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Gene Dmel\ATP7

General Information
Symbol	Dmel\ATP7	Species	D. melanogaster
Name	ATP7	Annotation symbol	CG1886
Feature type	protein_coding_gene	FlyBase ID	FBgn0030343
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	DmATP7
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10F1-10F2	Sequence location	X:11,749,066..11,757,861 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ATP7 is referred to in FlyBase by the symbol Dmel\ATP7 (CG1886, FBgn0030343). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: copper ion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: cellular copper ion homeostasis; copper ion transport; larval development; developmental pigmentation; adult chitin-containing cuticle pigmentation. 12 alleles are reported. The phenotypes of these alleles are annotated with: trident; trichogen cell; adult thorax; adult cuticle; adult thoracic sensillum; mesothoracic tergum; scutellar bristle; tergite; scutellum. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, P-type, cytoplasmic transduction domain A; ATPase, P type, cation/copper-transporter; ATPase, P-type phosphorylation site; ATPase, P-type, ATPase-associated domain; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; ATPase, P-type, cytoplasmic domain N; ATPase, P-type, heavy metal translocating; ATPase, cation-transporting, domain N; HAD-like domain; Haloacid dehalogenase-like hydrolase; Heavy metal-associated domain, HMA; Heavy metal-associated domain, copper ion-binding; Heavy-metal-associated, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634704_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ATP7. Gene sequence location is X:11749066..11757861.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Lye et al., 2011, PLoS ONE 6(10): e26867 Sequence features BKN20492 HFA19819
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10F1-10F2   Limits computationally determined from genome sequence between P{EP}EP345&P{EP}EP1409 and P{EP}ATP7EP308
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ATP7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ATP7-RB FBtr0273257  NM_132528   4220   1254
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ATP7-PB   FBpp0271765   136.1   1254   6.13     NP_572756   AAF48104
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (IPR001757) Heavy metal-associated domain, HMA (IPR006121) Heavy metal-associated domain, copper ion-binding (IPR006122) ATPase, P type, cation/copper-transporter (IPR006403) ATPase, P-type, heavy metal translocating (IPR006416) ATPase, P-type, ATPase-associated domain (IPR008250) Heavy-metal-associated, conserved site (IPR017969) ATPase, P-type phosphorylation site (IPR018303) Haloacid dehalogenase-like hydrolase (IPR005834) HAD-like domain (IPR023214) ATPase, P-type, cytoplasmic domain N (IPR023299) ATPase, P-type, cytoplasmic transduction domain A (IPR023300) ATPase, cation-transporting, domain N (IPR023306)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48104   AI532051   BF485538   BF488789   BF490825   BF496110   BF499576   BF499686   BF501319   BF505051   BF505446   BF505672   BG634486   BG636165   BT014649   CO155047   CO184592   CO188392   CO266206   CO266264   EC051835   EC051868   EC052359   EC052876   EC052910   EC053382   EC056260   EC061586   EC199023   EC209507   EC264706   GH943163   GH944074   GH952239   GH956178   GH957074   GH958367   GH960307   GH969112   GH973056   GH973788   GH978272   GH982782   GH983796   GH984703   GH984712
