norgate et al., 2006)

located_in plasma membrane

inferred from direct assay

(Norgate et al., 2006)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR027256

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001185001

(GO Reference Genome Project, 2011-)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN001185001

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

COPPER TRANSPORTING P-ATPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

P-type divalent copper transporter activity

Cu(2+)(in) + ATP + H2O = Cu(2+)(out) + ADP + phosphate + H(+) (7.2.2.9)

RHEA 10376: P-type monovalent copper transporter activity

Cu(+)(in) + ATP + H2O = Cu(+)(out) + ADP + phosphate + H(+) (7.2.2.8)

RHEA 25792: ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

COPPER TRANSPORTING P-ATPASES -: Cu²⁺ transporting ATPases are type IB P-ATPases that utilize the hydrolysis of ATP to drive the transmembrane transport of Cu²⁺. They play a key role in cellular Cu²⁺ efflux. (Adapted from FBrf0205413).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ATP7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VYT4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ATP7-RB

FBtr0273257

NM_132528

4230

1254

ATP7-RC

FBtr0334454

NM_001272537

5157

1254

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ATP7-PB

FBpp0271765

136.1

1254

6.13

FBpp0306530

136.1

1254

6.13

Q9VYT4

NP_001259466

AGB95309

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1254 aa isoforms: ATP7-PB, ATP7-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ATP7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ATP7_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.90

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval tracheal system

(Norgate et al., 2006)

embryonic/larval tracheal dorsal trunk

(Norgate et al., 2006)

tracheal primordium

(Norgate et al., 2006)

embryonic/larval tracheal section

(Norgate et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Norgate et al., 2006)

located_in plasma membrane

inferred from direct assay

(Norgate et al., 2006)

Expression Deduced from Reporters

Reporter: P{ATP7-GAL4.B}

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

larval brain

(Burke et al., 2008)

larval peripheral nervous system | segmentally repeated

(Burke et al., 2008)

mouthpart

(Burke et al., 2008)

third instar larval stage

interneuron | subset of larval abdominal neuromere

(Sellami et al., 2012)

peptidergic neuron | subset of larval abdominal neuromere

(Sellami et al., 2012)

peptidergic neuron | subset of embryonic/larval hypocerebral ganglion

(Sellami et al., 2012)

endocrine neuron | subset of retrocerebral complex

(Sellami et al., 2012)

larval insulin secreting cell of pars intercerebralis | subset

(Sellami et al., 2012)

endocrine neuron | subset of larval abdomen

(Sellami et al., 2012)

larval ventral nerve cord

(Burke et al., 2008)

embryonic/larval salivary gland

(Burke et al., 2008)

gonad

(Burke et al., 2008)

gastric caecum

(Burke et al., 2008)

embryonic/larval copper cell

(Burke et al., 2008)

embryonic/larval anterior midgut | restricted

(Burke et al., 2008)

embryonic/larval posterior midgut | restricted

(Burke et al., 2008)

embryonic/larval hindgut

(Burke et al., 2008)

embryonic/larval Malpighian tubule

(Burke et al., 2008)

larval Va Capability neuron

(Sellami et al., 2012)

adult stage

labellum

(Burke et al., 2008)

maxillary palp

(Burke et al., 2008)

third segment of antenna

(Burke et al., 2008)

leg sensillum

(Burke et al., 2008)

wing sensillum

(Burke et al., 2008)

adult gut

(Burke et al., 2008)

adult stage | male

testis

(Burke et al., 2008)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ATP7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ATP7

View exonic expression by tissue for Dmel\ATP7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32142/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030343

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030343

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030343

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1886

Flygut - An atlas of the Drosophila adult midgut

FBgn0030343

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ATP7

Transgenic constructs containing regulatory region of ATP7

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6243

(Ryder, 2004.4.26)

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

ATP7^ΔP17

lethal | chemical conditional, with Scer\GAL4^mex1.2.1

ATP7^UAS.Tag:FLAG

lethal | embryonic stage | germline clone | maternal effect

ATP7^ΔP17

lethal | first instar larval stage

ATP7^ΔP17

lethal | pupal stage, with Scer\GAL4^tracheal

ATP7^UAS.Tag:FLAG

lethal - all die before end of larval stage

ATP7^ΔP17

lethal - all die before end of pupal stage, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

lethal - all die before end of pupal stage, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

partially lethal - majority die, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

partially lethal - majority die | third instar larval stage, with Scer\GAL4^tracheal

