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Gene Dmel\CG11590

General Information
Symbol	Dmel\CG11590	Species	D. melanogaster
Name		Annotation symbol	CG11590
Feature type	protein_coding_gene	FlyBase ID	FBgn0030545
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12E3-12E3	Sequence location	X:14,094,237..14,094,940 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11590 (FBgn0030545). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: response to metal ion. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Divalent ion tolerance protein, CutA; Nitrogen regulatory PII-like, alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635969_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11590. Gene sequence location is X:14094237..14094940.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN21770 HFA19411
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12E3-12E3   Limits computationally determined from genome sequence between P{EP}EP1595EP1595 and P{EP}l(1)G0007EP764
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11590 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11590-RA FBtr0073899  NM_132717   704   198
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11590-PA   FBpp0073716   21.4   198   7.24     NP_572945   AAF48350
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Divalent ion tolerance protein, CutA (IPR004323) Nitrogen regulatory PII-like, alpha/beta (IPR011322)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48350   AY118865 AAM50725   BI353754   BP557078   BT032680   CO181738   CO281142   CO309337   CO310305   CO329622   CO339223   EC075785   EC210630   EC216217   EC256700   GH739407   GH739772   GH741934   GH742684   GH743039   GH743571   GH743601   GH743830   GH744035   GH745810   GH762610   GH763441   GH763731   GH764066   GH765746   GH767240   GH769238   GH769841   GH779447
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSE7 Q9VY55
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0030545    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0030545 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0030545 expression level Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3661) embryo 02-04hr  (1778) embryo 04-06hr  (1378) embryo 06-08hr  (1706) embryo 08-10hr  (1406) embryo 10-12hr  (1748) embryo 12-14hr  (1306) embryo 14-16hr  (1347) embryo 16-18hr  (989) embryo 18-20hr  (869) embryo 20-22hr  (723) embryo 22-24hr  (530) larva L1  (1162) larva L2  (1440) larva L3 12hr old  (1513) larva L3 puffstage 1-2  (2549) larva L3 puffstage 3-6  (3408) larva L3 puffstage 7-9  (3751) white prepupae new  (3511) white prepupae 12hr  (3700) white prepupae 24hr  (3964) pupae 2d postWPP  (3270) pupae 3d postWPP  (1857) pupae 4d postWPP  (1576) adult male 01day  (2662) adult male 05day  (3632) adult male 30day  (3470) adult female 01day  (2127) adult female 05day  (2345) adult female 30day  (2490) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3661) embryo 02-04hr  (1778) embryo 04-06hr    1378 embryo 06-08hr  (1706) embryo 08-10hr  1406 embryo 10-12hr  (1748) embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2  1440 larva L3 12hr old  (1513) larva L3 puffstage 1-2  (2549) larva L3 puffstage 3-6  (3408) larva L3 puffstage 7-9  (3751) white prepupae new  (3511) white prepupae 12hr  (3700) white prepupae 24hr  (3964) pupae 2d postWPP  (3270) pupae 3d postWPP  (1857) pupae 4d postWPP  (1576) adult male 01day  (2662) adult male 05day  (3632) adult male 30day  (3470) adult female 01day  (2127) adult female 05day  (2345) adult female 30day  (2490) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0030545 expression level Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3661) embryo 02-04hr  (1778) embryo 04-06hr  (1378) embryo 06-08hr  (1706) embryo 08-10hr  (1406) embryo 10-12hr  (1748) embryo 12-14hr  (1306) embryo 14-16hr  (1347) embryo 16-18hr  (989) embryo 18-20hr  (869) embryo 20-22hr  (723) embryo 22-24hr  (530) larva L1  (1162) larva L2  (1440) larva L3 12hr old  (1513) larva L3 puffstage 1-2  (2549) larva L3 puffstage 