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYT4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030343    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030343 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030343 expression level Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4383) embryo 02-04hr  (1800) embryo 04-06hr  (1010) embryo 06-08hr  (1917) embryo 08-10hr  (1939) embryo 10-12hr  (2383) embryo 12-14hr  (1874) embryo 14-16hr  (3105) embryo 16-18hr  (2052) embryo 18-20hr  (1271) embryo 20-22hr  (1842) embryo 22-24hr  (1471) larva L1  (2191) larva L2  (1966) larva L3 12hr old  (1658) larva L3 puffstage 1-2  (1007) larva L3 puffstage 3-6  (1631) larva L3 puffstage 7-9  (1936) white prepupae new  (3612) white prepupae 12hr  (2687) white prepupae 24hr  (2413) pupae 2d postWPP  (3555) pupae 3d postWPP  (2087) pupae 4d postWPP  (2848) adult male 01day  (3679) adult male 05day  (4253) adult male 30day  (4893) adult female 01day  (3084) adult female 05day  (2732) adult female 30day  (2966) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4383) embryo 02-04hr  (1800) embryo 04-06hr    1010 embryo 06-08hr  (1917) embryo 08-10hr  (1939) embryo 10-12hr  (2383) embryo 12-14hr  (1874) embryo 14-16hr  (3105) embryo 16-18hr  (2052) embryo 18-20hr    1271 embryo 20-22hr  (1842) embryo 22-24hr  1471 larva L1  (2191) larva L2  (1966) larva L3 12hr old  (1658) larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6  (1631) larva L3 puffstage 7-9  (1936) white prepupae new  (3612) white prepupae 12hr  (2687) white prepupae 24hr  (2413) pupae 2d postWPP  (3555) pupae 3d postWPP  (2087) pupae 4d postWPP  (2848) adult male 01day  (3679) adult male 05day  (4253) adult male 30day  (4893) adult female 01day  (3084) adult female 05day  (2732) adult female 30day  (2966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030343 expression level Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4383) embryo 02-04hr  (1800) embryo 04-06hr  (1010) embryo 06-08hr  (1917) embryo 08-10hr  (1939) embryo 10-12hr  (2383) embryo 12-14hr  (1874) embryo 14-16hr  (3105) embryo 16-18hr  (2052) embryo 18-20hr  (1271) embryo 20-22hr  (1842) embryo 22-24hr  (1471) larva L1  (2191) larva L2  (1966) larva L3 12hr old  (1658) larva L3 puffstage 1-2  (1007) larva L3 puffstage 3-6  (1631) larva L3 puffstage 7-9  (1936) white prepupae new  (3612) white prepupae 12hr  (2687) white prepupae 24hr  (2413) pupae 2d postWPP  (3555) pupae 3d postWPP  (2087) pupae 4d postWPP  (2848) adult male 01day  (3679) adult male 05day  (4253) adult male 30day  (4893) adult female 01day  (3084) adult female 05day  (2732) adult female 30day  (2966) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4383) embryo 02-04hr  1800 embryo 04-06hr    1010 embryo 06-08hr  1917 embryo 08-10hr  1939 embryo 10-12hr  2383 embryo 12-14hr  1874 embryo 14-16hr  (3105) embryo 16-18hr  2052 embryo 18-20hr    1271 embryo 20-22hr  1842 embryo 22-24hr  1471 larva L1  2191 larva L2  1966 larva L3 12hr old  1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6  1631 larva L3 puffstage 7-9  1936 white prepupae new  (3612) white prepupae 12hr  (2687) white prepupae 24hr  2413 pupae 2d postWPP  (3555) pupae 3d postWPP  2087 pupae 4d postWPP  (2848) adult male 01day  (3679) adult male 05day  (4253) adult male 30day  (4893) adult female 01day  (3084) adult female 05day  (2732) adult female 30day  (2966) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4383 embryo 02-04hr    1800 embryo 04-06hr    1010 embryo 06-08hr    1917 embryo 08-10hr    1939 embryo 10-12hr    2383 embryo 12-14hr    1874 embryo 14-16hr    3105 embryo 16-18hr    2052 embryo 18-20hr    1271 embryo 20-22hr    1842 embryo 22-24hr    1471 larva L1    2191 larva L2    1966 larva L3 12hr old    1658 larva L3 puffstage 1-2    1007 larva L3 