FlyBase Gene Report: Dmel\Ir11a

General Information

Symbol

Dmel\Ir11a

Species

D. melanogaster

Name

Ionotropic receptor 11a

Annotation Symbol

CG15732

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030385

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

11A9-11A9

Sequence location

X:12,375,596..12,377,755 [-]

Recombination map

1-38

RefSeq locus

NC_004354 REGION:12375596..12377755

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ligand-gated ion channel activity

inferred from sequence model

(Benton et al., 2009)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sensory perception of taste

inferred from expression pattern

(Croset et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus

inferred from sequence or structural similarity with FLYBASE:Ir92a; FB:FBgn0038789

(Benton et al., 2009)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Benton et al., 2009)

Gene Group (FlyBase)

DIVERGENT IONOTROPIC RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Solute-binding protein family 3/N-terminal domain of MltF

Summaries

Gene Group (FlyBase)

DIVERGENT IONOTROPIC RECEPTORS -: Divergent Ionotropic Receptors (IR), members of the IR family of ligand-gated ion channels, are largely species-specific, with low amino acid sequence identity. Expressed in gustatory organs, they are believed to be taste receptors. (Adapted from FBrf0211681).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir11a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VYN4)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir11a-RB

FBtr0336964

NM_132567

1980

642

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ir11a-PB

FBpp0307907

73.5

642

10.20

Q9VYN4

NP_572795

AAF48158

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Solute-binding protein family 3/N-terminal domain of MltF

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VYN4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir11a using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir11a-GAL4.C}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gustatory receptor neuron | subset of epiphysis

(Croset et al., 2010)

gustatory receptor neuron of the dorsal organ

(Sánchez-Alcañiz et al., 2018)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ir11a in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir11a

View exonic expression by tissue for Dmel\Ir11a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32189/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030385

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030385

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030385

Flygut - An atlas of the Drosophila adult midgut

FBgn0030385

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir11a

Transgenic constructs containing regulatory region of Ir11a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Ir11a^KK104276

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Ir11a^GD3331

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ir11a^GD3331

viable, with Scer\GAL4^Mef2.PR

Ir11a^GD3331

viable, with Scer\GAL4^pnr-MD237

Ir11a^GD3331

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRID1

2 of 15

Yes

Hsap\GRID2

2 of 15

Yes

Hsap\GRIK3

2 of 15

Yes

Hsap\GRIN2C

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gria1

1 of 15

Yes

Mmus\Gria2

1 of 15

Yes

Mmus\Gria3

1 of 15

Yes

Mmus\Gria4

1 of 15

Yes

Mmus\Grid1

1 of 15

Yes

Mmus\Grid2

1 of 15

Yes

Mmus\Grik1

1 of 15

Yes

Mmus\Grik2

1 of 15

Yes

Mmus\Grik3

1 of 15

Yes

Mmus\Grik4

1 of 15

Yes

Mmus\Grik5

1 of 15

Yes

Mmus\Grin2a

1 of 15

Yes

Mmus\Grin2b

1 of 15

Yes

Mmus\Grin2c

1 of 15

Yes

Mmus\Grin2d

1 of 15

Yes

Mmus\Grin3a

1 of 15

Yes

Mmus\Grin3b

1 of 15

Yes

Rattus norvegicus (Norway rat) (13)

Rnor\Gria3

1 of 13

Yes

Rnor\Gria4

1 of 13

Yes

Rnor\Grid2

1 of 13

Yes

Rnor\Grik2

1 of 13

Yes

Rnor\Grik3

1 of 13

Yes

Rnor\Grik4

1 of 13

Yes

Rnor\Grik5

1 of 13

Yes

Rnor\Grin2a

1 of 13

Yes

Rnor\Grin2b

1 of 13

Yes

Rnor\Grin2c

1 of 13

Yes

Rnor\Grin2d

1 of 13

Yes

Rnor\Grin3a

1 of 13

Yes

Rnor\Grin3b

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (12)

Xtro\gria1

1 of 12

Yes

Xtro\gria3

1 of 12

Yes

Xtro\gria4

1 of 12

Yes

Xtro\grid1

1 of 12

Yes

Xtro\grid2

1 of 12

Yes

Xtro\grik1

1 of 12

Yes

Xtro\grik4

1 of 12

Yes

Xtro\grik5-like.1

1 of 12

Yes

Xtro\grin2b

1 of 12

Yes

Xtro\grin2c

1 of 12

Yes

Xtro\grin2d

1 of 12

Yes

Xtro\grin3b

1 of 12

Yes

Danio rerio (Zebrafish) (28)

