FlyBase Gene Report: Dmel\CG1847

FK506-BINDING PROTEINS -: FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CG1847 or the JBrowse view of Dmel\CG1847 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG1847-RA

FBtr0073567

NM_132530

1776

320

CG1847-RC

FBtr0330413

NM_167311

1776

342

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG1847-PA

FBpp0073411

37.2

320

7.50

NP_572758

AAF48106

CG1847-PC

FBpp0303439

39.7

342

7.79

NP_727574

AAN09304

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG1847 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG1847_1

Linkouts

Gene Ontology (1 term)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein binding

inferred from biological aspect of ancestor with PANTHER:PTN000133437

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 5 -- 7

amnioserosa anlage

(Dominguez et al., 2016)

dorsal ectoderm

(Dominguez et al., 2016)

embryonic stage 11 -- 12

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

crystal cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG1847 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG1847

View exonic expression by tissue for Dmel\CG1847

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030345

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030345

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1847-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1847

Flygut - An atlas of the Drosophila adult midgut

FBgn0030345

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG1847

Stages(s) 1-3
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG1847

Transgenic constructs containing regulatory region of CG1847

Deletions and Duplications ( 1 )

Disrupted in

Df(1)Exel6243

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

CG1847^exon1-3

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG1847^GD9582

viable, with Scer\GAL4^Mef2.PR

CG1847^GD9582

viable, with Scer\GAL4^pnr-MD237

CG1847^GD9582

viable, with Scer\GAL4^tin.CΔ4

CG1847^GD9582

Other Phenotypes

Allele

pain response defective | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG1847^GD9582

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\AIP

14 of 15

Yes

Hsap\AIPL1

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Aip

14 of 15

Yes

Mmus\Aipl1

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (15)

Rnor\Aip

13 of 13

Yes

Rnor\Aipl1

12 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Fkbp14

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\aip

12 of 12

Yes

Xtro\aipl1

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (18)

Drer\aip

14 of 15

Yes

Drer\aipl1

12 of 15

Yes

Drer\LOC100534741

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\fkbp10b

1 of 15

Drer\fkbp11

1 of 15

Drer\si:ch73-199g24.2

1 of 15

Drer\si:ch211-208h16.4

1 of 15

Drer\tomm34

1 of 15

Drer\tomm70a

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\aipr-1

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (14)

Atha\PAS1

2 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Yes

Atha\ROF1

1 of 9

Atha\TPR6

1 of 9

Yes

Atha\TWD1

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\FPR1

1 of 15

Yes

Scer\FPR2

1 of 15

Yes

Scer\FPR3

1 of 15

Yes

Scer\FPR4

1 of 15

Yes

Scer\TOM70

1 of 15

Yes

Scer\TOM71

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\fkbp39

1 of 12

Yes

Spom\fkh1

1 of 12

Yes

Spom\SPAC27F1.06c

1 of 12

Yes

Spom\tom70

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BIG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\CG1847

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14946

Drosophila persimilis

Dper\GL20154

Drosophila willistoni

Dwil\GK25427

Drosophila virilis

Dvir\GJ19310

Drosophila mojavensis

Dmoj\GI14657

Drosophila grimshawi

Dgri\GH11919

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507T5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17007604

Glossina morsitans

Tsetse fly

Gmor\GMOY002873

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10688

Mayetiola destructor

Hessian fly

Mdes\Mdes006154

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012809

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009021

Anopheles darlingi

American malaria mosquito

Adar\ADAC002551

Anopheles gambiae

Malaria mosquito

Agam\AGAP011684

Anopheles gambiae

Malaria mosquito

Agam\AGAP000725

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018866

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09RO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005285

Danaus plexippus

Monarch butterfly

Dple\DPOGS207722-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015311

Apis florea

Little honeybee

Aflo\2261016148

Apis mellifera

Western honey bee

Amel\Ame.7893

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13915

Bombus terrestris

Buff-tailed bumblebee

Bter\15215380

Linepithema humile

Argentine ant

Lhum\LH24805

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002aec

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006790

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09759

Tribolium castaneum

Red flour beetle

Tcas\TC002337

Pediculus humanus

Human body louse

Phum\PHUM016580

Rhodnius prolixus

Kissing bug

Rpro\RPRC001971

Cimex lectularius

Bed bug

Clec\CLEC001828

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002873

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10664

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09NR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009222

Ixodes scapularis

Black-legged tick

Isca\ISCW018497

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81028.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81027.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g04470

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_325741

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C69 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Aip

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004992

Gallus gallus

Domestic chicken

Ggal\AIPL1

Gallus gallus

Domestic chicken

Ggal\AIP

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

shu

1 of 10

Spag1

1 of 10

Tom70

1 of 10

zda

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

pituitary adenoma 1, multiple types

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

AIP; aryl hydrocarbon receptor interacting protein

model of growth hormone secreting pituitary adenoma

IEA

(FlyBase, 2019-)

AIPL1; aryl hydrocarbon receptor interacting protein like 1

model of Leber congenital amaurosis 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AIP; aryl hydrocarbon receptor interacting protein

14 of 15

605555

PITUITARY ADENOMA 1, MULTIPLE TYPES; PITA1

growth hormone secreting pituitary adenoma

AIPL1; aryl hydrocarbon receptor interacting protein like 1

12 of 15

604392

LEBER CONGENITAL AMAUROSIS 4; LCA4

Leber congenital amaurosis 4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

CG1847

Hsap\AIP

(Aflorei et al., 2018)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58549

DroID - A comprehensive database of gene and protein interactions.

FBgn0030345

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32144

MIST (protein-protein) - An integrated Molecular Interaction Database

CG1847

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-37

Cytogenetic map

10F2-10F2

Sequence location

X:11,869,170..11,871,168 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10F2-10F2

Limits computationally determined from genome sequence between P{EP}ATP7^EP308 and P{EP}EP1451&P{EP}EP1629

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-37

(FlyBase, 2016)

1-36.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

32600

w^* P{EP}CG1847^G1839

76425

y¹ sc^* v¹ sev²¹; P{TKO.GS00595}attP40

77233

y¹ sc^* v¹ sev²¹; P{TOE.GS01047}attP40

44490

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02409}attP2

VDRC

v43701

w¹¹¹⁸; P{GD9582}v43701

v43702

w¹¹¹⁸; P{GD9582}v43702/TM3

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

DPiM_HL02936

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030345

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030345

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32144

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32144

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030345

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030345

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG1847_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1847

Flygut - An atlas of the Drosophila adult midgut

FBgn0030345

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32144

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002337

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1847

modMine - A data warehouse for the modENCODE project

FBgn0030345

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aryl hydrocarbon receptor signalling

Linkouts

BioGRID - A database of protein and genetic interactions.

58549

DPiM - Drosophila Protein interaction map

FBgn0030345

DroID - A comprehensive database of gene and protein interactions.

FBgn0030345

DRSC - Results frm RNAi screens

FBgn0030345

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030345

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1847-RA

FlyMine - An integrated database for Drosophila genomics

FBgn0030345

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32144

MIST (protein-protein) - An integrated Molecular Interaction Database

CG1847

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Aryl hydrocarbon receptor signalling

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG1847

(Aflorei et al., 2018, Ghartey-Kwansah et al., 2018, Transgenic RNAi Project members, 2017-, Liang et al., 2014, Luck et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Preall et al., 2012, Jungreis et al., 2011, Buffin and Gho, 2010, Ni et al., 2010.12.1, Gilfillan et al., 2007)

Name Synonyms

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (36)

Report Sections

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