puffstage 3-6    1631 larva L3 puffstage 7-9    1936 white prepupae new    3612 white prepupae 12hr    2687 white prepupae 24hr    2413 pupae 2d postWPP    3555 pupae 3d postWPP    2087 pupae 4d postWPP    2848 adult male 01day    3679 adult male 05day    4253 adult male 30day    4893 adult female 01day    3084 adult female 05day    2732 adult female 30day    2966 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030343    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030343 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030343 expression level Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030343 expression level Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    22.65 Larval Midgut    126.6 Larval Hindgut    53.6 Larval Malpighian Tubules    88.5 Larval Fat Body    74.1 Larval Salivary Gland    19.1 Larval Trachea    27.55 Larval Carcass    29.4 Adult Head    44.9 Adult Eye    44.15 Adult Brain    31.7 Adult Thoracic-Abdominal Ganglion    30.5 Adult Crop    35.5 Adult Midgut    69.2 Adult Hindgut    58.7 Adult Malpighian Tubules    117 Adult Fat Body    38 Adult Salivary Gland no informative data Adult Heart    61.425 Adult VirginFemale Spermatheca    23 Adult InseminatedFemale Spermatheca    22.1 Adult Ovary    58.1 Adult Testis    249.9 Adult Male Accessory Gland    46 Adult Carcass    53.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    44.9   NA  Eye    44.15   NA  Brain    31.7   22.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    30.5   NA  Crop    35.5   126.6  Midgut    69.2   53.6  Hindgut    58.7   88.5  Malpighian Tubules    117   74.1  Fat Body    38   19.1  Salivary Gland    no informative data   NA  Heart    61.425   27.55  Trachea    NA   NA  VirginFemale Spermatheca    23   NA  InseminatedFemale Spermatheca    22.1   NA  Ovary    58.1   NA  Testis    249.9   NA  Male Accessory Gland    46   29.4  Carcass    53.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030343 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1886-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | maternal effect ATP7ΔP17 lethal | first instar larval stage ATP7ΔP17 lethal | pupal stage, with Scer\GAL4tracheal ATP7Scer\UAS.T:Zzzz\FLAG semi-lethal | third instar larval stage, with Scer\GAL4tracheal ATP7Scer\UAS.T:Zzzz\FLAG viable, with Scer\GAL4pnr-MD237 ATP7GD3322 Other Phenotypes Allele body color defective, with Scer\GAL4Act5C.PI ATP7Scer\UAS.T:Zzzz\FLAG body color defective, with Scer\GAL4pnr-MD237 ATP7GD3322 ATP7Scer\UAS.T:Zzzz\FLAG body color defective, with Scer\GAL4ptc-559.1 ATP7CPC.Scer\UAS.T:Zzzz\FLAG ATP7MBS.Scer\UAS.T:Zzzz\FLAG ATP7TAP.Scer\UAS.T:Zzzz\FLAG body color defective | adult stage, with Scer\GAL4pnr-MD237 ATP7GD3322 ATP7Scer\UAS.T:Zzzz\FLAG visible, with Scer\GAL4pnr-MD237 ATP7GD3322 Phenotype manifest in Allele adult cuticle, with Scer\GAL4pnr-MD237 ATP7GD3322 ATP7Scer\UAS.T:Zzzz\FLAG adult thoracic sensillum, with Scer\GAL4pnr-MD237 ATP7Scer\UAS.T:Zzzz\FLAG adult thorax, with Scer\GAL4pnr-MD237 ATP7Scer\UAS.T:Zzzz\FLAG macrochaeta & mesothoracic tergum, with Scer\GAL4pnr-MD237 ATP7Scer\UAS.T:Zzzz\FLAG mesothoracic tergum ATP7ΔP17 mesothoracic tergum, with Scer\GAL4pnr-MD237 ATP7GD3322 ATP7Scer\UAS.T:Zzzz\FLAG mouth hooks | first instar larval stage ATP7ΔP17 scutellar bristle, with Scer\GAL4ptc-559.1 ATP7Scer\UAS.T:Zzzz\FLAG scutellum, with Scer\GAL4pnr-MD237 ATP7Scer\UAS.T:Zzzz\FLAG scutellum, with Scer\GAL4ptc-559.1 ATP7Scer\UAS.T:Zzzz\FLAG tergite ATP7ΔP17 tergite, with Scer\GAL4Act5C.PI ATP7Scer\UAS.T:Zzzz\FLAG trichogen cell, with Scer\GAL4pnr-MD237 ATP7GD3322 trident, with Scer\GAL4pnr-MD237 ATP7Scer\UAS.T:Zzzz\FLAG trident, with Scer\GAL4ptc-559.1 ATP7MBS.Scer\UAS.T:Zzzz\FLAG ATP7CPC.Scer\UAS.T:Zzzz\FLAG ATP7TAP.Scer\UAS.T:Zzzz\FLAG
