FlyBase Gene Report: Dmel\Usp7

General Information

Symbol

Dmel\Usp7

Species

D. melanogaster

Name

Ubiquitin-specific protease 7

Annotation Symbol

CG1490

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030366

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

11A1-11A2

Sequence location

X:12,022,837..12,029,032 [-]

Recombination map

1-38

RefSeq locus

NC_004354 REGION:12022837..12029032

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables thiol-dependent ubiquitin-specific protease activity

inferred from direct assay

(Sun et al., 2019, Zhou et al., 2015, van der Knaap et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cysteine-type endopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN002541993

(assigned by GO_Central )

(Gaudet et al., 2011)

enables thiol-dependent ubiquitin-specific protease activity

inferred from sequence or structural similarity with UniProtKB:Q93009

(assigned by UniProt )

(UniProt Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN002541993

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chromatin silencing

inferred from genetic interaction with FLYBASE:Pc; FB:FBgn0003042

(van der Knaap et al., 2005)

involved_in histone deubiquitination

inferred from direct assay

(van der Knaap et al., 2005)

involved_in negative regulation of hippo signaling

inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456

(Sun et al., 2019)

involved_in positive regulation of smoothened signaling pathway

inferred from mutant phenotype

(Zhou et al., 2015)

involved_in protein deubiquitination

inferred from direct assay

(Sun et al., 2019, Zhou et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in protein deubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN002541993

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q93009

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in regulation of protein stability

inferred from biological aspect of ancestor with PANTHER:PTN002363832

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in ubiquitin-dependent protein catabolic process

inferred from electronic annotation with InterPro:IPR018200

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Zhou et al., 2015)

located_in nucleus

inferred from direct assay

(Zhou et al., 2015, van der Knaap et al., 2005)

located_in polytene chromosome

inferred from direct assay

(van der Knaap et al., 2010)

part_of protein-containing complex

inferred from physical interaction with FLYBASE:bur; FB:FBgn0000239

(van der Knaap et al., 2005)

located_in transcriptionally silent chromatin

inferred from direct assay

(van der Knaap et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN002541993

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002541993

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q93009

(assigned by UniProt )

(UniProt Curators, 2002-)

Gene Group (FlyBase)

USP DEUBIQUITINASES

Pathway (FlyBase)

Positive Regulators of Hedgehog Signaling Pathway

Negative Regulators of Hippo Signaling Pathway

Protein Family (UniProt)

Belongs to the peptidase C19 family. (Q9VYQ8)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

USP DEUBIQUITINASES -: The Ubiquitin Specific Proteases (USP) is the largest sub-family of deubiquitinases. They are cysteine proteases and catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. USP deubiquitinases belong to MEROPS family C19. (Adapted from PMID:19626045).

Pathway (FlyBase)

Positive Regulators of Hedgehog Signaling Pathway -: Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
Negative Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).

Protein Function (UniProtKB)

Hydrolase that deubiquitinates target proteins.

(UniProt, Q9VYQ8)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Usp7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Usp7-RB

FBtr0073641

NM_132551

5642

1129

Usp7-RC

FBtr0342732

NM_001298220

4880

1125

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Usp7-PB

FBpp0073474

130.4

1129

5.90

NP_572779

AAF48134

Usp7-PC

FBpp0309600

130.0

1125

5.84

NP_001285149

AHN59619

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Usp7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Usp7_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Zhou et al., 2015)

located_in nucleus

inferred from direct assay

(Zhou et al., 2015, van der Knaap et al., 2005)

located_in polytene chromosome

inferred from direct assay

(van der Knaap et al., 2010)

part_of protein-containing complex

inferred from physical interaction with FLYBASE:bur; FB:FBgn0000239

(van der Knaap et al., 2005)

located_in transcriptionally silent chromatin

inferred from direct assay

(van der Knaap et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Usp7 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Usp7

View exonic expression by tissue for Dmel\Usp7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030366

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030366

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1490-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1490

Flygut - An atlas of the Drosophila adult midgut

FBgn0030366

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Usp7

Transgenic constructs containing regulatory region of Usp7

Deletions and Duplications ( 1 )

Duplicated in

Dp(1;3)DC514

(Popodi et al., 2010-)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | male

