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Gene Dmel\CG1622

General Information
Symbol	Dmel\CG1622	Species	D. melanogaster
Name		Annotation symbol	CG1622
Feature type	protein_coding_gene	FlyBase ID	FBgn0030468
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11E9-11E9	Sequence location	X:13,191,115..13,193,943 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG1622 (FBgn0030468). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: mRNA splicing, via spliceosome. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Pre-mRNA-splicing factor 38. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1635704_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG1622. Gene sequence location is X:13191115..13193943.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11E9-11E9   Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG1622 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG1622-RA FBtr0073757  NM_132644   1682   398 CG1622-RB FBtr0310465  NM_001272583   1693   178 CG1622-RC FBtr0339945     1987   141
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG1622-PA   FBpp0073588   45.5   398   9.70     NP_572872   AAF48249 CG1622-PB   FBpp0302613   20.0   178   7.05     NP_001259512   AGB95354 CG1622-PC   FBpp0308968   15.7   141   9.69
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pre-mRNA-splicing factor 38 (IPR005037)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201905   AA246306   AA246519   AA438865   AA439852   AA536250   AA538578   AA539443   AA735351   AA736114   AA804034   AA816353   AA979508   AE014298 AAF48249   AE014298 AGB95354   AI514689   AI541613   AW941361   AY122136 AAM52648   BG637819   BI230008   BI355223   BI356216   BI365711   BT088797   BT125945   CO279803   CO299613   CO305268   CO314301   CO315938   CO317614   CO318601   EC052111   EC061260   EC084220   EC090467   EC198356   EC211060   EC215491   EC215494   EC226861   EC238445   EC249121   EL869888   EL869889   EV583826   EV593559
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYE9 Q8MR43
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary  (658) Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary  658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    476.55 Larval Midgut    66.3 Larval Hindgut    146.7 Larval Malpighian Tubules    72.5 Larval Fat Body    79.9 Larval Salivary Gland    177.7 Larval Trachea    230.3 Larval Carcass    164.975 Adult Head    87 Adult Eye    85.075 Adult Brain    221.3 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    97.5 Adult Midgut    64.2 Adult Hindgut    82.5 Adult Malpighian Tubules    99.2 Adult Fat Body    72.4 Adult Salivary Gland    87.5 Adult Heart    68.475 Adult VirginFemale Spermatheca    113.7 Adult InseminatedFemale Spermatheca    130.5 Adult Ovary    658 Adult Testis    79.6 Adult Male Accessory Gland    111.4 Adult Carcass    71.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    87   NA  Eye    85.075   NA  Brain    221.3   476.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    144.1   NA  Crop    97.5   66.3  Midgut    64.2   146.7  Hindgut    82.5   72.5  Malpighian Tubules    99.2   79.9  Fat Body    72.4   177.7  Salivary Gland    87.5   NA  Heart    68.475   230.3  Trachea    NA   NA  VirginFemale Spermatheca    113.7   NA  InseminatedFemale Spermatheca    130.5   NA  Ovary    658   NA  Testis    79.6   NA  Male Accessory Gland    111.4   164.975  Carcass    71.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    230 ovary, mated 4-day female    206 testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (60) central nervous system, larvae L3  (71) central nervous system, pupae P8  (34) head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male  (29) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8  (34) carcass, larvae L3 wandering  (36) carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (230) ovary, mated 4-day female  (206) testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (230) ovary, mated 4-day female  (206) testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    230 ovary, mated 4-day female    206 testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    230 ovary, mated 4-day female    206 testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (60) central nervous system, larvae L3  (71) central nervous system, pupae P8  (34) head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male  29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8  (34) carcass, larvae L3 wandering  (36) carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (230) ovary, mated 4-day female  (206) testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female  (230) ovary, mated 4-day female  (206) testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    60 central nervous system, larvae L3    71 central nervous system, pupae P8    34 head, virgin 1-day female    19 head, virgin 4-day female    24 head, virgin 20-day female    14 head, mated 1-day female    14 head, mated 4-day female    16 head, mated 20-day female    13 head, mated 1-day male    23 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    13 digestive system, 4-day adult    20 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    12 fat body, pupae P8    34 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    19 carcass, 20-day adult    15 ovary, virgin 4-day female    230 ovary, mated 4-day female    206 testis, mated 4-day male    21 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (98) embryo 04-06hr  (61) embryo 06-08hr  (67) embryo 08-10hr  (60) embryo 10-12hr  (53) embryo 12-14hr  (31) embryo 14-16hr  (35) embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day  (28) adult female 05day  (48) adult female 30day  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (98) embryo 04-06hr  (61) embryo 06-08hr  (67) embryo 08-10hr  (60) embryo 10-12hr  (53) embryo 12-14hr  31 embryo 14-16hr  (35) embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day  28 adult female 05day  (48) adult female 30day  (49) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    98 embryo 04-06hr    61 embryo 06-08hr    67 embryo 08-10hr    60 embryo 10-12hr    