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of ATP7 Class Mutagen Stocks Known lesion ATP7EP308 P-element activity 1 -- ATP7EY07895 gain of function allele 1 -- ATP7GS6038 0 -- ATP7ΔP17 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ATP7 Class Mutagen Stocks Known lesion ATP7GD3322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ATP7JF01534 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ATP7KK100396 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ATP7CPC.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis 0 Yes ATP7MBS.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis 0 Yes ATP7Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes ATP7TAP.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis 0 Yes ATP7VDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6243 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3322} NA P{KK100396} NA P{TRiP.JF01534} NA P{UAS-ATP7.CPC.FLAG} NA P{UAS-ATP7.FLAG} NA P{UAS-ATP7.MBS1.FLAG} NA P{UAS-ATP7.TAP.FLAG} NA characterization construct P{VDRC.ATP7.U} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}ATP7EP308 NA P{EPgy2}ATP7EY07895 NA P{GSV3}ATP7GS6038 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
copper ion transmembrane transporter activity inferred from mutant phenotype (Southon et al., 2004)
Biological Process
CV term Evidence References
adult chitin-containing cuticle pigmentation inferred from mutant phenotype (Norgate et al., 2006) cellular copper ion homeostasis inferred from mutant phenotype (Southon et al., 2004) copper ion transport inferred from mutant phenotype (Burke et al., 2004) developmental pigmentation inferred from mutant phenotype (Norgate et al., 2006) larval development inferred from mutant phenotype (Norgate et al., 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Norgate et al., 2006) plasma membrane inferred from direct assay (Norgate et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001757, InterPro:IPR006403, InterPro:IPR018303 (FlyBase Curators et al., 2004-) copper-exporting ATPase activity inferred from sequence or structural similarity with EMBL:U38477 (FlyBase, 1992-) copper ion binding inferred from sequence or structural similarity with UniProtKB:P35670 (Southon et al., 2004)
Biological Process
CV term Evidence References
ATP biosynthetic process inferred from electronic annotation with InterPro:IPR006416 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR006416 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ATP7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58547 DroID - A comprehensive database of gene and protein interactions. • FBgn0030343 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32142
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19483 Dere\GG18448 Dgri\GH24662 Dmoj\GI16124 Dpse\GA22624 Dsec\GM13114 Dsim\GD17052 Dvir\GJ16403 Dwil\GK14532 Dyak\GE15670
Curated drosophilid orthologs	Dpse\GA15105
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003433-PA Aedes aegypti (mosquito) AGAP011754-PA Anopheles gambiae (mosquito) XP_395837.2 Apis mellifera (honey bee) XP_001945540.1 Acyrthosiphon pisum (pea aphid) At5g44790.1 Arabidopsis thaliana (wall cress) 330 Batrachochytrium dendrobatidis (chytrid fungus) 63720 Branchiostoma floridae (lancelet) XP_001891680.1 Brugia malayi (roundworm nematode) BGIBMGA011235-PA Bombyx mori (silk worm) ENSBTAP00000013214 Bos taurus (bovine) CAL0000959 Candida albicans (a form of yeast) CN07284 Caenorhabditis brenneri (small nematode) CBP34775 Caenorhabditis briggsae (nematode) CE26305 Caenorhabditis elegans (worm) ENSCAFP00000025432 