3-6  (3408) larva L3 puffstage 7-9  (3751) white prepupae new  (3511) white prepupae 12hr  (3700) white prepupae 24hr  (3964) pupae 2d postWPP  (3270) pupae 3d postWPP  (1857) pupae 4d postWPP  (1576) adult male 01day  (2662) adult male 05day  (3632) adult male 30day  (3470) adult female 01day  (2127) adult female 05day  (2345) adult female 30day  (2490) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3661) embryo 02-04hr  1778 embryo 04-06hr    1378 embryo 06-08hr  1706 embryo 08-10hr  1406 embryo 10-12hr  1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2  1440 larva L3 12hr old  1513 larva L3 puffstage 1-2  (2549) larva L3 puffstage 3-6  (3408) larva L3 puffstage 7-9  (3751) white prepupae new  (3511) white prepupae 12hr  (3700) white prepupae 24hr  (3964) pupae 2d postWPP  (3270) pupae 3d postWPP  1857 pupae 4d postWPP  1576 adult male 01day  (2662) adult male 05day  (3632) adult male 30day  (3470) adult female 01day  2127 adult female 05day  2345 adult female 30day  (2490) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3661 embryo 02-04hr    1778 embryo 04-06hr    1378 embryo 06-08hr    1706 embryo 08-10hr    1406 embryo 10-12hr    1748 embryo 12-14hr    1306 embryo 14-16hr    1347 embryo 16-18hr    989 embryo 18-20hr    869 embryo 20-22hr    723 embryo 22-24hr    530 larva L1    1162 larva L2    1440 larva L3 12hr old    1513 larva L3 puffstage 1-2    2549 larva L3 puffstage 3-6    3408 larva L3 puffstage 7-9    3751 white prepupae new    3511 white prepupae 12hr    3700 white prepupae 24hr    3964 pupae 2d postWPP    3270 pupae 3d postWPP    1857 pupae 4d postWPP    1576 adult male 01day    2662 adult male 05day    3632 adult male 30day    3470 adult female 01day    2127 adult female 05day    2345 adult female 30day    2490 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0030545    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0030545 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0030545 expression level Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body  (705.5) Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0030545 expression level Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body  705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    301.4 Larval Midgut    186.5 Larval Hindgut    197.1 Larval Malpighian Tubules    298.3 Larval Fat Body    705.5 Larval Salivary Gland    479.4 Larval Trachea    303.55 Larval Carcass    249.325 Adult Head    139.3 Adult Eye    192.425 Adult Brain    120.8 Adult Thoracic-Abdominal Ganglion    120.2 Adult Crop    185.1 Adult Midgut    138 Adult Hindgut    159.3 Adult Malpighian Tubules    146.6 Adult Fat Body    155.9 Adult Salivary Gland    193.8 Adult Heart    221.625 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    302.3 Adult Ovary    182.5 Adult Testis    138.5 Adult Male Accessory Gland    476.7 Adult Carcass    123.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    139.3   NA  Eye    192.425   NA  Brain    120.8   301.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    120.2   NA  Crop    185.1   186.5  Midgut    138   197.1  Hindgut    159.3   298.3  Malpighian Tubules    146.6   705.5  Fat Body    155.9   479.4  Salivary Gland    193.8   NA  Heart    221.625   303.55  Trachea    NA   NA  VirginFemale Spermatheca    313.5   NA  InseminatedFemale Spermatheca    302.3   NA  Ovary    182.5   NA  Testis    138.5   NA  Male Accessory Gland    476.7   249.325  Carcass    123.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030545 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11590-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 CG11590GD4999 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG11590 Class Mutagen Stocks Known lesion CG11590G17161 P-element activity 1 -- CG11590HP10984 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11590 Class Mutagen Stocks Known lesion CG11590GD4999 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11590KK101719 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4999} NA P{KK101719} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG11590G17161 NA P{EPg}CG11590HP10984 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to metal ion inferred from electronic annotation with InterPro:IPR004323 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11590 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58738 DroID - A comprehensive database of gene and protein interactions. • FBgn0030545 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32368