ATP7^UAS.Tag:FLAG

partially lethal - majority live, with Scer\GAL4^elav-C155

ATP7^UAS.Tag:FLAG

viable, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

viable, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ATP7^GD3322

viable, with Scer\GAL4^Mef2.PR

ATP7^GD3322

viable, with Scer\GAL4^pnr-MD237

ATP7^GD3322

viable, with Scer\GAL4^tin.CΔ4

ATP7^GD3322

viable | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

viable | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

Sterility

Allele

male sterile, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

male sterile, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^Act5C.PI

ATP7^UAS.Tag:FLAG

abnormal body color, with Scer\GAL4^pnr-MD237

abnormal body color, with Scer\GAL4^ptc-559.1

abnormal body color | adult stage, with Scer\GAL4^pnr-MD237

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

ATP7^EY07895

abnormal neuroanatomy, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

ATP7^UAS.cBa

abnormal oxidative stress response, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

abnormal size, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

chemical sensitive, with Scer\GAL4^elav-C155

ATP7^UAS.Tag:FLAG

chemical sensitive, with Scer\GAL4^mex1.2.1

ATP7^UAS.Tag:FLAG

decreased body size | larval stage

ATP7^ΔP17

short lived, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

short lived, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

short lived | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

short lived | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

some die during larval stage

ATP7^ΔP17

some die during pharate adult stage, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

some die during pupal stage, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

some die during pupal stage, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

visible, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

visible, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

visible, with Scer\GAL4^elav-C155

ATP7^UAS.Tag:FLAG

visible, with Scer\GAL4^elav-C155, Scer\GAL80^CCAP.PL

ATP7^UAS.Tag:FLAG

visible, with Scer\GAL4^pnr-MD237

visible | adult stage, with Scer\GAL4^pnr-MD237

visible | adult stage | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

visible | adult stage | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

Phenotype manifest in

Allele

abdominal tergite

ATP7^ΔP17

abdominal tergite, with Scer\GAL4^Act5C.PI

ATP7^UAS.Tag:FLAG

adult abdomen, with Scer\GAL4^pnr-MD237

adult cuticle, with Scer\GAL4^pnr-MD237

adult cuticle | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

adult cuticle | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

adult thoracic sensillum, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

adult thorax, with Scer\GAL4^pnr-MD237

eye, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

eye, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

eye | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

eye | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

macrochaeta, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

macrochaeta, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

macrochaeta & mesothoracic tergum, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

macrochaeta | absent, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

macrochaeta | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

macrochaeta | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

mesonotum

ATP7^ΔP17

mesonotum, with Scer\GAL4^pnr-MD237

microchaeta, with ATP7^UAS.cBa, Scer\GAL4^ATP7.PB

ATP7^ΔP17

microchaeta, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.cBa

microchaeta | absent, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

microchaeta | nutrition conditional, with ATP7^UAS.EYFP, Scer\GAL4^ATP7.PB

ATP7^ΔP17

microchaeta | nutrition conditional, with ATP7^ΔP17, Scer\GAL4^ATP7.PB

ATP7^UAS.EYFP

mouth hook

ATP7^ΔP17

mouth hook | first instar larval stage

ATP7^ΔP17

neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

ATP7^UAS.cBa

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

ATP7^UAS.cBa

pupal brain, with Scer\GAL4^NP2020

ATP7^RNAi.Sym.UAS

scutellar bristle, with Scer\GAL4^ptc-559.1

ATP7^UAS.Tag:FLAG

scutellum, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

scutellum, with Scer\GAL4^ptc-559.1

ATP7^UAS.Tag:FLAG

trichogen cell, with Scer\GAL4^pnr-MD237

ATP7^GD3322

trident, with Scer\GAL4^pnr-MD237

ATP7^UAS.Tag:FLAG

trident, with Scer\GAL4^ptc-559.1

wing, with Scer\GAL4^elav-C155

ATP7^UAS.Tag:FLAG

wing, with Scer\GAL4^elav-C155, Scer\GAL80^CCAP.PL

ATP7^UAS.Tag:FLAG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\ATP7A

13 of 14

Yes

Hsap\ATP7B

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Atp7b

13 of 14

Yes

Rnor\Atp7a

12 of 14

Yes

Rnor\Atp2c1

1 of 14

Mus musculus (laboratory mouse) (4)

Mmus\Atp7a

13 of 14

Yes

Mmus\Atp7b

12 of 14

Yes

Mmus\Atp2c1

1 of 14

Mmus\Atp2c2

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\atp7b

10 of 13

Yes

Xtro\atp7a

9 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (4)

