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Gene Dmel\regucalcin

General Information
Symbol	Dmel\regucalcin	Species	D. melanogaster
Name	regucalcin	Annotation symbol	CG1803
Feature type	protein_coding_gene	FlyBase ID	FBgn0030362
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11A1-11A1	Sequence location	X:11,906,410..11,911,409 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene regucalcin is referred to in FlyBase by the symbol Dmel\regucalcin (CG1803, FBgn0030362). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: multicellular organism reproduction. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: SMP-30/Gluconolaconase/LRE-like region; Senescence marker protein-30 (SMP-30); Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, adult hindgut, adult salivary gland, adult ovary. Gene sequence location is X:11906410..11911409.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11A1-11A1   Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138EP1313
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\regucalcin for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) regucalcin-RA FBtr0073575  NM_167314   1151   303 regucalcin-RB FBtr0073577  NM_167315   1459   303 regucalcin-RC FBtr0073576  NM_132547   1097   303 regucalcin-RD FBtr0073578  NM_167316   1083   319
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein regucalcin-PA   FBpp0073419   33.6   303   6.31     NP_727586   AAF48129 regucalcin-PB   FBpp0073421   33.6   303   6.31     NP_727587   AAF48128 regucalcin-PC   FBpp0073420   33.6   303   6.31     NP_572775   AAF48130 regucalcin-PD   FBpp0073422   35.4   319   6.30     NP_727588   AAN09306
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Six-bladed beta-propeller, TolB-like (IPR011042) Senescence marker protein-30 (SMP-30) (IPR005511) SMP-30/Gluconolaconase/LRE-like region (IPR013658)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392874   AA699076   AE014298 AAF48128   AE014298 AAF48129   AE014298 AAF48130   AE014298 AAN09306   AB036904 BAA99283   AI063226   AI063263   AI109687   AI110120   AI110146   AI110189   AI134722   AI257222   AI257474   AI258383   AI258770   AI258889   AI259491   AI260532   AI292804   AI293805   AI295429   AI296947   AI297845   AI386880   AI405579   AI517086   AI517186   AI517746   AI532351   AW944328   AY118643 AAM50012   AY232162   BF489597   BF496374   BF497428   BF500523   BG633801   BG635960   BG637530   BG638003   BG640495   BI142198   BI173641   BI352553   BI353121   BI355598   BI570657   BI570670   BI570696   BI570939   BI571525   BI571755   BI572282   BI572299   BI574503   BI583562   BI583758   BI585839   BI590770   BI591081   BI591290   BI591673   BI606925   BI609643   BI610742   BI627943   BI629811   BI633862   BI637013   BI640742   BT099564   CA803575   CA806644   CA806934   CA807312   CA807768   CK131968   CK657144   CK657676   CK658491   CK659024   CK659107   CK659162   CK659226   CK659384   CK659709   CK660024   CK660327   CK661460   CK661790   CK661952   CK662172   CO152713   CO152835   CO153304   CO154059   CO154113   CO154542   CO154659   CO154761   CO155628   CO156197   CO156223   CO156260   CO156767   CO182611   CO184174   CO185139   CO193380   CO265590   CO269190   CO270244   CO294741   CO304717   CO317590   CO319139   CO333366   CO335676   CO335864   CO336037   CO336192   CO336641   CO337548   CO338117   CO338545   CO338867   CO342338   EC064121   EC070880   EC084292   EC089915   EC197225   EC220436   EC238657   EC239859   EC249053   EC260484   EC260812   EC261118   EC262294   EC262570   EC262606   EC263022   EC263080   EC263563   EC263772   EC264471   EC264615   EC264834   EC265602   EC265975   EC266510   EC266896   EC267265   EC267589   EC267726   EC267743   EC267936   EL871718   EL871719   EL871980   EV595729
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q76NR6 Q9VYR1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) extracellular space inferred from direct assay (Findlay et al., 2009, Findlay et al., 2008) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult midgut, adult hindgut, adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female    113 head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male    107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae    142 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    363 fat body, white prepupae    81 fat body, pupae P8    316 carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male    293 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3  (53) central nervous system, pupae P8    9 head, virgin 1-day female  (95) head, virgin 4-day female  (66) head, virgin 20-day female  (113) head, mated 1-day female  (76) head, mated 4-day female  (90) head, mated 20-day female  (96) head, mated 1-day male  (92) head, mated 4-day male  (107) head, mated 20-day male  (99) salivary gland, larvae L3 wandering  (50) salivary gland, white prepupae  (142) digestive system, larvae L3 wandering  (38) digestive system, 1-day adult  (56) digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (363) fat body, white prepupae  (81) fat body, pupae P8  (316) carcass, larvae