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15955 Dere\GG17833 Dgri\GH12292 Dmoj\GI15537 Dper\GL12908 Dpse\GA22719 Dsec\GM17662 Dvir\GJ14881 Dwil\GK25753 Dyak\GE17126
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012710-PA Aedes aegypti (mosquito) AGAP000670-PA Anopheles gambiae (mosquito) XP_001947398.1 Acyrthosiphon pisum (pea aphid) At2g33740.2 Arabidopsis thaliana (wall cress) 215555 Branchiostoma floridae (lancelet) BGIBMGA002398-PA Bombyx mori (silk worm) ENSBTAP00000002142 Bos taurus (bovine) CN02054 Caenorhabditis brenneri (small nematode) ENSCAFP00000001427 Canis familiaris (dog) CPIJ014659 Culex pipens (mosquito) ENSCPOP00000007865 Cavia porcellus (guinea pig) 153114 Capitella spl (polychaete worm) 230292 Daphnia pulex (daphnia) 93647 Daphnia pulex (daphnia) ENSDARP00000070936 Danio rerio (zebra fish) ENSECAP00000013838 Equus caballus (horse) ENSGACP00000002401 Gymnopilus aculeatus (mushroom) ENSGALP00000038103 Gallus gallus (chicken) 169296 Hypsipyla robusta (cedar shoot borer) ENSP00000363609 Homo sapiens (human) 173015 Lottia gigantea (owl limpet) ENSMODP00000024493 Monodelphis domestica (gray opossum) ENSMMUP00000033834 Macaca mulatta (rhesus monkey) ENSMUSP00000025027 Mus musculus (house mouse) 247162 Nematostella vectensis (starlet anemone) XP_001607859.1 Nasonia vitripennis (wasp) ENSOANP00000001758 Ornithorynchus anatinus (platypus) ENSORLP00000013522 Oryzias latipes (japanese killifish) LOC_Os03g08800.1 Oryza sativa (asian rice) PFL2375c Plasmodium falciparum (protozoal parasite) PHUM008323-PA Pediculus humanus (human body louse) ENSPPYP00000018454 Pongo pygmaeus (orangutan) 643847 Populus trichocarpa (black cottonwood) ENSPTRP00000030825 Pan troglodytes (chimpanzee) ENSRNOP00000000568 Rattus norvegicus (norway rat) XP_001181724.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200476.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975254.1 Tribolium castaneum (red flour beetle) Tc00.1047053504411.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053504717.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053505009.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506489.59 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022008 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000034 Takifugu rubripes (pufferfish Takifugu) 3689.m00159 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054431 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10367 LH15266 ISCW024356 FBgn0234607 FBgn0227712 FBgn0202085 FBgn0172570 JGI_V11_230292 JGI_V11_93647 FBgn0244122 FBgn0150514 FBgn0138286 FBgn0119771 FBgn0110054 FBgn0092978 CPIJ014659 BGIBMGA002398 ACYPI006776 GB14175 AGAP000670 AAEL012715 AAEL012710 AAEL012706 AAEL011339 PB23098 PHUM291250 GLEAN_00882
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	33585 w* P{EP}CG11590G17161 21904 w1118 P{EPg}CG11590HP10984
VDRC	v104170 P{KK101719}VIE-260B v19867 w1118; P{GD4999}v19867
Genomic Clones ( 1 )
	BACR12J05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM24986
Other clones	FI09726
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	39085 81918 191061 214321.15 EC14905 EK156044 EK217359 EK221203 EK293251 EP01248 FGM307B11 RP001005026 RP001011005 RP001021108 RP001023264 RP001023566 RP001024808 RP001025380 RP001026940 RP001031247 RP001035433 RP001037189 RP001044848 RP001047328 RP001047581 RP001049881 RP001052841 RP001053186 RP001056140 RP001056779
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030545 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32368
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG11590 BcDNA:GM24986 (FlyBase, 1996-)
