• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Fbxl4

General Information
Symbol	Dmel\Fbxl4	Species	D. melanogaster
Name	F box and leucine-rich-repeat gene 4	Annotation symbol	CG1839
Feature type	protein_coding_gene	FlyBase ID	FBgn0030555
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dFbxl4
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12E5-12E5	Sequence location	X:14,128,446..14,131,956 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene F box and leucine-rich-repeat gene 4 is referred to in FlyBase by the symbol Dmel\Fbxl4 (CG1839, FBgn0030555). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: deactivation of rhodopsin mediated signaling. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: F-box domain, cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629569_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Fbxl4. Gene sequence location is X:14128446..14131956.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12E5-12E5   Limits computationally determined from genome sequence between P{EP}l(1)G0007EP764 and P{EP}EP1599
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fbxl4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fbxl4-RA FBtr0073923  NM_132723   2894   669
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fbxl4-PA   FBpp0073740   75.7   669   5.89     NP_572951   AAF48359
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • F-box domain, cyclin-like (IPR001810)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA538971   AA696309   AA697669   AA816644   AA978556   AE014298 AAF48359   AI133962   AI402255   AY069093 AAL39238   BI482967   BI485427   BI568227   BI586542   BI587131   BI587376   BI604845   BI612621   BI614046   BI618006   BI622170   BI623820   BI626486   BI631097   CO263649   CO277354   CO281595   CO293323   CO310842   CO328371   CO330609   CO341841   CZ480146   CZ486608   CZ486609   CZ488421   CZ488422   EC067449   EC084892   EC087604   EC197784   EC219660   EC247125   EC252741   EC252760   EV595938
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VY46
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   retina   (Xu et al., 2004)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye    1222.625 Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye  (1222.625) Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye  (1222.625) Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye    1222.625 Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye    1222.625 Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye  (1222.625) Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye  1222.625 Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    67.975 Larval Midgut    43.9 Larval Hindgut    51.6 Larval Malpighian Tubules    70.2 Larval Fat Body    41.8 Larval Salivary Gland    45.6 Larval Trachea    53.525 Larval Carcass    54.225 Adult Head    335.3 Adult Eye    1222.625 Adult Brain    139.3 Adult Thoracic-Abdominal Ganglion    105.4 Adult Crop    46.9 Adult Midgut    34.8 Adult Hindgut    44.8 Adult Malpighian Tubules    68.9 Adult Fat Body    52.7 Adult Salivary Gland    52.3 Adult Heart    82.375 Adult VirginFemale Spermatheca    59.2 Adult InseminatedFemale Spermatheca    65.7 Adult Ovary    112.6 Adult Testis    14.8 Adult Male Accessory Gland    67.8 Adult Carcass    54.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    335.3   NA  Eye    1222.625   NA  Brain    139.3   67.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    105.4   NA  Crop    46.9   43.9  Midgut    34.8   51.6  Hindgut    44.8   70.2  Malpighian Tubules    68.9   41.8  Fat Body    52.7   45.6  Salivary Gland    52.3   NA  Heart    82.375   53.525  Trachea    NA   NA  VirginFemale Spermatheca    59.2   NA  InseminatedFemale Spermatheca    65.7   NA  Ovary    112.6   NA  Testis    14.8   NA  Male Accessory Gland    67.8   54.225  Carcass    54.