L3 wandering  (97) carcass, 1-day adult  (87) carcass, 4-day adult  (48) carcass, 20-day adult  (35) ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male  (96) accessory gland, mated 4-day male  (293) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female  (113) head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male  107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae  (142) digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (363) fat body, white prepupae    81 fat body, pupae P8  (316) carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male  (293) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female    113 head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male    107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae    142 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    363 fat body, white prepupae    81 fat body, pupae P8    316 carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male    293 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female    113 head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male    107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae    142 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    363 fat body, white prepupae    81 fat body, pupae P8    316 carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male    293 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3  (53) central nervous system, pupae P8    9 head, virgin 1-day female  (95) head, virgin 4-day female  (66) head, virgin 20-day female  (113) head, mated 1-day female  (76) head, mated 4-day female  (90) head, mated 20-day female  (96) head, mated 1-day male  (92) head, mated 4-day male  (107) head, mated 20-day male  (99) salivary gland, larvae L3 wandering  (50) salivary gland, white prepupae  (142) digestive system, larvae L3 wandering  (38) digestive system, 1-day adult  (56) digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (363) fat body, white prepupae  (81) fat body, pupae P8  (316) carcass, larvae L3 wandering  (97) carcass, 1-day adult  (87) carcass, 4-day adult  (48) carcass, 20-day adult  (35) ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male  (96) accessory gland, mated 4-day male  (293) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female  113 head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male  107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae  142 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering  (363) fat body, white prepupae    81 fat body, pupae P8  (316) carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male  (293) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    53 central nervous system, pupae P8    9 head, virgin 1-day female    95 head, virgin 4-day female    66 head, virgin 20-day female    113 head, mated 1-day female    76 head, mated 4-day female    90 head, mated 20-day female    96 head, mated 1-day male    92 head, mated 4-day male    107 head, mated 20-day male    99 salivary gland, larvae L3 wandering    50 salivary gland, white prepupae    142 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    56 digestive system, 4-day adult    22 digestive system, 20-day adult    19 fat body, larvae L3 wandering    363 fat body, white prepupae    81 fat body, pupae P8    316 carcass, larvae L3 wandering    97 carcass, 1-day adult    87 carcass, 4-day adult    48 carcass, 20-day adult    35 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    96 accessory gland, mated 4-day male    293 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1    297 larva L2    523 larva L3 12hr old    567 larva L3 puffstage 1-2    922 larva L3 puffstage 3-6    521 larva L3 puffstage 7-9    304 white prepupae new    441 white prepupae 12hr    675 white prepupae 24hr    297 pupae 2d postWPP    154 pupae 3d postWPP    58 pupae 4d postWPP    296 adult male 01day    231 adult male 05day    174 adult male 30day    135 adult female 01day    152 adult female 05day    54 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr  (28) embryo 10-12hr  (54) embryo 12-14hr  (30) embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr  (57) embryo 20-22hr  (94) embryo 22-24hr  (97) larva L1  (297) larva L2  (523) larva L3 12hr old  (567) larva L3 puffstage 1-2  (922) larva L3 puffstage 3-6  (521) larva L3 puffstage 7-9  (304) white prepupae new  (441) white prepupae 12hr  (675) white prepupae 24hr  (297) pupae 2d postWPP  (154) pupae 3d postWPP  (58) pupae 4d postWPP  (296) adult male 01day  (231) adult male 05day  (174) adult male 30day  (135) adult female 01day  (152) adult female 05day  (54) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1  (297) larva L2  (523) larva L3 12hr old  (567) larva L3 puffstage 1-2  (922) larva L3 puffstage 3-6  (521) larva L3 puffstage 7-9  (304) white prepupae new  (441) white prepupae 12hr  (675) white prepupae 24hr  (297) pupae 2d postWPP  (154) pupae 3d postWPP    58 pupae 4d postWPP  (296) adult male 01day  (231) adult male 05day  (174) adult male 30day  (135) adult female 01day  (152) adult female 05day    54 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1    