53 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    25 embryo 18-20hr    13 embryo 20-22hr    19 embryo 22-24hr    17 larva L1    17 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    13 white prepupae new    13 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    10 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    7 adult male 30day    7 adult female 01day    28 adult female 05day    48 adult female 30day    49 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    144 Schneider line 2 Sg4    128 embryonic 1182-4H    55 embryonic GM2    143 embryonic Kc167    118 embryonic S1    81 embryonic S3    117 leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    146 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5    128 mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2    115 ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (144) Schneider line 2 Sg4  (128) embryonic 1182-4H  (55) embryonic GM2  (143) embryonic Kc167  (118) embryonic S1  (81) embryonic S3  (117) leg disc CME L1  (90) wing disc CME-W2  (79) wing disc ML-DmD8  (77) wing disc ML-DmD9  (76) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (146) wing disc ML-DmD32  (67) haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (82) antennal disc ML-DmD20-c5  (128) mixed discs ML-DmD4-c1  (91) CNS ML-DmBG1-c1  (77) CNS ML-DmBG2-c2  (97) tumorous blood cells mbn2  (115) ovary fGS/OSS  (77) ovary OSC  (78) ovary OSS  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (144) Schneider line 2 Sg4  (128) embryonic 1182-4H    55 embryonic GM2  (143) embryonic Kc167  (118) embryonic S1    81 embryonic S3  (117) leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21  (146) wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5  (128) mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2  (115) ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    144 Schneider line 2 Sg4    128 embryonic 1182-4H    55 embryonic GM2    143 embryonic Kc167    118 embryonic S1    81 embryonic S3    117 leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    146 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5    128 mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2    115 ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    144 Schneider line 2 Sg4    128 embryonic 1182-4H    55 embryonic GM2    143 embryonic Kc167    118 embryonic S1    81 embryonic S3    117 leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    146 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5    128 mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2    115 ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (144) Schneider line 2 Sg4  (128) embryonic 1182-4H  (55) embryonic GM2  (143) embryonic Kc167  (118) embryonic S1  (81) embryonic S3  (117) leg disc CME L1  (90) wing disc CME-W2  (79) wing disc ML-DmD8  (77) wing disc ML-DmD9  (76) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (146) wing disc ML-DmD32  (67) haltere disc ML-DmD17-c3  (76) eye-antennal disc ML-DmD11  (82) antennal disc ML-DmD20-c5  (128) mixed discs ML-DmD4-c1  (91) CNS ML-DmBG1-c1  (77) CNS ML-DmBG2-c2  (97) tumorous blood cells mbn2  (115) ovary fGS/OSS  (77) ovary OSC  (78) ovary OSS  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (144) Schneider line 2 Sg4  128 embryonic 1182-4H    55 embryonic GM2  143 embryonic Kc167  118 embryonic S1    81 embryonic S3  117 leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21  (146) wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5  128 mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2  115 ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    144 Schneider line 2 Sg4    128 embryonic 1182-4H    55 embryonic GM2    143 embryonic Kc167    118 embryonic S1    81 embryonic S3    117 leg disc CME L1    90 wing disc CME-W2    79 wing disc ML-DmD8    77 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    146 wing disc ML-DmD32    67 haltere disc ML-DmD17-c3    76 eye-antennal disc ML-DmD11    82 antennal disc ML-DmD20-c5    128 mixed discs ML-DmD4-c1    91 CNS ML-DmBG1-c1    77 CNS ML-DmBG2-c2    97 tumorous blood cells mbn2    115 ovary fGS/OSS    77 ovary OSC    78 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    150 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    171 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    108 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  (30) heat shock, 4-day adult  (47) Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult  (57) Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (150) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (45) Ethanol 2.5% 3 hrs, larvae L3  (98) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (171) Caffeine 25 mg/ml 48 hrs, 4-day adult  (52) Paraquat 5 mM 48 hrs, 4-day adult  (108) Paraquat 10 mM 48 hrs, 4-day adult  (65) Rotenone 2 μg 12 hrs, larvae L3  (31) Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (150) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (171) Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult  (108) Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    150 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    171 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    108 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    150 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    171 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    108 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  30 heat shock, 4-day adult  (47) Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult  (57) Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (150) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (45) Ethanol 2.5% 3 hrs, larvae L3  (98) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (171) Caffeine 25 mg/ml 48 hrs, 4-day adult  (52) Paraquat 5 mM 48 hrs, 4-day adult  (108) Paraquat 10 mM 48 hrs, 4-day adult  (65) Rotenone 2 μg 12 hrs, larvae L3  31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult  (150) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (171) Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult  108 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    