The gene Ndc80 is referred to in FlyBase by the symbol Dmel\Ndc80 (CG9938, FBgn0030500). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic metaphase plate congression; chromosome segregation; mitotic spindle organization; neurogenesis. 11 alleles are reported. The phenotypes of these alleles are annotated with: metaphase; trichogen cell; condensed nuclear chromosome; spindle; mesothoracic tergum; nucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: Kinetochore protein Ndc80. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630409_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ndc80. Gene sequence location is X:13503698..13506009.
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modENCODE Temporal Expression Data for FBgn0030500
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
[download data (TSV)]
Guide to modENCODE expression level colors
No expression (0 - 0)
Extremely low expression (1 - 10)
Very low expression (11 - 100)
Low expression (101 - 400)
Moderate expression (401 - 1400)
Moderately high expression (1401 - 4000)
High expression (4001 - 10000)
Very high expression (10001 - 100000)
Extremely high expression (100001 - 2000000)
Linear, scaled to maximum FBgn0030500 expression level
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
Linear, scaled to Very low expression
Developmental Stage
Expression Level
embryo 00-02hr
(2822)
embryo 02-04hr
(1328)
embryo 04-06hr
(3358)
embryo 06-08hr
(2662)
embryo 08-10hr
(1538)
embryo 10-12hr
(639)
embryo 12-14hr
(267)
embryo 14-16hr
(137)
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
(158)
larva L3 puffstage 1-2
(248)
larva L3 puffstage 3-6
(335)
larva L3 puffstage 7-9
(375)
white prepupae new
(319)
white prepupae 12hr
(589)
white prepupae 24hr
(464)
pupae 2d postWPP
(153)
pupae 3d postWPP
85
pupae 4d postWPP
(136)
adult male 01day
(161)
adult male 05day
(218)
adult male 30day
(219)
adult female 01day
(608)
adult female 05day
(1309)
adult female 30day
(1486)
Expression Level Scale
None
Extremely low
Very low
Low
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(2822)
embryo 02-04hr
1328
embryo 04-06hr
(3358)
embryo 06-08hr
(2662)
embryo 08-10hr
(1538)
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to maximum FBgn0030500 expression level
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
log, scaled to Very low expression
Developmental Stage
Expression Level
embryo 00-02hr
(2822)
embryo 02-04hr
(1328)
embryo 04-06hr
(3358)
embryo 06-08hr
(2662)
embryo 08-10hr
(1538)
embryo 10-12hr
(639)
embryo 12-14hr
(267)
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
(158)
larva L3 puffstage 1-2
(248)
larva L3 puffstage 3-6
(335)
larva L3 puffstage 7-9
(375)
white prepupae new
(319)
white prepupae 12hr
(589)
white prepupae 24hr
(464)
pupae 2d postWPP
(153)
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
(161)
adult male 05day
(218)
adult male 30day
(219)
adult female 01day
(608)
adult female 05day
(1309)
adult female 30day
(1486)
Expression Level Scale
None
Extremely low
Very low
Low
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(2822)
embryo 02-04hr
1328
embryo 04-06hr
(3358)
embryo 06-08hr
(2662)
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
2822
embryo 02-04hr
1328
embryo 04-06hr
3358
embryo 06-08hr
2662
embryo 08-10hr
1538
embryo 10-12hr
639
embryo 12-14hr
267
embryo 14-16hr
137
embryo 16-18hr
85
embryo 18-20hr
95
embryo 20-22hr
48
embryo 22-24hr
67
larva L1
84
larva L2
107
larva L3 12hr old
158
larva L3 puffstage 1-2
248
larva L3 puffstage 3-6
335
larva L3 puffstage 7-9
375
white prepupae new
319
white prepupae 12hr
589
white prepupae 24hr
464
pupae 2d postWPP
153
pupae 3d postWPP
85
pupae 4d postWPP
136
adult male 01day
161
adult male 05day
218
adult male 30day
219
adult female 01day
608
adult female 05day
1309
adult female 30day
1486
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
FlyAtlas Anatomical Expression Data for FBgn0030500
Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary.
[download data (TSV)]
Guide to FlyAtlas expression level colors
No expression (0 - 9.999)
Low expression (10 - 99.999)
Moderate expression (100 - 499.999)
High level expression (500 - 999.999)
Very high expression (1000 - 25000)
Linear, scaled to maximum FBgn0030500 expression level
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to maximum FBgn0030500 expression level
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
152.45
Larval Midgut
no informative data
Larval Hindgut
17.9
Larval Malpighian Tubules
23
Larval Fat Body
no informative data
Larval Salivary Gland
65.6
Larval Trachea
37.675
Larval Carcass
no informative data
Adult Head
5.4
Adult Eye
4.2
Adult Brain
8.9
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
9.2
Adult Malpighian Tubules
8.4
Adult Fat Body
5.4
Adult Salivary Gland
no informative data
Adult Heart
9.275
Adult VirginFemale Spermatheca
9.9
Adult InseminatedFemale Spermatheca
6.1
Adult Ovary
354
Adult Testis
37.8
Adult Male Accessory Gland
6.5
Adult Carcass
no informative data
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
no informative data
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
no informative data
Larval Salivary Gland
Larval Trachea
Larval Carcass
no informative data
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
no informative data
Adult Crop
no informative data
Adult Midgut
no informative data
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
no informative data
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
no informative data
FlyAtlas Organ/Tissue Expression, larval vs. adult
Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 9 )
Please Note
This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see GBrowse for alignment of the cDNAs and ESTs
to the gene model.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle and a spindle that is aberrantly long when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Kebab: Kinetochore and EB1 Associated Basic Protein That Dynamically Changes Its Localisation during Drosophila Mitosis. [FBrf0215262]
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Przewloka et al., 2011, Curr. Biol. 21(5): 399--405
CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151]
Venkei et al., 2011, Genetics 187(1): 131--140
Drosophila mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. [FBrf0212773]
Blanco et al., 2010, BMC Dev. Biol. 10: 94
Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Schittenhelm et al., 2010, J. Cell Sci. 123(21): 3768--3779
Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. [FBrf0212150]