297 larva L2    523 larva L3 12hr old    567 larva L3 puffstage 1-2    922 larva L3 puffstage 3-6    521 larva L3 puffstage 7-9    304 white prepupae new    441 white prepupae 12hr    675 white prepupae 24hr    297 pupae 2d postWPP    154 pupae 3d postWPP    58 pupae 4d postWPP    296 adult male 01day    231 adult male 05day    174 adult male 30day    135 adult female 01day    152 adult female 05day    54 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1    297 larva L2    523 larva L3 12hr old    567 larva L3 puffstage 1-2    922 larva L3 puffstage 3-6    521 larva L3 puffstage 7-9    304 white prepupae new    441 white prepupae 12hr    675 white prepupae 24hr    297 pupae 2d postWPP    154 pupae 3d postWPP    58 pupae 4d postWPP    296 adult male 01day    231 adult male 05day    174 adult male 30day    135 adult female 01day    152 adult female 05day    54 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr  28 embryo 10-12hr  (54) embryo 12-14hr  30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr  (57) embryo 20-22hr  (94) embryo 22-24hr  (97) larva L1  (297) larva L2  (523) larva L3 12hr old  (567) larva L3 puffstage 1-2  (922) larva L3 puffstage 3-6  (521) larva L3 puffstage 7-9  (304) white prepupae new  (441) white prepupae 12hr  (675) white prepupae 24hr  (297) pupae 2d postWPP  (154) pupae 3d postWPP  (58) pupae 4d postWPP  (296) adult male 01day  (231) adult male 05day  (174) adult male 30day  (135) adult female 01day  (152) adult female 05day  (54) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1  (297) larva L2  (523) larva L3 12hr old  (567) larva L3 puffstage 1-2  (922) larva L3 puffstage 3-6  (521) larva L3 puffstage 7-9  (304) white prepupae new  (441) white prepupae 12hr  (675) white prepupae 24hr  (297) pupae 2d postWPP  (154) pupae 3d postWPP    58 pupae 4d postWPP  (296) adult male 01day  (231) adult male 05day  (174) adult male 30day  135 adult female 01day  (152) adult female 05day    54 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    28 embryo 10-12hr    54 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    57 embryo 20-22hr    94 embryo 22-24hr    97 larva L1    297 larva L2    523 larva L3 12hr old    567 larva L3 puffstage 1-2    922 larva L3 puffstage 3-6    521 larva L3 puffstage 7-9    304 white prepupae new    441 white prepupae 12hr    675 white prepupae 24hr    297 pupae 2d postWPP    154 pupae 3d postWPP    58 pupae 4d postWPP    296 adult male 01day    231 adult male 05day    174 adult male 30day    135 adult female 01day    152 adult female 05day    54 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    242 Schneider line 2 Sg4    291 embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3    816 leg disc CME L1    203 wing disc CME-W2    136 wing disc ML-DmD8    100 wing disc ML-DmD9    186 wing disc ML-DmD16-c3    376 wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    424 mixed discs ML-DmD4-c1    937 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    985 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (242) Schneider line 2 Sg4  (291) embryonic 1182-4H  (30) embryonic GM2  (88) embryonic Kc167  (34) embryonic S1  26 embryonic S3  (816) leg disc CME L1  (203) wing disc CME-W2  (136) wing disc ML-DmD8  (100) wing disc ML-DmD9  (186) wing disc ML-DmD16-c3  (376) wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (424) mixed discs ML-DmD4-c1  (937) CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2  (88) tumorous blood cells mbn2  (985) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (242) Schneider line 2 Sg4  (291) embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3  (816) leg disc CME L1  (203) wing disc CME-W2  (136) wing disc ML-DmD8    100 wing disc ML-DmD9  (186) wing disc ML-DmD16-c3  (376) wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5  (424) mixed discs ML-DmD4-c1  (937) CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2  (985) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    242 Schneider line 2 Sg4    291 embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3    816 leg disc CME L1    203 wing disc CME-W2    136 wing disc ML-DmD8    100 wing disc ML-DmD9    186 wing disc ML-DmD16-c3    376 wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    424 mixed discs ML-DmD4-c1    937 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    985 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    242 Schneider line 2 Sg4    291 embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3    816 leg disc CME L1    203 wing disc CME-W2    136 wing disc ML-DmD8    100 wing disc ML-DmD9    186 wing disc ML-DmD16-c3    376 wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    424 mixed discs ML-DmD4-c1    937 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    985 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (242) Schneider line 2 Sg4  (291) embryonic 1182-4H  30 embryonic GM2  (88) embryonic Kc167  (34) embryonic S1  26 embryonic S3  (816) leg disc CME L1  (203) wing disc CME-W2  (136) wing disc ML-DmD8  (100) wing disc ML-DmD9  (186) wing disc ML-DmD16-c3  (376) wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11  (57) antennal disc ML-DmD20-c5  (424) mixed discs ML-DmD4-c1  (937) CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2  (88) tumorous blood cells mbn2  (985) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (242) Schneider line 2 Sg4  (291) embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3  (816) leg disc CME L1  (203) wing disc CME-W2  136 wing disc ML-DmD8    100 wing disc ML-DmD9  (186) wing disc ML-DmD16-c3  (376) wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5  (424) mixed discs ML-DmD4-c1  (937) CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2  (985) ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    242 Schneider line 2 Sg4    291 embryonic 1182-4H    30 embryonic GM2    88 embryonic Kc167    34 embryonic S1    26 embryonic S3    816 leg disc CME L1    203 wing disc CME-W2    136 wing disc ML-DmD8    100 wing disc ML-DmD9    186 wing disc ML-DmD16-c3    376 wing disc ML-DmD21    14 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    57 antennal disc ML-DmD20-c5    424 mixed discs ML-DmD4-c1    937 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    88 tumorous blood cells mbn2    985 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult    172 Cadmium 50 mM 6 hrs, larvae L3    606 Cadmium 50 mM 12 hrs, larvae L3    479 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    212 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    177 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    340 Ethanol 10% 3 hrs, larvae L3    374 Caffeine 1.5 mg/ml 4 hrs, larvae L3    303 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3    356 Rotenone 8 μg 12 hrs, larvae L3    374 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  (33) heat shock, 4-day adult  (172) Cadmium 50 mM 6 hrs, larvae L3  (606) Cadmium 50 mM 12 hrs, larvae L3  (479) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3  (212) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (177) Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3  (340) Ethanol 10% 3 hrs, larvae L3  (374) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (303) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (52) Rotenone 2 μg 12 hrs, larvae L3  (356) Rotenone 8 μg 12 hrs, larvae L3  (374) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult  (172) Cadmium 50 mM 6 hrs, larvae L3  (606) Cadmium 50 mM 12 hrs, larvae L3  (479) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3  (212) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (177) Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3  (340) Ethanol 10% 3 hrs, larvae L3  (374) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (303) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3  (356) Rotenone 8 μg 12 hrs, larvae L3  (374) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult    172 Cadmium 50 mM 6 hrs, larvae L3    606 Cadmium 50 mM 12 hrs, larvae L3    479 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    212 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    177 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    340 Ethanol 10% 3 hrs, larvae L3    374 Caffeine 1.5 mg/ml 4 hrs, larvae L3    303 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3    356 Rotenone 8 μg 12 hrs, larvae L3    374 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult    172 Cadmium 50 mM 6 hrs, larvae L3    606 Cadmium 50 mM 12 hrs, larvae L3    479 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    212 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    177 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    340 Ethanol 10% 3 hrs, larvae L3    374 Caffeine 1.5 mg/ml 4 hrs, larvae L3    303 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3    356 Rotenone 8 μg 12 hrs, larvae L3    374 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  (33) heat shock, 4-day adult  (172) Cadmium 50 mM 6 hrs, larvae L3  (606) Cadmium 50 mM 12 hrs, larvae L3  (479) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3  (212) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (177) Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3  (340) Ethanol 10% 3 hrs, larvae L3  (374) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (303) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  (36) Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  (52) Rotenone 2 μg 12 hrs, larvae L3  (356) Rotenone 8 μg 12 hrs, larvae L3  (374) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult  (172) Cadmium 50 mM 6 hrs, larvae L3  (606) Cadmium 50 mM 12 hrs, larvae L3  (479) Cadmium 50 mM 48 hrs, 4-day adult  (220) Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3  (212) Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3  (177) Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3  (340) Ethanol 10% 3 hrs, larvae L3  (374) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (303) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3  (356) Rotenone 8 μg 12 hrs, larvae L3  (374) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    33 heat shock, 4-day adult    172 Cadmium 50 mM 6 hrs, larvae L3    606 Cadmium 50 mM 12 