Canis familiaris (dog) CAGL0M08602g Candida glabrata (haploid yeast) ENSCINP00000014894 Ciona intestinalis (sea squirt) JA01944 Caenorhabditis japonica (nematode) CMP215C Cyanidioschyzon merolae (red alga) cn14138 Cryptococcus neoformans (yeast-like fungus) CPIJ010121 Culex pipens (mosquito) CPIJ019347 Culex pipens (mosquito) ENSCPOP00000017865 Cavia porcellus (guinea pig) 121438 Chlamidomonas reinhardtii (green alga) RP45150 Caenorhabditis remanei (nematode) ENSCSAVP00000013525 Ciona savignyi (sedentary tunicate) 32189 Capitella spl (polychaete worm) DDB0235190 Dictyostelium discoideum (amoeba) DEHA2G07986g Debaryomyces Hansenii (yeast) 300029 Daphnia pulex (daphnia) ENSDARP00000054976 Danio rerio (zebra fish) ENSECAP00000015148 Equus caballus (horse) NP_415017.1 Escherichia coli K12 (bacteria) ENSGACP00000024000 Gymnopilus aculeatus (mushroom) ENSGALP00000012813 Gallus gallus (chicken) GL50803_39843 Giardia lamblia (flagellated protozoan) 79679 Hypsipyla robusta (cedar shoot borer) ENSP00000355170 Homo sapiens (human) ISCW016768-PA Ixodes scapularis (deer tick) KLLA0F07447g Kluyveromyces lactis (yeast) 136210 Lottia gigantea (owl limpet) LmjF33.2090 Leishmania major (virus) 27752 Monocosta brevicollis (choanoflagellate) ENSMODP00000004937 Monodelphis domestica (gray opossum) ENSMMUP00000016908 Macaca mulatta (rhesus monkey) ENSMUSP00000058840 Mus musculus (house mouse) 87416 Nematostella vectensis (starlet anemone) ENSOANP00000003795 Ornithorynchus anatinus (platypus) ENSORLP00000007175 Oryzias latipes (japanese killifish) LOC_Os04g46940.1 Oryza sativa (asian rice) 28276 Ostreococcus tauri (green alga) PHUM000131-PA Pediculus humanus (human body louse) PP00352 Pristionchus pacificus (nematode) 192723 Physcomitrella patens (moss) ENSPPYP00000022942 Pongo pygmaeus (orangutan) 71434 Phytophthora ramorum (sudden oak death pathogen) 108217 Phytophthora sojae (root rot pathogen) 757010 Populus trichocarpa (black cottonwood) ENSPTRP00000037927 Pan troglodytes (chimpanzee) PVX_098690 Plasmodium vivax (protozoal parasite) ENSRNOP00000054880 Rattus norvegicus (norway rat) 4755765 Sorghum bicolor (sorghum) YBR295W Saccharomyces cerevisiae (budding yeast) Smp_144970 Schistosoma mansoni (trematode parasite) SPBC29A3.01 Schizosaccharomyces pombe (fission yeast) XP_001186876.1 Strongylocentrotus purpuratus (purple sea urchin) 31523 Trichoplax adhaerens (metazoa) XP_968455.2 Tribolium castaneum (red flour beetle) Tc00.1047053503703.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011785 Tetraodon nigroviridis (green spotted pufferfish) 263051 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034454 Takifugu rubripes (pufferfish Takifugu) 3684.m00046 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000044753 Xenopus tropicalis (frog) YALI0D27038g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50107 LH18614 ISCW018777 ISCW016768 FBgn0233239 FBgn0216538 FBgn0203587 FBgn0188624 FBgn0168045 JGI_V11_300029 FBgn0244027 FBgn0150502 FBgn0138873 FBgn0132118 FBgn0110662 FBgn0096490 CPIJ010121 CPIJ019347 BGIBMGA011235 ACYPI000725 GB10214 AGAP011754 AAEL003433 PB24999 PHUM283310 GLEAN_15818
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10114 w1118 P{EP}ATP7EP308 31083 y1 v1; P{TRiP.JF01534}attP2 16866 y1 w67c23 P{EPgy2}ATP7EY07895
VDRC	v108159 P{KK100396}VIE-260B v8315 w1118; P{GD3322}v8315
Genomic Clones ( 2 )
	BACR12H01 BACR46E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE21490
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07213 AT07674 AT07945 AT09824 AT14164 AT14315 AT16608 AT19569 AT24432 AT27429 AT30709 SD03413 SD13765
