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Gene Dmel\Tango4

General Information
Symbol	Dmel\Tango4	Species	D. melanogaster
Name	Transport and Golgi organization 4	Annotation symbol	CG1796
Feature type	protein_coding_gene	FlyBase ID	FBgn0030365
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11A1-11A1	Sequence location	X:11,915,101..11,916,779 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transport and Golgi organization 4 is referred to in FlyBase by the symbol Dmel\Tango4 (CG1796, FBgn0030365). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: Golgi organization; protein secretion. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1625006_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tango4. Gene sequence location is X:11915097..11916781.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11A1-11A1   Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138EP1313
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tango4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tango4-RA FBtr0073622  NM_132550   1620   482
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tango4-PA   FBpp0073459   52.7   482   9.83     NP_572778   AAF48133
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264359   AA264395   AA391249   AA391551   AA392317   AA735140   AA820780   AA820896   AA951765   AA979195   AE014298 AAF48133   AI455517   AI455805   AI512096   AI512782   AI514722   AI516177   AI520303   AI546186   AY051707 AAK93131   BG638423   BG639109   BI165998   BI169144   BI172337   BI214307   BI230362   BI232457   BI233011   BI234350   BI235226   BI237757   BI239634   BI243064   BI352012   BI355512   BI364656   BI367613   BI370686   BI370696   BI370758   BI371489   BI372480   BI482555   BI486082   BI578896   BI638156   BX046275   BX062826   CO343256   EC226781   EC259530   EL874005   EL874006   EL874253   EL874254   EL874357   EL874358   EV575068   EV579747   EV586538   EV586666   EV586702   EV587430   EV589042   EV589169   EV589174   EV589944   EV590185   EV590327   EV591854
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytosol inferred from direct assay (Bard et al., 2006) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    223.725 Larval Midgut    51.9 Larval Hindgut    64.3 Larval Malpighian Tubules    87.1 Larval Fat Body    166.6 Larval Salivary Gland    104.4 Larval Trachea    136.15 Larval Carcass    81.125 Adult Head    64.4 Adult Eye    76.85 Adult Brain    94.3 Adult Thoracic-Abdominal Ganglion    77.9 Adult Crop    79.3 Adult Midgut    50.5 Adult Hindgut    60.4 Adult Malpighian Tubules    71.5 Adult Fat Body    66.8 Adult Salivary Gland    89 Adult Heart    55.45 Adult VirginFemale Spermatheca    78.6 Adult InseminatedFemale Spermatheca    92.9 Adult Ovary    266.8 Adult Testis    21.5 Adult Male Accessory Gland    77.3 Adult Carcass    80.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    64.4   NA  Eye    76.85   NA  Brain    94.3   223.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    77.9   NA  Crop    79.3   51.9  Midgut    50.5   64.3  Hindgut    60.4   87.1  Malpighian Tubules    71.5   166.6  Fat Body    66.8   104.4  Salivary Gland    89   NA  Heart    55.45   136.15  Trachea    NA   NA  VirginFemale Spermatheca    78.6   NA  InseminatedFemale Spermatheca    92.9   NA  Ovary    266.8   NA  Testis    21.5   NA  Male Accessory Gland    77.3   81.125  Carcass    80.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    3 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    3 head, mated 4-day male    4 head, mated 20-day male    4 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    0 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    21 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    142 embryo 04-06hr    101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (142) embryo 04-06hr  (101) embryo 06-08hr  (77) embryo 08-10hr  (67) embryo 10-12hr  (81) embryo 12-14hr  (34) embryo 14-16hr  (49) embryo 16-18hr  (30) embryo 18-20hr    20 embryo 20-22hr  (28) embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day  (30) adult female 05day  (37) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr  (142) embryo 04-06hr  101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    142 embryo 04-06hr    101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    142 embryo 04-06hr    101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (94) embryo 02-04hr  (142) embryo 04-06hr  (101) embryo 06-08hr  (77) embryo 08-10hr  (67) embryo 10-12hr  (81) embryo 12-14hr  (34) embryo 14-16hr  (49) embryo 16-18hr  30 embryo 18-20hr    20 embryo 20-22hr  28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day  30 adult female 05day  (37) adult female 30day  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr  142 embryo 04-06hr  101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    94 embryo 02-04hr    142 embryo 04-06hr    101 embryo 06-08hr    77 embryo 08-10hr    67 embryo 10-12hr    81 embryo 12-14hr    34 embryo 14-16hr    49 embryo 16-18hr    30 embryo 18-20hr    20 embryo 20-22hr    28 embryo 22-24hr    21 larva L1    22 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    12 white prepupae new    12 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    11 pupae 3d postWPP    6 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    8 adult male 30day    9 adult female 01day    30 adult female 05day    37 adult female 30day    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (31) Schneider line 2 Sg4  (32) embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1  26 embryonic S3    12 leg disc CME L1  26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21  (36) wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  31 Schneider line 2 Sg4  