hrs, larvae L3    479 Cadmium 50 mM 48 hrs, 4-day adult    220 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    212 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    177 Zinc 4.5 mM 48 hrs, 4-day adult    24 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    340 Ethanol 10% 3 hrs, larvae L3    374 Caffeine 1.5 mg/ml 4 hrs, larvae L3    303 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    36 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    52 Rotenone 2 μg 12 hrs, larvae L3    356 Rotenone 8 μg 12 hrs, larvae L3    374 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_04 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • SD03837 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030362 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC18536;CG1803-RA;HDC18536
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU regucalcinKK112078 viable regucalcinf06398 viable, with Scer\GAL4pnr-MD237 regucalcinGD8809 Sterility Allele fertile regucalcinf06398 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of regucalcin Class Mutagen Stocks Known lesion regucalcinf06398 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of regucalcin Class Mutagen Stocks Known lesion regucalcinGD8809 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes regucalcinHMS01598 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes regucalcinKK112078 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes regucalcinNIG.1803R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8809} NA P{KK112078} NA P{NIG.1803R} NA P{TRiP.HMS01598} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}regucalcinf06398 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
multicellular organism reproduction inferred from expression pattern (Findlay et al., 2009, Findlay et al., 2008)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004) extracellular space inferred from direct assay (Findlay et al., 2009, Findlay et al., 2008) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
regucalcin - 14-3-3ε experimental knowledge based (Guruharsha et al., 2011) regucalcin - 14-3-3ζ experimental knowledge based (Guruharsha et al., 2011) regucalcin - ATPsyn-β experimental knowledge based (Guruharsha et al., 2011) regucalcin - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Acon anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Act88F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Adh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Adk2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) regucalcin - Akap200 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Ald anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - AnxB10 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG10184 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG10638 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG10802 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG11236 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG11267 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG11796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG12200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG12203 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG12796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG14715 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG1532 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) regucalcin - CG15818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG16817 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG17470 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG18081 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG2608 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG2852 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG2862 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG3038 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG31712 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG34172 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG3955 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG4091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG4598 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG5045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG5174 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG5500 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG5646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG5844 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG5986 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG6084 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG6171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG7049 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG7834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG8036 experimental knowledge based (Guruharsha et al., 2011) regucalcin - CG8117 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) regucalcin - CG8132 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG8568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG8924 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - CG8993 