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    3 head, virgin 1-day female    10 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    11 head, mated 4-day female    10 head, mated 20-day female    12 head, mated 1-day male    17 head, mated 4-day male    16 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    2 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    10 ovary, mated 4-day female    8 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    25 embryo 02-04hr    14 embryo 04-06hr    15 embryo 06-08hr    20 embryo 08-10hr    15 embryo 10-12hr    13 embryo 12-14hr    8 embryo 14-16hr    8 embryo 16-18hr    6 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    5 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    16 white prepupae new    21 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    8 pupae 3d postWPP    8 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    12 adult male 30day    13 adult female 01day    14 adult female 05day    14 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    4 embryonic GM2    6 embryonic Kc167    6 embryonic S1    5 embryonic S3    3 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    4 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    5 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    2 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    4 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1839-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Fbxl4e02322 Fbxl4f04022 viable, with Scer\GAL4pnr-MD237 Fbxl4GD5204 Sterility Allele fertile Fbxl4e02322 Fbxl4f04022 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Fbxl4 Class Mutagen Stocks Known lesion Fbxl4e02322 piggyBac transposase 2 -- Fbxl4f04022 piggyBac transposase 2 -- Fbxl4f05794 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fbxl4 Class Mutagen Stocks Known lesion Fbxl4GD5204 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Fbxl4JF01323 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fbxl4hs.PH in vitro construct - regulatory fusion 0 Yes Fbxl4KK102053 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Fbxl4trp.PH in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5204} NA P{KK102053} NA P{TRiP.JF01323} NA heat-shock construct P{hs-Fbxl4.H} NA characterization construct P{trp-Fbxl4.H} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Fbxl4e02322 NA PBac{WH}Fbxl4f04022 NA PBac{WH}Fbxl4f05794 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
deactivation of rhodopsin mediated signaling inferred from genetic interaction with Camta (Han et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fbxl4 allele Gene References unspecified Camta (Han et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0030555 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32378
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PG6KD Dipteran inclusive ortholog search EOG6J9N72 Insect inclusive ortholog search EOG6J9KTX Arthropod inclusive ortholog search EOG6573NM Metazoa inclusive ortholog search EOG61ZT3V
Orthologs in Drosophila Species (EOG6PG6KD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fbxl4     Drosophila simulans   Dsim\GD15856 Y   Drosophila sechellia   Dsec\GM17562 Y   Drosophila erecta   Dere\GG19464 Y   Drosophila yakuba   Dyak\GE16119 Y   Drosophila ananassae   Dana\GF15988 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14916 Y   Drosophila persimilis   Dper\GL13001 Y   Drosophila persimilis   Dper\GL26962     Drosophila willistoni   Dwil\GK24976 Y   Drosophila virilis   Dvir\GJ19097 Y   Drosophila mojavensis   Dmoj\GI15977 Y   Drosophila grimshawi   Dgri\GH11799 Y
Orthologs in non-Drosophila Dipterans (EOG6J9N72)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011921   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014330   Anopheles gambiae Malaria mosquito  Agam\AGAP000471   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801634
Orthologs in non-Dipteran Insects (EOG6J9KTX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51964   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011408   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10007   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20262   Atta cephalotes Leafcutter ant  Acep\ACEP12432   Atta cephalotes Leafcutter ant  Acep\ACEP12228   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12933   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15284   Linepithema humile Argentine ant  Lhum\LH20693   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22993   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16200   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16779   Solenopsis invicta Red fire ant  Sinv\SINV13697   Solenopsis invicta Red fire ant  Sinv\SINV17196   Solenopsis invicta Red fire ant  Sinv\SINV21712   Solenopsis invicta Red fire ant  Sinv\SINV11753   Solenopsis invicta Red fire ant  Sinv\SINV22021   Solenopsis invicta Red fire ant  Sinv\SINV17254   Solenopsis invicta Red fire ant  Sinv\SINV17200   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006333   Bombyx mori Silkmoth  Bmor\BGIBMGA005238   Pediculus humanus Human body louse  Phum\PHUM257210   Tribolium castaneum Red flour beetle  Tcas\TC005799