32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1  26 embryonic S3    12 leg disc CME L1  26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21  (36) wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    32 embryonic 1182-4H    16 embryonic GM2    11 embryonic Kc167    20 embryonic S1    26 embryonic S3    12 leg disc CME L1    26 wing disc CME-W2    14 wing disc ML-DmD8    20 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    36 wing disc ML-DmD32    19 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    21 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    11 ovary fGS/OSS    14 ovary OSC    3 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD24662 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030365 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1796-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Tango4GD8618 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Tango4 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tango4 Class Mutagen Stocks Known lesion Tango4GD8618 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tango4KK109170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Tango4NIG.1796R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tango4T:SV5\V5 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8618} NA P{KK109170} NA P{NIG.1796R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2011-06-28)
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
Golgi organization inferred from mutant phenotype (Bard et al., 2006) protein secretion inferred from mutant phenotype (Bard et al., 2006)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytosol inferred from direct assay (Bard et al., 2006) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tango4 - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Arpc3B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - BCAS2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Tango4 - Bacc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Bx42 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Tango4 - CG11208 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG11594 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG13041 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG14641 experimental knowledge based (Guruharsha et al., 2011) Tango4 - CG15043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG15084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG15161 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG16789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG17187 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG17273 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG3061 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG31835 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG3492 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG3995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG4164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG4415 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG6015 experimental knowledge based (Guruharsha et al., 2011) Tango4 - CG6227 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG6665 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG6674 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG7137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG7669 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG7739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG7888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG8006 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Tango4 - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Cpr100A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Hydr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Incenp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Mcm5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Mcm7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Mcr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Msr-110 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Pkc53E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - Timp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - ash2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - botv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - dpr18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - l(1)G0469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - l(2)k12914 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - mRpL47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - nct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - pes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - rap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - snf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - ste24a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - t anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - yellow-c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tango4 - yellow-f2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tango4 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58573 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030365 DroID - A comprehensive database of gene and protein interactions. • FBgn0030365 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32168 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VYQ9
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T4DF5 Dipteran inclusive ortholog search EOG69601B Insect inclusive ortholog search EOG6S1S3M Arthropod inclusive ortholog search EOG6DR7TT Metazoa inclusive ortholog search EOG6MD8SH