30 heat shock, 4-day adult    47 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    21 Cadmium 50 mM 48 hrs, 4-day adult    57 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    150 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    45 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    20 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    171 Caffeine 25 mg/ml 48 hrs, 4-day adult    52 Paraquat 5 mM 48 hrs, 4-day adult    108 Paraquat 10 mM 48 hrs, 4-day adult    65 Rotenone 2 μg 12 hrs, larvae L3    31 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • GM12605 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030468 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1622-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG1622 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG1622GD9165 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG1622 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG1622 Class Mutagen Stocks Known lesion CG1622GD9165 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1622KK108079 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9165} NA P{KK108079} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011 (Herold et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG1622 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58665 DroID - A comprehensive database of gene and protein interactions. • FBgn0030468 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32282
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6H1BG8 Dipteran inclusive ortholog search EOG64J2T8 Insect inclusive ortholog search EOG6WPZZ7 Arthropod inclusive ortholog search EOG6MPG5T Metazoa inclusive ortholog search EOG60PH1H
Orthologs in Drosophila Species (EOG6H1BG8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG1622     Drosophila simulans   Dsim\GD17111     Drosophila sechellia   Dsec\GM11616     Drosophila erecta   Dere\GG17767 Y   Drosophila yakuba   Dyak\GE17058 Y   Drosophila ananassae   Dana\GF19399 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14052 Y   Drosophila willistoni   Dwil\GK25077 Y   Drosophila virilis   Dvir\GJ16827 Y   Drosophila mojavensis   Dmoj\GI15920 Y   Drosophila grimshawi   Dgri\GH12816 Y
Orthologs in non-Drosophila Dipterans (EOG64J2T8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017400   Anopheles gambiae Malaria mosquito  Agam\AGAP004698   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004501   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004500
Orthologs in non-Dipteran Insects (EOG6WPZZ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46131   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023737   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20611   Atta cephalotes Leafcutter ant  Acep\ACEP12855   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17422   Linepithema humile Argentine ant  Lhum\LH21736   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25629   Solenopsis invicta Red fire ant  Sinv\SINV17435   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005727   Bombyx mori Silkmoth  Bmor\BGIBMGA007945   Pediculus humanus Human body louse  Phum\PHUM210830   Tribolium castaneum Red flour beetle  Tcas\TC004390
Orthologs in non-Insect Arthropods (EOG6MPG5T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Nbn   Ixodes scapularis Deer tick  Isca\ISCW000387
Orthologs in non-Arthropod Metazoa (EOG60PH1H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y108G3AL.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026332gn   Danio rerio Zebrafish  Drer\prpf38b   Xenopus tropicalis Western clawed frog  Xtro\prpf38b   Gallus gallus Domestic chicken  Ggal\PRPF38B   Mus musculus House mouse  Mmus\Prpf38b   Rattus norvegicus Norway rat  Rnor\Prpf38b   Homo sapiens Human  Hsap\PRPF38B
Human Orthologs (1)
Gene OMIM HGNC Hsap\PRPF38B
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG17767 Drosophila yakuba Dyak\GE17058 Drosophila ananassae Dana\GF19399 Drosophila pseudoobscura pseudoobscura Dpse\GA14052 Drosophila willistoni Dwil\GK25077 Drosophila virilis Dvir\GJ16827 Drosophila mojavensis Dmoj\GI15920 Drosophila grimshawi Dgri\GH12816
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v100715 P{KK108079}VIE-260B v38915 w1118; P{GD9165}v38915/TM3
Genomic Clones ( 2 )
	BACR13N03 BACR27O05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM12605 GM25235
Other clones	FI05227
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM12149 GM29977 LD01255 LD03987 LD05457 LD13238 LD14530 LD16743 LD17569 LD18141 LD21159 LD34115 LD41177 RE27924 RE42313 RE51078 SD05619
Other clones	19985 20135 28143 50087 125558 160391 161339 164320 164335 211112.1 Dmel_dig_008950_0636_0664 Dmel_neb_008750_0643_3059 EC052111 EK136047 EK175933 EK235655 EK247842 EK263151 EK268622 EK273157 IP02014 LD05169
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030468 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32282
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132644 NM_001272583 RefSeq (Proteins) • NP_572872 NP_001259512 DDBJ / EMBL / GenBank • AA804034 AAF48249 AAM52648 AGB95354 AW941361 AY122136 Entrez Gene - A searchable database of RefSeq genes. • 32282 UniProtKB/TrEMBL • Q8MR43 Q9VYE9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pre-mRNA-splicing factor 38 (IPR005037) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM12605
Linkouts
	BioGRID - A database of protein and genetic interactions • 58665 DroID - A comprehensive database of gene and protein interactions. • FBgn0030468 DRSC - Results from RNAi screens. • FBgn0030468 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030468 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1622-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030468 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32282 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32282 modMine - Data generated by the modENCODE project. • FBgn0030468
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG1622 (Keleman et al., 2009.8.5, Herold et al., 2009)
Name Synonym
Secondary FlyBase IDs
References ( 10 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]