FB2020_06, released Dec 22, 2020

Gene: Dmel\CG1847

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General Information
Symbol
Dmel\CG1847
Species
D. melanogaster
Name
Annotation Symbol
CG1847
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030345
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
10F2-10F2
Sequence location
X:11,869,170..11,871,168 [+]
Recombination map

1-37

RefSeq locus
NC_004354 REGION:11869170..11871168
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FK506-BINDING PROTEINS -
FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CG1847 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.51

Double stop-codon suppression (UAG, UAG) postulated; FBrf0243886.

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
gene_with_stop_codon_read_through
(FlyBase Genome Annotators, 2019-, Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG1847-RA
FBtr0073567
NM_132530
1776
320
CG1847-RC
FBtr0330413
NM_167311
1776
342
CG1847-RD
FBtr0479842
NM_001382046
1776
390
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG1847-PA
FBpp0073411
37.2
320
7.50
NP_572758
AAF48106
CG1847-PC
FBpp0303439
39.7
342
7.79
NP_727574
AAN09304
CG1847-PD
FBpp0428178
45.0
390
8.25
QJC18367
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG1847 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 11 -- 12
procrystal cell
(Fisher et al., 2012)
embryonic stage 13 -- 16
crystal cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG1847 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG1847
Transgenic constructs containing regulatory region of CG1847
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AIP
14 of 15
Yes
Yes
 
13  
Hsap\AIPL1
12 of 15
No
Yes
Hsap\SPAG1
1 of 15
No
No
Hsap\TOMM34
1 of 15
No
No
Hsap\TOMM70
1 of 15
No
No
3  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aip
14 of 15
Yes
Yes
Mmus\Aipl1
11 of 15
No
Yes
Mmus\Spag1
1 of 15
No
No
Mmus\Tomm34
1 of 15
No
No
Mmus\Tomm70a
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Aip
13 of 13
Yes
Yes
Rnor\Aipl1
12 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\aip
13 of 12
Yes
Yes
Xtro\aipl1
10 of 12
No
Yes
Xtro\spag1
1 of 12
No
No
Xtro\tomm70
1 of 12
No
No
Danio rerio (Zebrafish) (5)
Drer\aip
12 of 15
Yes
Yes
Drer\aipl1
12 of 15
Yes
Yes
Drer\LOC100534741
6 of 15
No
Yes
Drer\tomm34
1 of 15
No
No
Drer\tomm70a
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\aipr-1
14 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\PAS1
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\TOM70
1 of 15
Yes
No
Scer\TOM71
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\tom70
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BIG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007289
Drosophila simulans
Dsim\GD17053
Drosophila sechellia
Dsec\GM13115
Drosophila erecta
Dere\GG18449
Drosophila yakuba
Dyak\GE15671
Drosophila ananassae
Dana\GF21573
Drosophila pseudoobscura pseudoobscura
Dpse\GA14946
Drosophila persimilis
Dper\GL20154
Drosophila willistoni
Dwil\GK25427
Drosophila virilis
Dvir\GJ19310
Drosophila mojavensis
Dmoj\GI14657
Drosophila grimshawi
Dgri\GH11919
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507T5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007604
Glossina morsitans
Tsetse fly
Gmor\GMOY002873
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10688
Mayetiola destructor
Hessian fly
Mdes\Mdes006154
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012809
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009021
Anopheles darlingi
American malaria mosquito
Adar\ADAC002551
Anopheles gambiae
Malaria mosquito
Agam\AGAP011684
Anopheles gambiae
Malaria mosquito
Agam\AGAP000725
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018866
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09RO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005285
Danaus plexippus
Monarch butterfly
Dple\DPOGS207722-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015311
Apis florea
Little honeybee
Aflo\2261016148
Apis mellifera
Western honey bee
Amel\Ame.7893
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13915
Bombus terrestris
Buff-tailed bumblebee
Bter\15215380
Linepithema humile
Argentine ant
Lhum\LH24805
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002aec
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006790
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09759
Tribolium castaneum
Red flour beetle
Tcas\TC002337
Pediculus humanus
Human body louse
Phum\PHUM016580
Rhodnius prolixus
Kissing bug
Rpro\RPRC001971
Cimex lectularius
Bed bug
Clec\CLEC001828
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002873
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10664
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09NR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009222
Ixodes scapularis
Black-legged tick
Isca\ISCW018497
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81028.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81027.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g04470
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_325741
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C69 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aip
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004992
Gallus gallus
Domestic chicken
Ggal\AIPL1
Gallus gallus
Domestic chicken
Ggal\AIP
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Spag1
1 of 10
Tom70
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
AIP; aryl hydrocarbon receptor interacting protein
14 of 15
605555
 
AIPL1; aryl hydrocarbon receptor interacting protein like 1
12 of 15
604392
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
CG1847
Hsap\AIP
(Aflorei et al., 2018)
Interactions
Summary of Physical Interactions
esyN Network Diagram
Interactions Browser
Summary of Genetic Interactions
esyN Network Diagram
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map

1-37

Cytogenetic map
10F2-10F2
Sequence location
X:11,869,170..11,871,168 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
10F2-10F2
Limits computationally determined from genome sequence between P{EP}ATP7EP308 and P{EP}EP1451&P{EP}EP1629
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

1-37

(FlyBase, 2016)

1-36.8

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (6)
Genomic Clones (9)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Additional comments
Other Comments
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 45 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (1)
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (39)