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - Ciao1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Clic experimental knowledge based (Guruharsha et al., 2011) regucalcin - CoIV anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Cpr11B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Crc experimental knowledge based (Guruharsha et al., 2011) regucalcin - Cyp1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Cyp4d2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - DNaseII anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Df31 experimental knowledge based (Guruharsha et al., 2011) regucalcin - E(spl)mγ-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - ERp60 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Eb1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Ef2b experimental knowledge based (Guruharsha et al., 2011) regucalcin - EndoGI experimental knowledge based (Guruharsha et al., 2011) regucalcin - Eno anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Gapdh1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Gapdh2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Gdi experimental knowledge based (Guruharsha et al., 2011) regucalcin - Gpdh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Gpo-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - GstE6 experimental knowledge based (Guruharsha et al., 2011) regucalcin - GstO3 experimental knowledge based (Guruharsha et al., 2011) regucalcin - GstS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Gαi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Hop experimental knowledge based (Guruharsha et al., 2011) regucalcin - Hsc70Cb experimental knowledge based (Guruharsha et al., 2011) regucalcin - Hsp60 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Hsp83 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Inos experimental knowledge based (Guruharsha et al., 2011) regucalcin - Jon65Aiv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Mdh2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - Mhc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Mip anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - Mlc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Mlc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Moe experimental knowledge based (Guruharsha et al., 2011) regucalcin - Nacα anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - Ndfip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Nlp experimental knowledge based (Guruharsha et al., 2011) regucalcin - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Oscp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - PI31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Pdi experimental knowledge based (Guruharsha et al., 2011) regucalcin - Pex16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Pgd experimental knowledge based (Guruharsha et al., 2011) regucalcin - Pgk experimental knowledge based (Guruharsha et al., 2011) regucalcin - Pglym78 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Prosα1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Prosα4 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Rae1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - RhoGDI experimental knowledge based (Guruharsha et al., 2011) regucalcin - RpS21 experimental knowledge based (Guruharsha et al., 2011) regucalcin - RpS5a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - SdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Sh3β experimental knowledge based (Guruharsha et al., 2011) regucalcin - Slbp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) regucalcin - Snp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Sod experimental knowledge based (Guruharsha et al., 2011) regucalcin - Spc25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Strn-Mlck anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - TER94 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Tango2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Tctp experimental knowledge based (Guruharsha et al., 2011) regucalcin - Tm2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Trx-2 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Trxr-1 experimental knowledge based (Guruharsha et al., 2011) regucalcin - Ubc12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - Uch experimental knowledge based (Guruharsha et al., 2011) regucalcin - Wwox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - awd experimental knowledge based (Guruharsha et al., 2011) regucalcin - blw experimental knowledge based (Guruharsha et al., 2011) regucalcin - bys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - capt experimental knowledge based (Guruharsha et al., 2011) regucalcin - cbs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - cib experimental knowledge based (Guruharsha et al., 2011) regucalcin - dUTPase experimental knowledge based (Guruharsha et al., 2011) regucalcin - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - eEF1δ experimental knowledge based (Guruharsha et al., 2011) regucalcin - eIF-5A experimental knowledge based (Guruharsha et al., 2011) regucalcin - fabp experimental knowledge based (Guruharsha et al., 2011) regucalcin - fax experimental knowledge based (Guruharsha et al., 2011) regucalcin - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - fln anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - flr experimental knowledge based (Guruharsha et al., 2011) regucalcin - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - kdn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - l(1)G0004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - l(2)37Cb experimental knowledge based (Guruharsha et al., 2011) regucalcin - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - mus209 experimental knowledge based (Guruharsha et al., 2011) regucalcin - porin anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) regucalcin - scf experimental knowledge based (Guruharsha et al., 2011) regucalcin - scu experimental knowledge based (Guruharsha et al., 2011) regucalcin - smt3 experimental knowledge based (Guruharsha et al., 2011) regucalcin - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) regucalcin - viaf experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) regucalcin - yip2 experimental knowledge based (Guruharsha et al., 2011) regucalcin - zip experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions regucalcin allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58570 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030362 DroID - A comprehensive database of gene and protein interactions. • FBgn0030362 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32165
Orthologs
OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69ZZ88 Dipteran inclusive ortholog search EOG6T1HW8 Insect inclusive ortholog search EOG6547VN Arthropod inclusive ortholog search EOG69P8F5 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG69ZZ88)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\regucalcin     Drosophila simulans   Dsim\GD17058 Y   Drosophila sechellia   Dsec\GM13249 Y   Drosophila erecta   Dere\GG17702 Y   Drosophila yakuba   Dyak\regucalcin Y   Drosophila ananassae   Dana\GF19376 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14770 Y   Drosophila persimilis   Dper\GL20270     Drosophila willistoni   Dwil\GK10081 Y   Drosophila virilis   Dvir\GJ18538 Y   Drosophila mojavensis   Dmoj\GI21765 Y   Drosophila grimshawi   Dgri\GH24165 Y
Orthologs in non-Drosophila Dipterans (EOG6T1HW8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013662 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000757 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001022 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001020 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001501 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007794 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008867 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007528 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007230 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801538 Y
Orthologs in non-Dipteran Insects (EOG6547VN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413627 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014157 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12434 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12435 Y Atta cephalotes Leafcutter ant  Acep\ACEP14412 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23599 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO23457 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22505 Y Linepithema humile Argentine ant  Lhum\LH15204 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20512 Y Solenopsis invicta Red fire ant  Sinv\SINV24114 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI49995 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003308 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006696 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005240 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011337 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011271 Y Pediculus humanus Human body louse  Phum\PHUM490500 Y Pediculus humanus Human body louse  Phum\PHUM479620 Y Pediculus humanus Human body louse  Phum\PHUM584070 Y Tribolium castaneum Red flour beetle  Tcas\TC013047 Y Tribolium castaneum Red flour beetle  Tcas\TC013050 Y Tribolium castaneum Red flour beetle  Tcas\TC013049 Y Tribolium castaneum Red flour beetle  Tcas\TC012187 Y Tribolium castaneum Red flour beetle  Tcas\TC013045 Y Tribolium castaneum Red flour beetle  Tcas\TC012276 Y Tribolium castaneum Red flour beetle  Tcas\TC012188 Y Tribolium castaneum Red flour beetle  Tcas\TC013046 Y Tribolium castaneum Red flour beetle  Tcas\TC013048 Y
Orthologs in non-Insect Arthropods (EOG69P8F5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW022358 Y Ixodes scapularis Deer tick  Isca\ISCW005090 Y Ixodes scapularis Deer tick  Isca\ISCW022359 Y Ixodes scapularis Deer tick  Isca\ISCW015725 Y Ixodes scapularis Deer tick  Isca\ISCW010163 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17058 Drosophila sechellia Dsec\GM13249 Drosophila erecta Dere\GG17702 Drosophila yakuba Dyak\regucalcin Drosophila ananassae Dana\GF19376 Drosophila pseudoobscura pseudoobscura Dpse\GA14770 Drosophila willistoni Dwil\GK10081 Drosophila virilis Dvir\GJ18538 Drosophila mojavensis Dmoj\GI21765 Drosophila grimshawi Dgri\GH24165