Other clones	13847 34885 35964 524378 EC28301 EC051835 EC051868 EC052359 EC052876 EC052910 EC053382 EC056260 EK039546 EK145425 EK145812 EN05255 RP004035490 RP004066552 RP004083749 RP004147390 RP004207062 RP004216475 RP004229067 RP004234072 RP004245644 RP004251748 RP004261719 RP004375799 RP004387291 RP004446100 RP004546607
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030343 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32142
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ATP7 CG1886 (Burke, 2004.2.24)
Source for database merge of
Additional comments
Other Comments
	ATP7 acts via copper-regulated trafficking to remove copper from cells. (Burke et al., 2004) Suppression of ATP7 levels by dsRNA interference in S2 cells increases accumulation of radio labelled copper. (Burke et al., 2004) dsRNA made from templates generated with primers directed against this gene used to investigate the role of this gene in copper homoeostasis in S2 cells. (Southon et al., 2004) S2 cells treated with ATP7 dsRNA show significantly increased copper accumulation. (Southon et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132528 RefSeq (Proteins) • NP_572756 DDBJ / EMBL / GenBank • AAF48104 BF490825 Entrez Gene - A searchable database of RefSeq genes. • 32142 UniProtKB/TrEMBL • Q9VYT4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (IPR001757) Heavy metal-associated domain, HMA (IPR006121) Heavy metal-associated domain, copper ion-binding (IPR006122) ATPase, P type, cation/copper-transporter (IPR006403) ATPase, P-type, heavy metal translocating (IPR006416) ATPase, P-type, ATPase-associated domain (IPR008250) Heavy-metal-associated, conserved site (IPR017969) ATPase, P-type phosphorylation site (IPR018303) Haloacid dehalogenase-like hydrolase (IPR005834) HAD-like domain (IPR023214) ATPase, P-type, cytoplasmic domain N (IPR023299) ATPase, P-type, cytoplasmic transduction domain A (IPR023300) ATPase, cation-transporting, domain N (IPR023306)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58547 DroID - A comprehensive database of gene and protein interactions. • FBgn0030343 DRSC - Results from RNAi screens. • FBgn0030343 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030343 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1886-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030343 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32142 InParanoid A subset of ortholog calls from InParanoid. • AAEL003433-PA Aedes aegypti (mosquito) AGAP011754-PA Anopheles gambiae (mosquito) XP_395837.2 Apis mellifera (honey bee) XP_001945540.1 Acyrthosiphon pisum (pea aphid) At5g44790.1 Arabidopsis thaliana (wall cress) 330 Batrachochytrium dendrobatidis (chytrid fungus) 63720 Branchiostoma floridae (lancelet) XP_001891680.1 Brugia malayi (roundworm nematode) BGIBMGA011235-PA Bombyx mori (silk worm) ENSBTAP00000013214 Bos taurus (bovine) CAL0000959 Candida albicans (a form of yeast) CN07284 Caenorhabditis brenneri (small nematode) CBP34775 Caenorhabditis briggsae (nematode) CE26305 Caenorhabditis elegans (worm) ENSCAFP00000025432 Canis familiaris (dog) CAGL0M08602g Candida glabrata (haploid yeast) ENSCINP00000014894 Ciona intestinalis (sea squirt) JA01944 Caenorhabditis japonica (nematode) CMP215C Cyanidioschyzon merolae (red alga) cn14138 Cryptococcus neoformans (yeast-like fungus) CPIJ010121 Culex pipens (mosquito) CPIJ019347 Culex pipens (mosquito) ENSCPOP00000017865 Cavia porcellus (guinea pig) 121438 Chlamidomonas reinhardtii (green alga) RP45150 Caenorhabditis remanei (nematode) ENSCSAVP00000013525 Ciona savignyi (sedentary tunicate) 32189 Capitella spl (polychaete worm) DDB0235190 Dictyostelium discoideum (amoeba) DEHA2G07986g Debaryomyces Hansenii (yeast) 300029 Daphnia