FB2020_01, released Feb 12, 2020

Gene: Dmel\BthD

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General Information
Symbol
Dmel\BthD
Species
D. melanogaster
Name
BthD selenoprotein
Annotation Symbol
CG11177
Feature Type
protein_coding_gene
FlyBase ID
FBgn0030501
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
BthD selenoprotein (BthD) encodes a protein involved in salivary gland development and lifespan determination. [Date last reviewed: 2019-09-19]
Other Summaries
Also Known As

SelH

Key Links
Genomic Location
Cytogenetic map
12A8-12A8
Sequence location
X:13,612,131..13,613,228 [+]
Recombination map

1-44

RefSeq locus
NC_004354 REGION:13612131..13613228
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
May be involved in a redox-related process. Required for survival and specifically for salivary gland morphogenesis.
(UniProt, Q9VYB0)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\BthD or the JBrowse view of Dmel\BthD for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.39

gene_with_stop_codon_redefined_as_selenocysteine ; SO:0000710

Stop-codon suppression (UGA as Sec) postulated (FBrf0137271).

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
gene_with_stop_codon_redefined_as_selenocysteine
(Martin-Romero et al., 2001)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
BthD-RA
FBtr0073806
NM_132675
977
249
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
BthD-PA
FBpp0073637
27.8
249
10.44
NP_572903
AAF48293
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\BthD using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (9 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
determination of adult lifespan
inferred from direct assay
(assigned by UniProt )
(Kwon et al., 2003)
embryo development ending in birth or egg hatching
inferred from direct assay
(assigned by UniProt )
(Castellano et al., 2001)
larval salivary gland morphogenesis
inferred from mutant phenotype
(Kwon et al., 2003)
salivary gland boundary specification
inferred from direct assay
(assigned by UniProt )
(Kwon et al., 2003)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
anatomical structure development
inferred from biological aspect of ancestor with PANTHER:PTN002132385
(assigned by GO_Central )
(Gaudet et al., 2011)
cell redox homeostasis
traceable author statement
(assigned by UniProt )
(Castellano et al., 2001)
response to redox state
non-traceable author statement
(assigned by UniProt )
(Martin-Romero et al., 2001)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Kwon et al., 2003)
Golgi apparatus
inferred from direct assay
(Kwon et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002132385
(assigned by GO_Central )
(Gaudet et al., 2011)
Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN002132385
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | intense

Comment: assayed 0-15 hr AEL

(Kwon et al., 2003)
larval stage
organism | faint
(Kwon et al., 2003)
adult stage | female
organism | intense
(Kwon et al., 2003)
adult stage | male
organism | faint
(Kwon et al., 2003)
Additional Descriptive Data

BthD transcript is detected at high levels in embryos from 0-5 hours AEL, and in adult females. BthD is detected at moderate levels from 5-15 hours ALE, and at negligible levels during all three larval instars, and in adult males.

(Kwon et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
ovariole
(Kwon et al., 2003)
oocyte
(Kwon et al., 2003)
embryonic stage 1 -- 4
organism | intense | ubiquitous | uniform

Comment: maternal contribution

(Kwon et al., 2003)
embryonic stage 5 -- 10
organism | faint | ubiquitous
(Kwon et al., 2003)
embryonic stage 14 -- 16
salivary gland body primordium | intense
(Kwon et al., 2003)
Additional Descriptive Data

BthD protein is is detected in ovarioles at all oogenesis stages. It is localized to the cytoplasm of oocytes, and is not detected in follicle or nurse cells. Maternally contributed BthD protein is detected in embryos until cellularization, and is much reduced by embryonic stage 10. BthD protein is detected in the salivary glands at stage 14, accumulating through stage 16.

(Kwon et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Kwon et al., 2003)
Golgi apparatus
inferred from direct assay
(Kwon et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\BthD in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of BthD
Transgenic constructs containing regulatory region of BthD
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SELENOH
6 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Selenoh
5 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Selenoh
3 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (1)
Drer\selenoh
3 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (2)
Atha\AT4G31360
4 of 9
Yes
Yes
Atha\AT2G24440
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190HMU )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\BthD
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008378
Drosophila simulans
Dsim\GD24812
Drosophila erecta
Dere\GG17796
Drosophila yakuba
Dyak\GE17092
Drosophila ananassae
Dana\GF21759
Drosophila pseudoobscura pseudoobscura
Dpse\GA27918
Drosophila willistoni
Dwil\GK25075
Drosophila virilis
Dvir\GJ19168
Drosophila grimshawi
Dgri\GH19705
Drosophila grimshawi
Dgri\GH12971
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0OOD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_52874
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG13186
3 of 10
CG15147
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SELENOH; selenoprotein H
    6 of 15
    607914
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        BthD - Sbp2
        electrophoretic mobility shift assay, autoradiography
        (Takeuchi et al., 2009)
        protein-protein
        Physical Interaction
        Assay
        References
        BthD - Arc1
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG1129
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG1218
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG1532
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG18787
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG18789
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG2540
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG4707
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG5746
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - CG7049
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - Ccs
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - Cpr11B
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - Fkbp12
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - Got1
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - RpS21
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - Wdr82
        experimental knowledge based
        (Guruharsha et al., 2011)
        BthD - knrl
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map

        1-44

        Cytogenetic map
        12A8-12A8
        Sequence location
        X:13,612,131..13,613,228 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        12A8-12A8
        Limits computationally determined from genome sequence between P{EP}CG1640EP1626 and P{EP}NFATEP1353&P{EP}NFATEP1508
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        1-44

        (FlyBase, 2016)

        1-43.6

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (3)
        Genomic Clones (5)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (22)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Kwon et al., 2003)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: BthD CG11177

          (FlyBase, 1996-)
          Source for database merge of
          Additional comments

          Source for identity of BthD CG11177 was sequence comparison ( date:010728 ).

          (FlyBase, 1996-)
          Other Comments
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 27 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (8)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (33)