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18973 w1118 PBac{WH}regucalcinf06398 36708 y1 sc* v1; P{TRiP.HMS01598}attP2/TM3, Sb1
Harvard	- PBac{WH}regucalcinf06398
VDRC	v105509 P{KK112078}VIE-260B v39946 w1118; P{GD8809}v39946 v39945 w1118; P{GD8809}v39945/TM3
Genomic Clones ( 2 )
	BACR12H01 BACR42F07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 157 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH22783 SD03837
Other clones	DPiM_SD03837 yak-ad_regucalcin
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10157 AT11593 AT15494 AT25675 AT29729 GH02783 GH02838 GH08940 GH09588 GH09629 GH09714 GH12259 GH15804 GH17243 GH25626 GH27719 GH27843 GH28804 GM19770 GM22293 GM31529 HL07420 LP01566 LP02045 LP02187 LP02914 LP04435 LP05528 LP05856 LP07030 LP09054 LP11075 LP12263 LP13092 LP15438 LP16443 LP16613 LP16724 LP16844 LP17112 LP17658 LP18242 LP18811 LP20983 LP21517 LP21786 LP22185 LP23217 LP24166 RE16710 RH04439 RH04789 RH05035 RH05424 RH05440 RH05466 RH05738 RH06536 RH06668 RH07040 RH07758 RH07777 RH14452 RH16440 RH22207 RH22443 RH24405 RH25528 RH58727 RH69440 RH73783 SD11524 SD13504 SD15589 SD16213 SD18890 SD23731 SD28038
Other clones	32737 78544 122969 164081 175527 214281.11 281544 473573 473701 521790 522267 523153 523859 523984 524092 525065 527240 527268 527311 528221 542614 542810 556925 557089 558074 569222 572779 576516 CK01.108D.F11 CK01.123B.H3 CK01.168D.G6 Dmel_neb_012850_0563_3184 EC23406 EC27273 EC29706 EC35685 EK093830 EK098024 EK143151 EK207557 EK245855 EK268554 EK276360 EK306718 EN00256 EN00548 EN01711 EN03406 EN03522 EN04326 EN04541 EN04741 EN06442 EN07539 EN07611 EN07654 EN09055 EN10951 EN11358 EN11713 EN12026 EN12939 EN14759 EN16003 EN17042 EN17832 EP14531 ESG011c.E21_F05 ESG014b.E21_E03 ESG015c.E21_F08 ESG017b.E21_F12 ESG019c.E21_B03 IP03778 IP03978 LD12015
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030362 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32165
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: regucalcin CG1803 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of regucalcin CG1803 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132547 NM_167314 NM_167315 NM_167316 RefSeq (Proteins) • NP_572775 NP_727586 NP_727587 NP_727588 DDBJ / EMBL / GenBank • AAF48128 AAF48129 AAF48130 AAM50012 AAN09306 AB036904 AI532351 AW944328 AY118643 BAA99283 Entrez Gene - A searchable database of RefSeq genes. • 32165 UniProtKB/TrEMBL • Q9VYR1 Q76NR6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Six-bladed beta-propeller, TolB-like (IPR011042) Senescence marker protein-30 (SMP-30) (IPR005511) SMP-30/Gluconolaconase/LRE-like region (IPR013658) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD03837
Linkouts
	BioGRID - A database of protein and genetic interactions • 58570 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030362 DroID - A comprehensive database of gene and protein interactions. • FBgn0030362 DRSC - Results from RNAi screens. • FBgn0030362 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030362 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • HDC18536;CG1803-RA;HDC18536 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030362 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32165 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32165 modMine - Data generated by the modENCODE project. • FBgn0030362
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG1803 (Klebes et al., 2005, Karlsson et al., 2004, Vierstraete et al., 2004, Vierstraete et al., 2003, Beller et al., 2006, Ni et al., 2011.7.19, Liu et al., 2009, Keleman et al., 2009.8.5, Reumer et al., 2009, Cammarato et al., 2011) regucalcin (Beller et al., 2006, Reis et al., 2011, Gilchrist et al., 2008, Straub et al., 2008, Carpenter et al., 2009, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) Regucalcin (Xun et al., 2009, Spresser et al., 2008) T1 (Vierstraete et al., 2004)
Name Synonym	regucalcin (Beller et al., 2006, Blanco et al., 2010, Arboleda-Bustos and Segarra, 2011, Reis et al., 2011, Findlay et al., 2009, Cammarato et al., 2011) Regucalcin (Butchar et al., 2012, Bozoky et al., 2009, Liu et al., 2009, Reumer et al., 2009)
Secondary FlyBase IDs
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 5 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Vesala et al., 2012, J. Insect Physiol. 58(5): 704--709 Photoperiodic regulation of cold tolerance and expression levels of regucalcin gene in Drosophila montana. [FBrf0218034] Arboleda-Bustos and Segarra, 2011, Mol. Biol. Evol. 28(8): 2185--2195 The Dca Gene Involved in Cold Adaptation in Drosophila melanogaster Arose by Duplication of the Ancestral regucalcin Gene. [FBrf0214573] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Reis et al., 2011, PLoS ONE 6(10): e25520 A Comparative Study of the Short Term Cold Resistance Response in Distantly Related Drosophila Species: The Role of regucalcin and Frost. [FBrf0216384] Show all research papers ...