Usp7^KG06814

lethal - all die before end of P-stage, with Scer\GAL4^sqh.PW

Usp7^KK100635

lethal - all die before end of pupal stage, with Scer\GAL4^dpp.PU

Usp7^KK100635

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Usp7^GD7628

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Usp7^GD7628

viable, with Scer\GAL4^tin.CΔ4

Usp7^GD7628

Sterility

Allele

sterile

Usp7^kim1

Other Phenotypes

Allele

body color defective, with Scer\GAL4^pnr-MD237

Usp7^GD7628

short lived, with Scer\GAL4^elav.PU

Usp7^KK100635

short lived, with Scer\GAL4^Mef2.PR

Usp7^GD7628

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Usp7^GD7628

some die during pharate adult stage, with Scer\GAL4^sqh.PW

Usp7^KK100635

some die during pupal stage, with Scer\GAL4^dpp.PU

Usp7^KK100635

some die during pupal stage, with Scer\GAL4^pnr-MD237

Usp7^GD7628

visible

Usp7^Δ35

visible, with Scer\GAL4^dpp.PU

Usp7^GD7628

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Usp7^GD7628

scutellar bristle, with Scer\GAL4^dpp.PU

Usp7^GD7628

wing

Usp7^Δ35

wing | progressive, with Scer\GAL4^elav.PU

Usp7^KK100635

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\USP7

13 of 15

Yes

Hsap\USP40

2 of 15

Yes

Hsap\USP47

2 of 15

Hsap\USP48

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Usp7

14 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Usp48

1 of 15

Yes

Rattus norvegicus (Norway rat) (11)

Rnor\Usp7

13 of 13

Yes

Rnor\LOC100911860

2 of 13

Yes

Rnor\Usp40

2 of 13

Yes

Rnor\Usp47

2 of 13

Rnor\Usp48

2 of 13

Yes

Rnor\LOC100911993

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (11)

Xtro\usp7

9 of 12

Yes

Xtro\usp40

2 of 12

Yes

Xtro\usp47

2 of 12

Xtro\usp48

2 of 12

Yes

Xtro\LOC101732921

1 of 12

Yes

Xtro\LOC108644520

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (9)

Drer\usp7

13 of 15

Yes

Drer\usp40

2 of 15

Yes

Drer\usp48

2 of 15

Yes

Drer\usp9

1 of 15

Drer\usp18

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\math-33

13 of 15

Yes

Cele\T05H10.1

2 of 15

Cele\usp-48

2 of 15

Yes

Cele\K02C4.3

1 of 15

Cele\K08B4.5

1 of 15

Yes

Cele\pqn-87

1 of 15

Yes

Cele\T24B8.7

1 of 15

Cele\usp-5

1 of 15

Cele\Y67D2.2

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\UBP12

9 of 9

Yes

Atha\UBP13

9 of 9

Yes

Atha\AT2G25330

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\UBP15

11 of 15

Yes

Scer\UBP2

1 of 15

Yes

Scer\UBP14

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\ubp5

11 of 12

Yes

Spom\ubp15

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919011U )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13337

Drosophila persimilis

Dper\GL20263

Drosophila willistoni

Dwil\GK25042

Drosophila virilis

Dvir\GJ18513

Drosophila mojavensis

Dmoj\GI21482

Drosophila grimshawi

Dgri\GH11908

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500N0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017982

Glossina morsitans

Tsetse fly

Gmor\GMOY006061

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13826

Mayetiola destructor

Hessian fly

Mdes\Mdes000449

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL017159

Anopheles darlingi

American malaria mosquito

Adar\ADAC004031

Anopheles gambiae

Malaria mosquito

Agam\AGAP008530

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010988

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00HP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA007315

Bombyx mori

Silkmoth

Bmor\BGIBMGA007317

Danaus plexippus

Monarch butterfly

Dple\DPOGS205354-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS213441-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006153

Heliconius melpomene

Postman butterfly

Hmel\HMEL009851

Apis florea

Little honeybee

Aflo\3065023092

Apis mellifera

Western honey bee

Amel\GB54054

Apis mellifera

Western honey bee

Amel\GB54053

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24138

Bombus terrestris

Buff-tailed bumblebee

Bter\15206902

Linepithema humile

Argentine ant

Lhum\LH22740

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0027ad

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG032954

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG031385

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG035969

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037343

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06910

Tribolium castaneum

Red flour beetle

Tcas\TC005316

Pediculus humanus

Human body louse

Phum\PHUM372710

Rhodnius prolixus

Kissing bug

Rpro\RPRC009938

Rhodnius prolixus

Kissing bug

Rpro\RPRC003715

Cimex lectularius

Bed bug

Clec\CLEC009624

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000343

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05037

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00GW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007491

Ixodes scapularis

Black-legged tick

Isca\ISCW015924

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72468.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g07270

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_327206

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01BK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027530gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Usp7

Ciona intestinalis

Vase tunicate

Cint\LOC100177157

Gallus gallus

Domestic chicken

Ggal\USP7

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (16)

