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Gene Dmel\CG1998

General Information
Symbol	Dmel\CG1998	Species	D. melanogaster
Name		Annotation symbol	CG1998
Feature type	protein_coding_gene	FlyBase ID	FBgn0030485
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11F4-11F4	Sequence location	X:13,303,402..13,307,107 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG1998 (FBgn0030485). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: C-4 methylsterol oxidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; fatty acid biosynthetic process. 10 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Fatty acid hydroxylase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, larval hindgut, adult heart, adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632313_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG1998. Gene sequence location is X:13303402..13307107.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides CG1998-PC Transcripts CG1998-RC
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11F4-11F4   Limits computationally determined from genome sequence between P{EP}CG1640EP1626 and P{EP}NFATEP1353&P{EP}NFATEP1508
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG1998 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Gene model reviewed during 5.45 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG1998-RA FBtr0073787  NM_132659   1770   406 CG1998-RB FBtr0301560  NM_001169268   1249   298 CG1998-RC FBtr0343148     1623   406
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG1998-PA   FBpp0073618   45.8   406   7.89     NP_572887   AAF48271 CG1998-PB   FBpp0290775   34.9   298   7.70     NP_001162739   ACZ95274 CG1998-PC   FBpp0309847   45.8   406   7.89
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fatty acid hydroxylase (IPR006694)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48271   AE014298 ACZ95274   AY071233 AAL48855   BI229232   BI232364   BI627827   CA803793   CA804049   CA804146   CA806182   CO275558   CO278686   CO283820   CO304630   CZ473267   CZ474714   CZ476794   CZ476795   CZ486602   CZ486603   CZ489102   CZ489103   EC066010   EC068169   EC087849   EC217214   EC243306   EC248316
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VYD2 E1JJN0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, adult hindgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, larval hindgut, adult heart, adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain  (705.2) Adult Thoracic-Abdominal Ganglion  (827.3) Adult Crop  (761.3) Adult Midgut    75.6 Adult Hindgut  (977.7) Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain  705.2 Adult Thoracic-Abdominal Ganglion  (827.3) Adult Crop  761.3 Adult Midgut    75.6 Adult Hindgut  (977.7) Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    243.05 Larval Midgut    19.3 Larval Hindgut    121 Larval Malpighian Tubules    24.6 Larval Fat Body    51.7 Larval Salivary Gland    12.9 Larval Trachea    202.375 Larval Carcass    85.9 Adult Head    355.8 Adult Eye    241.125 Adult Brain    705.2 Adult Thoracic-Abdominal Ganglion    827.3 Adult Crop    761.3 Adult Midgut    75.6 Adult Hindgut    977.7 Adult Malpighian Tubules    21.7 Adult Fat Body    221.9 Adult Salivary Gland    109.3 Adult Heart    311.225 Adult VirginFemale Spermatheca    152.9 Adult InseminatedFemale Spermatheca    118.1 Adult Ovary    21.2 Adult Testis    135.5 Adult Male Accessory Gland    89.4 Adult Carcass    191 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    355.8   NA  Eye    241.125   NA  Brain    705.2   243.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    827.3   NA  Crop    761.3   19.3  Midgut    75.6   121  Hindgut    977.7   24.6  Malpighian Tubules    no informative data   51.7  Fat Body    221.9   no informative data  Salivary Gland    109.3   NA  Heart    311.225   202.375  Trachea    NA   NA  VirginFemale Spermatheca    152.9   NA  InseminatedFemale Spermatheca    118.1   NA  Ovary    21.2   NA  Testis    135.5   NA  Male Accessory Gland    89.4   85.9  Carcass    191 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    14 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    16 head, mated 4-day female    13 head, mated 20-day female    10 head, mated 1-day male    22 head, mated 4-day male    23 head, mated 20-day male    19 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    11 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    13 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    13 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    15 pupae 3d postWPP    7 pupae 4d postWPP    11 adult male 01day    14 adult male 05day    19 adult male 30day    19 adult female 01day    7 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2  (34) ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (33) Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2  (34) ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    33 Schneider line 2 Sg4    8 embryonic 1182-4H    2 embryonic GM2    3 embryonic Kc167    13 embryonic S1    13 embryonic S3    5 leg disc CME L1    7 wing disc CME-W2    11 wing disc ML-DmD8    11 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    4 wing disc ML-DmD21    22 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    34 ovary fGS/OSS    2 ovary OSC    16 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    7 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_04 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • RE26969 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030485 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1998-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG1998GD3346 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG1998GD3346 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 CG1998GD3346
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of CG1998 Class Mutagen Stocks Known lesion CG1998d01642 1 -- CG1998d03218 1 -- CG1998f04011 piggyBac transposase 1 -- CG1998f06396 piggyBac transposase 1 -- CG1998d03277 P-element activity 0 -- CG1998d05760 P-element activity 0 -- CG1998d09532 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG1998 Class Mutagen Stocks Known lesion CG1998GD3346 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG1998KK108676 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG1998NIG.1998R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3346} NA P{KK108676} NA P{NIG.1998R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG1998f04011 NA PBac{WH}CG1998f06396 NA insertion of mobile activating element P{XP}CG1998d01642 NA P{XP}CG1998d03218 NA P{XP}CG1998d03277 NA P{XP}CG1998d05760 NA P{XP}CG1998d09532 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