Drer\atp7a

12 of 14

Yes

Drer\atp7b

12 of 14

Yes

Drer\atp1a1a.3

1 of 14

Drer\atp1a1a.5

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\cua-1

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP011754

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\HMA5

12 of 13

Yes

Atha\RAN1

12 of 13

Yes

Atha\HMA1

3 of 13

Yes

Atha\HMA2

3 of 13

Yes

Atha\HMA3

3 of 13

Yes

Atha\HMA4

3 of 13

Yes

Atha\PAA1

3 of 13

Yes

Atha\PAA2

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G22910

1 of 13

Atha\AT4G11730

1 of 13

Yes

Atha\AT5G53010

1 of 13

Atha\ECA2

1 of 13

Atha\HA1

1 of 13

Yes

Atha\HA2

1 of 13

Yes

Atha\HA3

1 of 13

Yes

Atha\HA4

1 of 13

Yes

Atha\HA5

1 of 13

Yes

Atha\HA6

1 of 13

Yes

Atha\HA7

1 of 13

Yes

Atha\HA8

1 of 13

Yes

Atha\HA9

1 of 13

Yes

Atha\HA11

1 of 13

Yes

Atha\PDR2

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\CCC2

12 of 13

Yes

Scer\PCA1

2 of 13

Yes

Scer\PMA1

2 of 13

Yes

Scer\PMA2

2 of 13

Yes

Scer\ENA1

1 of 13

Scer\PMC1

1 of 13

Scer\PMR1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ccc2

12 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\copA

10 of 11

Yes

Ecol\zntA

4 of 11

Yes

Ecol\kdpB

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ATP7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 9 )

Allele

Disease

Evidence

References

ATP7^UAS.cBa

model of metal metabolism disorder

CEA

(Hartwig et al., 2021, Comstra et al., 2017)

ATP7^KK100396

model of metal metabolism disorder

CEA

(Hartwig et al., 2021, Zlatic et al., 2018)

ATP7^ΔP17

model of Menkes disease

CEA

(Norgate et al., 2006)

ATP7^UAS.Tag:FLAG

model of Menkes disease

CEA

(Hwang et al., 2014)

model of metal metabolism disorder

CEA

(Hartwig et al., 2021, Zlatic et al., 2018)

ATP7^{MBS.UAS.Tag:FLAG}

model of metal metabolism disorder

CEA

(Zlatic et al., 2018)

ATP7^{TAP.UAS.Tag:FLAG}

model of metal metabolism disorder

CEA

(Zlatic et al., 2018)

ATP7^RNAi.Sym.UAS

model of Menkes disease

CEA

(Bahadorani et al., 2010)

ATP7^UAS.GFP

model of metal metabolism disorder

CEA

(Bakkar et al., 2021)

ATP7^RNAi.UAS.cUa

model of metal metabolism disorder

CEA

(Bakkar et al., 2021)

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

ATP7B; ATPase copper transporting beta

model of Wilson disease

IEA

(FlyBase, 2019-)

ATP7A; ATPase copper transporting alpha

model of occipital horn syndrome

IEA

(FlyBase, 2019-)

model of Menkes disease

IEA

(FlyBase, 2019-)

model of X-linked distal spinal muscular atrophy 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

ATP7^GD3322

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Xiao et al., 2013)

ameliorates Menkes disease

modeled by slmb^GD10682

(Zhang et al., 2020)

ATP7^UAS.cBa

model of metal metabolism disorder

is ameliorated by Cog1^e02840

(Hartwig et al., 2021, Comstra et al., 2017)

is ameliorated by Cog8^HMC03886

(Hartwig et al., 2021)

ATP7^EY07895

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Xiao et al., 2013, Cao et al., 2008)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lang et al., 2013)

ATP7^ΔP17

model of Menkes disease

is ameliorated by ATP7^UAS.Tag:FLAG

(Norgate et al., 2006)

ATP7^UAS.Tag:FLAG

ameliorates Menkes disease

modeled by ATP7^ΔP17

(Norgate et al., 2006)

model of metal metabolism disorder

is ameliorated by Uch^GD11265

(Zlatic et al., 2018)

ATP7^RNAi.Sym.UAS

model of Menkes disease

is ameliorated by MTF-1^Tub.PY

(Bahadorani et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATP7A; ATPase copper transporting alpha

13 of 14

ATPase, Cu(2+)-TRANSPORTING, ALPHA POLYPEPTIDE; ATP7A

ATP7B; ATPase copper transporting beta

13 of 14

606882

WILSON DISEASE; WND

Wilson disease

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ATP7

suppressible

Cog1

(Comstra et al., 2017)