Gene Symbol

Score

Source

Alignment

faf

3 of 10

Usp47

3 of 10

DUBAI

2 of 10

puf

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

not

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

USP7; ubiquitin specific peptidase 7

13 of 15

602519

HAO-FOUNTAIN SYNDROME; HAFOUS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Usp7 - EcR

pull down, autoradiography

(van der Knaap et al., 2010)

Usp7 - His2B

enzymatic study, western blot

(van der Knaap et al., 2005)

Usp7 - bur

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based, ion exchange chromatography, anti bait coimmunoprecipitation, peptide massfingerprinting, western blot

(Zhou et al., 2015, Guruharsha et al., 2011, van der Knaap et al., 2005)

Usp7 - ci

anti tag coimmunoprecipitation, anti tag western blot, pull down

(Sun et al., 2019, Zhou et al., 2015)

Usp7 - mdlc

experimental knowledge based

(Guruharsha et al., 2011)

Usp7 - p53

enzymatic study, western blot

(van der Knaap et al., 2005)

Usp7 - yki

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Sun et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Usp7|bur

enhanceable

Bre1

(van der Knaap et al., 2010)

Usp7

enhanceable

bur

(van der Knaap et al., 2010)

Usp7|bur

enhanceable

EcR

(van der Knaap et al., 2010)

Usp7|bur

suppressible

EcR

(van der Knaap et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bchs

enhanceable

Usp7

(Simonsen et al., 2007)

Dronc

enhanceable

Usp7

(Sinenko, 2017)

enhanceable

Usp7

(van der Knaap et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58574

DroID - A comprehensive database of gene and protein interactions.

FBgn0030366

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32169

MIST (genetic) - An integrated Molecular Interaction Database

Usp7

MIST (protein-protein) - An integrated Molecular Interaction Database

Usp7

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Hedgehog Signaling Pathway -: Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
Negative Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

FoxO signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-38

Cytogenetic map

11A1-11A2

Sequence location

X:12,022,837..12,029,032 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11A1-11A2

Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138^EP1313

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-38

(FlyBase, 2016)

1-37.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

81449

y¹ v¹; P{TKO.GS04695}attP40

14505

y¹ P{SUPor-P}Usp7^KG06814/FM7c, sn⁺

34708

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01187}attP2

67127

y¹ w^* Usp7^B P{neoFRT}19A/Dp(1;Y)BSC1, y⁺ w^67c23 P{lacW}Smr^G0060/C(1)RA, y¹

VDRC

v110324

P{KK100635}VIE-260B

v18231

w¹¹¹⁸; P{GD7628}v18231

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (113)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030366

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030366

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32169

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Sun et al., 2019)

polyclonal

(van der Knaap et al., 2005)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Usp7 CG1490

(van der Knaap et al., 2005)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32169

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VYQ8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030366

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030366

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Usp7_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1490

Flygut - An atlas of the Drosophila adult midgut

FBgn0030366

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32169

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005316

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1490

modMine - A data warehouse for the modENCODE project

FBgn0030366

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VYQ8

Linkouts

BioGRID - A database of protein and genetic interactions.

58574

DroID - A comprehensive database of gene and protein interactions.

FBgn0030366

DRSC - Results frm RNAi screens

FBgn0030366

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030366

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1490-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030366

FlyMine - An integrated database for Drosophila genomics

FBgn0030366

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32169

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

FoxO signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

Usp7

MIST (protein-protein) - An integrated Molecular Interaction Database

Usp7

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG1490

(Çiçek et al., 2016, Hosono et al., 2015, Zhou et al., 2015, Engel et al., 2014, White-Grindley et al., 2014, Tsou et al., 2012, Zhang et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Weake et al., 2008, Zhang et al., 2008, Simonsen et al., 2007, Pilot et al., 2006, Giot et al., 2003, Chen and Fischer, 2000)

Q9VYQ8

(Clague et al., 2013)

USP7

(Sinenko, 2017, Reddy et al., 2014, Xia et al., 2012, Moshkin et al., 2009, Weake et al., 2008, Schuettengruber et al., 2007, van der Knaap et al., 2005)

Usp-7

(Zhang et al., 2012)

Usp7

(Graves et al., 2020, Wei et al., 2020, Meltzer et al., 2019, Sun et al., 2019, Transgenic RNAi Project members, 2017-, Derkacheva et al., 2016, Zhou et al., 2015, Zirin et al., 2015, Amaral et al., 2014, Engel et al., 2014, White-Grindley et al., 2014, Esslinger et al., 2013, Yamamoto et al., 2013-, Tsou et al., 2012, Popodi et al., 2010-, Pospisilik et al., 2010, van der Knaap et al., 2010)

Name Synonyms

Ubiquitin-specific protease 7

(Graves et al., 2020)

ubiquitin-specific protease 7

(van der Knaap et al., 2010, van der Knaap et al., 2005)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (67)

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