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Gene Dmel\Aven

General Information
Symbol	Dmel\Aven	Species	D. melanogaster
Name	Aven ortholog	Annotation symbol	CG15727
Feature type	protein_coding_gene	FlyBase ID	FBgn0030410
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11B5-11B5	Sequence location	X:12,522,403..12,523,631 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Aven ortholog is referred to in FlyBase by the symbol Dmel\Aven (CG15727, FBgn0030410). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: negative regulation of mitosis. 3 alleles are reported. The phenotypes of these alleles are annotated with: ovary; adult fat body. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1627409_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG15727. Gene sequence location is X:12522403..12523631.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11B5-11B5   Limits computationally determined from genome sequence between P{EP}CG11138EP1313 and P{EP}EP1632&P{EP}EP1449
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aven for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aven-RA FBtr0073709  NM_132589   1165   294
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aven-PA   FBpp0073542   31.8   294   6.06     NP_572817   AAF48184
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48184   AY071046 AAL48668   BF504611   BF504633   BI171704   BI610974   BI619310   BI622004   CO177423   CO263042   EC195726   EC208147   EC231193
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYK8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 1 -- 4   organism | ubiquitous   (Zou et al., 2011) embryonic stage 5   yolk   (Zou et al., 2011) Comment:NOT pole cell yolk nucleus   (Zou et al., 2011) Comment:NOT cell nuclei embryonic stage 6 -- 8   organism | ubiquitous   • cytoplasm (Zou et al., 2011) mesoderm   • cytoplasm (Zou et al., 2011) Comment:slightly enriched embryonic stage 9 -- 13   organism | ubiquitous   (Zou et al., 2011) amnioserosa   (Zou et al., 2011) embryonic stage 13   ventral nerve cord   (Zou et al., 2011) ectoderm   (Zou et al., 2011) embryonic stage 16   embryonic/larval salivary gland   (Zou et al., 2011) embryonic/larval Malpighian tubule   (Zou et al., 2011) embryonic/larval tracheal system   (Zou et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytosol inferred from direct assay (Zou et al., 2011) nucleus inferred from direct assay (Zou et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult thoracico-abdominal ganglion, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    52.55 Larval Midgut    49.5 Larval Hindgut    48.9 Larval Malpighian Tubules    76.2 Larval Fat Body    50.1 Larval Salivary Gland    74.9 Larval Trachea    57.65 Larval Carcass    44.35 Adult Head    63.8 Adult Eye    116.45 Adult Brain    72 Adult Thoracic-Abdominal Ganglion    126.1 Adult Crop    54.9 Adult Midgut    44.4 Adult Hindgut    37.6 Adult Malpighian Tubules    40.8 Adult Fat Body    37.1 Adult Salivary Gland    31.1 Adult Heart    29.675 Adult VirginFemale Spermatheca    40 Adult InseminatedFemale Spermatheca    45.4 Adult Ovary    159.4 Adult Testis    60.3 Adult Male Accessory Gland    44.4 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.8   NA  Eye    116.45   NA  Brain    72   52.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    126.1   NA  Crop    54.9   49.5  Midgut    44.4   48.9  Hindgut    37.6   76.2  Malpighian Tubules    40.8   50.1  Fat Body    37.1   74.9  Salivary Gland    31.1   NA  Heart    29.675   57.65  Trachea    NA   NA  VirginFemale Spermatheca    40   NA  InseminatedFemale Spermatheca    45.4   NA  Ovary    159.4   NA  Testis    60.3   NA  Male Accessory Gland    44.4   44.35  Carcass    38.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    5 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    19 ovary, mated 4-day female    21 testis, mated 4-day male    9 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    21 embryo 04-06hr    15 embryo 06-08hr    8 embryo 08-10hr    8 embryo 10-12hr    7 embryo 12-14hr    4 embryo 14-16hr    7 embryo 16-18hr    5 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    7 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    7 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    7 pupae 2d postWPP    7 pupae 3d postWPP    6 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    11 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    6 embryonic 1182-4H    24 embryonic GM2    6 embryonic Kc167    7 embryonic S1    8 embryonic S3    3 leg disc CME L1    10 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    10 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    4 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    5 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    10 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    13 ovary OSC    18 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    6 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE13534 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030410 