ATP7

suppressible

Ctr1A

(Binks et al., 2010, Norgate et al., 2006)

ATP7

suppressible

Ctr1B

(Binks et al., 2010)

ATP7

suppressible

MTF-1

(Bahadorani et al., 2010)

ATP7

enhanceable

Mvl

(Southon et al., 2008)

ATP7

suppressible

Psn

(Southon et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ctr1B

suppressible

ATP7

(Binks et al., 2010)

Gclc

enhanceable

ATP7

(Mercer et al., 2016)

Grx1

enhanceable

ATP7

(Mercer and Burke, 2016)

slmb

suppressible

ATP7

(Zhang et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58547

DroID - A comprehensive database of gene and protein interactions.

FBgn0030343

MIST (genetic) - An integrated Molecular Interaction Database

32142

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ion transport by P-type ATPases

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-37

Cytogenetic map

10F1-10F2

Sequence location

X:11,855,022..11,864,754 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10F1-10F2

Limits computationally determined from genome sequence between P{EP}EP345&P{EP}EP1409 and P{EP}ATP7^EP308

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-37

(FlyBase, 2016)

1-36.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31083

y¹ v¹; P{TRiP.JF01534}attP2

82712

y¹ v¹; P{TKO.GS05055}attP40

16866

y¹ w^67c23 P{EPgy2}ATP7^EY07895

10114

w¹¹¹⁸ P{EP}ATP7^EP308 CG10347^EP308

86461

y¹ w^* TI{CRIMIC.TG4.1}ATP7^{CR01597-TG4.1}

80395

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06631}attP40

57055

y¹ w^* ATP7^B P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

57056

y¹ w^* ATP7^O P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

VDRC

v108159

P{KK100396}VIE-260B

v8315

w¹¹¹⁸; P{GD3322}v8315

v318182

PBac{fTRG00684.sfGFP-TVPTBF}VK00033

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (42)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE21490

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030343

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030343

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

ATP7 acts via copper-regulated trafficking to remove copper from cells.

(Burke et al., 2004)

Suppression of ATP7 levels by dsRNA interference in S2 cells increases accumulation of radio labelled copper.

(Burke et al., 2004)

dsRNA made from templates generated with primers directed against this gene used to investigate the role of this gene in copper homoeostasis in S2 cells.

(Southon et al., 2004)

S2 cells treated with ATP7 dsRNA show significantly increased copper accumulation.

(Southon et al., 2004)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: ATP7 CG1886

(Burke, 2004.2.24)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Atp7

(Green et al., 2022, Zlatic et al., 2018)

Atp7A

(Klimaczewski et al., 2018)

CG1886

(Zlatic et al., 2018, Haelterman et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Cui et al., 2008, Ni et al., 2008, Inlow and Restifo, 2004, Southon et al., 2004, Driscoll and Gerstbrein, 2003)

DmATP7

(Reed et al., 2018, Lenartowicz et al., 2015, Lang et al., 2013, Southon et al., 2013, Xiao et al., 2013, Chang et al., 2011, Bahadorani et al., 2010, Binks et al., 2010, Norgate et al., 2010, Southon et al., 2010, Burke et al., 2008, Allan et al., 2007, Balamurugan et al., 2007, Norgate et al., 2006, Norgate et al., 2005, Southon et al., 2004)

atp7

(Reed et al., 2018)

dATP7

(Bakkar et al., 2021)

dmATP7

(Burke et al., 2008, Burke et al., 2004)

lincRNA.S9122

(FlyBase Genome Annotators, 2014, Young et al., 2012)

Name Synonyms

ATP7

(Graves et al., 2020)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32142

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BF490825

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VYT4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VYT4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VYT4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32142/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030343

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030343

FlyMine - An integrated database for Drosophila genomics

FBgn0030343

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1886

MARRVEL_MODEL - MARRVEL (model organism gene)

32142

Linkouts

BioGRID - A database of protein and genetic interactions.

58547

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030343

DroID - A comprehensive database of gene and protein interactions.

FBgn0030343

DRSC - Results frm RNAi screens

FBgn0030343

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ATP7_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030343

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030343

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1886

Flygut - An atlas of the Drosophila adult midgut

FBgn0030343

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030343

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030914

MIST (genetic) - An integrated Molecular Interaction Database

32142

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ion transport by P-type ATPases

References (90)

The following external sites may use different assemblies or annotations than FlyBase.

4.90

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