Orthologs in Drosophila Species (EOG6T4DF5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tango4     Drosophila simulans   Dsim\GD17060 Y   Drosophila sechellia   Dsec\GM13251 Y   Drosophila erecta   Dere\GG17704 Y   Drosophila yakuba   Dyak\GE16491 Y   Drosophila ananassae   Dana\GF19378 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14743 Y   Drosophila persimilis   Dper\GL20273 Y   Drosophila willistoni   Dwil\GK10085 Y   Drosophila virilis   Dvir\GJ18540 Y   Drosophila mojavensis   Dmoj\GI21768 Y   Drosophila grimshawi   Dgri\GH24167 Y
Orthologs in non-Drosophila Dipterans (EOG69601B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010588   Anopheles gambiae Malaria mosquito  Agam\AGAP005631   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004561
Orthologs in non-Dipteran Insects (EOG6S1S3M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44597   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006717   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12167   Atta cephalotes Leafcutter ant  Acep\ACEP18048   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21637   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19497   Linepithema humile Argentine ant  Lhum\LH24730   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24443   Solenopsis invicta Red fire ant  Sinv\SINV18633   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005470   Bombyx mori Silkmoth  Bmor\BGIBMGA010974   Pediculus humanus Human body louse  Phum\PHUM407120   Tribolium castaneum Red flour beetle  Tcas\TC001100
Orthologs in non-Insect Arthropods (EOG6DR7TT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Rnd2   Ixodes scapularis Deer tick  Isca\ISCW018505
Orthologs in non-Arthropod Metazoa (EOG6MD8SH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tag-135   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027070gn   Danio rerio Zebrafish  Drer\plrg1   Xenopus tropicalis Western clawed frog  Xtro\plrg1   Gallus gallus Domestic chicken  Ggal\PLRG1   Mus musculus House mouse  Mmus\Plrg1   Rattus norvegicus Norway rat  Rnor\Plrg1   Homo sapiens Human  Hsap\ENSG00000171566
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000171566
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17060 Drosophila sechellia Dsec\GM13251 Drosophila erecta Dere\GG17704 Drosophila yakuba Dyak\GE16491 Drosophila ananassae Dana\GF19378 Drosophila pseudoobscura pseudoobscura Dpse\GA14743 Drosophila persimilis Dper\GL20273 Drosophila willistoni Dwil\GK10085 Drosophila virilis Dvir\GJ18540 Drosophila mojavensis Dmoj\GI21768 Drosophila grimshawi Dgri\GH24167
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v101441 P{KK109170}VIE-260B v44862 w1118; P{GD8618}v44862/CyO
Genomic Clones ( 1 )
	BACR42F07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 63 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24662
Other clones	DPiM_LD24662
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM17230 GM31171 LD01427 LD08039 LD08106 LD10450 LD10572 LD11142 LD24828 LD32474 LD33494 LD35505 LD40424 LD41219 LD41954 LD43801 LD43802 LD44812 LD46292 RE06015 RE10159 RE10235 RE14682 RE20076 RE28526 RE29276 RE30033 RE31043 RE34046 RE36178 RE40609 RE49822 RE53414 RE57405 RE57417 RE57493 RE58393 RE59452 RE65258 RE69455 RE72840 SD20375
Other clones	159561 214417.8 Dmel_dig_018132_0711_0587 Dmel_dig_021135_0601_3319 Dmel_neb_011448_0131_0934 Dmel_neb_012741_0323_2599 Dmel_neb_013356_0393_0914 Dmel_neb_013563_0431_3440 Dmel_neb_013734_0328_2854 Dmel_neb_013977_0138_2402 Dmel_neb_014038_0385_2545 Dmel_neb_014175_0367_2454 Dmel_neb_014626_0194_2363 Dmel_neb_014758_0102_0382 Dmel_neb_015519_0396_1556 EP16415 IP14078 IP14278 IP14378
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030365 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32168
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tango4 CG1796 (Bard et al., 2006)
Source for database merge of
Additional comments
Other Comments
	dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) dsRNA directed against Tango4 inhibits protein secretion in S2 cells and results in fusion of Golgi membranes with the endoplasmic reticulum in more than 50% of the treated cells. (Bard et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132550 RefSeq (Proteins) • NP_572778 DDBJ / EMBL / GenBank • AA820780 AAF48133 AAK93131 AI455517 AY051707 Entrez Gene - A searchable database of RefSeq genes. • 32168 UniProtKB/TrEMBL • Q9VYQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat, conserved site (IPR019775) G-protein beta WD-40 repeat (IPR020472) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24662
Linkouts
	BioGRID - A database of protein and genetic interactions • 58573 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030365 DroID - A comprehensive database of gene and protein interactions. • FBgn0030365 DRSC - Results from RNAi screens. • FBgn0030365 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030365 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1796-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030365 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32168 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32168 modMine - Data generated by the modENCODE project. • FBgn0030365 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VYQ9
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG1796 (Bard et al., 2006, Stuart et al., 2007, Keleman et al., 2009.8.5, Herold et al., 2009) TANGO4 (Bard et al., 2006) Tango4 (Herold et al., 2009, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Transport and Golgi organization 4 (Bard et al., 2006)
Secondary FlyBase IDs
References ( 19 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Stuart et al., 2007, Nature 445(7123): 95--101 A systems biology analysis of the Drosophila phagosome. [FBrf0195342] Bard et al., 2006, Nature 439(7076): 604--607 Functional genomics reveals genes involved in protein secretion and Golgi organization. [FBrf0191232]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]