pulex (daphnia) ENSDARP00000054976 Danio rerio (zebra fish) ENSECAP00000015148 Equus caballus (horse) NP_415017.1 Escherichia coli K12 (bacteria) ENSGACP00000024000 Gymnopilus aculeatus (mushroom) ENSGALP00000012813 Gallus gallus (chicken) GL50803_39843 Giardia lamblia (flagellated protozoan) 79679 Hypsipyla robusta (cedar shoot borer) ENSP00000355170 Homo sapiens (human) ISCW016768-PA Ixodes scapularis (deer tick) KLLA0F07447g Kluyveromyces lactis (yeast) 136210 Lottia gigantea (owl limpet) LmjF33.2090 Leishmania major (virus) 27752 Monocosta brevicollis (choanoflagellate) ENSMODP00000004937 Monodelphis domestica (gray opossum) ENSMMUP00000016908 Macaca mulatta (rhesus monkey) ENSMUSP00000058840 Mus musculus (house mouse) 87416 Nematostella vectensis (starlet anemone) ENSOANP00000003795 Ornithorynchus anatinus (platypus) ENSORLP00000007175 Oryzias latipes (japanese killifish) LOC_Os04g46940.1 Oryza sativa (asian rice) 28276 Ostreococcus tauri (green alga) PHUM000131-PA Pediculus humanus (human body louse) PP00352 Pristionchus pacificus (nematode) 192723 Physcomitrella patens (moss) ENSPPYP00000022942 Pongo pygmaeus (orangutan) 71434 Phytophthora ramorum (sudden oak death pathogen) 108217 Phytophthora sojae (root rot pathogen) 757010 Populus trichocarpa (black cottonwood) ENSPTRP00000037927 Pan troglodytes (chimpanzee) PVX_098690 Plasmodium vivax (protozoal parasite) ENSRNOP00000054880 Rattus norvegicus (norway rat) 4755765 Sorghum bicolor (sorghum) YBR295W Saccharomyces cerevisiae (budding yeast) Smp_144970 Schistosoma mansoni (trematode parasite) SPBC29A3.01 Schizosaccharomyces pombe (fission yeast) XP_001186876.1 Strongylocentrotus purpuratus (purple sea urchin) 31523 Trichoplax adhaerens (metazoa) XP_968455.2 Tribolium castaneum (red flour beetle) Tc00.1047053503703.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011785 Tetraodon nigroviridis (green spotted pufferfish) 263051 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034454 Takifugu rubripes (pufferfish Takifugu) 3684.m00046 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000044753 Xenopus tropicalis (frog) YALI0D27038g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32142 modMine - Data generated by the modENCODE project. • FBgn0030343 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50107 LH18614 ISCW018777 ISCW016768 FBgn0233239 FBgn0216538 FBgn0203587 FBgn0188624 FBgn0168045 JGI_V11_300029 FBgn0244027 FBgn0150502 FBgn0138873 FBgn0132118 FBgn0110662 FBgn0096490 CPIJ010121 CPIJ019347 BGIBMGA011235 ACYPI000725 GB10214 AGAP011754 AAEL003433 PB24999 PHUM283310 GLEAN_15818
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	ATP7 (Cao et al., 2008, Southon et al., 2008, Doumanis et al., 2009, Wasbrough et al., 2010) CG1886 (Southon et al., 2004, Inlow and Restifo, 2004, Driscoll and Gerstbrein, 2003, Cui et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2008) DmATP7 (Southon et al., 2004, Norgate et al., 2005, Allan et al., 2007, Norgate et al., 2006, Balamurugan et al., 2007, Binks et al., 2010, Chang et al., 2011, Bahadorani et al., 2010) dmATP7 (Burke et al., 2004)
Name Synonym	ATP7
Secondary FlyBase IDs
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Lye et al., 2011, PLoS ONE 6(10): e26867 Detection of genetically altered copper levels in Drosophila tissues by synchrotron x-ray fluorescence microscopy. [FBrf0216605] Bahadorani et al., 2010, Dis. Model Mech. 3(1-2): 84--91 A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. [FBrf0209723] Binks et al., 2010, J. Biol. Inorg. Chem. 15(4): 621--628 Tissue-specific interplay between copper uptake and efflux in Drosophila. [FBrf0210589] Show all research papers ...