Additional comments	Source for merge of CG11590 BcDNA:GM24986 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132717 RefSeq (Proteins) • NP_572945 DDBJ / EMBL / GenBank • AAF48350 AAM50725 AY118865 BI353754 Entrez Gene - A searchable database of RefSeq genes. • 32368 UniProtKB/TrEMBL • Q8MSE7 Q9VY55
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Divalent ion tolerance protein, CutA (IPR004323) Nitrogen regulatory PII-like, alpha/beta (IPR011322)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58738 DroID - A comprehensive database of gene and protein interactions. • FBgn0030545 DRSC - Results from RNAi screens. • FBgn0030545 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030545 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11590-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030545 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32368 InParanoid A subset of ortholog calls from InParanoid. • AAEL012710-PA Aedes aegypti (mosquito) AGAP000670-PA Anopheles gambiae (mosquito) XP_001947398.1 Acyrthosiphon pisum (pea aphid) At2g33740.2 Arabidopsis thaliana (wall cress) 215555 Branchiostoma floridae (lancelet) BGIBMGA002398-PA Bombyx mori (silk worm) ENSBTAP00000002142 Bos taurus (bovine) CN02054 Caenorhabditis brenneri (small nematode) ENSCAFP00000001427 Canis familiaris (dog) CPIJ014659 Culex pipens (mosquito) ENSCPOP00000007865 Cavia porcellus (guinea pig) 153114 Capitella spl (polychaete worm) 230292 Daphnia pulex (daphnia) 93647 Daphnia pulex (daphnia) ENSDARP00000070936 Danio rerio (zebra fish) ENSECAP00000013838 Equus caballus (horse) ENSGACP00000002401 Gymnopilus aculeatus (mushroom) ENSGALP00000038103 Gallus gallus (chicken) 169296 Hypsipyla robusta (cedar shoot borer) ENSP00000363609 Homo sapiens (human) 173015 Lottia gigantea (owl limpet) ENSMODP00000024493 Monodelphis domestica (gray opossum) ENSMMUP00000033834 Macaca mulatta (rhesus monkey) ENSMUSP00000025027 Mus musculus (house mouse) 247162 Nematostella vectensis (starlet anemone) XP_001607859.1 Nasonia vitripennis (wasp) ENSOANP00000001758 Ornithorynchus anatinus (platypus) ENSORLP00000013522 Oryzias latipes (japanese killifish) LOC_Os03g08800.1 Oryza sativa (asian rice) PFL2375c Plasmodium falciparum (protozoal parasite) PHUM008323-PA Pediculus humanus (human body louse) ENSPPYP00000018454 Pongo pygmaeus (orangutan) 643847 Populus trichocarpa (black cottonwood) ENSPTRP00000030825 Pan troglodytes (chimpanzee) ENSRNOP00000000568 Rattus norvegicus (norway rat) XP_001181724.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200476.1 Strongylocentrotus purpuratus (purple sea urchin) XP_975254.1 Tribolium castaneum (red flour beetle) Tc00.1047053504411.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053504717.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053505009.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506489.59 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022008 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000000034 Takifugu rubripes (pufferfish Takifugu) 3689.m00159 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000054431 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32368 modMine - Data generated by the modENCODE project. • FBgn0030545 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10367 LH15266 ISCW024356 FBgn0234607 FBgn0227712 FBgn0202085 FBgn0172570 JGI_V11_230292 JGI_V11_93647 FBgn0244122 FBgn0150514 FBgn0138286 FBgn0119771 FBgn0110054 FBgn0092978 CPIJ014659 BGIBMGA002398 ACYPI006776 GB14175 AGAP000670 AAEL012715 AAEL012710 AAEL012706 AAEL011339 PB23098 PHUM291250 GLEAN_00882
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:GM24986   CG11590 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0063185
References ( 11 )
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2010.12.22, GE836.xml GE836.xml [FBrf0212684] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Levis, 2009.8.13, Release 5 sequence localizations for HP and DP lines. Release 5 sequence localizations for HP and DP lines. [FBrf0208533] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]