Drer\gria1a

1 of 15

Yes

Drer\gria1b

1 of 15

Yes

Drer\gria2a

1 of 15

Yes

Drer\gria2b

1 of 15

Yes

Drer\gria3a

1 of 15

Yes

Drer\gria3b

1 of 15

Yes

Drer\gria4b

1 of 15

Yes

Drer\grid1a

1 of 15

Yes

Drer\grid1b

1 of 15

Yes

Drer\grid2

1 of 15

Yes

Drer\grik1a

1 of 15

Yes

Drer\grik1b

1 of 15

Yes

Drer\grik2

1 of 15

Yes

Drer\grik4

1 of 15

Yes

Drer\grin2aa

1 of 15

Yes

Drer\grin2ab

1 of 15

Yes

Drer\grin2bb

1 of 15

Yes

Drer\grin2ca

1 of 15

Yes

Drer\grin2cb

1 of 15

Yes

Drer\grin2da

1 of 15

Yes

Drer\grin3a

1 of 15

Yes

Drer\grin3ba

1 of 15

Yes

Drer\LOC100149482

1 of 15

Yes

Drer\LOC100331381

1 of 15

Yes

Drer\LOC100334689

1 of 15

Yes

Drer\LOC100537813

1 of 15

Yes

Drer\si:ch211-251b21.1

1 of 15

Yes

Drer\si:dkey-183j2.10

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-5

2 of 15

Yes

Cele\glr-8

2 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (68)

Gene Symbol

Score

Source

Alignment

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030385

MIST (protein-protein) - An integrated Molecular Interaction Database

Ir11a

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-38

Cytogenetic map

11A9-11A9

Sequence location

X:12,375,596..12,377,755 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11A9-11A9

Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138^EP1313

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-38

(FlyBase, 2016)

1-38.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

61898

y¹ v¹; P{TRiP.HMJ23453}attP40

41742

w^*; Bl¹/CyO; P{Ir11a-GAL4.C}attP2

93530

w^* TI{CRIMIC.TG4.2}Ir11a^{CR60207-TG4.2}

VDRC

v100422

P{KK104276}VIE-260B

v39576

w¹¹¹⁸; P{GD3331}v39576

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030385

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32189

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ir11a CG15732

(Benton et al., 2009)

Source for database merge of

Additional comments

The Ir11a gene, one of 44 "divergent" ionotropic receptor genes in D. melanogaster, may have been derived from an ancestral ionotropic receptor gene by retroposition, and in some cases, subsequent gene duplication.

(Croset et al., 2010)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 22 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32189

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF48158

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VYN4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VYN4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VYN4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32189/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030385

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030385

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030385

Flygut - An atlas of the Drosophila adult midgut

FBgn0030385

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32189

InterPro - A database of protein families, domains and functional sites

Solute-binding protein family 3/N-terminal domain of MltF

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG15732

MARRVEL_MODEL - MARRVEL (model organism gene)

32189

modMine - A data warehouse for the modENCODE project

FBgn0030385

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0030385

DRSC - Results frm RNAi screens

FBgn0030385

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030385

FlyMine - An integrated database for Drosophila genomics

FBgn0030385

MIST (protein-protein) - An integrated Molecular Interaction Database

Ir11a

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

11a

(Ni, 2020)

CG15732

(Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Keleman et al., 2009.8.5, Lee et al., 2009, Perkins et al., 2009)

CT35969

(Littleton and Ganetzky, 2000)

DmelIR11a

(Croset et al., 2010)

IR11a

(Ni, 2020, Rimal and Lee, 2018, Ahn et al., 2017, Croset et al., 2010, Benton et al., 2009)

Ir11a

(Guo et al., 2020, Shahandeh et al., 2020, Gene Disruption Project members, 2018-, Ganguly et al., 2017, Arguello et al., 2016, dos Santos, 2014, Vernes, 2014, Tsubouchi et al., 2012, Bellen et al., 2011)

Q9VYN4_DROME

(Fukuyama et al., 2012)

Name Synonyms

CG15732

Ionotropic receptor 11a

(Tsubouchi et al., 2012)

ionotropic receptor 11a

(Benton et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (34)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections