FlyBase Gene Report: Dmel\Set2

General Information

Symbol

Dmel\Set2

Species

D. melanogaster

Name

SET domain containing 2

Annotation Symbol

CG1716

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030486

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Snapshot

SET domain containing 2 (Set2) encodes an essential histone methyltransferase that marks active gene bodies with H3K36me3. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dHypb, dSet2

Key Links

Genomic Location

Cytogenetic map

11F4-11F5

Sequence location

X:13,413,242..13,421,024 [+]

Recombination map

1-43

RefSeq locus

NC_004354 REGION:13413242..13421024

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables histone methyltransferase activity (H3-K36 specific)

inferred from mutant phenotype

(Stabell et al., 2007)

enables phosphoprotein binding

inferred from physical interaction with FLYBASE:RpII215; FB:FBgn0003277

(Stabell et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR017956

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables histone methyltransferase activity (H3-K36 specific)

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(assigned by GO_Central )

(Gaudet et al., 2011)

enables histone-lysine N-methyltransferase activity

inferred from sequence or structural similarity with UniProtKB:Q9BZ95

(assigned by UniProt )

(UniProt Curators, 2002-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in ecdysone receptor-mediated signaling pathway

inferred from genetic interaction with FLYBASE:EcR; FB:FBgn0000546

(Stabell et al., 2007)

involved_in histone H3-K36 methylation

inferred from mutant phenotype

(Larschan et al., 2007)

involved_in instar larval development

inferred from mutant phenotype

(Stabell et al., 2007)

involved_in wing disc development

inferred from mutant phenotype

(Stabell et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in histone methylation

inferred from sequence or structural similarity with UniProtKB:Q9BZ95

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in regulation of transcription, DNA-templated

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Stabell et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002739645

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SET DOMAIN LYSINE METHYLTRANSFERASES

Protein Family (UniProt)

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (Q9VYD1)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SET DOMAIN LYSINE METHYLTRANSFERASES -: SET domain lysine methyltransferases (KMTs) catalyze the addition of methyl groups to lysine residues. SET domain KMTs possess a domain that was original characterized in the D.mel KMTs Su(var)3-9, E(z) and trx. (Adapted from FBrf0216343).

Protein Function (UniProtKB)

Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity).

(UniProt, Q9VYD1)

Summary (Interactive Fly)

Histone 3 methyltransferase involved in dosage compensation, puparium formation and adult development

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Set2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Set2-RA

FBtr0073779

NM_132660

7583

2362

Set2-RB

FBtr0301559

NM_001169269

7372

2313

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Set2-PA

FBpp0073610

262.3

2362

5.73

NP_572888

AAF48273

Set2-PB

FBpp0290774

256.8

2313

6.20

NP_001162740

ACZ95275

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Set2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Set2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Stabell et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Set2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Set2

View exonic expression by tissue for Dmel\Set2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030486

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030486

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1716-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1716

Flygut - An atlas of the Drosophila adult midgut

FBgn0030486

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Set2

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Set2

Transgenic constructs containing regulatory region of Set2

Deletions and Duplications ( 1 )

Disrupted in

Df(1)Exel6246

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage

Set2¹

lethal - all die before end of larval stage, with Scer\GAL4^da.G32

Set2^dsRNA.UAS

lethal - all die before end of P-stage

Set2¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Set2^GD5042

viable, with Scer\GAL4^Mef2.PR

Set2^GD5042

viable, with Scer\GAL4^pnr-MD237

Set2^GD5042

viable, with Scer\GAL4^tin.CΔ4

Set2^GD5042

Other Phenotypes

Allele

developmental rate defective | larval stage, with Scer\GAL4^da.G32

Set2^dsRNA.UAS

majority die during pupal stage

Set2¹

some die during larval stage

Set2¹

some die during third instar larval stage

Set2¹

some die during third instar larval stage, with Scer\GAL4^da.G32

Set2^dsRNA.UAS

visible, with Scer\GAL4^ap-md544

Set2^dsRNA.UAS

visible | adult stage, with Scer\GAL4^nub.PK

Set2^HMS00583

visible | recessive | somatic clone

Set2¹

Phenotype manifest in

Allele

eye | somatic clone

Set2¹

posterior crossvein, with Scer\GAL4^nub.PK

Set2^HMS00583

wing, with Scer\GAL4^ap-md544

Set2^dsRNA.UAS

wing vein, with Scer\GAL4^nub.PK

Set2^HMS00583

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SETD2

11 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Setd2

10 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (17)

Rnor\Setd2

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (16)

Xtro\setd2

4 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (27)

Drer\setd2

6 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\LOC103910708

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\met-1

8 of 15

Yes

Cele\set-12

5 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\EFS

3 of 9

Yes

Atha\ASHH1

1 of 9

Yes

Atha\ASHH3

1 of 9

Yes

Atha\ASHH4

1 of 9

Yes

Atha\SDG4

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\SET2

5 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\set2

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190185 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14357

Drosophila persimilis

Dper\GL27000

Drosophila willistoni

Dwil\GK25076

Drosophila virilis

Dvir\GJ19006

Drosophila virilis

Dvir\GJ13235

Drosophila mojavensis

Dmoj\GI12297

Drosophila grimshawi

Dgri\GH16034

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501ZV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017756

Glossina morsitans

Tsetse fly

Gmor\GMOY010695

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00891

Mayetiola destructor

Hessian fly

Mdes\Mdes005832

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006013

Anopheles darlingi

American malaria mosquito

Adar\ADAC001196

Anopheles gambiae

Malaria mosquito

Agam\AGAP011688

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005876

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01OD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA003106

Danaus plexippus

Monarch butterfly

Dple\DPOGS201316-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201317-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL017250

Apis florea

Little honeybee

Aflo\2451681300

Apis mellifera

Western honey bee

Amel\GB51706

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25117

Bombus terrestris

Buff-tailed bumblebee

Bter\15208214

Linepithema humile

Argentine ant

Lhum\LH24846

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001e3e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003836

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07161

Tribolium castaneum

Red flour beetle

Tcas\TC014310

Pediculus humanus

Human body louse

Phum\PHUM463920

Rhodnius prolixus

Kissing bug

Rpro\RPRC001422

Cimex lectularius

Bed bug

Clec\CLEC005584

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006794

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI56665

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02205

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01MB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR002837

Ixodes scapularis

Black-legged tick

Isca\ISCW013039

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70004.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79909.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g00050

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_319776

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G040P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Setd2

Ciona intestinalis

Vase tunicate

Cint\LOC100177167

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000014317

Gallus gallus

Domestic chicken

Ggal\SETD2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

2 of 10

NSD

2 of 10

Set1

2 of 10

trr

2 of 10

CG4565

1 of 10

egg

1 of 10

G9a

1 of 10

Lpt

1 of 10

MBD-R2

1 of 10

pps

1 of 10

PR-Set7

1 of 10

Su(var)3-9

1 of 10

trx

1 of 10

upSET

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SETD2; SET domain containing 2, histone lysine methyltransferase

11 of 15

612778

LUSCAN-LUMISH SYNDROME; LLS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Set2 - RpII215

anti bait coimmunoprecipitation, western blot

(Stabell et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Set2

enhanceable

EcR

(Stabell et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58681

DroID - A comprehensive database of gene and protein interactions.

FBgn0030486

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32301

MIST (protein-protein) - An integrated Molecular Interaction Database

Set2

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Lysine degradation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-43

Cytogenetic map

11F4-11F5

Sequence location

X:13,413,242..13,421,024 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11F4-11F5

Limits computationally determined from genome sequence between P{EP}CG1640^EP1626 and P{EP}NFAT^EP1353&P{EP}NFAT^EP1508

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-43

(FlyBase, 2016)

1-43.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

77916

y¹ w^* Set2¹/FM7h

24108

y¹ w¹¹¹⁸; P{UAS-Set2.IR}21

31355

y¹ v¹; P{TRiP.JF01313}attP2

42511

y¹ v¹; P{TRiP.HMJ02076}attP40

55221

y¹ v¹; P{TRiP.GLC01838}attP40

83381

y¹ w^*; P{Set2-GFP.FPTB}attP40

77917

y¹ w^* Set2¹; P{Set2^+t10.3}2

78749

y¹ sc^* v¹ sev²¹; P{TOE.GS02288}attP40

33706

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00583}attP2

VDRC

v106459

P{KK102455}VIE-260B

v30707

w¹¹¹⁸; P{GD5042}v30707

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (38)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030486

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030486

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32301

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mazina et al., 2018)

monoclonal polyclonal

(Bell et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Set2 CG1716

(Stabell et al., 2007)

Source for database merge of

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32301

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VYD1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

E1JJN9

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030486

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030486

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Set2_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1716

Flygut - An atlas of the Drosophila adult midgut

FBgn0030486

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32301

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014310

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1716

modMine - A data warehouse for the modENCODE project

FBgn0030486

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VYD1

Linkouts

BioGRID - A database of protein and genetic interactions.

58681

DroID - A comprehensive database of gene and protein interactions.

FBgn0030486

DRSC - Results frm RNAi screens

FBgn0030486

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0030486

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1716-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030486

FlyMine - An integrated database for Drosophila genomics

FBgn0030486

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32301

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Lysine degradation

MIST (protein-protein) - An integrated Molecular Interaction Database

Set2

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Name Synonyms

CG1716

Drosophila Hypb

(Bell et al., 2008)

SET domain containing 2

Set2

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (59)

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