C-4 methylsterol oxidase activity inferred from sequence or structural similarity with UniProtKB:Q15800 (FlyBase, 1992-) iron ion binding inferred from electronic annotation with InterPro:IPR006694 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
fatty acid biosynthetic process inferred from electronic annotation with InterPro:IPR006694 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR006694 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG1998 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030485 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32300
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QVCZ0 Dipteran inclusive ortholog search EOG68SH30 Insect inclusive ortholog search EOG6RR5CX Arthropod inclusive ortholog search EOG6RXWFS Metazoa inclusive ortholog search EOG6DG2G4
Orthologs in Drosophila Species (EOG6QVCZ0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG1998     Drosophila simulans   Dsim\GD15886 Y   Drosophila sechellia   Dsec\GM11491 Y   Drosophila erecta   Dere\GG19505 Y   Drosophila yakuba   Dyak\GE16159 Y   Drosophila ananassae   Dana\GF22423 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15176 Y   Drosophila persimilis   Dper\GL27003 Y   Drosophila willistoni   Dwil\GK25860 Y   Drosophila virilis   Dvir\GJ19339 Y   Drosophila mojavensis   Dmoj\GI14598 Y   Drosophila grimshawi   Dgri\GH24046 Y
Orthologs in non-Drosophila Dipterans (EOG68SH30)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012298 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000131 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000091 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017305 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009044 Y
Orthologs in non-Dipteran Insects (EOG6RR5CX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409360   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012074   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21122   Atta cephalotes Leafcutter ant  Acep\ACEP21024   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15947   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12523   Linepithema humile Argentine ant  Lhum\LH24004   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25085   Solenopsis invicta Red fire ant  Sinv\SINV18739   Pediculus humanus Human body louse  Phum\PHUM371030   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07511
Orthologs in non-Insect Arthropods (EOG6RXWFS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Sdcbp2   Ixodes scapularis Deer tick  Isca\ISCW007511
Orthologs in non-Arthropod Metazoa (EOG6DG2G4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F49E12.9 Y Caenorhabditis elegans Nematode  Cele\F49E12.10 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022050gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025401gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018974gn Y Danio rerio Zebrafish  Drer\zgc:55420 Y Xenopus tropicalis Western clawed frog  Xtro\c5orf4 Y Gallus gallus Domestic chicken  Ggal\C5orf4 Y Rattus norvegicus Norway rat  Rnor\LOC691221 Y Homo sapiens Human  Hsap\C5orf4 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\C5orf4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15886 Drosophila sechellia Dsec\GM11491 Drosophila erecta Dere\GG19505 Drosophila yakuba Dyak\GE16159 Drosophila ananassae Dana\GF22423 Drosophila pseudoobscura pseudoobscura Dpse\GA15176 Drosophila persimilis Dper\GL27003 Drosophila willistoni Dwil\GK25860 Drosophila virilis Dvir\GJ19339 Drosophila mojavensis Dmoj\GI14598 Drosophila grimshawi Dgri\GH24046
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Harvard	- P{XP}CG1998d01642 - P{XP}CG1998d03218 - PBac{WH}CG1998f04011 - PBac{WH}CG1998f06396
VDRC	v108357 P{KK108676}VIE-260B v37395 w1118; P{GD3346}v37395 v37396 w1118; P{GD3346}v37396/TM3
Genomic Clones ( 2 )
	BACR08A22 BACR27O05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE26969
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE28418 RH69274
Other clones	103916 146993 CK01.2D.G3 CK01.112A.E4 CK01.141C.E5 EK117919 EK131003 EK164523 EK245338 ESG012b.E21_C02 ESG0110c.E21.1_D09 ESG0111d.B21.1_E07 ESG0112b.B21_C09
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030485 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32300
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132659 NM_001169268 RefSeq (Proteins) • NP_572887 NP_001162739 DDBJ / EMBL / GenBank • AAF48271 AAL48855 ACZ95274 AY071233 BI229232 CZ473267 CZ474714 CZ476794 CZ476795 CZ486602 CZ486603 CZ489102 CZ489103 Entrez Gene - A searchable database of RefSeq genes. • 32300 UniProtKB/TrEMBL • E1JJN0 Q9VYD2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fatty acid hydroxylase (IPR006694) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE26969
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030485 DRSC - Results from RNAi screens. • FBgn0030485 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030485 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1998-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030485 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32300 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32300 modMine - Data generated by the modENCODE project. • FBgn0030485
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG1998 (Shen et al., 2010, Vinci et al., 2008, Lebo et al., 2009, Keleman et al., 2009.8.5, Behm-Ansmant et al., 2006, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Shen et al., 2010, J. Lipid Res. 51(10): 2985--2992 Drosophila lacks C20 and C22 PUFAs. [FBrf0211788] Lebo et al., 2009, BMC Genomics 10: 80 Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. [FBrf0207472] Vinci et al., 2008, PLoS ONE 3(8): e2883 Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. [FBrf0205755] Behm-Ansmant et al., 2006, Genes Dev. 20(14): 1885--1898 mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. [FBrf0194513] Gleason et al., 2005, Genetics 171(4): 1789--1798 Quantitative trait loci for cuticular hydrocarbons associated with sexual isolation between Drosophila simulans and D. sechellia. [FBrf0190723] Santos and Lehmann, 2004, Dev. Cell 6(2): 283--293 Isoprenoids control germ cell migration downstream of HMGCoA reductase. [FBrf0174539]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]