Orthologs in non-Insect Arthropods (EOG6573NM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI
Orthologs in non-Arthropod Metazoa (EOG61ZT3V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\fbxl4   Xenopus tropicalis Western clawed frog  Xtro\fbxl4   Gallus gallus Domestic chicken  Ggal\FBXL4   Mus musculus House mouse  Mmus\Fbxl4   Rattus norvegicus Norway rat  Rnor\Fbxl4   Homo sapiens Human  Hsap\FBXL4
Human Orthologs (1)
Gene OMIM HGNC Hsap\FBXL4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15856 Drosophila sechellia Dsec\GM17562 Drosophila erecta Dere\GG19464 Drosophila yakuba Dyak\GE16119 Drosophila ananassae Dana\GF15988 Drosophila pseudoobscura pseudoobscura Dpse\GA14916 Drosophila persimilis Dper\GL13001 Drosophila willistoni Dwil\GK24976 Drosophila virilis Dvir\GJ19097 Drosophila mojavensis Dmoj\GI15977 Drosophila grimshawi Dgri\GH11799
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	18041 w1118 PBac{RB}Fbxl4e02322 18725 w1118 PBac{WH}Fbxl4f04022 31363 y1 v1; P{TRiP.JF01323}attP2
Harvard	- PBac{RB}Fbxl4e02322 - PBac{WH}Fbxl4f04022 - PBac{WH}Fbxl4f05794
VDRC	v15475 w1118; P{GD5204}v15475 v15476 w1118; P{GD5204}v15476
Genomic Clones ( 1 )
	BACR12J05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11272
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM07426 LD03027 LD18653 LD31231 RE65778 RE68747 RH26604 RH27605 RH28040 RH39633 RH41554 RH43329 RH48516 RH54005 RH56169 RH60507 RH67444 RH70332
Other clones	5114 42734 73295 100383 192017 214213.14 214287.8 CK01.106D.D12 Dmel_neb_014447_0578_1089 EK089148 EK123926 EK157647 EK202563 EK222811 EK295717 EP09064 EP13249 HL02957
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0030555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32378
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Fbxl4 CG1839 (Han et al., 2006)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132723 RefSeq (Proteins) • NP_572951 DDBJ / EMBL / GenBank • AAF48359 AAL39238 AI133962 AI402255 AY069093 CZ480146 CZ486608 CZ486609 CZ488421 CZ488422 Entrez Gene - A searchable database of RefSeq genes. • 32378 UniProtKB/TrEMBL • Q9VY46
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • F-box domain, cyclin-like (IPR001810)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0030555 DRSC - Results from RNAi screens. • FBgn0030555 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0030555 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1839-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0030555 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32378 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32378 modMine - Data generated by the modENCODE project. • FBgn0030555
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG1839 (Yang et al., 2005, Han et al., 2006, Ni et al., 2008, Roberts et al., 2012, Keleman et al., 2009.8.5) dFbxl4 (Han et al., 2006, Gong et al., 2007) Fbxl4   FBXL4 (Roberts et al., 2012)
Name Synonym	CG1839 (Yang et al., 2005, ) F box and leucine-rich-repeat gene 4 (Han et al., 2006)
Secondary FlyBase IDs
References ( 19 )
Research paper	Dui et al., 2012, J. Genet. Genomics 39(8): 397--413 A Systematic Phenotypic Screen of F-box Genes Through a Tissue-specific RNAi-based Approach in Drosophila. [FBrf0219135] Roberts et al., 2012, PLoS ONE 7(2): e31284 Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development. [FBrf0217546] Ni et al., 2008, Nat. Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406] Gong et al., 2007, J. Biol. Chem. 282(29): 21253--21258 A potential dimerization region of dCAMTA is critical for termination of fly visual response. [FBrf0200865] Han et al., 2006, Cell 127(4): 847--858 The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor. [FBrf0192912] Yang et al., 2005, Nucleic Acids Res. 33(17): e148 Isolation of mRNA from specific tissues of Drosophila by mRNA tagging. [FBrf0191351] Jin et al., 2004, Genes Dev. 18(21): 2573--2580 Systematic analysis and nomenclature of mammalian F-box proteins. [FBrf0182983] Xu et al., 2004, EMBO J. 23(4): 811--822 A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. [FBrf0174603] Das et al., 2002, Dev. Genes Evol. 212(3): 134--140 A conserved F-box gene with unusual transcript localization. [FBrf0148953]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Ou et al., 2003, Trends Genet. 19(7): 382--389 Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. [FBrf0160832]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]