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15727-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | temperature conditional, with Scer\GAL4Act5C.PU AvenGD9098 lethal | larval stage | temperature conditional, with Scer\GAL4da.G32 AvenGD9098 lethal | pupal stage | heat sensitive, with Scer\GAL4Cg.PA AvenGD9098 lethal | pupal stage | heat sensitive, with Scer\GAL4fat AvenGD9098 lethal | pupal stage | temperature conditional, with Scer\GAL4Act5C.PU AvenGD9098 lethal | pupal stage | temperature conditional, with Scer\GAL4da.G32 AvenGD9098 viable, with Scer\GAL4elav.PU AvenGD9098 viable, with Scer\GAL4GMR.PU AvenGD9098 viable, with Scer\GAL4pnr-MD237 AvenGD9098 viable, with Scer\GAL4ptc-559.1 AvenGD9098 Other Phenotypes Allele decreased cell size, with Scer\GAL4Cg.PA AvenGD9098 mitotic cell cycle defective, with Scer\GAL4Cg.PA AvenGD9098 Phenotype manifest in Allele adult fat body, with Scer\GAL4Cg.PA AvenGD9098 ovary, with Scer\GAL4Cg.PA AvenGD9098
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Aven Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aven Class Mutagen Stocks Known lesion AvenGD9098 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AvenKK111074 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AvenNIG.15727R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.15727R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of mitosis inferred from mutant phenotype (Zou et al., 2011)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (Zou et al., 2011) nucleus inferred from direct assay (Zou et al., 2011)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aven - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aven - robl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aven allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030410 DroID - A comprehensive database of gene and protein interactions. • FBgn0030410
Orthologs
OrthoDB Orthologs (15) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R50P4 Dipteran inclusive ortholog search EOG62BXJN Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6R50P4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aven     Drosophila simulans   Dsim\GD15922 Y   Drosophila sechellia   Dsec\GM11540 Y   Drosophila erecta   Dere\GG19543 Y   Drosophila yakuba   Dyak\GE16205 Y   Drosophila ananassae   Dana\GF20895 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13916 Y   Drosophila persimilis   Dper\GL13152 Y   Drosophila willistoni   Dwil\GK25407 Y   Drosophila virilis   Dvir\GJ16651 Y   Drosophila mojavensis   Dmoj\GI16157 Y   Drosophila grimshawi   Dgri\GH24827 Y
Orthologs in non-Drosophila Dipterans (EOG62BXJN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003394   Anopheles gambiae Malaria mosquito  Agam\AGAP002117   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010270
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15922 Drosophila sechellia Dsec\GM11540 Drosophila erecta Dere\GG19543 Drosophila yakuba Dyak\GE16205 Drosophila ananassae Dana\GF20895 Drosophila pseudoobscura pseudoobscura Dpse\GA13916 Drosophila persimilis Dper\GL13152 Drosophila willistoni Dwil\GK25407 Drosophila virilis Dvir\GJ16651 Drosophila mojavensis Dmoj\GI16157 Drosophila grimshawi Dgri\GH24827
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v102198 P{KK111074}VIE-260B v19577 w1118; P{GD9098}v19577
Genomic Clones ( 2 )
	BACR39P03 BACR48G08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE13534
Other clones	DPiM_RE13534
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06206 AT06231 RH17023 RH50322 RH53809
Other clones	CK01.64C.C8 CK01.104A.E10 EK053431 EK087151
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030410 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32215
Antibody Information
Other Information
Discoverer
Etymology
	Named according to its human ortholog. (Zou et al., 2011)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Aven CG15727 (Zou et al., 2011)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132589 RefSeq (Proteins) • NP_572817 DDBJ / EMBL / GenBank • AAF48184 AAL48668 AY071046 BI171704 Entrez Gene - A searchable database of RefSeq genes. • 32215 UniProtKB/TrEMBL • Q9VYK8
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE13534
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0030410 DroID - A comprehensive database of gene and protein interactions. • FBgn0030410 DRSC - Results from RNAi screens. • FBgn0030410 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030410 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15727-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030410 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32215 modMine - Data generated by the modENCODE project. • FBgn0030410
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Aven   CG15727 (Keleman et al., 2009.8.5, Zou et al., 2011, Japanese National Institute of Genetics, 2012.5.21) dAven (Zou et al., 2011)
Name Synonym	Aven ortholog
Secondary FlyBase IDs
References ( 10 )
Research paper	Zou et al., 2011, Cell Cycle 10(6): 989--998 Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven. [FBrf0213442]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]